Drug and alcohol dependence reports最新文献

{"title":"Assessment of the associative determinants of tolerance to the effects of cannabis extract on exploratory behavior in rats","authors":"Felipe I. Varas ,&nbsp;Gonzalo Miguez ,&nbsp;Vanetza E. Quezada-Scholz ,&nbsp;Esperanza Ibáñez-Jiménez ,&nbsp;Camila Aguilar ,&nbsp;Simón Ramírez ,&nbsp;Jonathan Badilla ,&nbsp;Felipe Alfaro ,&nbsp;Francisca Bertin ,&nbsp;Javier Bustamante ,&nbsp;Rocío Angulo ,&nbsp;José A. Fuentealba ,&nbsp;Alvaro Vergés ,&nbsp;Mario A. Laborda","doi":"10.1016/j.dadr.2025.100344","DOIUrl":"10.1016/j.dadr.2025.100344","url":null,"abstract":"<div><div>Experimental evaluation of cannabis tolerance has lacked an associative learning approach, focusing primarily on physiological variables. The present study assessed acute effects, chronic tolerance, and contextual specificity, exploring a potential associative component underlying cannabis tolerance. Sixteen adult Sprague-Dawley rats of both sexes were assigned to two groups, one receiving vaporized administrations of cannabis and the other receiving the vehicle substance, in two different counterbalanced contexts. An initial measurement was performed to assess acute effects, followed by four measurements to evaluate the development of chronic tolerance, and a final measurement to test the context specificity of tolerance, comparing the responses to the usual administration context and a novel context. Ten behaviors were analyzed in an open field. Acute effects were observed in seven indicators, corresponding to greater exploration activity in the group that received the drug compared to the control group. In five of these, the data also showed the development of chronic tolerance to the effects of cannabis on exploration, which was indicated by a progressive decrease in exploratory activity in the drug group. However, no evidence of context specificity was found in any variables in which chronic tolerance was observed. We discuss factors that may be related to the lack of contextual specificity of cannabis tolerance. Together, our findings show that a single administration of cannabis induces acute effects, and repeated exposure leads to chronic tolerance, ultimately reducing exploratory behavior.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100344"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reported outcomes from a community naloxone training and distribution program","authors":"Kevin Frederiks ,&nbsp;Maxwell Everett ,&nbsp;Kristen Gilmore Powell ,&nbsp;N. Andrew Peterson ,&nbsp;Suzanne Borys ,&nbsp;Donald K. Hallcom ,&nbsp;Nina A. Cooperman","doi":"10.1016/j.dadr.2025.100341","DOIUrl":"10.1016/j.dadr.2025.100341","url":null,"abstract":"<div><div>The United States opioid epidemic is an enormous public health crisis, claiming over 500,000 lives between 1999 and 2020. However, the increased availability of naloxone has saved many lives and led to the development of community-based naloxone training and distribution programs. We developed a naloxone education and distribution program in New Jersey in 2017. This program provides a 60-minute training for community members in various settings, such as police departments, community centers, etc. Participants were instructed to call the training and distribution program if they used their naloxone kit, and the program would replace it. Callers were asked a short survey about behaviors during the naloxone administration and overdose outcome. From January 2018 through June 2022, 191 calls to report an overdose and request a new kit were received. Overall, 70 (37 %) of the reported naloxone administrations were by police, 38 (20 %) family/friends, and 50 (26 %) strangers. The most common actions taken during the overdose included: 162 (85 %) calling EMS; 161 (84 %) staying with the person who overdosed until EMS arrived; and 131 (69 %) checking the individual who overdosed for signs of breathing. Individuals who helped with an overdose were able to revive the person in 172 (90 %) of the reported overdoses. Our data suggests that participants in these programs will use naloxone for opioid overdoses whether the victim is known to the participant or a stranger. Future research should focus on understanding outcomes of and behaviors during overdose episodes that are not reported to the program.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in motives for attempts to reduce alcohol consumption among risky adult drinkers in England: A representative population survey, 2017–2024","authors":"Dimitra Kale ,&nbsp;Vera Buss ,&nbsp;Melissa Oldham ,&nbsp;Jamie Brown ,&nbsp;Lion Shahab ,&nbsp;Sarah Jackson","doi":"10.1016/j.dadr.2025.100340","DOIUrl":"10.1016/j.dadr.2025.100340","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the motives for reducing alcohol consumption, how they differ among various population groups, and how they have evolved over time is crucial for designing effective public health interventions. This study estimated time trends in motives for attempts to reduce alcohol consumption among risky adult drinkers in England between 2017 and 2024 and explored differences by sociodemographics and alcohol consumption levels.