Current research in neurobiology最新文献

{"title":"Ouabain increases neuronal differentiation of hippocampal neural precursor cells","authors":"Ana Maria Orellana , Natacha Medeiros S. Port's , Larissa de Sá Lima , Jacqueline Alves Leite , Diana Zukas Andreotti , Paula Fernanda Kinoshita , Arthur B. Cantanzaro , João Agostinho M. Neto , Cristoforo Scavone , Elisa M. Kawamoto","doi":"10.1016/j.crneur.2025.100147","DOIUrl":"10.1016/j.crneur.2025.100147","url":null,"abstract":"","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"8 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal dynamics of offline transcranial ultrasound stimulation","authors":"Cyril Atkinson-Clement ,&nbsp;David Howett ,&nbsp;Mohammad Alkhawashki ,&nbsp;James Ross ,&nbsp;Ben Slater ,&nbsp;Marilyn Gatica ,&nbsp;Fabien Balezeau ,&nbsp;Chencheng Zhang ,&nbsp;Jerome Sallet ,&nbsp;Chris Petkov ,&nbsp;Marcus Kaiser","doi":"10.1016/j.crneur.2025.100148","DOIUrl":"10.1016/j.crneur.2025.100148","url":null,"abstract":"<div><div>Transcranial ultrasound stimulation (TUS) is a promising non-invasive neuromodulation modality, characterized by deep-brain accuracy and the capability to induce longer-lasting effects. However, most TUS datasets are underpowered, hampering efforts to identify TUS longevity and temporal dynamics. This primate case was studied awake with over 50 fMRI datasets, with and without left anterior hippocampus TUS. We therefore amassed the highest-powered TUS dataset to date required to reveal TUS longevity and dynamics. Most of the effects were found in the TUS region itself and alongside the default mode and sensorimotor networks. Seed-based functional connectivity exhibited a time-constrained alteration which dissipated ∼60 min post-TUS. Intrinsic activity measure and regional homogeneity displayed extended diffusivity and longer durations. This high-powered dataset allowed predicting TUS using pre-stimulation features that can now extend to modeling of individuals scanned less extensively. This case report reveals the diversity of TUS temporal dynamics to help to advance long-lasting human applications.</div></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"8 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid degeneration and neurochemical plasticity of the lateral geniculate nucleus following lesions of the primary visual cortex in marmoset monkeys","authors":"Gaoyuan Ma,&nbsp;Jonathan M. Chan,&nbsp;Katrina H. Worthy,&nbsp;Marcello G.P. Rosa,&nbsp;Nafiseh Atapour","doi":"10.1016/j.crneur.2024.100141","DOIUrl":"10.1016/j.crneur.2024.100141","url":null,"abstract":"<div><div>Lesions of the primary visual cortex (V1) cause retrograde neuronal degeneration, volume loss and neurochemical changes in the lateral geniculate nucleus (LGN). Here we characterised the timeline of these processes in adult marmoset monkeys, after various recovery times following unilateral V1 lesions. Observations in NeuN-stained sections obtained from animals with short recovery times (2, 3 or 14 days) showed that the volume and neuronal density in the LGN ipsilateral to the lesions were similar to those in the contralateral hemispheres. However, neuronal density in the lesion projection zone of LGN dropped rapidly thereafter, with approximately 50% of the population lost within a month post-lesion. This level of neuronal loss remained stable for over three years post-lesion. In comparison, shrinkage of the LGN volume progressed more gradually, not reaching a stable value until 6 months post lesion. We also determined the time course of the expression of the calcium-binding protein calbindin (CB) in magnocellular (M) and parvocellular (P) layer neurons, a form of neurochemical plasticity previously reported to be triggered by V1 lesions. We found that CB expression could be detected in surviving M and P neurons as early as two weeks after lesion, with the percentage of neurons showing this neurochemical phenotype gradually increasing over 6 months. Thus, neurochemical change precedes neuronal degeneration, suggesting it may be linked to a protective mechanism. This study highlights the limited time window for any possible interventions aimed at reducing secondary neuronal loss in the visual afferent pathways following damage to V1.</div></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"8 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinotopic biases in contextual feedback signals to V1 for object and scene processing","authors":"Matthew A. Bennett ,&nbsp;Lucy S. Petro ,&nbsp;Clement Abbatecola ,&nbsp;Lars F. Muckli","doi":"10.1016/j.crneur.2024.100143","DOIUrl":"10.1016/j.crneur.2024.100143","url":null,"abstract":"<div><div>Identifying the objects embedded in natural scenes relies on recurrent processing between lower and higher visual areas. How is cortical feedback information related to objects and scenes organised in lower visual areas? The spatial organisation of cortical feedback converging in early visual cortex during object and scene processing could be retinotopically specific as it is coded in V1, or object centred as coded in higher areas, or both. Here, we characterise object and