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Repeated measures latent class analysis identifies unique daily cocaine-use patterns and associated clinical characteristics: A timeline followback-based analytic approach 重复测量潜类分析确定独特的每日可卡因使用模式和相关的临床特征:基于时间轴跟踪的分析方法
IF 3.5
Drug and alcohol dependence reports Pub Date : 2026-09-01 Epub Date: 2026-08-26 DOI: 10.1016/j.dadr.2026.100472
Alixandria T. Mascarin, William Burstein, Lana R. Grasser, Mark K. Greenwald
{"title":"Repeated measures latent class analysis identifies unique daily cocaine-use patterns and associated clinical characteristics: A timeline followback-based analytic approach","authors":"Alixandria T. Mascarin,&nbsp;William Burstein,&nbsp;Lana R. Grasser,&nbsp;Mark K. Greenwald","doi":"10.1016/j.dadr.2026.100472","DOIUrl":"10.1016/j.dadr.2026.100472","url":null,"abstract":"<div><h3>Background</h3><div>Cocaine use poses significant health risks and treatment challenges. Individual patterns of multi-daily use and their association with clinical characteristics remain poorly understood. Novel approaches that differentiate cocaine-use patterns may improve clinical understanding and guide treatments. This study aimed to identify distinct patterns of cocaine use with a timeline follow-back (TLFB) approach and to evaluate relationships with demographics, cocaine-use severity, and negative emotionality.</div></div><div><h3>Methods</h3><div>Data were collected from 109 (88 male) non-treatment seeking people who use cocaine (mean <u>+</u> SD age 45.6<u>+</u>7.1 years) through past 15-day TLFB interviews tracking daily cocaine use and amounts. Bias-adjusted 3-step repeated-measures latent class analysis identified distinct patterns of daily binary (yes/no) cocaine use. Predictors of class membership including age, income, negative emotionality (depression and anxiety symptoms), and cocaine-use severity were evaluated via regression models as part of the last step of the 3-step RM-LCA approach.</div></div><div><h3>Results</h3><div>Three cocaine-use patterns emerged: high variability across days (Class 1, <em>n</em> = 36), infrequent use (Class 2, <em>n</em> = 52), and consistent use across days (Class 3, <em>n</em> = 21). Consistent use class reported higher daily cocaine-use amounts and cocaine craving than high-variability and infrequent use classes; consistent use class also reported higher income than infrequent use. Infrequent use class reported lower income compared to high variability use.</div></div><div><h3>Discussion</h3><div>This study identifies distinct patterns of cocaine use associated with different behavioral and demographic characteristics, providing a foundation for tailored treatment development and stratification. Future work should expand these methods and findings to explore the broader context of polysubstance use.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"20 ","pages":"Article 100472"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When control isn’t controlled: How different experimental sham control conditions complicate TMS evidence in addiction 当控制不受控制时:不同的实验假控制条件如何使TMS成瘾证据复杂化
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-06-01 Epub Date: 2026-05-23 DOI: 10.1016/j.dadr.2026.100450
Ghazaleh Soleimani, Zhihe Zhao, Malte R. Güth, Alexander Opitz
{"title":"When control isn’t controlled: How different experimental sham control conditions complicate TMS evidence in addiction","authors":"Ghazaleh Soleimani,&nbsp;Zhihe Zhao,&nbsp;Malte R. Güth,&nbsp;Alexander Opitz","doi":"10.1016/j.dadr.2026.100450","DOIUrl":"10.1016/j.dadr.2026.100450","url":null,"abstract":"","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"19 ","pages":"Article 100450"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Service utilization patterns in cocaine use disorder: A data-driven study 可卡因使用障碍的服务利用模式:数据驱动的研究
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-06-01 Epub Date: 2026-05-23 DOI: 10.1016/j.dadr.2026.100447
Carlotta Riemerschmid , Larissa Schwarzkopf , Gabriele Koller , Elena Gomes de Matos , Esther Neumeier , Sally Olderbak , Eva Hoch
