Clone and Contradistinction—Mycosis Fungoides

Abstract

Mycosis fungoides is a peripheral T cell lymphoma engendered from mature, post-thymic T lymphocytes representing with cutaneous patches, plaques, tumours and erythroderma. Mycosis fungoides demonstrates a ‘bathing trunk’ distribution wherein gluteal region, trunk and proximal limbs appear incriminated. Mycosis fungoides enunciates enhanced expression of Th2 gene along with Th2 associated cytokine production and activation of nuclear factor kappa B (NFkB). Lesions depict a band-like infiltrate of atypical lymphoid cells within papillary dermis with focal fibroplasia and Pautrier’s micro-abscesses. Neoplastic cells display mature T cell phenotype and are immune reactive to CD45RO+, TCRβ+, CD2+, CD3+, CD4+, CD5+or CD7+. Photodynamic therapy, retinoids, targeted therapy, biologic therapy, radiation, chemotherapy or allogenic haematopoietic stem cell transplant may be adopted to treat mycosis fungoides.