Drug discovery today. Disease mechanisms最新文献

WITHDRAWN: Novel Immunological Targets in Rheumatic Diseases: Clues from Current Therapies 撤回:风湿病的新免疫靶点:来自当前治疗的线索

Drug discovery today. Disease mechanisms Pub Date : 2014-03-12 DOI: 10.1016/J.DDMEC.2013.09.002

F. D’Acquisto, L. Rattazzi, Giuseppa Piras, Maria Letteria Galuppo

引用次数: 0

Skin cancer viruses: bench to bedside – HPV, HHV8 and Merkel cell carcinoma virus 皮肤癌病毒:从实验室到床边- HPV, HHV8和默克尔细胞癌病毒

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.05.001

Mathew Hughes, Ling Gao

引用次数: 4

Genetic bases and pathogenic mechanisms of nephronophthisis 肾病的遗传基础和致病机制

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.10.001

Marion Delous , Helori M. Gaudé , Sophie Saunier

引用次数: 4

Molecular testing in the diagnosis of melanocytic tumors 分子检测在黑色素细胞肿瘤诊断中的应用

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.05.002

Jeffrey P. North

{"title":"Molecular testing in the diagnosis of melanocytic tumors","authors":"Jeffrey P. North","doi":"10.1016/j.ddmec.2013.05.002","DOIUrl":"10.1016/j.ddmec.2013.05.002","url":null,"abstract":"<div>Fluorescent in situ hybridization (FISH) and comparative genomic hybridization (CGH) are molecular techniques that have become valuable adjuncts in the diagnosis of histopathologically ambiguous melanocytic tumors. These techniques detect the presence of chromosomal gains or losses that are characteristic of malignant transformation in melanocytic neoplasms. CGH and FISH have been used to characterize distinct genomic characteristics of melanocytic tumors at various anatomic sites and tumors with certain histopathologic features (e.g. spitzoid, blue nevus-like, congenital nevi). Recent developments in this field include the transition of CGH from a research tool to a clinically available test and a new FISH probe set targeting chromosomal loci 11q13, 8q24, 6p25 and 9p21 that reportedly distinguishes melanoma from melanocytic nevi with a sensitivity and specificity of 94% and 98% respectively. Genomic analysis of melanocytic tumors also provides prognostic information. This review discusses these new advances in molecular diagnostics in melanoma and future directions in the field.</div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"10 3","pages":"Pages e107-e112"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2013.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86947558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

State-of-the art approaches to understanding diseases of the skin 用最先进的方法来了解皮肤疾病

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.09.001

Eric L. Simpson, Howard Maibach

引用次数: 0

STAT3 signaling in polycystic kidney disease STAT3信号在多囊肾病中的作用

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.03.001

Thomas Weimbs , Jeffrey J. Talbot

引用次数: 27

Understanding itch in skin disease 了解皮肤疾病中的瘙痒

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.02.002

Mikael David Langner, Martin Steinhoff

引用次数: 1

Planar cell polarity (PCP) and Wnt signaling in renal disease 平面细胞极性(PCP)和Wnt信号在肾脏疾病中的作用

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.12.001

Athina Ganner, Soeren Lienkamp, Gerd Walz

{"title":"Planar cell polarity (PCP) and Wnt signaling in renal disease","authors":"Athina Ganner, Soeren Lienkamp, Gerd Walz","doi":"10.1016/j.ddmec.2013.12.001","DOIUrl":"10.1016/j.ddmec.2013.12.001","url":null,"abstract":"<div>Dysfunctional cilia cause kidney cysts. Most cilia are non-motile (primary) microtubular organelles expressed on epithelial cells that are thought to translate global positional cues into planar cell polarity (PCP), a pathway ascribed to non-canonical Wnt signaling. The PCP pathways then seem to ensure normal renal development by orienting the spindle axis of dividing epithelial cells along the axis of the developing kidney tubule (oriented cell division), and/or by orchestrating cell migration and intercalation, a morphogenetic program observed during vertebrate gastrulation (convergent extension). PCP signaling requires a set of proteins originally identified as PCP core proteins in Drosophila. Several observations now suggest that intact ciliogenesis and ciliary functions require the presence of PCP proteins, while the subcellular localization of core PCP proteins is not affected by ciliary defects. Furthermore, ciliary defects may be overcome by enhanced cell intercalation controlled by the PCP pathway, opening potentially exciting new avenues to prevent cyst formation.</div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"10 3","pages":"Pages e159-e166"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2013.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91033149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal cystic disease: from mechanisms to drug development 肾囊性疾病:从机制到药物开发

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.03.003

I-Chun Tsai, Nicholas Katsanis

引用次数: 1

Pathomechanistic paradigms in autoimmune blistering diseases 自身免疫性水疱病的病理机制范式

Drug discovery today. Disease mechanisms Pub Date : 2013-12-01 DOI: 10.1016/j.ddmec.2013.06.004

Pamela Aubert, Kim B. Yancey

{"title":"Pathomechanistic paradigms in autoimmune blistering diseases","authors":"Pamela Aubert, Kim B. Yancey","doi":"10.1016/j.ddmec.2013.06.004","DOIUrl":"10.1016/j.ddmec.2013.06.004","url":null,"abstract":"<div>Autoimmune blistering diseases are classified by clinical, histological, and immunopathologic findings. As demonstrated by traditional immunofluorescence microscopy studies of patient skin and serum samples, these diseases develop as a consequence of loss of immunologic tolerance to self (i.e. skin) and are mediated by disease-specific autoantibodies. Subsequently, such autoantibodies were used to identify and characterize disease-specific target autoantigens in skin which interestingly are now recognized to be important structural proteins that mediate cell:cell or cell:matrix adhesion. In parallel with these advances, additional studies showed that patient autoantibodies are pathogenic in in vivo passive transfer animal models. Recent advances have explored pathomechanisms of disease and shown that autoantibodies disrupt cell:cell and cell:matrix adhesion by direct effects as well as secondary downstream events. Elucidation of variables that initiate loss of tolerance to skin, production of pathogenic (i.e. disease-causing) autoantibodies, and downstream disease pathomechanisms hold the potential to identify new target directed therapies that control these life threatening disorders without associated generalized immunosuppression, secondary infections, or drug toxicities.</div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"10 3","pages":"Pages e95-e100"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2013.06.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73144640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0