Current research in medical sciences最新文献

{"title":"Progress in the Study of Esophageal Cancer-Related Genes and Their Therapeutic Modalities","authors":"Siping Qin","doi":"10.56397/crms.2023.03.14","DOIUrl":"https://doi.org/10.56397/crms.2023.03.14","url":null,"abstract":"Esophageal cancer is a prevalent malignant tumor of the digestive tract that has a high mortality rate, posing a severe threat to human life. The development of esophageal cancer is the result of multiple factors, and the process of carcinogenesis is accompanied by abnormal expression of several genes. Mutations in oncogenes and tumor suppressor genes result in changes in their expression and activity, playing a crucial role in the occurrence, development, pathological staging, and prognosis of esophageal cancer. This paper aims to review and study recent research on esophageal cancer, including basic information, related genes, and treatment modalities, in order to explore new ideas and research bases for the diagnosis and treatment of esophageal cancer.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85985222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 9-Year-Old Child with Kawasaki Disease Complicated with Mycoplasma Infection: A Case Report and Literature Review","authors":"Nairong Gao, F. Zhao, Yile Kou, Qian Bai, H. Ding","doi":"10.56397/crms.2023.03.10","DOIUrl":"https://doi.org/10.56397/crms.2023.03.10","url":null,"abstract":"Kawasaki disease (KD), also known as cutaneous mucosal lymph node syndrome, is an immune-mediated vasculitis, which is easy to involve small and medium-sized arteries, especially coronary arteries, and can cause a variety of cardiac sequelae. It primarily affects children from 6 months to 5 years old. In recent years, it has been reported that the incidence of KD is gradually increasing, and there are some reports of KD in teenagers and even adults. By reporting the clinical data of a 9-year-old KD child with mycoplasma infection who presented to children’s Hospital of Second Affiliated Hospital of Shaanxi University of Chinese Medicine and reviewing relevant literature, this paper aims to provide clinical reference for the prevention and treatment of missed diagnosis of KD in older children.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"229 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77601096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Latest Development of Sanfu Herbal Patch in the Treatment of Allergic Rhinitis","authors":"Yunchuan Tian, Yonglian Tang, Jiang Xiao, Rongkun Li, Qingyang Zhu","doi":"10.56397/crms.2023.03.12","DOIUrl":"https://doi.org/10.56397/crms.2023.03.12","url":null,"abstract":"Allergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mainly mediated by IgE after the body is exposed to allergens (Guidelines for diagnosis and treatment of allergic rhinitis, 2010), with paroxysmal episodes of frequent sneezing, a large amount of watery nose, nasal congestion, thickening of the nasal mucosa as the main characteristics (Xuting Ye, Shuili Zheng, & Zhihua Wang, 2016), because it can further induce bronchial asthma, allergic conjunctivitis, otitis media, sinusitis, tracheal and bronchitis, pharyngitis and other diseases, which has a great impact on the quality of life of patients (Chun Wang, Lili Jiang, Zhendong Shi, et al., 2019). Sanfu herbal patch, a method of traditional Chinese medicine winter disease summer treatment, can effectively improve individual immunity and reduce the occurrence of winter diseases. At present, studies have found that the traditional Chinese medicine Sanfu herbal patch as a complementary and alternative treatment of allergic rhinitis has significant effects.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89682520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Research Progress of Cone-Beam Breast Computed Tomography in Clinical Application","authors":"Rui Wang, Z. Ouyang","doi":"10.56397/crms.2023.03.16","DOIUrl":"https://doi.org/10.56397/crms.2023.03.16","url":null,"abstract":"Cone-beam breast computed tomography (CBBCT) is a specialized imaging modality for breast examination that can generate high-resolution three-dimensional images with 3D isotropic resolution. This method has high sensitivity and better displays breast cancer lesions and microcalcifications, especially in the dense breast. When combined with CBBCT plain and enhanced scans, the efficiency of diagnosis and treatment can be further improved. Enhanced CT scans provide a better display of the morphological characteristics of tumor lesions, surrounding tissues, and blood vessels, thereby providing more comprehensive diagnostic information. The imaging manifestations of breast cancer on CBBCT are closely related to the molecular subtypes and immunohistochemical receptor status of the tumor. By incorporating imaging characteristics, the molecular subtypes, and the status of immunohistochemical receptors of breast cancer, the diagnosis and evaluation of the disease can be predicted and assessed accurately. In recent years, CBBCT has shown great potential in the diagnosis and evaluation of breast cancer. This article provides a review of the operational characteristics of cone beam breast CT and the recent research progress in the diagnosis and evaluation of breast diseases.