scene-related feedback information to V1. Participants identified foreground objects or background scenes in images with occluded central and peripheral subsections, allowing us to isolate feedback activity to foveal and peripheral regions of V1. Using fMRI and multivoxel pattern classification, we found that background scene information is projected to both foveal and peripheral V1 but can be disrupted in the fovea by a sufficiently demanding object discrimination task, during which we found evidence of foveal object decoding when using naturalistic stimuli. We suggest that the feedback connections during scene perception project back to earlier visual areas an automatic sketch of occluded information to the predicted retinotopic location. In the case of a cognitive task however, feedback pathways project content to foveal retinotopic space, potentially for introspection, functioning as a cognitive active blackboard and not necessarily predicting the object's location. This feedback architecture could reflect the internal mapping in V1 of the brain's endogenous models of the visual environment that are used to predict perceptual inputs.</div></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"8 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct functional cerebral hypersensitivity networks during incisional and inflammatory pain in rats","authors":"Silke Kreitz ,&nbsp;Bruno Pradier ,&nbsp;Daniel Segelcke ,&nbsp;Saeedeh Amirmohseni ,&nbsp;Andreas Hess ,&nbsp;Cornelius Faber ,&nbsp;Esther M. Pogatzki-Zahn","doi":"10.1016/j.crneur.2024.100142","DOIUrl":"10.1016/j.crneur.2024.100142","url":null,"abstract":"<div><div>Although the pathophysiology of pain has been investigated tremendously, there are still many open questions with regard to specific pain entities and their pain-related symptoms. To increase the translational impact of (preclinical) animal neuroimaging pain studies, the use of disease-specific pain models, as well as relevant stimulus modalities, are critical. We developed a comprehensive framework for brain network analysis combining functional magnetic resonance imaging (MRI) with graph-theory (GT) and data classification by linear discriminant analysis. This enabled us to expand our knowledge of stimulus modalities processing under incisional (INC) and pathogen-induced inflammatory (CFA) pain entities compared to acute pain conditions. GT-analysis has uncovered specific features in pain modality processing that align well with those previously identified in humans. These include areas such as S1, M1, CPu, HC, piriform, and cingulate cortex. Additionally, we have identified unique Network Signatures of Pain Hypersensitivity (NSPH) for INC and CFA. This leads to a diminished ability to differentiate between stimulus modalities in both pain models compared to control conditions, while also enhancing aversion processing and descending pain modulation. Our findings further show that different pain entities modulate sensory input through distinct NSPHs. These neuroimaging signatures are an important step toward identifying novel cerebral pain biomarkers for certain diseases and relevant outcomes to evaluate target engagement of novel therapeutic and diagnostic options, which ultimately can be translated to the clinic.</div></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"8 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of Embelin in Benzo[α]pyrene induced cognitive and memory impairment in experimental model of mice","authors":"Akansh Goal,&nbsp;Khadga Raj,&nbsp;Shamsher Singh,&nbsp;Rimpi Arora","doi":"10.1016/j.crneur.2023.100122","DOIUrl":"10.1016/j.crneur.2023.100122","url":null,"abstract":"<div><p>Alzheimer's disease (AD) is a neurodegenerative disease that affects the neurons in the hippocampus, resulting in cognitive and memory impairment. The most prominent clinical characteristics of AD are the production of amyloid-beta (Aβ) plaques, neurofibrillary tangles, and neuroinflammation in neurons. It has been proven that embelin (Emb) possesses antioxidant, anti-inflammatory, and neuroprotective properties. Therefore, we assessed the therapeutic potential of Emb in Benzo [α]pyrene (BaP)-induced cognitive impairment in experimental mice. BaP (5 mg/kg, i. p) was given to mice daily for 28 days, and Emb (2.5, 5, and 10 mg/kg, i. p) was given from 14 to 28 days of a protocol. In addition, locomotor activity was evaluated using open-field and spatial working, and non-spatial memory was evaluated using novel object recognition tasks (NORT), Morris water maze (MWM), and Y- maze. At the end of the study, the animal tissue homogenate was used to check biochemicals, neuroinflammation, and neurotransmitter changes. BaP-treated mice showed a significant decline in locomotor activity, learning and memory deficits and augmented oxidative stress (lipid peroxidation, nitrite, and GSH). Further, BaP promoted the release of inflammatory tissue markers, decreased acetylcholine, dopamine, GABA, serotonin, and norepinephrine, and increased glutamate concentration. However, treatment with Emb at dose-dependently prevented biochemical changes, improved antioxidant levels, reduced neuroinflammation, restored neurotransmitter concentration, and inhibited the NF-κB pathway. The current study's finding suggested that Emb improved cognitive functions through antioxidant, anti-inflammatory, and neuroprotective mechanisms and inhibition of acetylcholinesterase (AChE) enzyme activities and Aβ-42 accumulation.