Current research in medical sciences最新文献

{"title":"A Collection of Studies on Anesthesia Modalities, Anesthetic Drugs and Circulatory Stability in Elderly Patients","authors":"Bing Lu","doi":"10.56397/crms.2023.09.05","DOIUrl":"https://doi.org/10.56397/crms.2023.09.05","url":null,"abstract":"With the increase in the proportion of elderly population in the society, China is gradually entering an aging society. Elderly patients may require anesthesia during medical treatment, and considering the relatively high surgical risk of elderly patients, comprehensive consideration must be given to the selection of anesthesia and the use of anesthetic drugs. Induction of general anesthesia is a process in which patients undergo reversible drug inhibition from a physiological state to a surgically operable anesthesia state within a short period of time, but tracheal intubation and anesthesia inhibition can trigger cardiovascular reactions, especially in elderly patients with poor circulatory function, which can lead to hemodynamic fluctuations and affect the stability of circulatory function. As elderly patients age, their organ function decreases, and their reserve function deficiency under anesthetic stress can increase the risk of adverse cardiovascular events. The hemodynamic fluctuations of patients during the induction period of general anesthesia are large, and it is important to reduce the hemodynamic fluctuations and maintain the stability of circulatory function to improve the safety of surgery. At present, the commonly used methods for induction of general anesthesia include manual intravenous push, target-controlled infusion and constant-rate infusion by infusion pump, and the commonly used drugs for induction of general anesthesia include intravenous sedative anesthetics, intravenous analgesics, muscle relaxants and inhaled anesthetics. Based on this paper, we analyze the effects of general anesthesia, epidural anesthesia, lumbar anesthesia, and epidural anesthesia in the application of surgery in elderly patients and general anesthesia induction in the circulatory stability of elderly patients for a review, in order to more accurately and better guide further clinical anesthesia research.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134994349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophobicity, Transport and Target Sites of Action Are Important for the Activity of Many Drugs","authors":"Rezk R. Ayyad, Ahmed M. Nejm, Yasser H. Abdelaleem, Ahmed R. Ayyad","doi":"10.56397/crms.2023.09.03","DOIUrl":"https://doi.org/10.56397/crms.2023.09.03","url":null,"abstract":"The Hydrophobicity mean the compounds which insoluble in water i.e., hate the water (not love the water). May be these compounds are lipid soluble, but not actually. This means these compounds may across the cell membrane of the cell. This transport of compounds through, simple diffusion, passive transport (active transport), transport by carrier (amino acids carrier), pinocytosis. And the binding of drugs with tissue (may be receptors or tissue reservoir as (fatty tissue and lipid soluble vitamins) and the carbohydrates (glucose convert to glycogen in the liver).","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Traditional Medicine, Chemical Composition and Pharmacological Activity of Pine Pollen","authors":"Xiuling Wei, Minghui Sun, Huaiyuan Zheng, An Yan, Yuxin Wei, Xuehai Wei, Shibo Zhao, Yunqi Liu","doi":"10.56397/crms.2023.09.02","DOIUrl":"https://doi.org/10.56397/crms.2023.09.02","url":null,"abstract":"In traditional Chinese medicine, “pine yellow” and “pine flower” are the pollen of Pinaceae, commonly Pinus Massoniana Lamb or Pinus tabulaeformis Carr. The pollen of Pinus Massoniana Lamb or Pinus tabulaeformis Carr is common. Pine flower is a unique species of medicinal and edible pollen in the Chinese pharmacopoeia, and is commonly found in ancient Chinese medical and herbal texts, such as “Derivatives of the Materia Medica”, “Classical Materia Medica”, and “Compendium of the Materia Medica”. In this paper, we review the source, history of traditional medicine, and progress of research on pharmacological activity of Chinese pine pollen in order to provide reference for better research on its value.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134994345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Research on Risk Factors for Disease Progression in Advanced Prostate Cancer","authors":"Jialiang Li, Jie Yang, Yunpeng He, Jianhe Liu","doi":"10.56397/crms.2023.09.06","DOIUrl":"https://doi.org/10.56397/crms.2023.09.06","url":null,"abstract":"Advanced prostate cancer has mostly lost the chance of surgery, and has a low 5-year survival rate and high mortality rate. Therefore, exploring the risk factors for advanced prostate cancer disease progression can help formulate scientific and standardized treatment plans and strategies for advanced prostate cancer disease progression. Intervention measures provide evidence to improve the quality of life and survival rate of patients. Based on the existing research reports at home and abroad, I reviewed the risk factors related to the progression of advanced prostate cancer.