</div></div><div><h3>Methods</h3><div>Data came from a nationally representative survey (Alcohol Toolkit Study), assessing 11,974 risky adult drinkers (mean [Standard Deviation] age= 45.8 [15.7] years, 60.1 % men) who made a past-year reduction attempt between January/2017 and August/2024. Participants reported factors motivating their most recent attempt (not mutually exclusive). We estimated time trends in the proportion of attempts to reduce alcohol consumption motivated by health concerns, cost, social factors (i.e., peer influence/support) and health professional advice, and calculated prevalence ratios (PRs) to compare changes in prevalence across the whole time series.</div></div><div><h3>Results</h3><div>Over the time series, there was a small increase in the proportion of attempts motivated by health concerns (70.5–76.8 %; PR=1.09, 95 %CI1.01–1.18). Attempts motivated by cost and social factors nearly doubled (10.7–20.2 %; PR=1.89, 95 %CI1.37–2.60; 13.3–25.5 %; PR=1.92, 95 %CI1.46–2.52, respectively). Attempts driven by health professional advice increased (4.4–7.0 %; PR=1.57, 95 %CI0.96–2.57). Women, individuals from less advantaged social grades and with AUDIT-C 5–7 exhibited more pronounced changes in the proportion of attempts motivated by health concerns. Cost was a more consistent driver of attempts for those aged≥ 65.</div></div><div><h3>Conclusions</h3><div>Health concerns remain the most common motive for attempts to reduce alcohol consumption, but the proportion of attempts motivated by cost and social factors nearly doubled over the study period. These findings suggest the need for public health interventions that consider both economic and social influences alongside health concerns to better support alcohol reduction.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100340"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methadone-involved overdose deaths in urban and rural communities before and after the public health emergency flexibilities for methadone take-home doses","authors":"Rebecca Arden Harris ,&nbsp;Judith A. Long ,&nbsp;Yuhua Bao ,&nbsp;Henry R. Kranzler ,&nbsp;Jeanmarie Perrone ,&nbsp;David S. Mandell","doi":"10.1016/j.dadr.2025.100339","DOIUrl":"10.1016/j.dadr.2025.100339","url":null,"abstract":"<div><h3>Background</h3><div>To mitigate COVID-19 exposure risks in methadone clinics, the Substance Abuse and Mental Health Services Administration (SAMHSA) issued a temporary modification of regulations in March 2020 to permit extended take-home methadone doses: up to 28 days of take-home methadone for stable patients and 14 days for those less stable. This study examined the association between the policy change and fatal methadone overdoses across the urban-rural continuum.</div></div><div><h3>Methods</h3><div>This interrupted time series analysis used the U.S. <span><span>National Vital Statistics System</span></span> (NVSS) 2018–2022 mortality data to examine monthly trends in methadone-involved overdose deaths before and after the policy change allowing more take-home methadone doses. Deaths were stratified into six urban-rural categories and by co-involvement of fentanyl.</div></div><div><h3>Results</h3><div>Prior to the policy change, trends in methadone-involved overdose deaths were either flat or declining across all urbanization categories. Following the policy change, deaths decreased significantly in Large Central Metro areas but increased in rural Micropolitan counties. No trend changes occurred in the other urban or rural categories. When stratified by fentanyl co-involvement, Large Central Metro areas experienced a decrease in methadone deaths with fentanyl, though not statistically significant, and a significant decrease without fentanyl. In rural Micropolitan counties, methadone deaths saw an increase with fentanyl co-involvement that did not reach significance, and a significant increase without fentanyl. Noncore counties saw a significant increase in deaths involving both methadone and fentanyl, with no notable change observed without fentanyl.</div></div><div><h3>Conclusions</h3><div>Results suggest the need to expand methadone access and treatment supports in underserved rural communities, recognizing that factors beyond the policy change may have contributed to the reported associations.