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Relationship between Medicaid coverage design and receipt of medication for alcohol use disorder (MAUD): Probability of receipt increases based on comprehensiveness of plan 医疗补助覆盖设计与接受酒精使用障碍(MAUD)药物治疗的关系:基于计划的全面性,接受药物治疗的可能性增加
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-08-22 DOI: 10.1016/j.dadr.2025.100374
Miguel Antonio Garcia Estrada , Shelby R. Steuart , Christina M. Andrews , Colleen M. Grogan , Olivia M. Hinds , Emily C. Lawler , Felipe Lozano-Rojas , Melissa A. Westlake , Lauren Peterson , Coady Wing , Amanda J. Abraham
{"title":"Relationship between Medicaid coverage design and receipt of medication for alcohol use disorder (MAUD): Probability of receipt increases based on comprehensiveness of plan","authors":"Miguel Antonio Garcia Estrada ,&nbsp;Shelby R. Steuart ,&nbsp;Christina M. Andrews ,&nbsp;Colleen M. Grogan ,&nbsp;Olivia M. Hinds ,&nbsp;Emily C. Lawler ,&nbsp;Felipe Lozano-Rojas ,&nbsp;Melissa A. Westlake ,&nbsp;Lauren Peterson ,&nbsp;Coady Wing ,&nbsp;Amanda J. Abraham","doi":"10.1016/j.dadr.2025.100374","DOIUrl":"10.1016/j.dadr.2025.100374","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) affects one in ten Americans. As one of the largest payers of AUD treatment in the United States, Medicaid managed care plays a key role in facilitating access to AUD treatment services and medications. However, little is known about how AUD coverage in Medicaid managed care organizations (MCOs) affects treatment receipt. We examined the relationship between the comprehensiveness of Medicaid MCO plan coverage of AUD treatment and receipt of medications for AUD (MAUD). We used Medicaid claims data from Kentucky (2016–2019); our final analytic sample consisted of 202,230 newly enrolled Medicaid beneficiaries. Kentucky quasi-randomly assigns Medicaid beneficiaries to one of five MCO plans with different AUD treatment coverage. We leveraged the random assignment to MCO plans using a Two-Stage Least Squares/Instrumental Variable (TSLS/IV) approach to estimate the effects of MCO plan comprehensiveness on receipt of MAUD. Diagnosis with AUD and receipt of MAUD was relatively uncommon— only 0.5 % of Medicaid beneficiaries were diagnosed with AUD and received MAUD across all plans. Results showed that for each additional AUD treatment modality covered, the probability of receiving MAUD increased by 6.7 % relative to the mean [mean: 0.5 %; difference per additional service/MAUD (in percentage points): 0.033; p &lt; 0.05]. Expanding coverage in the least comprehensive MCO plan to match the most comprehensive plan would increase the probability of receiving MAUD by 47 %. Overall, study findings indicate that when insurance plans cover a broader array of AUD treatment services and medications, patients are more likely to receive MAUD.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100374"},"PeriodicalIF":2.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of screening and assessment tools for diagnosing opioid use disorder: A systematic review 用于诊断阿片类药物使用障碍的筛查和评估工具的实施:系统回顾
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-08-20 DOI: 10.1016/j.dadr.2025.100375
Audrey Lopez, Audrey Sarah Cohen, Francine Vega, Tiffany Champagne-Langabeer
{"title":"Implementation of screening and assessment tools for diagnosing opioid use disorder: A systematic review","authors":"Audrey Lopez,&nbsp;Audrey Sarah Cohen,&nbsp;Francine Vega,&nbsp;Tiffany Champagne-Langabeer","doi":"10.1016/j.dadr.2025.100375","DOIUrl":"10.1016/j.dadr.2025.100375","url":null,"abstract":"<div><h3>Introduction</h3><div>As the prevalence of opioid use disorder (OUD) continues to rise, early detection by medical professionals can often be the first step in linking individuals to treatment. This systematic review was designed to identify implemented OUD screening and assessment tools with studies published from January 2019 through June 2024, uncover common themes associated with implementation, and determine if these tools were recommended in clinical practice.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted within PubMed, EMBASE, and Web of Science using the keywords ‘opioid use disorder,’ ‘documentation,’ and ‘screening assessment tool.’ Three investigators independently reviewed titles, abstracts, and full-text articles for inclusion and exclusion criteria and inclusion within the study. The Johns Hopkins Evidence-Based Practice model was used to appraise evidence level, quality, and common themes.</div></div><div><h3>Results</h3><div>The initial literature search yielded 914 articles for review, with 19 remaining in the final selection. Of the 19 articles, 15 provided quantitative results of an implemented OUD screening or assessment tool, and 4 offered qualitative results about the value of implemented tools within a clinical practice. 15 of the articles recommended a screening or diagnostic assessment tool. Key themes included the insufficiency of a single assessment tool, inconsistent documentation of OUD diagnoses and symptoms, and variable tool completion.</div></div><div><h3>Conclusion</h3><div>Diagnosing OUD is complex and dynamic. This review highlights the value of screening and assessment tools in identifying individuals and initiating opioid use-related care. Future research should explore implementing artificial intelligence and patient-centered care to assist with OUD screening and assessment.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100375"},"PeriodicalIF":2.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodevelopmental effects of perinatal exposure to cannabis on progeny: A narrative review 围产期接触大麻对后代神经发育的影响:一篇叙述性综述
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-08-19 DOI: 10.1016/j.dadr.2025.100372
Chidimma Doris Azubuike , Oliver Grundmann , Amie J. Goodin
{"title":"Neurodevelopmental effects of perinatal exposure to cannabis on progeny: A narrative review","authors":"Chidimma Doris Azubuike ,&nbsp;Oliver Grundmann ,&nbsp;Amie J. Goodin","doi":"10.1016/j.dadr.2025.100372","DOIUrl":"10.1016/j.dadr.2025.100372","url":null,"abstract":"<div><h3>Objective</h3><div>The certainty of effects on neurodevelopmental outcomes resulting from perinatal cannabis exposure is yet to be established. This review synthesizes current clinical and preclinical evidence on neurodevelopment and related functional outcomes in offspring exposed to cannabis during pregnancy or early childhood. Additionally, gaps in the literature and suggestions to bridge these gaps are provided.</div></div><div><h3>Method</h3><div>A PubMed database search identified highest level of evidence studies focusing on <em>in utero</em> and early childhood cannabis exposure using keywords broadly describing outcomes alongside informal, spontaneous, and reference searches to supplement search hits. Priority was given to recent clinical studies. Findings were categorized into cognitive measures (memory, attention, and executive functioning), and diagnosis of mental health disorders (including: autism spectrum disorder [ASD], Attention deficit and hyperactivity disorder [ADHD], depression, anxiety, learning delays, and school-related performance). `</div></div><div><h3>Results</h3><div>Findings on effects on cognition, autism, and learning are not consistent; however, compared to children who were unexposed, prenatally exposed children consistently have higher ADHD risk, and no significant association with anxiety and depression. Exposure to higher concentrations of tetrahydrocannabinol was found to be associated with more aggressive behavior in males compared to females.</div></div><div><h3>Conclusion</h3><div>Most findings on perinatal cannabis exposure remain inconclusive. To enhance our understanding of associated neurodevelopmental effects, future research should reassess exposure over time, employ standardized cognitive measures, use reliable exposure assessments, and methods that consider cannabis concentration and composition across generations.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100372"},"PeriodicalIF":2.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beliefs and perceived benefits and harms of perinatal cannabis use among pre- and post-pregnancy women 怀孕前和怀孕后妇女围产期使用大麻的信念和感知的益处和危害
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-08-19 DOI: 10.1016/j.dadr.2025.100371