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"410 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76716985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Brief Analysis on the Modulation Effect of Ba Duan Jin on Non-Motor Symptoms of Parkinson’s Disease","authors":"Kefan Li, Jun Li","doi":"10.56397/crms.2023.03.08","DOIUrl":"https://doi.org/10.56397/crms.2023.03.08","url":null,"abstract":"Parkinson’s disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. The non-motor symptoms of PD, such as depression and anxiety, are often ignored in the face of typical motor symptoms such as tremor and bradykinesia. Non-motor symptoms in PD will not only increase the burden of patients, affect the quality of life, but also reduce the effect of PD drug treatment. A vicious circle is formed. At present, PD cannot be cured. Drugs are the first-line treatment, but long-term use in clinical practice will bring various side effects. Clinical studies have shown that Ba duan Jin as an adjuvant treatment can improve the non-motor symptoms of PD and delay the progression of PD. However, the regulatory mechanism of Ba duan jin on non-motor symptoms of PD is still unclear, which needs to be further elaborated in combination with the theory of traditional Chinese medicine.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83372062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significance of Oral Health Prevention and Care for Oral Health","authors":"Yunchuan Tian, Yonglian Tang, Jiang Xiao, Rongkun Li, Qingyang Zhu","doi":"10.56397/crms.2023.03.09","DOIUrl":"https://doi.org/10.56397/crms.2023.03.09","url":null,"abstract":"With the development of medical science and the improvement of people’s health, oral health has been listed as one of the world health standards, an integral and important part of the quality of life (Keqin Rao, 2005). The development of oral diseases has seriously affected people’s work and life. To fundamentally control the occurrence of oral diseases, the most important measure is based on prevention.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88542994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Baduanjin Exercise on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis","authors":"M. Guo, Mengyuan Cai, Hui Wang, Zhipeng Hu, H. Feng, C. Xie","doi":"10.56397/crms.2023.03.15","DOIUrl":"https://doi.org/10.56397/crms.2023.03.15","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) refers to a metabolic disorder characterized by persistent hyperglycemia. Uncontrolled blood glucose levels over time may lead to serious complications, possibly even death. As an adjunctive treatment for T2DM, increasing numbers of clinical studies have demonstrated that Baduanjin (the Eight Section Brocades)—one of Traditional Asian exercise may effectively control fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and 2h postprandial plasma glucose (P2hPG) as well as blood lipid levels of diabetic patients. However, the primary evidence demonstrating the clinical benefit of Baduanjin exercise in diabetic patients remains insufficient, especially the intervention effect on glucose and lipid metabolism is not fully understood. Objectives: The purpose of this study is to examine the effects of Baduanjin exercise on glucose and lipid metabolism in individuals with type 2 diabetes in randomized controlled trials (RCTs). Methods: Nine electronic databases were searched from the database’s inception until January 31th, 2023, without regard to language constraints (PubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (WAN FANG), VIP information resource integration service platform (CQVIP) and China Biology Medicine (CBM)). Furthermore, information concerning unpublished or continuing clinical trials was searched within the National Institutes of Health clinical registry Clinical Trials, the International Clinical Trials Registry Platform, and the Chinese Clinical Trials Registry. RCTs that examined the effect of Baduanjin exercise on glucose and lipid metabolism were identified. The primary outcomes of this study were fasting plasma glucose (FPG), 2h postprandial plasma glucose (P2hPG) and glycosylated hemoglobin (HbA1c). The literature was chosen based on inclusion and exclusion criteria, with the Baduanjin exercise