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Drug discovery today. Disease mechanisms最新文献

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Regulation of pathogen metabolism by small RNA 小RNA对病原体代谢的调控
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.09.001
Kristine B. Arnvig, Douglas B. Young
{"title":"Regulation of pathogen metabolism by small RNA","authors":"Kristine B. Arnvig,&nbsp;Douglas B. Young","doi":"10.1016/j.ddmec.2010.09.001","DOIUrl":"10.1016/j.ddmec.2010.09.001","url":null,"abstract":"<div><p><span>There is a growing appreciation of the important role of small RNA<span> (sRNA) molecules in post-transcriptional regulation of bacterial gene<span> expression. sRNA transcripts are encoded within intergenic regions or in antisense orientation to mRNA transcripts, and sRNA regulation plays a central role in the response to stress stimuli encountered by pathogens during infection. We discuss the potential importance of sRNA in the pathogenesis of </span></span></span><span><em>Mycobacterium tuberculosis</em></span>.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e19-e24"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77729675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The role of mycobacterial lipids in host pathogenesis 分枝杆菌脂质在宿主发病机制中的作用
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.09.003
Catherine Astarie-Dequeker, J. Nigou, C. Passemar, C. Guilhot
{"title":"The role of mycobacterial lipids in host pathogenesis","authors":"Catherine Astarie-Dequeker,&nbsp;J. Nigou,&nbsp;C. Passemar,&nbsp;C. Guilhot","doi":"10.1016/j.ddmec.2010.09.003","DOIUrl":"10.1016/j.ddmec.2010.09.003","url":null,"abstract":"<div><p><span>Several mycobacteria are remarkably successful human pathogens that cause wellknown infections such as tuberculosis and leprosy or emerging diseases such as </span><span><em>Buruli ulcer</em></span><span><span>. On encountering the virulent mycobacteria, the host develops a strong immune response which is dedicated to combat the invasion while bacilli have evolved several strategies to counteract and adapt to this hostile environment. Being positioned at the bacterial surface, mycobacterial </span>lipids contribute to the interplay between host and pathogen. This review will briefly discuss some unusual mycobacterial lipids that have been identified, focusing on their immunomodulatory properties.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e33-e41"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89035040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Mechanisms underlying mycobacterial infections 分枝杆菌感染的机制
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.09.005
Helena I Boshoff, Kapil Tahlan
{"title":"Mechanisms underlying mycobacterial infections","authors":"Helena I Boshoff,&nbsp;Kapil Tahlan","doi":"10.1016/j.ddmec.2010.09.005","DOIUrl":"10.1016/j.ddmec.2010.09.005","url":null,"abstract":"","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e1-e3"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29465394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Systems biology approaches to understanding mycobacterial survival mechanisms 了解分枝杆菌生存机制的系统生物学方法
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.09.008
Helena I.M. Boshoff , Desmond S. Lun
{"title":"Systems biology approaches to understanding mycobacterial survival mechanisms","authors":"Helena I.M. Boshoff ,&nbsp;Desmond S. Lun","doi":"10.1016/j.ddmec.2010.09.008","DOIUrl":"10.1016/j.ddmec.2010.09.008","url":null,"abstract":"<div><p>The advent of high-throughput platforms for the interrogation of biological systems at the cellular and molecular levels has allowed living cells to be observed and understood at a hitherto unprecedented level of detail and has enabled the construction of comprehensive, predictive <em>in silico</em><span> models. Here, we review the application of such high-throughput, systems-biological techniques to mycobacteria – specifically to the pernicious human pathogen </span><span><em>Mycobacterium tuberculosis</em></span><span><span> (MTb) and its ability to survive in human hosts. We discuss the development and application of transcriptomic, </span>proteomic<span>, regulomic, and metabolomic techniques for MTb as well as the development and application of genome-scale </span></span><em>in silico</em> models. Thus far, systems-biological approaches have largely focused on <em>in vitro</em> models of MTb growth; reliably extending these approaches to <em>in vivo</em> conditions relevant to infection is a significant challenge for the future that holds the ultimate promise of novel chemotherapeutic interventions.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e75-e82"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29465395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis 针对ESX-1介导的结核分枝杆菌发病机制的抗毒药物研究
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.09.002
Jeffrey M. Chen , Florence Pojer , Benjamin Blasco, Stewart T. Cole