{"title":"Service utilization patterns in cocaine use disorder: A data-driven study","authors":"Carlotta Riemerschmid ,&nbsp;Larissa Schwarzkopf ,&nbsp;Gabriele Koller ,&nbsp;Elena Gomes de Matos ,&nbsp;Esther Neumeier ,&nbsp;Sally Olderbak ,&nbsp;Eva Hoch","doi":"10.1016/j.dadr.2026.100447","DOIUrl":"10.1016/j.dadr.2026.100447","url":null,"abstract":"<div><h3>Background</h3><div>Over the past decade, cocaine use disorders (CoUD) have become increasingly prevalent in Europe’s outpatient addiction care settings. This study examines clinically meaningful subgroups among individuals seeking outpatient care for CoUD in Berlin, a metropolitan area with particularly high prevalence rates to inform treatment strategies.</div></div><div><h3>Methods</h3><div>Using 2024 person-level routine data of the Berlin Addiction Care Statistical Service, latent class analyses (LCA) were conducted to identify subgroups among clients entering outpatient care with primary CoUD (<em>n</em> = 1223) based on patterns of substance use disorder (SUD) comorbidity and cocaine use prior to admission. Identified classes were subsequently compared with respect to sociodemographic characteristics and treatment-related variables applying Holm-Bonferroni adjusted group comparisons.</div></div><div><h3>Results</h3><div>A three-class solution best fitted the data: (1) CoUD-only (low comorbidity), (2) CoUD+Alcohol Use Disorders (AUD), and (3) CoUD+Multiple SUDs. The CoUD+AUD class was more likely to be employed and tertiary educated. The CoUD-only class showed more first-time treatment entries, shorter treatment duration, and lower rates of scheduled completion and symptom improvement. The CoUD+Multiple SUDs class showed comparable treatment outcomes to the CoUD-only class.</div></div><div><h3>Discussion</h3><div>These findings underscore the importance of recognizing heterogeneity in care needs among individuals with CoUD. Tailored treatment approaches, including early-stage interventions for less complex cases and integrated strategies for those with comorbid SUDs, may enhance treatment effectiveness and optimize resource allocation.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"19 ","pages":"Article 100447"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between neighborhood disadvantage, cannabis use, and patient-reported outcomes among patients with cancer 癌症患者中社区劣势、大麻使用和患者报告结果之间的关系
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-06-01 Epub Date: 2026-05-23 DOI: 10.1016/j.dadr.2026.100449
Brittney Greene , Shilpa Ghosh , Craig Colder , Salimah Meghani , Brooke Worster , Rebecca Ashare
{"title":"Associations between neighborhood disadvantage, cannabis use, and patient-reported outcomes among patients with cancer","authors":"Brittney Greene ,&nbsp;Shilpa Ghosh ,&nbsp;Craig Colder ,&nbsp;Salimah Meghani ,&nbsp;Brooke Worster ,&nbsp;Rebecca Ashare","doi":"10.1016/j.dadr.2026.100449","DOIUrl":"10.1016/j.dadr.2026.100449","url":null,"abstract":"<div><h3>Introduction</h3><div>Cannabis use is proliferating among oncological populations. However, research is limited on whether cannabis routes and sources are associated with neighborhood disadvantage and whether it moderates the relationship between neighborhood disadvantage and patient-reported outcomes (PROs). This analysis evaluates the relationship between neighborhood disadvantage and cannabis source and route, and their association with PROs.</div></div><div><h3>Methods</h3><div>Analyses included 106 patients with cancer from varying levels of neighborhood disadvantage. Logistic regressions tested the association of neighborhood disadvantage with cannabis source (i.e., regulated vs. unregulated) and route (i.e., inhaled vs. consumed/other formulations). Multilevel regressions tested the association of neighborhood disadvantage with PROs (e.g., anxiety, depression, sleep quality, pain, quality of life) and moderation by cannabis variables.