serving as the primary method for the experimental group. Selection, data collection and extraction of studies were conducted separately by at least two reviewers, with disagreements resolved through discussion. The mean difference (MD) with a 95% confidence interval (CI) was employed for continuous outcomes. Analysis of data and subgroups, as well as sensitivity analysis, were performed utilizing Review Manager V.5.4.1 (RevMan V.5.4.1) and Stata/MP 17.0. Results: This meta-analysis comprised twenty-six original studies with 1,779 individuals. Glucose metabolism: As a result of the pooled analysis, it demonstrated that combination treatment resulted in a reduction in the HbA1c (MD: -0.73, 95% CI: -0.91 to -0.55, P<0.00001), FPG (MD −1.14, 95% CI −1.38 to −0.90, P<0.00001), P2hPG (MD: -1.22, 95% CI: -1.66 to -0.78, P<0.00001), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (MD: -0.59, 95% CI: -1.07 to -0.11, P＝0.02), and Fasting Insuli","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90795079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Spleen and Yin Prescription in the Treatment of Primary Sjogren Syndrome and Its Impact on Disease Activity","authors":"Na Zhou, Lin Wang, Junjie Chen, Ze-xian Wang, Yanhong Tao, Chuanbing Huang","doi":"10.56397/crms.2023.03.02","DOIUrl":"https://doi.org/10.56397/crms.2023.03.02","url":null,"abstract":"Objective: To study the clinical efficacy of primary Sjogren syndrome and the effect of disease activity. Methods: The 60 patients from January 2021 to January 2022 respectively, and divided into two groups according to random numbers, hydroxychloroquine sulfate, 30 patients, clinical effect combined with hydroxychloroquine sulfate, inflammatory index, complement levels, and immunoglobulins (ESR, RF, CRP, C3, C4, IgG, IgA, IgM), ESSDAI, ESSPRI, and adverse effects. Results: The total response rate of the two groups was 86.67% (26/30) and 73.33% (22/30), respectively, comparing with the treatment group (P <0.05). Comparison between groups found that no differences in CRP, C4, IgA, and IgM were significant (P>0.05). After treatment, peripheral ESR, RF, IgG decreased, complement C3 levels increased (P <0.05), the ESSDAI score and ESSPRI score of the two groups also decreased (P<0.05). On the Traditional Chinese medicine symptom integral, the treatment group had better results in improving dry mouth, dry throat, dry eyes, dry skin, five upset heat, and joint pain(P<0.05), and no adverse reactions were found in either group. Conclusion: The treatment group can effectively improve the clinical efficacy, reduce the level of inflammatory indicators and disease activity, and see no obvious adverse reactions, which can be effectively used in clinical practice.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"61 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91419951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Auricular Acupressure Combined with Traditional Chinese Medicine for the Treatment of Chronic Prostatitis","authors":"Xu Cen, Yali Pan","doi":"10.56397/crms.2022.12.05","DOIUrl":"https://doi.org/10.56397/crms.2022.12.05","url":null,"abstract":"The etiology of chronic prostatitis is complex, the onset is slow, the delay is difficult to heal, and it is easy to recur. Western medicine is mainly based on drug relief, the efficacy is not good, Chinese medicine treatment of such diseases has a long history, the efficacy is accurate, the means are rich, now reported a case as follows.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80809989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clone and Contradistinction—Mycosis Fungoides","authors":"Anu Bajaj","doi":"10.56397/crms.2022.12.01","DOIUrl":"https://doi.org/10.56397/crms.2022.12.01","url":null,"abstract":"Mycosis fungoides is a peripheral T cell lymphoma engendered from mature, post-thymic T lymphocytes representing with cutaneous patches, plaques, tumours and erythroderma. Mycosis fungoides demonstrates a ‘bathing trunk’ distribution wherein gluteal region, trunk and proximal limbs appear incriminated. Mycosis fungoides enunciates enhanced expression of Th2 gene along with Th2 associated cytokine production and activation of nuclear factor kappa B (NFkB). Lesions depict a band-like infiltrate of atypical lymphoid cells within papillary dermis with focal fibroplasia and Pautrier’s micro-abscesses. Neoplastic cells display mature T cell phenotype and are immune reactive to CD45RO+, TCRβ+, CD2+, CD3+, CD4+, CD5+or CD7+. Photodynamic therapy, retinoids, targeted therapy, biologic therapy, radiation, chemotherapy or allogenic haematopoietic stem cell transplant may be adopted to treat mycosis fungoides.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75040508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}