Rebecca K. Denson , Mayra Guerrero , William Bond , Anna Patterson , Gina May , Tamar Polatsek , Robin J. Mermelstein
{"title":"Beliefs and perceived benefits and harms of perinatal cannabis use among pre- and post-pregnancy women","authors":"Rebecca K. Denson ,&nbsp;Mayra Guerrero ,&nbsp;William Bond ,&nbsp;Anna Patterson ,&nbsp;Gina May ,&nbsp;Tamar Polatsek ,&nbsp;Robin J. Mermelstein","doi":"10.1016/j.dadr.2025.100371","DOIUrl":"10.1016/j.dadr.2025.100371","url":null,"abstract":"<div><h3>Background</h3><div>Cannabis use in pregnancy is increasing, despite evidence linking perinatal cannabis use (PCU) to maternal and infant health risks. To investigate factors contributing to increasing PCU, this study used qualitative interviews to examine beliefs and perceptions of PCU.</div></div><div><h3>Methods</h3><div>Semi-structured qualitative interviews with pre- and post-pregnancy women examined beliefs and perceived benefits and harms of PCU. Interviews were transcribed and coded using a combined inductive/deductive approach. Thematic analysis identified themes related to beliefs, benefits, and harms associated with PCU.</div></div><div><h3>Results</h3><div>Twenty participants (50 % Black/African-American, 50 % White, 10 % Hispanic/Latina, mean age = 29.8 years) completed the study. Participants held contradictory beliefs about the safety of PCU, expressing ideas about both safety and potential harms. Perceived harms included themes of harm to infant/fetus, harm to pregnant women, and route of administration. Although most (75 %) participants had heard of potential PCU-related harms, participants were unsure about the accuracy of this information. Only one participant experienced PCU-related harm during pregnancy. Almost all (90 %) participants perceived benefits of PCU; these centered on coping with mental health symptoms, alleviation of pregnancy-related symptoms, and improved parenting experiences. Participants felt cannabis was effective in relieving perinatal symptoms of anxiety, depression, nausea, and vomiting.</div></div><div><h3>Conclusions</h3><div>Perceived benefits and perceptions that PCU is safe may underlie increasing prevalence. However, these beliefs and perceptions are nuanced, and may be influenced more by personal experience than information received about PCU risks. Education addressing pregnant women’s desire for credible, evidence-based information on PCU is crucial to inform decision-making and mitigate potential risks.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100371"},"PeriodicalIF":2.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of physical activity on substance use experimentation and initiation among adolescents: Results from the ABCD Study® cohort 体育活动对青少年物质使用实验和开始的影响:来自ABCD研究®队列的结果
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-08-18 DOI: 10.1016/j.dadr.2025.100373
Christine M. Kaiver , Erin L. Thompson , Samuel W. Hawes , Sarah M. Lehman , Ashley R. Adams , David Wing , Angela R. Laird , Raul Gonzalez
{"title":"The impact of physical activity on substance use experimentation and initiation among adolescents: Results from the ABCD Study® cohort","authors":"Christine M. Kaiver ,&nbsp;Erin L. Thompson ,&nbsp;Samuel W. Hawes ,&nbsp;Sarah M. Lehman ,&nbsp;Ashley R. Adams ,&nbsp;David Wing ,&nbsp;Angela R. Laird ,&nbsp;Raul Gonzalez","doi":"10.1016/j.dadr.2025.100373","DOIUrl":"10.1016/j.dadr.2025.100373","url":null,"abstract":"<div><div>Physical Activity (PA) is important for mental, physical, and brain health. Adolescence is marked by increased engagement in risky substance use (SU) behaviors, which can negatively affect brain development. This study aims to determine if PA influences SU experimentation and initiation among adolescents. We predicted higher levels of PA would be associated with less SU, with a larger effect in more vigorous compared to light PA. A sample of 2541 participants from the Adolescent Brain Cognitive Development (ABCD) Study provided three weeks of Fitbit-measured PA data at the 2-year follow-up, and SU outcomes at the 3- and 4-year follow-up. SU outcomes of experimentation (i.e., sip/puff/try of alcohol, nicotine, or cannabis) and