</div></div><div><h3>Results</h3><div>Neighborhood disadvantage did not uniquely predict cannabis source or route (<em>p</em>’s &gt; .05) or PROs (<em>p</em>’s &gt; .05). Conversely, household income predicted pain interference and severity, quality of life, and depression, indicating that lower household income was associated with worse outcomes (<em>p</em>’s &lt; .05). There was a significant interaction between neighborhood disadvantage and visit for both pain interference (<em>b</em>=-1.37, 95%CI [-2.4,-0.3], <em>p</em> = .01) and sleep quality (<em>b</em>=1.74, 95%CI [-0.001,3.5], <em>p</em> = .05). Cannabis route significantly moderated the relationship between neighborhood disadvantage and anxiety (<em>b</em>=-5.32, 95%CI [-10.2,-0.4], <em>p</em> = .03). The interaction was driven by reversed scores between patients using inhaled and consumed/other formulations at different levels of neighborhood disadvantage.</div></div><div><h3>Conclusion</h3><div>Although the composite index of neighborhood disadvantage was not associated with cannabis use or PROs, our data suggest that income and cannabis route may be key factors associated with health disparities among patients with cancer.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"19 ","pages":"Article 100449"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cordycepin alleviates nicotine withdrawal-induced anxiety via AMPK/CREB/BDNF pathway activation in the hippocampus of male mice 虫草素通过激活雄鼠海马AMPK/CREB/BDNF通路缓解尼古丁戒断引起的焦虑
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-06-01 Epub Date: 2026-05-19 DOI: 10.1016/j.dadr.2026.100446
Tianqi Wang , Shu Tian , Mengru He , Siyu Tang , Xinyu Ji , Qixin Deng , Wenjuan Zhang , Ge Jin , Jian Mao , Haifeng Zhang
{"title":"Cordycepin alleviates nicotine withdrawal-induced anxiety via AMPK/CREB/BDNF pathway activation in the hippocampus of male mice","authors":"Tianqi Wang ,&nbsp;Shu Tian ,&nbsp;Mengru He ,&nbsp;Siyu Tang ,&nbsp;Xinyu Ji ,&nbsp;Qixin Deng ,&nbsp;Wenjuan Zhang ,&nbsp;Ge Jin ,&nbsp;Jian Mao ,&nbsp;Haifeng Zhang","doi":"10.1016/j.dadr.2026.100446","DOIUrl":"10.1016/j.dadr.2026.100446","url":null,"abstract":"<div><div>Nicotine withdrawal-induced anxiety is a key contributor to the return to cigarette smoking. Cordycepin, an adenosine analogue, is hypothesized to counteract the withdrawal-induced decline in hippocampal AMP/ATP ratios and consequent AMP-activated protein kinase (AMPK) dephosphorylation, as its monophosphate derivative structurally mimics AMP and directly activates AMPK. In this study, a mouse model of chronic nicotine exposure followed by withdrawal was used to investigate whether cordycepin mitigates nicotine withdrawal-induced anxiety and its underlying mechanisms. Our results revealed that chronic nicotine exposure significantly elevated hippocampal AMPK phosphorylation, whereas nicotine withdrawal led to a sharp decline in p-AMPK levels (p-AMPK/t-AMPK: <em>F</em> = 23.11, <em>P</em> &lt; 0.001), concomitant with pronounced anxiety-like behaviors in the elevated plus maze (open-arm time: <em>F</em> = 16.18, <em>P</em> &lt; 0.01) and open field tests (center time: <em>F</em> = 6.63, <em>P</em> &lt; 0.01). Pretreatment with cordycepin (10<!--> <!-->mg/kg) effectively alleviated nicotine withdrawal-induced anxiety-like behaviors (open-arm time: <em>F</em> = 11.74, <em>P</em> &lt; 0.01; center time: <em>F</em> = 5.79, <em>P</em> &lt; 0.01), an effect that was counteracted by the AMPK inhibitor Compound C. Further mechanistic studies <em>via</em> Western blot and immunohistochemical analyses demonstrated that cordycepin activated the hippocampal AMPK/CREB/BDNF signaling pathway, restoring withdrawal-induced reductions in p-AMPK, p-CREB, and BDNF expression. This effect was further validated in PC12 cell experiments. In conclusion, cordycepin alleviates nicotine withdrawal-induced anxiety by activating the AMPK/CREB/BDNF pathway, offering preliminary experimental evidence for its potential as an adjunctive therapy for smoking cessation.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"19 ","pages":"Article 100446"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional intervention improved dietary intake among patients receiving methadone maintenance treatment 营养干预改善了接受美沙酮维持治疗的患者的饮食摄入
