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Duodecim; laaketieteellinen aikakauskirja最新文献

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Biobanks and Comprehensive Cancer Center Finland (FICAN) as institutions enabling clinical drug testing. 生物银行和芬兰综合癌症中心(FICAN)作为临床药物测试的机构。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Olli Carpén, Tuula Helander
{"title":"Biobanks and Comprehensive Cancer Center Finland (FICAN) as institutions enabling clinical drug testing.","authors":"Olli Carpén,&nbsp;Tuula Helander","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical trials aiming at developing targeted drug therapies require the identification of appropriate patient groups, utilizing both clinical information and the biological profile of the disease. The Finnish healthcare system provides exceptional possibilities for utilizing health data in identifying patient groups, planning of clinical sample studies and recruiting patients. Biobanks established at university hospitals together with the regional cancer centers play a central role in collecting biological specimens and attaching health data to the specimens. Combined with longitudinal health data, the collections of tissue specimens obtained in connection with the diagnosis offer versatile possibilities for the development of companion diagnostics of targeted drugs. Specimens collected on the basis of informed consent in connection with diagnosis and treatment enable the identification of patients suitable for drug trials, and a contact according to the consent. In the development of new functions, national collaboration - both geographical and between research infrastuctures - becomes of paramount importance. Combining the resources of biobanks, the genome strategy and the Comprehensive Cancer Center, an enabling legislation and, above all, patients with a positive attitude towards examinations, offer excellent possibilities for Finland to become the model country of individualized treatment.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disordered eating behavior in boys of draft age - the population-based MOPO study. 应征年龄男孩饮食行为紊乱——基于人群的MOPO研究。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Marjukka Nurkkala, Raija Korpelainen, Anna-Maria Teeriniemi, Sirkka Keinänen-Kiukaanniemi, Marja Vanhala
{"title":"Disordered eating behavior in boys of draft age - the population-based MOPO study.","authors":"Marjukka Nurkkala,&nbsp;Raija Korpelainen,&nbsp;Anna-Maria Teeriniemi,&nbsp;Sirkka Keinänen-Kiukaanniemi,&nbsp;Marja Vanhala","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Eating disorders in boys are poorly detected in health care.</p><p><strong>Material and methods: </strong>Among 922 boys attending evaluation for military service in Oulu, In 2013, disordered eating behavior was assessed by the SCOFF and Eating Disorder Inventory questionnaires (Drive fir thinness and Bulimia).</p><p><strong>Results: </strong>Disordered eating behavior was present in 129 (14%) boys, of whom 57 (44%) were overweight. Every fourth overweight by had symptoms of eating disorders, typically constant thoughts of weight loss.</p><p><strong>Conclusions: </strong>Screening of eating disorders should be included in medical examinations, especially in overweight boys.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35217612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Entrustable professional activity (EPA) reshapes the practice of specialist training. 委托专业活动(EPA)重塑了专业培训的实践。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Leila Niemi-Murola
{"title":"Entrustable professional activity (EPA) reshapes the practice of specialist training.","authors":"Leila Niemi-Murola","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In addition to medical expertise, competence-based medical training comprises communication and collaboration skills, professionalism, and leadership skills. Continuous feedback is essential for learning and development, and feedback only from the medical specialist examination taken in the end of training does not ensure thorough specialist training. Entrustable professional activity (EPA) is a unit of professional practice, defined as tasks or responsibilities typical of the specialty. EPA translates competence-based training into manageable and meaningful entities and provides tools for the evaluation of medical competence.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35217614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthy habits - healthy brain. 健康的习惯——健康的大脑。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Timo Strandberg, Miia Kivipelto
{"title":"Healthy habits - healthy brain.","authors":"Timo Strandberg,&nbsp;Miia Kivipelto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A multifactorial memory disease with old-age onset forms a continuum having at one end a \"clear\" Alzheimer-type form, with a pathophysiology involving a central role played by the accumulation of amyloid protein, and a purely arterial disease at the other end. Most of the cases exhibit a mixed form. As the options of prevention of arterial diseases are well known, this will also provide possibilities for extensive prevention of memory diseases. Central measures include physical activity, a healthy diet and intervention in risk factors - early enough, of course. What is good for the heart is generally good for the brain as well.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35223667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on current care guideline: Cytological changes in the cervix, vagina and vulva. 当前护理指南的更新:宫颈、阴道和外阴的细胞学变化。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
{"title":"Update on current care guideline: Cytological changes in the cervix, vagina and vulva.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Annually approximately 160 new cervical cancers are diagnosed in Finland. Screening has decreased both incidence and mortality by 80%. Both primary HPV-testing and Pap smear can be used in screening. In the future HPV vaccination will decrease the number of cervical cancers. Abnormal findings in Pap smears indicate management. LSIL lesions are followed up especially among young women and HSIL lesions treated. Follow-up after treatment should be reliably arranged, because increased risk of cancer remains ever after treatment.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35223669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance of gene defects in B-cell lymphomas. b细胞淋巴瘤基因缺陷的临床意义。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Annika Pasanen, Leo Meriranta, Sirpa Leppä