initiation (i.e., full drink of alcohol, more than a puff/try of nicotine or cannabis, or anything else) were examined dichotomously (i.e., yes/no). Logistic regression analyses were conducted, controlling for demographics, externalizing, and depressive symptoms endorsed on Child Behavior Checklist (CBCL). Total PA was associated with 24 % decreased odds in SU initiation (OR 0.82, 95 % CI 0.69–0.99, <em>p</em> &lt; .05). After examining PA intensities more closely, light PA predicted 26 % decreased odds of SU initiation (OR 0.73, 95 % CI 0.61–0.88, p = .001). No significant associations emerged between PA and experimentation, or moderate and vigorous PA and initiation. More engagement in total and light PA reduced the odds of SU initiation, suggesting that low-intensity activity, not moderate or vigorous PA, may provide protection against adolescent SU. Future research should examine underlying mechanisms and contextual factors that account for these results.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100373"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemsex and sexual risk behavior among MSM on PrEP in Stockholm, Sweden 瑞典斯德哥尔摩的男男性接触者中使用PrEP的化学性行为和性风险行为
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-08-10 DOI: 10.1016/j.dadr.2025.100367
Rost Elin , Westergren Victor , Luksha Yauheni , Anna Mia Ekström , Lindberg Daniel
{"title":"Chemsex and sexual risk behavior among MSM on PrEP in Stockholm, Sweden","authors":"Rost Elin ,&nbsp;Westergren Victor ,&nbsp;Luksha Yauheni ,&nbsp;Anna Mia Ekström ,&nbsp;Lindberg Daniel","doi":"10.1016/j.dadr.2025.100367","DOIUrl":"10.1016/j.dadr.2025.100367","url":null,"abstract":"<div><h3>Background</h3><div>Chemsex, typically defined as the use of specific psychoactive substances to enhance sexual experiences, has been linked to increased sexual health risks among men who have sex with men (MSM). This study examines frequency of chemsex use and associations between chemsex, risk-taking, and sexual practices among MSM on pre-exposure prophylaxis against HIV (PrEP) attending Sweden’s largest sexual health clinic.</div></div><div><h3>Methods</h3><div>A survey among MSM on PrEP (n = 290) mapped demographics, sexualized drug use, sexual practices, and alcohol use at Venhälsan, (South General Hospital), Stockholm, Sweden.</div></div><div><h3>Results</h3><div>18 % engaged in chemsex at least once in the past year and 49 % of respondents using chemsex reported high-risk alcohol use or alcohol dependence and 13 % classified as dependent. Most individuals on PrEP practiced unprotected sex, 42 % used condoms as passive/bottom, only 31 % as active/top. Chemsex tripled the odds of not using a condom at least 50 % of the time: adjusted for age, education, AUDIT, and being born in Sweden. Participants using chemsex were 3 times more likely, to have more than 14 temporary partners (past year) and were twice as likely to engage in group sex (82 %) compared to those not using chemsex (40 %).</div></div><div><h3>Conclusions</h3><div>Chemsex was associated with a threefold increased risk of condomless sex and showed a significant link to alcohol dependency. While PrEP offers effective protection against HIV infection, it does not prevent sexually transmitted infections. Health professionals and social workers should identify MSM who engage in chemsex and tailor interventions to address their specific needs.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100367"},"PeriodicalIF":2.9,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Receiving coupons and discounts for nicotine pouches is associated with current use of nicotine pouches among United States adults: Results from the population assessment of tobacco and health (PATH) study wave 7 (2022-2023). 在美国成年人中,接受尼古丁袋的优惠券和折扣与尼古丁袋的当前使用有关:烟草与健康人口评估(PATH)研究第7波(2022-2023)的结果。
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-08-06 eCollection Date: 2025-09-01 DOI: 10.1016/j.dadr.2025.100370
Juhan Lee, Frank Merenda, Andrea H Weinberger