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-06-01 Epub Date: 2026-05-22 DOI: 10.1016/j.dadr.2026.100448
Dror Ben Noach , Anat Sason , Ronit Anbar , Limor Ben Haim , Miriam Adelson , Einat Peles
{"title":"Nutritional intervention improved dietary intake among patients receiving methadone maintenance treatment","authors":"Dror Ben Noach ,&nbsp;Anat Sason ,&nbsp;Ronit Anbar ,&nbsp;Limor Ben Haim ,&nbsp;Miriam Adelson ,&nbsp;Einat Peles","doi":"10.1016/j.dadr.2026.100448","DOIUrl":"10.1016/j.dadr.2026.100448","url":null,"abstract":"<div><h3>Objectives</h3><div>As patients receiving methadone maintenance treatment (MMT) exhibit elevated rates of overweight, and poor dietary quality, we studied the effectiveness of a group nutritional-therapy on dietary quality, anthropometric measures, body composition, and quality of life.</div></div><div><h3>Methods</h3><div>A randomized controlled trial among MMT patients with BMI ≥ 25<!--> <!-->kg/m² was assessed. The intervention group (n = 42) received 10 weekly group nutritional therapy sessions, and controls (n = 28) received a single 15-minute individual nutritional session. Anthropometric measurements, body composition analysis (bio-impedance analysis), dietary intake evaluation, and quality of life (SF-36) were assessed. Data were analyzed using repeated-measures analyses.</div></div><div><h3>Results</h3><div>Intervention and control groups had reductions in body fat percentage (p = 0.008) with comparable proportions of patients who lost weight (42.9% and 50%, respectively, p = 0.6). Water consumption increased and ultra-processed food consumption decreased in both groups. The intervention group only demonstrated caloric reduction in carbohydrate (48.2% to 44.7%) and increase in protein (13.8% to 16.9%). Physical-functioning domain of quality of life was maintained in the intervention group but declined in controls. When stratified by weight loss, scores improved among participants who lost weight in the intervention group, but declined among those who did not, as well as among all participants in the control group regardless of weight change.</div></div><div><h3>Conclusions</h3><div>Intervention effectively improved dietary quality in MMT patients, and among those who succeeded in losing weight, it also improved quality of life (physical-functioning). The brief nutritional guidance provided to controls, and the increased dietary awareness from study participation, may have contributed to general nutritional improvements.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"19 ","pages":"Article 100448"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Who uses legal cannabis and why? Cluster profiles of participants in a Swiss regulated sales pilot trial 谁在使用合法的大麻,为什么?瑞士监管销售试点试验参与者的集群概况。
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-06-01 Epub Date: 2026-05-19 DOI: 10.1016/j.dadr.2026.100445
Maëlle Dreifuss Bisson , Tamara Corino , Tatiana Aboulafia Brakha , Federico Seragnoli , Laura Toso , Sandro Cattacin , Daniele Zullino , Lucas Spierer , Lucien Rochat
{"title":"Who uses legal cannabis and why? Cluster profiles of participants in a Swiss regulated sales pilot trial","authors":"Maëlle Dreifuss Bisson ,&nbsp;Tamara Corino ,&nbsp;Tatiana Aboulafia Brakha ,&nbsp;Federico Seragnoli ,&nbsp;Laura Toso ,&nbsp;Sandro Cattacin ,&nbsp;Daniele Zullino ,&nbsp;Lucas Spierer ,&nbsp;Lucien Rochat","doi":"10.1016/j.dadr.2026.100445","DOIUrl":"10.1016/j.dadr.2026.100445","url":null,"abstract":"<div><h3>Background</h3><div>As cannabis regulation expands, it is important to understand who enrolls in legal non-medical cannabis programs and how participant profiles relate to harm. We identified participant profiles in Geneva’s pilot trial, <em>La Cannabinothèque</em>, using motives for cannabis use, knowledge of lower-risk use, and perceived risk, and examined differences in key outcomes.</div></div><div><h3>Methods</h3><div>Baseline data from 1290 people who use cannabis (PWUC) were analysed. Hierarchical clustering (Ward) followed by K-means refinement supported a four-cluster solution (Cramer’s V = 0.563). Clusters were compared on problematic cannabis use and consumption frequency, mental health symptoms, and quality of life.