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100339"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid medication doses among safer supply clients: Current safer supply doses and previous OAT experience","authors":"Gillian Kolla ,&nbsp;Kaitlin Fajber ,&nbsp;Andrea Sereda ,&nbsp;Cassidy Morris ,&nbsp;Perri Deacon ,&nbsp;Lauren E. Cipriano","doi":"10.1016/j.dadr.2025.100338","DOIUrl":"10.1016/j.dadr.2025.100338","url":null,"abstract":"<div><h3>Introduction</h3><div>Safer opioid supply (SOS) is a harm reduction approach to prescribing pharmaceutical opioids to people at high risk of overdose from the toxic unregulated drug supply. Previous research demonstrates positive health outcomes and reductions in overdose mortality among SOS clients; however few reports describe previous opioid agonist treatment history prior to initiating SOS, or the medication combinations and doses prescribed within SOS programs.</div></div><div><h3>Methods</h3><div>We used convenience sampling to collect survey data from 95 SOS program clients in London, Canada. We use descriptive statistics to analyze survey data and report on OAT history prior to initiating SOS, including maximum methadone dose. We also report on current SOS medication combinations and doses.</div></div><div><h3>Findings</h3><div>Previous experience with OAT was common and reported by 87 % of SOS clients. Mean highest dose of methadone ever received was 95<!--> <!-->mg (range: 20–200<!--> <!-->mg), with close to 40 % reporting doses of ≥ 120<!--> <!-->mg. 95 % of SOS clients reported prescriptions for immediate-release tablet hydromorphone; 28 % were receiving hydromorphone monotherapy; 68 % were receiving hydromorphone alongside a long-acting opioid, and 5 % receiving hydromorphone alongside 2 long-acting opioids. Total average milligram morphine equivalent (MME) doses of combination SOS prescriptions (MME 1616) were similar to high dose methadone (120<!--> <!-->mg = MME 1440).</div></div><div><h3>Conclusions</h3><div>Previous high dose OAT experience was common among SOS clients prior to enrollment in the SOS program. Our results may inform the individualization of high dose opioid prescriptions for people with high tolerance due to exposure to unregulated fentanyl.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100338"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory study on the use of sexually transmitted infection prevention and contraception methods among women and men who use unprescribed opioids","authors":"Joy D. Scheidell ,&nbsp;Sophia Dakoulas ,&nbsp;Teresa Chueng ,&nbsp;Katrina Ciraldo ,&nbsp;Belén Hervera ,&nbsp;Muthoni Mahachi ,&nbsp;Luther C. Elliott ,&nbsp;Alex S. Bennet","doi":"10.1016/j.dadr.2025.100337","DOIUrl":"10.1016/j.dadr.2025.100337","url":null,"abstract":"<div><h3>Introduction</h3><div>The dual epidemics of sexually transmitted infections (STIs) and unprescribed opioid use persist globally, including in the United States. This study addresses gaps in STI prevention and contraception among people who use unprescribed opioids in New York City (NYC), focusing on both men and women.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional substudy from November 2021-August 2022 assessing sexual health with a one-time survey within a longitudinal cohort study among people who use unprescribed opioids in NYC that collected baseline data during 2019–2020. We measured sociodemographic characteristics, substance use history, sexual partnerships and STI prevention and contraception categorized as providing effective prevention versus none/ineffective. We estimated the prevalence of lack of effective STI prevention and contraception and potential correlates among males and females.</div></div><div><h3>Results</h3><div>The analytic sample included 108 participants (54 % male, 46 % female) with a mean age of 46 years. No/ineffective STI prevention was most common among reproductive-age females (81 %) and lowest among males (67 %) and no/less effective contraception was reported by approximately 90 % of participants. No/ineffective STI prevention and contraception were differentially associated with factors such as sexual partnerships, substance use treatment, and healthcare utilization among males and females.</div></div><div><h3>Discussion</h3><div>Findings highlight the need for improved provision of effective STI and pregnancy prevention methods for both men and women who use drugs. There is a critical need to expand access to sexual and reproductive health services for people who use drugs, including integrating these services into diverse healthcare and drug-service settings.