{"title":"Role and Challenges of Endoscopic Ultrasonography-Guided Tissue Acquisition for Para-Aortic Lymph Node Staging.","authors":"Kosuke Minaga, Masatoshi Kudo","doi":"10.1111/den.15065","DOIUrl":"https://doi.org/10.1111/den.15065","url":null,"abstract":"","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serious adverse events associated with bowel preparation for colonoscopy in Japan: Systematic review.","authors":"Toshihiro Tadano, Koichiro Abe, Seiju Sasaki, Teruhiko Terasawa, Satoyo Hosono, Takafumi Katayama, Keika Hoshi, Tomio Nakayama, Chisato Hamashima","doi":"10.1111/den.15055","DOIUrl":"https://doi.org/10.1111/den.15055","url":null,"abstract":"<p><strong>Objectives: </strong>Bowel preparation for colonoscopy can lead to serious adverse events (AEs), raising significant safety concerns in colorectal cancer (CRC) screening. A systematic review of these serious AEs in Japan was performed to explore potential management strategies.</p><p><strong>Methods: </strong>The Ovid-MEDLINE and Ichushi databases were searched from inception to March 2024. Domestic studies that reported serious AEs in adults aged 18 years and older who were administered bowel cleansing agents or laxatives for a scheduled colonoscopy, regardless of its purpose, were extracted. Serious AEs were defined as those requiring hospitalization or extended hospital stays. Selected studies were assessed for quality verification using the established checklist.</p><p><strong>Results: </strong>A total of 5049 articles were identified through database searches, and 54 articles were extracted based on selection criteria. Reports of the frequency of serious AEs were based on one case series study, which found 13.9 cases of bowel obstruction and 2.3 cases of bowel perforation per 100,000 colonoscopies. Multiple serious AEs caused by different agents were identified in 78 cases across 54 articles. These AEs were predominantly observed in elderly individuals and those with comorbidities. Though most cases were associated with diagnostic tests for symptomatic patients, some were also observed in primary screening or fecal test-positive individuals. The most common AE was induced by bowel obstruction, primarily in abdominally symptomatic patients, including one fatality.</p><p><strong>Conclusion: </strong>The frequency and characteristics of serious AEs associated with bowel preparation for colonoscopy in Japan were presented. These findings may contribute to managing these AEs, specifically in CRC screening.</p>","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and Safety of a Novel Rotatable Sphincterotome for Endoscopic Sphincterotomy in Patients With Roux-en-Y Gastrectomy During Balloon Enteroscopy-Assisted ERCP (With Video).","authors":"Yuki Tanisaka, Shomei Ryozawa, Masafumi Mizuide, Akashi Fujita, Ryuichi Watanabe, Kengo Komori","doi":"10.1111/den.15066","DOIUrl":"https://doi.org/10.1111/den.15066","url":null,"abstract":"<p><p>Endoscopic sphincterotomy (EST) is challenging for patients with surgically altered anatomy (SAA). The blades of conventional sphincterotomes designed for SAA do not always face the correct direction of EST. We aimed to evaluate the efficacy and safety of a novel rotatable sphincterotome for EST in patients undergoing Roux-en-Y gastrectomy during balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (BE-ERCP). Patients with Roux-en-Y gastrectomy who underwent BE-ERCP and EST using a novel rotatable sphincterotome between April 2024 and February 2025 were analyzed. Overall, 30 patients were attempted EST with a novel rotatable sphincterotome. EST, including adjustment of the blade to the correct incision direction, was successfully performed in all patients. The median time to complete EST was 3 min. Adverse events occurred in one case of mild post-ERCP pancreatitis. There was no bleeding or perforation associated with EST. No significant differences were observed in the success rate of EST, time to complete EST, or adverse event rate between the experienced endoscopists and trainee fellows. The use of a novel rotatable sphincterotome for EST during BE-ERCP was technically feasible and safe in patients who underwent Roux-en-Y gastrectomy, which may help standardize EST in patients with SAA.</p>","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vikram Bhatia, Rajan Vijayaraghavan, Ananthu Narayan, Suguna Sree Aakula