</p></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"6 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665945X23000505/pdfft?md5=04467b5e8a8dd40ebf8dd9b01aabac44&pid=1-s2.0-S2665945X23000505-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decrease in phase slip rates and phase cone structures during seizure evolution and epileptogenic activities derived from microgrid ECoG data","authors":"Ceon Ramon ,&nbsp;Alexander Doud ,&nbsp;Mark D. Holmes","doi":"10.1016/j.crneur.2024.100126","DOIUrl":"10.1016/j.crneur.2024.100126","url":null,"abstract":"<div><p>Sudden phase changes are related to cortical phase transitions, which likely change in frequency and spatial distribution as epileptogenic activity evolves. A 100 s long section of micro-ECoG data obtained before and during a seizure was selected and analyzed. In addition, nine other short-duration epileptic events were also examined. The data was collected at 420 Hz, imported into MATLAB, downsampled to 200 Hz, and filtered in the 1–50 Hz band. The Hilbert transform was applied to compute the analytic phase, which was then unwrapped, and detrended to look for sudden phase changes. The phase slip rate (counts/s) and its acceleration (counts/s²) were computed with a stepping window of 1-s duration and with a step size of 5 ms. The analysis was performed for theta (3–7 Hz), alpha (7–12 Hz), and beta (12–30 Hz) bands. The phase slip rate on all electrodes in the theta band decreased while it increased for the alpha and beta bands during the seizure period. Similar patterns were observed for isolated epileptogenic events. Spatiotemporal contour plots of the phase slip rates were also constructed using a montage layout of 8 × 8 electrode positions. These plots exhibited dynamic and oscillatory formation of phase cone-like structures which were higher in the theta band and lower in the alpha and beta bands during the seizure period and epileptogenic events. These results indicate that the formation of phase cones might be an excellent biomarker to study the evolution of a seizure and also the cortical dynamics of isolated epileptogenic events.</p></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"6 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665945X24000032/pdfft?md5=298bae3fdfba77f22697ec3bc3b8391d&pid=1-s2.0-S2665945X24000032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal insulin attenuates hypoxia-ischemia-induced short-term sensorimotor behavioral disturbances, neuronal apoptosis, and brain damage in neonatal rats","authors":"Chirag P. Talati ,&nbsp;Jonathan W. Lee ,&nbsp;Silu Lu ,&nbsp;Norma B. Ojeda ,&nbsp;Varsha Prakash ,&nbsp;Nilesh Dankhara ,&nbsp;Tanner C. Nielson ,&nbsp;Sara P. Sandifer ,&nbsp;Gene L. Bidwell III ,&nbsp;Yi Pang ,&nbsp;Lir-Wan Fan ,&nbsp;Abhay J. Bhatt","doi":"10.1016/j.crneur.2023.100123","DOIUrl":"https://doi.org/10.1016/j.crneur.2023.100123","url":null,"abstract":"<div><p>There is a significant need for additional therapy to improve outcomes for newborns with acute Hypoxic-ischemic (HI) encephalopathy (HIE). New evidence suggests that insulin could be neuroprotective. This study aimed to investigate whether intranasal insulin attenuates HI-induced brain damage and neurobehavioral dysfunction in neonatal rats. Postnatal day 10 (P10), Sprague-Dawley rat pups were randomly divided into Sham + Vehicle, Sham + Insulin, HI + Vehicle, and HI + Insulin groups with equal male-to-female ratios. Pups either had HI by permanent ligation of the right common carotid artery followed by 90 min of hypoxia (8% O2) or sham surgery followed by room air exposure. Immediately after HI or Sham, pups were given fluorescence-tagged insulin (Alex-546-insulin)/vehicle, human insulin (25 μg), or vehicle in each nare under anesthesia. Shortly after administration, widespread Alex-546-insulin-binding cells were detected in the brain, primarily co-localized with neuronal nuclei-positive neurons on double-immunostaining. In the hippocampus, phospho-Akt was activated in a subset of Alex-546-insulin double-labeled cells, suggesting activation of the Akt/PI3K pathway in these neurons. Intranasal insulin (InInsulin) reduced HI-induced sensorimotor behavioral disturbances at P11. InInsulin prevented HI-induced increased Fluoro-Jade C+ degenerated neurons, cleaved caspase 3+ neurons, and volume loss in the ipsilateral brain at P11. There was no sex-specific response to HI or insulin. The findings confirm that intranasal insulin provides neuroprotection against HI brain injury in P10 rats associated with activation of intracellular cell survival signaling. If further pre-clinical research shows long-term benefits, intranasal insulin has the potential to be a promising non-invasive therapy to improve outcomes for newborns with HIE.