{"title":"Receiving coupons and discounts for nicotine pouches is associated with current use of nicotine pouches among United States adults: Results from the population assessment of tobacco and health (PATH) study wave 7 (2022-2023).","authors":"Juhan Lee, Frank Merenda, Andrea H Weinberger","doi":"10.1016/j.dadr.2025.100370","DOIUrl":"10.1016/j.dadr.2025.100370","url":null,"abstract":"<p><strong>Background: </strong>The rising use of nicotine pouches has emerged as a public health concern. Increasing use might be driven by exposure to marketing (e.g., discounts, coupons) but little is known about marketing and nicotine pouch use. This study is the first to use United States (US) nationally representative data to examine the relationship between exposure to discounts and coupons for nicotine pouches and nicotine pouch use among US adults.</p><p><strong>Methods: </strong>Using respondents from the Population Assessment of Tobacco and Health (PATH) Study Wave 7 (2022-2023) dataset (N = 27,712), we examined the association between past 12-month exposure to nicotine pouch discounts/coupons and past-30-day nicotine pouch use, adjusting for sociodemographic, psychological, and behavioral covariates.</p><p><strong>Results: </strong>Among respondents, 0.3 % (weighted) reported past-12-month receipt of discounts or coupons for nicotine pouches, and 0.8 % reported past-30-day use of nicotine pouches, with a significant bivariate association (p < 0.001). After controlling for covariates, individuals exposed to discounts or coupons for nicotine pouches during the past 12 months were more likely to report past-30-day use of nicotine pouches (adjusted odds ratio=33.85, 95 % confidence interval=19.13, 59.92).</p><p><strong>Conclusions: </strong>Exposure to discounts/coupons for nicotine pouches was associated with an increased risk of product use in the past 30 days among US adults. Continual surveillance of tobacco marketing strategies and sustained research efforts are necessary to inform tobacco control efforts and cessation strategies related to nicotine pouches.</p>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"100370"},"PeriodicalIF":2.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A preliminary investigation of tobacco co-use on endocannabinoid activity in people with cannabis use 烟草共同使用对大麻使用者内源性大麻素活性的初步调查
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-07-30 DOI: 10.1016/j.dadr.2025.100369
Rachel A. Rabin , Joseph Farrugia , Ranjini Garani , Romina Mizrahi , Pablo Rusjan
{"title":"A preliminary investigation of tobacco co-use on endocannabinoid activity in people with cannabis use","authors":"Rachel A. Rabin ,&nbsp;Joseph Farrugia ,&nbsp;Ranjini Garani ,&nbsp;Romina Mizrahi ,&nbsp;Pablo Rusjan","doi":"10.1016/j.dadr.2025.100369","DOIUrl":"10.1016/j.dadr.2025.100369","url":null,"abstract":"<div><div>Tobacco is commonly co-used with cannabis. This is unfortunate because tobacco co-use exacerbates select clinical consequences associated with cannabis use. Evidence demonstrates that low levels of anandamide, a prominent endocannabinoid, correlate with worse clinical outcomes. Fatty acid amide hydrolase (FAAH) degrades anandamide, and greater FAAH levels may underlie poorer clinical outcomes in people who co-use relative to those who use only cannabis. Therefore, we tested whether tobacco co-use increases FAAH levels beyond those associated with cannabis use alone. Cannabis-using participants (N = 13) were parsed into individuals with daily tobacco use (CT, n = 5) and no current tobacco use (CAN, n = 8). We evaluated group differences in FAAH, quantified using positron emission tomography and [<sup>11</sup>C]CURB, while controlling for sex and FAAH genotype in the prefrontal cortex, hippocampus, thalamus, sensorimotor striatum, substantia nigra, and cerebellum. A significant group x ROI interaction for [<sup>11</sup>C]CURB λk<sub>3</sub> [F(5, 45)= 3.15, p = 0.016] emerged. Bonferroni-corrected post-hoc tests indicated greater FAAH levels in CT compared to CAN in the substantia nigra (p = 0.023, d=1.54) and cerebellum (p = 0.003, d=1.76), while a trend emerged in the sensorimotor striatum (p = 0.054, d=1.33). Preliminary findings suggest that tobacco co-use is associated with elevated FAAH activity relative to cannabis-only use, which may underlie poorer clinical outcomes associated with co-use.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100369"},"PeriodicalIF":2.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of hepatitis C serostatus on health service utilization for opioid-related harms among individuals prescribed opioid agonist therapy: A longitudinal prospective cohort study 丙型肝炎血清状况对阿片类药物激动剂治疗个体阿片类药物相关危害的卫生服务利用的影响:一项纵向前瞻性队列研究