</div></div><div><h3>Results</h3><div>Cluster 1 (<em>High motives – Low safer-use knowledge – Moderate risk perception</em>; 9.9%) showed high endorsement of all motives, lower-risk knowledge, and moderate to elevated perceived risk, and had the highest problematic use/frequency and poorer health indicators. Cluster 2 (<em>Moderate motives – Average safer-use knowledge – Low risk perception</em>; 26.7%) had moderate motives (relatively higher enhancement/social), average knowledge, lower perceived risk, and the lowest problematic use with better health indicators. Cluster 3 (<em>Low motives – High safer-use knowledge – High risk perception</em>; 29.4%) combined low-to-average motives with the highest knowledge and perceived risk, yet showed frequent use and problematic use comparable to Cluster 1. Cluster 4 (<em>Minimal motives – Low safer-use knowledge – Very low risk perception</em>; 34.0%) reported minimal motives, low knowledge and perceived risk, and low use/cannabis-related harms; members were older with later initiation.</div></div><div><h3>Conclusions</h3><div>Findings support the link between coping-related motivation and problematic use, but the high-risk profile of Cluster 3 despite strong knowledge and risk awareness suggests that information and perception alone may not reduce harm. Profile-tailored harm reduction and integrated support may be needed within regulated cannabis frameworks.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"19 ","pages":"Article 100445"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engaging communities in recovery: Evaluation of a patient and family advisory committee supporting implementation of the Road to Recovery model of substance use care in British Columbia 使社区参与康复:对支持实施不列颠哥伦比亚省药物使用康复之路模式的病人和家属咨询委员会的评价
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-06-01 Epub Date: 2026-05-20 DOI: 10.1016/j.dadr.2026.100444
David Chang , Seonaid Nolan , Jeffrey Morgan , Andrea Ryan , Clint Barton , Robert Chippeway , Nichola Hall , Colin Gregory , Erika Mundel , Travis De Wolfe , Cheyenne Johnson , Brittany B. Dennis
{"title":"Engaging communities in recovery: Evaluation of a patient and family advisory committee supporting implementation of the Road to Recovery model of substance use care in British Columbia","authors":"David Chang ,&nbsp;Seonaid Nolan ,&nbsp;Jeffrey Morgan ,&nbsp;Andrea Ryan ,&nbsp;Clint Barton ,&nbsp;Robert Chippeway ,&nbsp;Nichola Hall ,&nbsp;Colin Gregory ,&nbsp;Erika Mundel ,&nbsp;Travis De Wolfe ,&nbsp;Cheyenne Johnson ,&nbsp;Brittany B. Dennis","doi":"10.1016/j.dadr.2026.100444","DOIUrl":"10.1016/j.dadr.2026.100444","url":null,"abstract":"<div><h3>Background</h3><div>The increasing presence of unpredictable toxic substances in the drug supply has intensified the need for substance use care models that integrate lived and living experience into program design and implementation. The Road to Recovery (R2R) initiative, launched in British Columbia in 2023, established a Patient and Family Advisory Committee (PFAC) to ensure clinical services and research processes reflect patient and family priorities. This study provides an early evaluation of the PFAC embedded within the R2R model.</div></div><div><h3>Methods</h3><div>A convergent mixed-methods design was used. An environmental scan of R2R administrative, clinical, and operational documents (2021–2025) described PFAC structure, membership, and program integration. This informed three virtual focus groups, conducted between May and June 2025 with PFAC members, research staff, and clinical operations leaders (n = 13). Discussions were audio-recorded, transcribed, and analyzed using inductive conventional content analysis.