{"title":"小RNA对病原体代谢的调控","authors":"Kristine B. Arnvig, Douglas B. Young","doi":"10.1016/j.ddmec.2010.09.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>There is a growing appreciation of the important role of small RNA<span> (sRNA) molecules in post-transcriptional regulation of bacterial gene<span> expression. sRNA transcripts are encoded within intergenic regions or in antisense orientation to mRNA transcripts, and sRNA regulation plays a central role in the response to stress stimuli encountered by pathogens during infection. We discuss the potential importance of sRNA in the pathogenesis of </span></span></span><span><em>Mycobacterium tuberculosis</em></span>.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 1","pages":"Pages e19-e24"},"PeriodicalIF":0.0000,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.001","citationCount":"7","resultStr":"{\"title\":\"Regulation of pathogen metabolism by small RNA\",\"authors\":\"Kristine B. Arnvig, Douglas B. Young\",\"doi\":\"10.1016/j.ddmec.2010.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>There is a growing appreciation of the important role of small RNA<span> (sRNA) molecules in post-transcriptional regulation of bacterial gene<span> expression. sRNA transcripts are encoded within intergenic regions or in antisense orientation to mRNA transcripts, and sRNA regulation plays a central role in the response to stress stimuli encountered by pathogens during infection. We discuss the potential importance of sRNA in the pathogenesis of </span></span></span><span><em>Mycobacterium tuberculosis</em></span>.</p></div>\",\"PeriodicalId\":72843,\"journal\":{\"name\":\"Drug discovery today. Disease mechanisms\",\"volume\":\"7 1\",\"pages\":\"Pages e19-e24\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.09.001\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug discovery today. Disease mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740676510000222\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676510000222","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
There is a growing appreciation of the important role of small RNA (sRNA) molecules in post-transcriptional regulation of bacterial gene expression. sRNA transcripts are encoded within intergenic regions or in antisense orientation to mRNA transcripts, and sRNA regulation plays a central role in the response to stress stimuli encountered by pathogens during infection. We discuss the potential importance of sRNA in the pathogenesis of Mycobacterium tuberculosis.
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