Current research in medical sciences最新文献

Advances in Skull Base Reconstruction After Transnasal Endoscopy 经鼻内窥镜手术后颅底重建的进展

Current research in medical sciences Pub Date : 2024-06-01 DOI: 10.56397/crms.2024.06.06

Shuai Tang, Gang Yang

{"title":"Advances in Skull Base Reconstruction After Transnasal Endoscopy","authors":"Shuai Tang, Gang Yang","doi":"10.56397/crms.2024.06.06","DOIUrl":"https://doi.org/10.56397/crms.2024.06.06","url":null,"abstract":"Endoscopic transnasal approach have experienced rapid development and gradual maturation in just a few decades (Kassam AB, Prevedello DM, Carrau RL, et al, 2011; Eloy J A, Vivero R J, Hoang K, et al, 2009). It has expanded from the removal of conventional pituitary tumours to the application of an endoscopic extended transsphenoidal approach for the resection of tumours in the intrasellar, suprasellar and even ventricular systems (Cappabianca P, Cavallo L M, Esposito F, et al, 2008). Larger bone and dural defects at the skull base, causing more severe postoperative complications and resulting in a multiplication of the healthcare burden (Eloy J A, Shukla P A, Choudhry O J, et al, 2013). Skull base Reconstruction after tumour removal has become a great challenge. Currently, skull base reconstruction is mainly divided into soft and rigid reconstruction, and soft reconstruction is represented by the technique of pedicled nasal septum mucosal flap (PNSF) (Thorp B D, Sreenath S B, Ebert C S, et al, 2014)0. As for rigid reconstruction, it is still controversial (Shin J, Forbes J, Lehner K, et al, 2019; Eloy J A, Shukla P A, Choudhry O J, et al, 2012). From the current studies, rigid reconstruction has a role that cannot be ignored. In this article, we will describe the development of skull base surgery and several high-profile skull base reconstruction techniques.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"42 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141232729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Clinical Fusion Model Based on Radiomics Features and Deep Learning for Predicting CDKN2A/B Homozygous Deletion Status in IDH-mutant Diffuse Astrocytoma 基于放射组学特征和深度学习的临床融合模型，用于预测 IDH 突变弥漫性星形细胞瘤的 CDKN2A/B 基因同源缺失状态

Current research in medical sciences Pub Date : 2024-06-01 DOI: 10.56397/crms.2024.06.07

Linling Wang, Yao Tang, Hongyu Pan, Zhi-Fei Wen, Xu Cao, Zhi Liu, Ming Wen, Liqiang Zhang

{"title":"A Clinical Fusion Model Based on Radiomics Features and Deep Learning for Predicting CDKN2A/B Homozygous Deletion Status in IDH-mutant Diffuse Astrocytoma","authors":"Linling Wang, Yao Tang, Hongyu Pan, Zhi-Fei Wen, Xu Cao, Zhi Liu, Ming Wen, Liqiang Zhang","doi":"10.56397/crms.2024.06.07","DOIUrl":"https://doi.org/10.56397/crms.2024.06.07","url":null,"abstract":"Purpose: To construct a fusion model for predicting CDKN2A/B homozygous deletion status in patients with isocitrate dehydrogenase (IDH)-mutant diffuse astrocytoma by combining the radiomics features and deep learning (DL). Methods: A total of 200 IDH-mutant astrocytoma (103 CDKN2A/B homozygous deletion (HD) and 97 CDKN2A/B non-homozygous deletion (NHD)) patients were retrospectively enrolled in the training cohort (n = 140) and the external test cohort (n = 60) for the prediction of CDKN2A/B homozygous deletion status in patients with IDH-mutant astrocytoma. DL model was constructed by SE-Net model, radiomics features of different regions (edema, tumor and overall lesion) were extracted using Pyradiomics, and radiomics model was built by selecting 4 features in the edema region and 7 features in the tumor region by the least absolute shrinkage and selection operator (LASSO). Finally, a fusion model was jointly constructed by the DL model, radiomics model, and clinical features. The predictive performance of the 3 models was evaluated using calibration curves and decision curves, and compared with the fusion model. Results: Based on the results of the different models, we finally selected a fusion model consisting of DL model, radiomics model, and clinical features. The fusion model showed the best performance with an area under the curve (AUC) of 0.958 in the training cohort and 0.914 in the test cohort. Conclusions: The clinical fusion model based on radiomics features and DL features showed good performance in predicting CDKN2A/B homozygous deletion status in patients with IDH-mutant diffuse astrocytoma. Key Points: 1) Used DL and radiomics to non-invasively predict the CDKN2A/B homozygous deletion status. 2) The model can predict CDKN2A/B homozygous deletion status in IDH-mutant astrocytoma patients. 3) Our result improved classification accuracy and demonstrated better performance in the fusion model.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Research Meta-Analysis of Clinical Nursing Combined with Chinese Medicine Appropriate Technology Assisted Treatment 临床护理结合中医适宜技术辅助治疗的研究荟萃分析