{"title":"Clinical significance of gene defects in B-cell lymphomas.","authors":"Annika Pasanen,&nbsp;Leo Meriranta,&nbsp;Sirpa Leppä","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphomas are a heterogenous group of malignant diseases. Identification of sub-groups has created pressure for a more detailed diagnosis and individualized treatment. Although the underlying genetic and molecular pathologic factors of the most common B-cell derived lymphomas, i.e. diffuse large B-cell lymphoma and follicular lymphoma, have become more accurate, prognosis is evaluated and treatment options still selected mainly on the basis of clinical variables. In the future, new generation sequencing methods that are becoming more common in clinical practice will allow the assessment of prognosis and treatment on the basis of biologic and genetic risk factors. To achieve this both comprehensive basic research and clinical drug trials taking the pathogenesis of different diseases into consideration are required.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35655440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health promotion among the population of foreign origin in Finland involves special issues. 在芬兰外籍人口中促进健康涉及一些特殊问题。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Anu E Castaneda, Hannamaria Kuusio, Natalia Skogberg, Karolina Tuomisto, Sinikka Kytö, Emmi Salmivuori, Satu Jokela, Johanna Mäki-Opas, Tiina Laatikainen, Päivikki Koponen
{"title":"Health promotion among the population of foreign origin in Finland involves special issues.","authors":"Anu E Castaneda,&nbsp;Hannamaria Kuusio,&nbsp;Natalia Skogberg,&nbsp;Karolina Tuomisto,&nbsp;Sinikka Kytö,&nbsp;Emmi Salmivuori,&nbsp;Satu Jokela,&nbsp;Johanna Mäki-Opas,&nbsp;Tiina Laatikainen,&nbsp;Päivikki Koponen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The population of foreign origin in Finland is a heterogenic group, diverse for example with respect to reasons for and age at migration. While migration to Finland is a recent phenomenon, the size of the population of foreign origin has grown rapidly and will continue to increase. Changes in the population structure need to be taken into account in health promotion. For example lifestyle, health status, functional capacity, mental health, infectious diseases and reproductive health differ in foreign origin population compared with the general Finnish population. These differences may provide opportunities but also create challenges for service provision and health promotion planning.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35655503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathogenesis of age-related macular degeneration - dialogue between autophagy and inflammasomes] . 年龄相关性黄斑变性的发病机制——自噬与炎性小体之间的对话。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Niko Kivinen, Ali Koskela, Anu Kauppinen, Kai Kaarniranta
{"title":"[Pathogenesis of age-related macular degeneration - dialogue between autophagy and inflammasomes] .","authors":"Niko Kivinen,&nbsp;Ali Koskela,&nbsp;Anu Kauppinen,&nbsp;Kai Kaarniranta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Age-related macular degeneration is a condition affecting central vision, and is the leading cause of blindness and visual impairment in the western countries. For a long time, inflammation has been associated with the pathogenesis of the condition, and according to current knowledge, inflammation in the retinal pigment epithelial cells (RPE) results from an impairment of intracellular cleansing systems. In combination with the degeneration of RPE cells, this eventually leads to the destruction of light-sensing cells. By influencing the accumulation or elimination of waste material or the inflammatory reaction following its accumulation we may in the future possibly slow the progression of the disease or, in the best case, even cure it.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FOUR score in monitoring the level of consciousness of an intensive care patient: first experience of the use of the Finnish language version. 监测重症监护病人意识水平的4分:第一次使用芬兰语版本的经验。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Atte Sivula, Teemu Luoto, Jani Heinilä, Heini Huhtala, Sari Karlsson, Arvi Yli-Hankala, Jaakko Långsjö
{"title":"FOUR score in monitoring the level of consciousness of an intensive care patient: first experience of the use of the Finnish language version.","authors":"Atte Sivula,&nbsp;Teemu Luoto,&nbsp;Jani Heinilä,&nbsp;Heini Huhtala,&nbsp;Sari Karlsson,&nbsp;Arvi Yli-Hankala,&nbsp;Jaakko Långsjö","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The goal was to increase the knowledge of Full Outline of UnResponsiveness (FOUR) score in Finland, release its Finnish version and to evaluate its usefulness in Finnish ICU patients.</p><p><strong>Materials and methods: </strong>The highest FOUR and Glasgow Coma Scale (GCS) scores of the adult ICU patients treated in Tampere University Hospital between 1st January and 31st October 2015 were analyzed retrospectively. In-hospital and 1-month mortality were the primary end-points.</p><p><strong>Results: </strong>The Finnish version of FOUR performed comparably to previous studies. The ability of FOUR to predict mortality was equal to GCS.</p><p><strong>Conclusions: </strong>FOUR is at least equal to GCS in predicting mortality of ICU patients.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35659173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of proximal humerus fractures in the elderly. 老年人肱骨近端骨折的治疗。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Antti P Launonen, Bakir O Sumrein, Vesa Lepola
{"title":"Treatment of proximal humerus fractures in the elderly.","authors":"Antti P Launonen,&nbsp;Bakir O Sumrein,&nbsp;Vesa Lepola","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A proximal humerus fracture typically occurs when an elderly woman falls directly onto her shoulder or on her outstretched arm. Local pain in the shoulder and immobility of the upper arm raise a suspicion of a significant injury. Other bone and tendon injuries in the shoulder region as well as dislocation of the shoulder should be considered on differential diagnosis. Diagnosis is achieved by plain X-ray. Most fractures can be treated conservatively. Consultation with an orthopedist is needed, if there are several fracture fragments with extensive dislocation.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35310768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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