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100337"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital detection of craving and stress for individuals in recovery from substance use disorder: A qualitative study","authors":"Jazmin Hampton ,&nbsp;Reynalde Eugene ,&nbsp;Nirzari Kapadia ,&nbsp;Emily Caggiano ,&nbsp;Amanda Geagea ,&nbsp;C. James Watson ,&nbsp;Stephanie Carreiro","doi":"10.1016/j.dadr.2025.100336","DOIUrl":"10.1016/j.dadr.2025.100336","url":null,"abstract":"<div><h3>Aims</h3><div>This study aims to 1) categorize experiences with stress and craving during substance use disorder (SUD) treatment, 2) explore perceptions of both clients and treatment providers towards a digital detection system for stress and craving during recovery, and 3) identify barriers and facilitators to adopting this technology during SUD treatment.</div></div><div><h3>Methods</h3><div>This was a qualitative study of people in recovery from SUD (clients) and healthcare providers from outpatient treatment facilities in the northeast United States. Clients were asked to use a digital health tool that detects physiological biomarkers of stress and craving (RAE Health) for 30 days alongside their usual treatment and to engage in a semi-structured interview upon completion. Providers were asked to participate in a one-time focus group.</div></div><div><h3>Results</h3><div>Thirty-one clients completed a semi-structured interview, and eleven providers participated in two focus groups. Four core themes emerged from the qualitative data: categorization of experiences with stress and craving, perceptions of digital detection systems, perceived barriers and facilitators of the system, and desired features of the system. Overall, client and provider perception were positive, and acceptability of the digital health tool was high.</div></div><div><h3>Conclusions</h3><div>A digital detection system for stress and craving during SUD recovery was perceived favorably by both clients and providers, with clients citing heightened awareness and providers citing opportunities for personalized care as promising use cases. Future iterations of digital health systems for this population should consider the ideal “dose” of the intervention to maximize benefit.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100336"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health clinicians’ perceptions on patient motivations and intervention engagement for prenatal cannabis use: A mixed methods study","authors":"Maha N. Mian ,&nbsp;Monique B. Does ,&nbsp;Andrea Altschuler ,&nbsp;Andrea Green ,&nbsp;Deborah R. Ansley ,&nbsp;Carley Castellanos ,&nbsp;Asma H. Asyyed ,&nbsp;Derek D. Satre ,&nbsp;Kelly C. Young-Wolff","doi":"10.1016/j.dadr.2025.100334","DOIUrl":"10.1016/j.dadr.2025.100334","url":null,"abstract":"<div><h3>Background</h3><div>Mental health clinicians are uniquely suited to support and provide important insights about substance use among pregnant patients. This mixed-methods study explored how mental health clinicians perceive and address prenatal cannabis use.</div></div><div><h3>Methods</h3><div>Participants were licensed mental health clinicians from Kaiser Permanente Northern California’s Early Start perinatal substance use screening and counseling program. Participants aimed to support patients’ goals for a healthy pregnancy. ESS completed a survey (<em>N</em> = 26; 100 % Female; 73.1 % White; <em>M</em>_age=48.1) and semi-structured interview (<em>n</em> = 14) on their perceptions about patients’ prenatal cannabis use and engagement in the ES program. Interviews were recorded, transcribed coded, and thematically analyzed.</div></div><div><h3>Results</h3><div>Survey results indicated clinicians perceive that nausea/morning sickness was the most common motive for prenatal cannabis use, and pregnant individuals were most likely to get information about prenatal cannabis use from their peers. Survey and interview results indicated clinicians most often used motivational interviewing, harm reduction, and psychoeducation to address cannabis use. Clinicians reported on psychotherapeutic factors (patient readiness, therapeutic rapport, and mental health support) that facilitate engagement and willingness to quit and/or reduce cannabis use during pregnancy. Other themes included ESS utilization of expertise in complementary mental health topics to support their work.</div></div><div><h3>Conclusions</h3><div>In this mixed-methods study, clinicians described several approaches to increase pregnant patients’ willingness to engage in perinatal substance use interventions, including eliciting motives for cannabis use and using patient-centered interventions focused on establishing rapport and addressing readiness to quit. Future interventions for patients might incorporate harm reduction and psychoeducation, address motivations for use and readiness to engage in care, emphasize peer support, and support the implementation of complementary interventions.