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Duodecim; laaketieteellinen aikakauskirja最新文献

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Drip-and-ship stroke thrombolysis in the emergency department of a healthcare center - a possibility for those fallen ill in rural settings. 医疗中心急诊科的点滴和船式卒中溶栓——对那些在农村环境中生病的人来说是一种可能性。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Joonas H Kauppila, Lasse Raatiniemi, Juha-Matti Isokangas, Matti Martikainen, Katja Piironen
{"title":"Drip-and-ship stroke thrombolysis in the emergency department of a healthcare center - a possibility for those fallen ill in rural settings.","authors":"Joonas H Kauppila,&nbsp;Lasse Raatiniemi,&nbsp;Juha-Matti Isokangas,&nbsp;Matti Martikainen,&nbsp;Katja Piironen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thrombolysis with tissue plasminogen activator is the mainstay in the treatment of acute stroke. Reducing the delay of thrombolysis treatment improves patient prognosis and reduces the incidence of complications. Variable telestroke regimens have improved the availability of stroke thrombolysis, especially in rural settings, where neurologists are not readily available. In the drip-and-ship strategy, stroke thrombolysis is initiated in a peripheral hospital and the patient is then transferred to a tertiary care unit. We report the first case of drip-and-ship stroke thrombolysis in a rural health care center in Northeastern Finland.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 2","pages":"167-71"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35223666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketamine as treatment for depression. 氯胺酮治疗抑郁症。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Tero Taiminen
{"title":"Ketamine as treatment for depression.","authors":"Tero Taiminen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ketamine infusions administered intravenously 1 to 3 times per week are the quickest and most effective treatment for depression. Short-course ketamine medication is established treatment both for unipolar depression and depressive episodes of bipolar affective disorder. Ketamine is suitable for initiating the treatment for treatment-resistant depression, alleviation of suicidal tendencies, and treatment of depressive patients suffering from simultaneous pain. The safety of prolonged treatment with ketamine is not known to sufficient degree. However, even long periods (up to 1.5 years) of ketamine treatment have not been associated with adverse effects. It would be appropriate to use short-course ketamine treatment more often than is currently done.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 1","pages":"52-60"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35306327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postpericardiotomy syndrome. Postpericardiotomy综合症。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Joonas Lehto, Juha Virolainen
{"title":"Postpericardiotomy syndrome.","authors":"Joonas Lehto,&nbsp;Juha Virolainen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery. In most cases it develops 2 to 3 weeks after the operation. An inflammatory reaction develops in the pericardium or pleural space with fever, chest pain and dyspnea as typical symptoms. The disease process is usually self-limiting. At present, the etiology is unknown, but an immunological mechanism is suspected as the cause of the disease. The incidence of PPS is essentially dependent on diagnostic criteria, patient group and type of operation. Treatment is carried out with anti-inflammatory analgesics, combined with colchicine in more severe cases.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 4","pages":"411-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35310778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-resolution CT of the lungs: Indications and diagnosis. 肺的高分辨率CT:适应症和诊断。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Helena Lauri
{"title":"High-resolution CT of the lungs: Indications and diagnosis.","authors":"Helena Lauri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>High-resolution computed tomography (HRCT) is a method of examination which is more precise than chest 2-rat in the diagnosis and monitoring of diseases of the lung tissue and the airways. Modern CT equipment enables a volume HRCT scan covering the whole lung tissue. HRCT slices can also be constructed from contrast-enhanced CT scans of the chest of the whole body. HRCT of the lungs can be applied to the diagnosis of both acute and more chronic diffuse diseases of the lung tissue and the airways. The best-known indications for HRCT include idiopathic interstitial pneumonias, such as idiopathic pulmonary fibrosis. High-resolution computed tomography has also become established in the diagnostics of pneumoconiosis, such as asbestosis. More acute indications for HRCT include various inflammations, drug reactions and diffuse alveolar injury. Medical history plays a central role in the interpretation of lung HRCT, because a finding in imaging examination is often unspecific. A good test requisition is therefore important.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 6","pages":"549-56"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages and cancer. 巨噬细胞与癌症。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Marko Salmi
{"title":"Macrophages and cancer.","authors":"Marko Salmi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Macrophages are an important type of white blood cells in the dialogue between inflammatory response and cancer. Macrophages can maintain a chronic inflammatory state that predisposes to the development of cancer. In the tumor, macrophages phagocytose and kill cancer cells directly and promote the generation of antitumoral cytotoxic lymphocyte response. Cancer cells, however, often modulate the functions of macrophages in several ways to promote tumor progression. Such protumoral macrophages increase neovascularization, produce molecules promoting the growth and dissemination of cancer cells, and suppress antitumoral immune responses. Hence, abundant macrophage infiltration correlates with poor prognosis in most types of cancer. Many cancer treatments also affect the antitumoral properties of macrophages. New drugs are developed to reduce the accumulation of macrophages into malignant tissue and to re-educate pro-tumoral macrophages to anti-tumoral macrophages and some of these drugs have already entered clinical trials.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 9","pages":"829-37"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35655437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Care Guideline: Heart failure. 当前护理指南:心力衰竭。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