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134994347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the Lifting of COVID-19 Restrictions on College Students’ Knowledge, Attitude, and Practice (KAP) in Self-Medication with Antibacterial Agents","authors":"Shiqi Zhao, Siying Yang, Xuanbo Zhao, Zongfeng Zou","doi":"10.56397/crms.2023.09.04","DOIUrl":"https://doi.org/10.56397/crms.2023.09.04","url":null,"abstract":"Objective: This study aims to investigate the Knowledge, Attitude, and Practice (KAP) of college students regarding self-medication with antibacterial agents before and after the lifting of COVID-19 restrictions, as well as the impact of the lifting of COVID-19 restrictions on college students’ KAP towards self-medication with antibacterial agents. We analyze the factors influencing college students’ self-medication with antibacterial agents and provide relevant reference data for the rational use of antibacterial agents for self-medication among college students. Methods: Non-probability sampling methods, including convenience sampling and quota sampling, were employed to collect data samples. College students were invited to participate in an online questionnaire survey that they completed independently, and the data were entered into Excel software for statistical analysis using SPSS 26.0 software. Results: Independent samples t-test and analysis of variance revealed that, before the lifting of pandemic restrictions, female college students scored higher than male students in KAP towards self-medication with antibacterial agents, with all differences being statistically significant (P<0.05). However, after the lifting of pandemic restrictions, the gender differences in these aspects diminished; College students from rural areas scored significantly higher than their urban counterparts in the knowledge of antibacterial agents both before and after the lifting of COVID-19 restrictions (P<0.05); Moreover, medical students had significantly higher attitude scores compared to science and engineering students before the lifting of pandemic restrictions (P<0.05), while social science students scored significantly higher in practice compared to science and engineering students both before and after the lifting of pandemic restrictions (P<0.05). Paired samples t-test indicated a significant improvement in knowledge and practice towards self-medication with antibacterial agents after the lifting of pandemic restrictions, with attitude showing no significant change. Multiple linear regression analysis demonstrated that, before the pandemic, there were significant differences in KAP based on gender and grade. However, after experiencing the pandemic, there were no longer significant differences in KAP among different genders and different grades, and this could be attributed to the impact of health education and campaigns during the pandemic. Conclusion: The lifting of COVID-19 restrictions has had a positive impact on college students’ knowledge and practice towards self-medication with antibacterial agents. Before and after the lifting of COVID-19 restrictions, the KAP of college students regarding self-medication with antibacterial agents were influenced by multiple factors. One important measure to enhance the rational use of antibacterial agents for self-medication among college students is to conduct health education courses in universities. Public ","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Collection of Regional Treatment Features of Chinese Traditional Medicine for Polycystic Ovary Syndrome","authors":"Xiuling Wei, Chunhong Pan, Shibo Zhao, An Yan","doi":"10.56397/crms.2023.09.07","DOIUrl":"https://doi.org/10.56397/crms.2023.09.07","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is one of the common female gynecological diseases that cause menstrual disorders, amenorrhea and infertility in women of childbearing age, polycystic ovary syndrome or PCOS is a disease that causes menstrual disorders, amenorrhea and infertility due to endocrine metabolic abnormalities. According to epidemiological research data in China, the incidence of PCOS in China is between 5% and 10%. The prevalence of PCOS in China is between 5% and 10%, which seriously affects female reproductive function. The disease is divided into Western medicine and Chinese medicine treatment two methods. However, due to the Western medicine treatment of this disease taking a long time and causing side effects, it is slowly not being used; Chinese medicine treatment of this disease, instead, uses evidence-based treatment and typology treatment. The effect is significant and gradually widely used in clinical. This paper summarizes the research and treatment of this disease in Chinese medicine in recent years and provides a reference value for the subsequent clinical treatment and research of this disease.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134994681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis of the Effect of Continuous Care on Patients with Type 2 Diabetes","authors":"Zang Lin, Yang Sen","doi":"10.56397/crms.2023.09.08","DOIUrl":"https://doi.org/10.56397/crms.2023.09.08","url":null,"abstract":"A meta-analysis was conducted to assess the effect of continuing care in patients with type 2 diabetes mellitus. Methods: A review of the PUBMED, CNKI, and Wan Fang databases was done, to find ten randomized controlled trials that used continuous care for patients with type 2 diabetes mellitus, and Review Manager 5.4 the Meta analysis was performed. Results: Meta-analysis showed that continuation of care could improve fasting blood glucose [MD=-2.17, 95% CI (-3.10, -1.23), P<0.00001], 2-hour postprandial blood glucose [MD=-2.58, 95% CI (-3.21, -1.96), P<0.00001], and glycosylated hemoglobin [MD=-1.20, 95%CI (-2.04, -0.36), P=0.005]. Conclusion: Continuous care is of great significance for the control of blood glucose in patients with type 2 diabetes.