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.04

Caiyan Lu, Lin Feng, Lin Feng

引用次数: 0

Treatment of Brain Metastasis of Small Cell Lung Cancer with PD-1 Inhibitor: A Case Report 用 PD-1 抑制剂治疗小细胞肺癌脑转移：病例报告

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.07

S.-E. Yang, Xiaohui Han, Shihua Liu, Jianqiang Lan, Aixia Sui

引用次数: 0

Research Progress of Chinese Medicine in the Treatment of Lumbar Intervertebral Disc Herniation of Qi Stagnation and Blood Stasis Type 中医药治疗气滞血瘀型腰椎间盘突出症的研究进展

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.08

Jiafeng Xiao

引用次数: 0

Retinol Metabolism and Neuroactive Ligand-Receptor Interactions Are Key Pathways Involved in Skeletal Muscle Stem Cells (MuSCs) Aging 视黄醇代谢和神经活性配体-受体相互作用是参与骨骼肌干细胞（MuSCs）衰老的关键途径

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.03

Ryan Ge

引用次数: 0

A Case of Intractable Vomiting Due to Superior Mesenteric Artery Syndrome 一例因肠系膜上动脉综合征引起的顽固性呕吐病例

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.02

Minghui Sun, Zhonggang Wu, Shibo Zhao, Huaiyuan Zheng

引用次数: 0

Mechanism of Action of Many Drugs Depend on Enzyme Inhibition 许多药物的作用机制取决于酶抑制作用

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.01

R. Ayyad, A. Nejm, Yasser Abdel Allem Hassan, Ahmed R. Ayyad

引用次数: 0

Advances in the Study of Pathological Histology and Pathogenesis of Endometrial Polyps 子宫内膜息肉病理组织学和发病机制研究进展

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.06

Aihua Dao, Chunhong Pan

{"title":"Advances in the Study of Pathological Histology and Pathogenesis of Endometrial Polyps","authors":"Aihua Dao, Chunhong Pan","doi":"10.56397/crms.2023.12.06","DOIUrl":"https://doi.org/10.56397/crms.2023.12.06","url":null,"abstract":"Endometrial polyps (EPs) are common gynecological diseases among women of childbearing age. They are formed by the proliferation of blood vessels and connective tissue in a portion of the endometrium, resulting in the formation of a polyp-like mass that protrudes into the uterine cavity and varies in size and number. Typically, the body of the uterus is the site of implantation of these polyp-like growths, which are attached to the medial wall of the uterine cavity by a long, thin tip. Irregular vaginal bleeding is the first clinical manifestation of endometrial polyps, and it can often lead to infertility. Studies have shown that the prevalence of endometrial polyps in the female population is approximately 25.0%. With the widespread use of hysteroscopic techniques in clinical practice, knowledge and diagnosis of endometrial polyps have significantly improved. However, pathological examination remains the “gold standard” for final diagnosis in clinical practice. This article aims to review the epidemiology, pathological histology, and pathogenesis of endometrial polyps to reveal their mechanisms and characteristics more accurately and guide further clinical research and treatment. The relevant progress in recent years in this field, both domestically and internationally, is reviewed below.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"119 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138608386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Research on the Etiology and Pathogenesis of Polycystic Ovary Syndrome 多囊卵巢综合症病因和发病机制研究的发展情况

Current research in medical sciences Pub Date : 2023-12-01 DOI: 10.56397/crms.2023.12.05

Guangcai Wei, Mei Wang, Yanmei Yang, Fengjie He

引用次数: 0