</p></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"6 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665945X23000517/pdfft?md5=e55477a14056d7c04a5102090ef21a73&pid=1-s2.0-S2665945X23000517-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling for neurosurgical laser interstitial thermal therapy with and without intracranial recording electrodes","authors":"Daniel W. Keefe ,&nbsp;David T. Christianson ,&nbsp;Greyson W. Davis ,&nbsp;Hiroyuki Oya ,&nbsp;Matthew A. Howard III ,&nbsp;Christopher I. Petkov ,&nbsp;Fatima Toor","doi":"10.1016/j.crneur.2024.100139","DOIUrl":"10.1016/j.crneur.2024.100139","url":null,"abstract":"<div><p>Laser thermal ablation has become a prominent neurosurgical treatment approach, but in epilepsy patients it cannot currently be safely implemented with intracranial recording electrodes that are used to study interictal or epileptiform activity. There is a pressing need for computational models of laser interstitial thermal therapy (LITT) with and without intracranial electrodes to enhance the efficacy and safety of optical neurotherapies. In this paper, we aimed to build a biophysical bioheat and ray optics model to study the effects of laser heating in the brain, with and without intracranial electrodes in the vicinity of the ablation zone during the LITT procedure. COMSOL Multiphysics finite element method (FEM) solver software was used to create a bioheat thermal model of brain tissue, with and without blood flow incorporation via Penne's model, to model neural tissue response to laser heating. We report that the close placement of intracranial electrodes can increase the maximum temperature of the brain tissue volume as well as impact the necrosis region volume if the electrodes are placed too closely to the laser coupled diffuse fiber tip. The model shows that an electrode displacement of 4 mm could be considered a safe distance of intracranial electrode placement away from the LITT probe treatment area. This work, for the first time, models the impact of intracranially implanted recording electrodes during LITT, which could improve the understanding of the LITT treatment procedure on the brain's neural networks a sufficient safe distance to the implanted intracranial recording electrodes. We recommend modeling safe distances for placing the electrodes with respect to the infrared laser coupled diffuse fiber tip.</p></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"7 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665945X24000160/pdfft?md5=b0aa36c26830c2f3500b6d7253f7ad15&pid=1-s2.0-S2665945X24000160-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal P300 asymmetry and congruence judgment: Retroactive switching is impaired during school day mornings in female adolescents","authors":"Gabriel E. Byczynski ,&nbsp;Amedeo D'Angiulli","doi":"10.1016/j.crneur.2024.100128","DOIUrl":"https://doi.org/10.1016/j.crneur.2024.100128","url":null,"abstract":"<div><p>Investigating frontal EEG asymmetry as a possible biomarker of cognitive control abilities is especially important in ecological contexts such as school and work. We used a novel approach combining judgment performance and hemispheric frontal event-related potential (ERP) P300 asymmetry (fP3As) to evaluate aspects of cognitive control (i.e., repetition and switching) in adolescent females over a two-week ordinary school period. While undergoing electroencephalographic recording, students performed a word-colour “Stroop-like” congruence judgment task during morning and afternoon sessions, on Mondays and Wednesdays. Proportion of incongruence and congruence trials was 75% and 25%, respectively. ERP analysis revealed larger “novelty” right hemispheric fP3As amplitude for infrequent congruence but equivalent or significantly smaller than left hemispheric fP3As amplitude for frequent incongruence. RTs increased with extent of right fP3As shift. Behaviorally, repeat trial pairs (i.e., congruent followed by congruent, incongruent followed by incongruent) generally did not differ by time or day and were associated with near-ceiling accuracy. In contrast, switch trial pairs (i.e., congruent followed by incongruent, incongruent followed by congruent) in the afternoon were slower and associated with lower accuracy at the expected 75% criterion rate (i.e., judging incongruence by default), dropping significantly below 75% in the mornings. Crucially, compared to afternoon, morning fP3As patterns did not change adaptively with switch trial pairs. Although retroactive switching during congruence judgment was affected at all testing times, we conclude it was most impaired in the mornings of both early and mid school weeks, supporting misalignment between adolescent circadian cycle and school start time. We discuss some implications for optimal learning of adolescents at school.</p></div>","PeriodicalId":72752,"journal":{"name":"Current research in neurobiology","volume":"6 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665945X24000056/pdfft?md5=180e96708b7e20b2e258a28bf0db7083&pid=1-s2.0-S2665945X24000056-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140330870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}