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100334"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between race-based bullying and nicotine vaping in adolescents","authors":"Christina Grimo ,&nbsp;Megan Magier ,&nbsp;Scott T. Leatherdale ,&nbsp;Karen A. Patte","doi":"10.1016/j.dadr.2025.100335","DOIUrl":"10.1016/j.dadr.2025.100335","url":null,"abstract":"<div><h3>Background</h3><div>Racialized youth face a higher risk of bullying victimization due to discriminatory bias which can lead to adverse health conditions and increased substance use. This study aimed to examine whether bullying victimization is associated with nicotine vaping, and whether race-based bullying was associated with greater odds of nicotine vaping than other forms of bullying.</div></div><div><h3>Methods</h3><div>Cross-sectional survey data were used from the COMPASS study collected during the 2022–2023 school year from 14,480 students attending secondary schools in Ontario, Canada. Associations between any bullying victimization (in the last 30 days) and nicotine vaping (≥2 times in the last 30 days), and then among bullied students, between race-based bullying and vaping, were explored using random intercept logistic regression models.</div></div><div><h3>Results</h3><div>One third (33.4 %) of students who reported race-based bullying engaged in vaping, in comparison to 29.4 % of students who were bullied for other reasons and 15.6 % of nonbullied students. Students who experienced bullying had higher odds (AOR 2.25, 95 % CI [2.03–2.50]) of vaping relative to nonbullied students. Among students who experienced bullying, there was no statistical difference in the odds of vaping between those who reported being bullied due to racial or cultural reasons and their peers who reported being bullied for reasons other than their race or culture (1.16, 95 % CI [0.81–1.67]).</div></div><div><h3>Conclusions</h3><div>Results suggest that while bullying is strongly associated with vaping among adolescents, being bullied for reasons such as race, culture, or ethnicity does not significantly alter the likelihood of vaping behaviour relative to other forms of bullying.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100335"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minority stress and stimulant use among US adult sexual minority men: A systematic review","authors":"Michael Miller-Perusse ,&nbsp;Keith J. Horvath ,&nbsp;Jessica L. Montoya ,&nbsp;David J. Moore ,&nbsp;Adam W. Carrico ,&nbsp;Vanessa B. Serrano","doi":"10.1016/j.dadr.2025.100333","DOIUrl":"10.1016/j.dadr.2025.100333","url":null,"abstract":"<div><h3>Purpose</h3><div>Minority stress theory posits health disparities among sexual minority men (SMM; i.e., non-heterosexual) result from experiences of sexual minority stigma (SMS). This systematic review synthesizes quantitative findings on the association between minority stress and stimulant use among US adult SMM.</div></div><div><h3>Methods</h3><div>PubMed, PsycInfo, CINAHL, and Scopus searches between November 2022 and October 2023 identified 991 studies, with 13 meeting selection criteria: English, peer-reviewed publication reporting an estimated minority stressor–stimulant use association among US adult SMM. Minority stressors included enacted, internalized, or anticipated SMS or identity concealment. Stimulants included methamphetamine, cocaine/crack cocaine, and diverted prescriptions. Proportions of studies and estimates indicating statistically significant associations were examined in total and for each minority stressor–stimulant pair.</div></div><div><h3>Results</h3><div>Many studies included primarily Black/Latino (69.2 %), urban (76.9 %), young adult samples (38.5 %). Significant associations were reported in 42.9 % (6/13) of studies but represented only 38.2 % (13/34) of unique estimates. Most estimates involving composite stimulant outcomes were nonsignificant (86.7 %, 13/15). Most estimates of enacted SMS–methamphetamine (66.7 %, 2/3), internalized SMS–methamphetamine (66.7 %, 4/6), and internalized SMS–cocaine/crack cocaine (83.3 %, 5/6) associations were significant. Findings suggest sexual orientation (i.e., gay vs bisexual) may moderate internalized SMS effects. Few studies examined prescription stimulants and none examined anticipated SMS or identity concealment.</div></div><div><h3>Conclusions</h3><div>Further research is needed examining the use of various stimulants independently, not in composite, and testing for moderation by sexual orientation. Findings suggest multi-level approaches targeting enacted SMS and individual-level approaches targeting internalized SMS may benefit SMM who use methamphetamine or cocaine/crack cocaine, respectively.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100333"},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}