</div></div><div><h3>Results</h3><div>The PFAC was established in September 2023, including 20-members since inception, representing people with lived and living experience and health system stakeholders. The committee contributed to operational and research improvements, including revisions to survey tools, development of family-oriented resources, and adjustments to clinical policies. Participants valued the PFAC’s role but identified challenges related to emotional safety, role clarity, orientation, and feedback processes. Findings informed six domains of recommendations.</div></div><div><h3>Conclusions</h3><div>This evaluation demonstrates that a PFAC embedded within a substance use care program can meaningfully influence clinical and research activities. Clear, transparent, and emotionally safe engagement structures are essential to support sustained participation and more effective recovery-oriented substance use care.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"19 ","pages":"Article 100444"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148183830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geographic differences in buprenorphine and methadone prescribing for surgical patients with opioid use disorder 阿片类药物使用障碍手术患者丁丙诺啡和美沙酮处方的地理差异
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-03-01 Epub Date: 2025-11-26 DOI: 10.1016/j.dadr.2025.100397
Caitlin P. Coates , Margaret McGlothlin Carroll , Janelle M. Richard , Wendy Y. Craig , Aurora N. Quaye
{"title":"Geographic differences in buprenorphine and methadone prescribing for surgical patients with opioid use disorder","authors":"Caitlin P. Coates ,&nbsp;Margaret McGlothlin Carroll ,&nbsp;Janelle M. Richard ,&nbsp;Wendy Y. Craig ,&nbsp;Aurora N. Quaye","doi":"10.1016/j.dadr.2025.100397","DOIUrl":"10.1016/j.dadr.2025.100397","url":null,"abstract":"<div><h3>Background</h3><div>Patients with opioid use disorder (OUD) frequently present for surgery while receiving medications for OUD (MOUD), typically buprenorphine or methadone. This study evaluated MOUD use among surgical patients with OUD in a health-system spanning both urban and rural areas in Maine; a predominantly rural state with a significant opioid crisis.</div></div><div><h3>Methods</h3><div>We retrospectively identified adult surgical patients with OUD admitted to MaineHealth hospitals from 2014 to 2023 who were receiving MOUD prior to the day of surgery. Demographics and clinical characteristics were collected; rural designation was determined using Rural-Urban Commuting Area codes. The primary outcome was the temporal trend in proportion of surgical patients with OUD receiving methadone versus buprenorphine prior to admission. Temporal trends and geographic differences were compared using chi-square tests (p &lt; 0.05).</div></div><div><h3>Results</h3><div>Of 2099 surgical patients on MOUD, 71.4 % received buprenorphine and 28.6 % methadone. Overall, rural patients were more likely to receive buprenorphine than urban patients (75.1 % vs. 68.5 %) (p &lt; 0.001). Buprenorphine prescribing increased from 52.0 % to 84.2 % in rural areas and from 59.3 % to 72.9 % in urban areas, with corresponding declines in methadone use (both p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Temporal trends showed a significant shift in MOUD prescribing over the study period, with buprenorphine use increasing and methadone use declining in rural and urban populations. Although both medications are considered safe in hospitalized and surgical patients, perioperative management remains inconsistent. Further work is needed to evaluate how these prescribing trends influence clinical outcomes and ensure perioperative protocols support continuity of care for patients with OUD.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"18 ","pages":"Article 100397"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “The experience of individuals living with alcohol use disorder within palliative care and end of life services: A scoping review” [Drug Alcohol Depend. 17 (2025) 100383] “在姑息治疗和临终服务中患有酒精使用障碍的个人的经历:范围审查”的勘误表[药物酒精依赖,17 (2025)100383]
IF 2.9
Drug and alcohol dependence reports Pub Date : 2026-03-01 Epub Date: 2026-03-11 DOI: 10.1016/j.dadr.2025.100401
Amélie Deschamps , Andrée-Anne Légaré , Anne-Marie Auger , Natalia Muñoz Gómez , Magaly Brodeur
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