{"title":"Trans-anorectal curved linear-array endoscopic ultrasound: Comprehensive pictorial guide (with videos).","authors":"Vikram Bhatia, Rajan Vijayaraghavan, Ananthu Narayan, Suguna Sree Aakula","doi":"10.1111/den.15057","DOIUrl":"https://doi.org/10.1111/den.15057","url":null,"abstract":"<p><p>Interest in using flexible endoscopic ultrasound (EUS) probes for transrectal applications is growing, including tissue sampling and therapeutic procedures. In this review, we describe of the techniques and anatomical considerations for trans-anorectal ultrasound using a flexible, curved linear array EUS probe (CLA-EUS). Orientation with flexible CLA-EUS in the ano-rectum can be challenging; bony structures should be used as the posterior reference and pelvic organs as the anterior reference structures. Key landmarks, including aortic division, iliac vessels and their divisions, and peritoneal reflections and recesses are described. These vascular and anatomical landmarks are essential for N and M staging of rectal cancers. The anatomy and zonal structure of the prostate, along with the appearance of seminal vesicles, ejaculatory ducts, bladder, ureters, uterus, cervix, and ovaries on CLA-EUS, are detailed. Finally, we describe the anatomy and imaging of the anal canal and pelvic floor muscles, emphasizing differences between CLA-EUS and radial EUS imaging techniques.</p>","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Revising the current consensus on the treatment of gastric neuroendocrine tumors.","authors":"Shigetaka Yoshinaga","doi":"10.1111/den.15062","DOIUrl":"https://doi.org/10.1111/den.15062","url":null,"abstract":"","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Grasp-and-lift technique - Novel cold forceps polypectomy technique for a gastric foveolar-type adenoma.","authors":"Nobuyuki Suzuki, Hiroya Ueyama, Akihito Nagahara","doi":"10.1111/den.15059","DOIUrl":"https://doi.org/10.1111/den.15059","url":null,"abstract":"","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Snooze but don't lose: Remimazolam for sedation in gastrointestinal endoscopy.","authors":"Yousuke Nakai","doi":"10.1111/den.15063","DOIUrl":"https://doi.org/10.1111/den.15063","url":null,"abstract":"","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wave height fluctuations in the waveforms of an endoscopic pressure study integrated system have the potential to predict acid reflux in gastroesophageal reflux disease (with video).","authors":"Satoshi Abiko, Yuto Shimamura, Haruhiro Inoue, Masachika Saino, Kei Ushikubo, Miyuki Iwasaki, Kazuki Yamamoto, Yohei Nishikawa, Ippei Tanaka, Hidenori Tanaka, Mayo Tanabe, Boldbaatar Gantuya, Manabu Onimaru, Naoya Sakamoto","doi":"10.1111/den.15049","DOIUrl":"https://doi.org/10.1111/den.15049","url":null,"abstract":"<p><strong>Objectives: </strong>The endoscopic pressure study integrated system (EPSIS) is a useful diagnostic tool for gastroesophageal reflux disease (GERD). Although wave height fluctuations have been observed in EPSIS waveforms, their clinical significance remains unclear. We hypothesized that the magnitude of these fluctuations may reflect lower esophageal sphincter functionality. This study aimed to evaluate the association between wave height fluctuations and objective acid reflux parameters.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients with GERD symptoms who underwent both EPSIS and 24-h multichannel intraluminal impedance-pH monitoring at a single tertiary center between June 2020 and December 2023. Abnormal acid reflux was defined as an acid exposure time (AET) ≥6.0%. Wave height was defined as the difference in intragastric pressure between the crest and trough of the EPSIS waveform. A diagnostic cut-off value for wave height was determined, and factors associated with elevated wave height were analyzed.</p><p><strong>Results: </strong>A total of 129 patients were included, of whom 29 (22.5%) had abnormal acid reflux. The median wave height was 2.5 mmHg. Patients with AET ≥6% had significantly higher wave heights than those with AET <6% (P = 0.0141). A wave height of 3.1 mmHg demonstrated optimal diagnostic performance for predicting abnormal AET. Multivariate analysis revealed that abnormal AET (odds ratio 3.43, 95% confidence interval 1.39-8.44, P = 0.0074) was independently associated with wave heights ≥3.1 mmHg.</p><p><strong>Conclusions: </strong>Wave height fluctuations in EPSIS waveforms may reflect lower esophageal sphincter dysfunction and serve as a novel predictor of pathological acid reflux in patients with GERD.</p>","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kaizen: Perpetual improvement in biliary ablation - From technical validation to clinical translation.","authors":"Eisuke Iwasaki, Fateh Bazerbachi","doi":"10.1111/den.15053","DOIUrl":"https://doi.org/10.1111/den.15053","url":null,"abstract":"","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic ultrasound-guided tissue acquisition for assessment of resectability in pancreatobiliary cancer.","authors":"Yasunobu Yamashita, Masayuki Kitano","doi":"10.1111/den.15052","DOIUrl":"https://doi.org/10.1111/den.15052","url":null,"abstract":"","PeriodicalId":72813,"journal":{"name":"Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}