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-07-29 DOI: 10.1016/j.dadr.2025.100368
Paige Guyatt , Glenda Babe , Anastasia Gayowsky , Tea Rosic , Myanca Rodrigues , Paxton Bach , Richard Perez , Claire de Oliveira , Jeffrey H. Samet , Geneviève Kerkerian , Jessica Hann , Joanna C. Dionne , Aijaz Ahmed , Donghee Kim , Seonaid Nolan , Lehana Thabane , Zainab Samaan , Brittany B. Dennis
{"title":"Impact of hepatitis C serostatus on health service utilization for opioid-related harms among individuals prescribed opioid agonist therapy: A longitudinal prospective cohort study","authors":"Paige Guyatt ,&nbsp;Glenda Babe ,&nbsp;Anastasia Gayowsky ,&nbsp;Tea Rosic ,&nbsp;Myanca Rodrigues ,&nbsp;Paxton Bach ,&nbsp;Richard Perez ,&nbsp;Claire de Oliveira ,&nbsp;Jeffrey H. Samet ,&nbsp;Geneviève Kerkerian ,&nbsp;Jessica Hann ,&nbsp;Joanna C. Dionne ,&nbsp;Aijaz Ahmed ,&nbsp;Donghee Kim ,&nbsp;Seonaid Nolan ,&nbsp;Lehana Thabane ,&nbsp;Zainab Samaan ,&nbsp;Brittany B. Dennis","doi":"10.1016/j.dadr.2025.100368","DOIUrl":"10.1016/j.dadr.2025.100368","url":null,"abstract":"<div><h3>Objectives</h3><div>Varied substance use outcomes have been reported among individuals with a hepatitis C viral (HCV) infection on opioid agonist treatment (OAT) for opioid use disorder. Accordingly, the current study sought to evaluate the association between HCV serostatus, among other factors, and opioid-related acute health service utilization (e.g., emergency department [ED] visits and hospitalizations) among individuals prescribed OAT.</div></div><div><h3>Methods</h3><div>Multi-site prospective cohort study data were used to characterize demographic characteristics, substance use patterns, and physical health amongst individuals prescribed OAT. Logistic regression models were built to estimate the association between HCV-seropositivity and opioid-related ED visits and hospitalizations over a three-year follow up period.</div></div><div><h3>Results</h3><div>Among 3430 participants, 10.6 % (<em>n</em> = 365) were HCV-seropositive. In the follow-up period, 21.3 % (<em>n</em> = 730) attended the ED and 8.7 % (<em>n</em> = 298) were hospitalized for opioid related-harms. HCV-seropositivity was associated with an increased incidence of ED visits for opioid poisoning (9.0 % vs 4.9 % for participants who were HCV-seronegative, p &lt; 0.01) and other opioid-related harms (22.5 % vs. 20.8 % for seronegative participants, p = 0.03). However, multiple logistical regression models showed no association between HCV serostatus and opioid-related health service utilization; rather, injection drug use was a significant predictor of opioid-related ED visits (OR 3.39, p &lt; 0.01) and hospitalizations (OR 1.21, p = 0.01).</div></div><div><h3>Conclusion</h3><div>Among individuals prescribed OAT, those with seropositive HCV have increased incidence of ED visits and hospitalizations for opioid-related harms, an association which may be driven by injection use practices. These findings highlight the importance of screening for injection use practices and health symptoms, as well as the potential role for targeting resources (e.g., harm reduction supplies, education regarding transmission) within this vulnerable subgroup.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"16 ","pages":"Article 100368"},"PeriodicalIF":2.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adapting the alcohol and alcohol problems perception questionnaire and the drug and drug problems perception questionnaire: A psychometric analysis of a person-centred approach 调整酒精和酒精问题认知问卷和毒品和毒品问题认知问卷:以人为本方法的心理测量学分析
IF 2.9
Drug and alcohol dependence reports Pub Date : 2025-07-26 DOI: 10.1016/j.dadr.2025.100366
Andrea RAYNAK , Michel Bédard , Brianne Wood , Christopher Mushquash
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