{"title":"Current Care Guideline: Heart failure.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Treatment of heart failure depends on etiology, left ventricular function and severity of symptoms. Appropriate diagnosis and treatment requires close collaboration between health care providers. In heart failure with reduced ejection fraction, pharmacological treatment and device therapies are based on solid scientific evidence. Less data exist on treatment of heart failure with preserved ejection fraction, where management of underlying diseases contributing to the syndrome is the primary goal. Patient education and self-care may reduce the need for hospitalizations and improve quality of life. Physical exercise reduces symptoms and improves exercise tolerance.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 9","pages":"893-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammations of the mammary gland. 乳腺炎症乳腺的炎症
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Tuomo Meretoja, Hanna Ihalainen, Marjut Leidenius
{"title":"Inflammations of the mammary gland.","authors":"Tuomo Meretoja,&nbsp;Hanna Ihalainen,&nbsp;Marjut Leidenius","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Breast inflammation, i.e. mastitis is an entity with a variable etiology and severity, typically affecting women of fertile age. In most cases, anamnesis reveals the etiology of the disease, bacterial puerperal mastitis associated with breastfeeding being the most common. Periductal mastitis is a breast inflammation typically associated with smoking in women of 40 to 50 years of age, localized to the region of the areola. Granulomatous mastitis and other rare breast inflammations usually require specialized care. Regardless of etiology, treatment of acute inflammation depends on the clinical picture and, with the exception of puerperal mastitis, emergency ultrasound imaging is often necessary in order to detect an abscess and drain it. In all cases of mastitis, the possibility of underlying malignancy as well as inflammatory breast cancer should be kept in mind. If specialized care is required, breast inflammation is treated in a breast, general or plastic surgery unit.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 9","pages":"855-61"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Care Guideline: Age-related macular degeneration (AMD). 当前护理指南:年龄相关性黄斑变性(AMD)。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
{"title":"Current Care Guideline: Age-related macular degeneration (AMD).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Age-related macular degeneration (AMD) is the main cause of visual impairment in developed countries. Several improvements in the visualization of posterior segment of the eye together with the introduction of intravitreal anti-VEGF treatment have revolutionized the prognosis of the wet form of AMD (wAMD). Increasing incidence of wAMD together with the limited resources of the healthcare systems pose challenges for the provision and development of care. In context of these current aspects, we aim to set evidence-based guidelines for diagnosis, treatment and follow-up of patients with wAMD.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 4","pages":"379-80"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35310771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traumatic hip dislocation in pediatric patients. 小儿外伤性髋关节脱位。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Antti Stenroos, Topi Laaksonen, Yrjänä Nietosvaara
{"title":"Traumatic hip dislocation in pediatric patients.","authors":"Antti Stenroos,&nbsp;Topi Laaksonen,&nbsp;Yrjänä Nietosvaara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Traumatic hip dislocations constitute approximately 5% of all pediatric dislocations and typically result from high-energy trauma. However, pediatric hip dislocations can also occur as a result of minor energy due to flexibility of the joint structures of the immature hip. Children with a posteriorly dislocated hip present with the injured hip in flexion, adduction and internal rotation. Spontaneous relocation of hip dislocation is frequent and a thorough physical examination of the whole lower extremity is always required to reduce the chance of missing hip dislocation/subluxation. Dislocated hips should be emergently repositioned under general anesthesia. MRI is indicated after reduction and in patients after spontaneous relocation if labral interposition is suspected in plain radiographs.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 8","pages":"749-52"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finland establishing the internet of genomics and health data. 芬兰正在建立基因组学和健康数据互联网。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Aarno Palotie, Samuli Ripatti
{"title":"Finland establishing the internet of genomics and health data.","authors":"Aarno Palotie,&nbsp;Samuli Ripatti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Genomic data, i.e. measurement of variation in the complete genome has revolutionized genetic research and changed our understanding of the pathogenetic mechanisms of diseases. Genomic data in combination with Finnish special strengths - population history, the nation's comprehensive health records and a strong research tradition in genetic epidemiology - has made Finland a testing laboratory for diseases of public health importance. At the same time, genomic research has changed into statistical evaluation of large masses of data - big data. New research knowledge is now descending to the prevention and treatment of diseases, and this will affect future medical practices. In this reform, Finland has a chance to be a key player. The change is, however, global, and the world will not wait that Finland is ready, but instead we have to take care of it ourselves. When successful, new kind of research will help better allocate health care resources, provide more individualized care and stimulate businesses based on new technology.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 8","pages":"771-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35656024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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