{"title":"Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis","authors":"Jeffrey M. Chen ,&nbsp;Florence Pojer ,&nbsp;Benjamin Blasco,&nbsp;Stewart T. Cole","doi":"10.1016/j.ddmec.2010.09.002","DOIUrl":"10.1016/j.ddmec.2010.09.002","url":null,"abstract":"<div><p>The control of tuberculosis (TB) in humans is heavily reliant on short course chemotherapy yet this intervention is increasingly menaced by widespread multi- and extensively drug resistant strains of <span><em>Mycobacterium tuberculosis</em></span><span>. New druggable targets and novel leads are required for TB drug discovery<span> to develop compounds with greater potency, and that are less prone to acquired drug resistance. As such, the concept of blocking the secretion of virulence proteins and modulating their effect with small molecules has gained increasing attention in recent years. Here, we propose targeting the principal virulence determinant of </span></span><em>M. tuberculosis</em><span>, the ESX-1 protein secretion<span> system and its downstream effects, to discover new drugs and augment the dwindling armoury of effective antitubercular agents.</span></span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e25-e31"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81491018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Transmission of MDR tuberculosis 耐多药结核病的传播
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.09.006
Qian Gao, Xia Li
{"title":"Transmission of MDR tuberculosis","authors":"Qian Gao,&nbsp;Xia Li","doi":"10.1016/j.ddmec.2010.09.006","DOIUrl":"10.1016/j.ddmec.2010.09.006","url":null,"abstract":"<div><p>Transmission of drug-resistant tuberculosis, especially multidrug-resistant tuberculosis and extensive drug-resistant tuberculosis is an important public health problem worldwide, particularly in high TB burden developing countries. DOTS does help by providing effective treatment but needs to be supplemented with aggressive case finding. A simple and efficient way to reduce the transmission of drug-resistant TB is urgently needed. Efficient rapid diagnostic techniques, aggressive case finding and improved patient management and optimized treatment need help to reduce community transmission of drug-resistant TB.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e61-e65"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77676471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Resuscitation promoting factors in bacterial population dynamics during TB infection 结核病感染期间细菌种群动态的复苏促进因素
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.08.003
Bavesh D. Kana, Valerie Mizrahi
{"title":"Resuscitation promoting factors in bacterial population dynamics during TB infection","authors":"Bavesh D. Kana,&nbsp;Valerie Mizrahi","doi":"10.1016/j.ddmec.2010.08.003","DOIUrl":"10.1016/j.ddmec.2010.08.003","url":null,"abstract":"<div><p><span><em>Mycobacterium tuberculosis</em></span><span><span> has five resuscitation promoting factors (Rpfs) which have been implicated in virulence and resuscitation from dormancy, possibly through cleavage of the β-1,4 glycosidic bond<span> in peptidoglycan. Several possibilities exist for the role of these factors in influencing bacterial population dynamics, during active and latent tuberculosis infection, by the stimulation of bacterial growth through re-modeling of peptidoglycan. As such, the Rpfs may represent an interesting new class of cell wall targets for tuberculosis </span></span>drug discovery.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e13-e18"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86592545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The role of DNA repair in M. tuberculosis pathogenesis DNA修复在结核分枝杆菌发病机制中的作用
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/j.ddmec.2010.08.002
Digby F. Warner
{"title":"The role of DNA repair in M. tuberculosis pathogenesis","authors":"Digby F. Warner","doi":"10.1016/j.ddmec.2010.08.002","DOIUrl":"10.1016/j.ddmec.2010.08.002","url":null,"abstract":"<div><p><span><em>Mycobacterium tuberculosis</em></span> is exposed to multiple genotoxic stresses during host infection. Although crucial for bacillary survival and strain evolution, including the emergence of drug resistance, the mechanisms governing genome maintenance and DNA damage tolerance in <em>M. tuberculosis</em> remain poorly understood. This review highlights evidence for the roles of the major DNA repair pathways in mycobacterial pathogenesis and considers their potential identification as targets for novel compounds, especially those designed to inhibit the evolution of resistance.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e5-e11"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73143075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Contents page. 内容页面。
Drug discovery today. Disease mechanisms Pub Date : 2010-03-01 DOI: 10.1016/S1740-6765(10)00032-5
{"title":"Contents page.","authors":"","doi":"10.1016/S1740-6765(10)00032-5","DOIUrl":"https://doi.org/10.1016/S1740-6765(10)00032-5","url":null,"abstract":"","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Page i"},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1740-6765(10)00032-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138203089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mitochondria as composer, conductor and orchestrator in the pathophysiology of systemic diseases 线粒体在全身性疾病的病理生理学中扮演作曲家、指挥家和指挥家的角色
Drug discovery today. Disease mechanisms Pub Date : 2009-01-01 DOI: 10.1016/j.ddmec.2010.04.001
Michael N. Sack, Paul M. Hwang
{"title":"The mitochondria as composer, conductor and orchestrator in the pathophysiology of systemic diseases","authors":"Michael N. Sack,&nbsp;Paul M. Hwang","doi":"10.1016/j.ddmec.2010.04.001","DOIUrl":"10.1016/j.ddmec.2010.04.001","url":null,"abstract":"","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"6 1","pages":"Pages e1-e2"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82659358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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