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Human Papillomavirus-Associated Oropharyngeal Cancer","authors":"Jiefan Zhao, Yuhui Zhao, Jianqi Gu, Qing Dong","doi":"10.56397/crms.2023.09.01","DOIUrl":"https://doi.org/10.56397/crms.2023.09.01","url":null,"abstract":"HPV-positive oropharyngeal carcinoma is classified as a distinct clinical entity that differs substantially from other types of head and neck tumors in terms of epidemiology, morphology, molecular and clinical features, treatment, and prognosis. The research progress in the above aspects is mainly reviewed.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Relationship Between Selenium and Bone: A Bibliometric Analysis Covering 1980-2023","authors":"Dongping Wan, Rui Tang, Shihang Cao, Qiang Zan","doi":"10.56397/crms.2023.06.12","DOIUrl":"https://doi.org/10.56397/crms.2023.06.12","url":null,"abstract":"Background: Selenium, an indispensable trace element in the human body, has been the subject of growing research that highlights its significant association with bone health. This project aims to employ the Bibliometrics method to comprehensively understand the research status of selenium and bone between 1980 and 2023. By utilizing visualizations to identify research hotspots and trends, we strive to shed light on the current state of knowledge in this field. Methods: Relevant articles on the topic of selenium and bone were retrieved from the Network Science Core Collection (WoSCC). Statistical and visual analysis was conducted using CiteSpace and VOSviewer. This analysis encompassed various aspects, including annual publication output, active countries, prolific institutions, authors, and keyword analysis. Results: A total of 864 relevant articles were retrieved for analysis, comprising 746 articles and 118 reviews. The number of publications in the field of selenium and bone has demonstrated a consistent upward trend over time. Notably, China emerged as the leading contributor in terms of publication output, with 195 articles, followed closely by the United States with 177 articles, and Germany with 50 articles. Among the institutions, Huazhong University of Science and Technology stood out as a core institution, while K. Sandeep Prabhu emerged as a prominent core author. The analysis of keyword frequency revealed the most frequently occurring terms in the publications. Selenium, with a count of 415, topped the list, followed by Bone (101), oxidative stress (91), zinc (87), osteoporosis (70), metabolism (66), copper (63), toxicity (62), supplementation (57), and nanoparticles (55). Notably, the emergence of Selenium nanoparticles and Scaffolds indicates novel research trends within the field. Conclusions: The research demonstrates an increasing number of publications focusing on the association between selenium and bone health in recent years, with China leading in terms of article output. Furthermore, prominent keywords such as selenium, bone, and oxidative stress indicate recurring themes in the literature, while emerging trends like selenium nanoparticles and scaffolds have gained significant attention.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79017240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Contrast-Enhanced Ultrasound Features in Predicting HER2 Positive and Ki67 High Expression in Invasive Breast Cancer of No Special Type","authors":"Huiying Huang, Xiaoling Huang","doi":"10.56397/crms.2023.06.09","DOIUrl":"https://doi.org/10.56397/crms.2023.06.09","url":null,"abstract":"Objective: To investigate the value of contrast-enhanced ultrasound features in predicting HER2 positive and Ki67 high expression in invasive breast cancer of no special type. Methods: Retrospective analysis was conducted on the correlation between contrast-enhanced ultrasound images of 92 patients with invasive breast cancer of no special type confirmed by pathology in our hospital and the expression of HER2 and Ki67, including 64 cases in the HER2 negative group and 28 cases in the positive group. Ki67 expression was low in 14 cases and high in 78 cases. The contrast-enhanced ultrasound indicators include: BI (Base Intensity), AT (Arrival Time), TTP (Time To Peak), PI (Peak Intensity), AS (Ascending Slope), DT/2 (Descending Time/2), DS (Descending Slope), AUC (Area Under Curve), maximum focal area ratio of before and after contrast-enhanced ultrasound (AR Area Ratio), Distance of anterior boundary of lesion to skin after contrast-enhanced ultrasound (DTS Distance to skin) and maximum diameter after contrast-enhanced ultrasound (D Diameter), and the above indexes were compared and analyzed in the negative and positive groups of HER2, and the low and high expression groups of Ki67. Results: Logistics regression analysis showed that DTS is an independent risk factor for HER2 positive (P＜0. 05). AR was an independent risk factor for Ki67 high expression (P＜0. 05). Conclusion: The combination of contra-enhanced ultrasound features has high diagnostic efficacy for HER2 positive and Ki67 high expression, which can provide an important reference.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90045422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}