结核病感染期间细菌种群动态的复苏促进因素

Bavesh D. Kana, Valerie Mizrahi
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引用次数: 7

摘要

结核分枝杆菌有5种复苏促进因子(Rpfs),它们可能通过肽聚糖中β-1,4糖苷键的裂解参与毒力和休眠复苏。在活动性和潜伏性结核感染期间,这些因素通过重塑肽聚糖刺激细菌生长,从而影响细菌种群动态,存在几种可能性。因此,Rpfs可能代表了结核病药物发现的一类有趣的细胞壁靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resuscitation promoting factors in bacterial population dynamics during TB infection

Mycobacterium tuberculosis has five resuscitation promoting factors (Rpfs) which have been implicated in virulence and resuscitation from dormancy, possibly through cleavage of the β-1,4 glycosidic bond in peptidoglycan. Several possibilities exist for the role of these factors in influencing bacterial population dynamics, during active and latent tuberculosis infection, by the stimulation of bacterial growth through re-modeling of peptidoglycan. As such, the Rpfs may represent an interesting new class of cell wall targets for tuberculosis drug discovery.

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