Communications medicine最新文献

{"title":"Longitudinal MRI identifies associations between cognitive decline, inflammatory markers, and hippocampal subregion volumes in individuals with knee osteoarthritis.","authors":"Yajun Wang, Guiyan Cai, Ming Li, Ruilin Chen, Peiling Zeng, Baoru Zhao, Jing Tao, Jiao Liu","doi":"10.1038/s43856-025-01104-1","DOIUrl":"10.1038/s43856-025-01104-1","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) is common in older adults and may relate to cognitive decline. We explore whether changes in specific brain areas and body inflammation levels help explain this connection, focusing on the hippocampus-a memory-critical brain region.</p><p><strong>Methods: </strong>We studied 36 older adults with KOA over time. Using brain scans, we measured volumes of hippocampal subregions (especially the fimbria). Blood tests tracked six inflammation markers, including brain-derived neurotrophic factor (BDNF), interferon-gamma (IFN-γ), programmed death 1(PD-1), recombinant cannabinoid receptor 1 (CNR1), recombinant cannabinoid receptor 2 (CNR2), and T cell immunoglobulin domain and mucin domain 3 (TIM3). Memory was tested using the Wechsler Memory Scale - Chinese Revision (WMS-CR), while global cognition used the Montreal Cognitive Assessment (MoCA). Relationships between knee pain, brain structure, inflammation, and cognition were analyzed statistically.</p><p><strong>Results: </strong>Here, we show that shrinking fimbria volume predicts cognitive decline in those developing dementia. We identify a robust correlation between fimbria volume and cognitive performance. Higher IFN-γ levels are protective against cognitive decline. Critically, fimbria volume serves as a mediator in the relationship between pain, TIM3/IFN-γ levels, and cognitive scores.</p><p><strong>Conclusions: </strong>Fimbria serves as a key pathway through which KOA may drive cognitive impairment, while IFN-γ could help protect memory. Monitoring these hippocampal changes and inflammation levels might help identify at-risk patients early.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"400"},"PeriodicalIF":5.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.","authors":"Odion O Ikhimiukor, Manuela Montoya-Giraldo, Stephanie S R Souza, Ifeoluwa J Akintayo, Nicole I Zac Soligno, Maitiú Marmion, Elissa M Eckhardt, Nisalda Carreiro, Adrienne A Workman, Isabella W Martin, Cheryl P Andam","doi":"10.1038/s43856-025-01109-w","DOIUrl":"10.1038/s43856-025-01109-w","url":null,"abstract":"<p><strong>Background: </strong>The polymyxin antibiotic colistin is used as a final line of treatment for life threatening infections caused by multidrug resistant and carbapenem-resistant Gram-negative bacteria. Mobile colistin resistance genes mcr-9 and mcr-10 are increasingly detected in Enterobacteriaceae but their epidemiology is poorly understood.</p><p><strong>Methods: </strong>The genetic characteristics of mcr-9 and mcr-10, being the only mobile colistin resistance genes detected in a local population of Enterobacter species isolated from bloodstream infections in Dartmouth Hitchcock Medical Center, USA, were elucidated and contextualized against a global dataset of mcr-9/10-bearing plasmids using genomic and phylogenetic tools.</p><p><strong>Results: </strong>Seven out of 59 Enterobacter isolates carry either an mcr-9 or mcr-10 on a plasmid with distinct single and multiple replicon configurations, including IncFIB(pECLA), IncFIB(K), IncFIA(HI1)-IncFIB(K), IncFIB(pECLA)--IncFII(pECLA) and IncFIB(K)--IncFII(pECLA), whereas two genomes harbor mcr-9 on their chromosome. Global contextualization reveals that allelic variants of mcr-9 and mcr-10 are widely disseminated across diverse Inc-type plasmids, transcending geographic and taxonomic boundaries. Plasmid-borne genes conferring resistance to other antimicrobial agents, such as aminoglycoside, tetracycline and trimethoprim, tend to co-occur with mcr-9.1 and mcr-9.2 alleles.</p><p><strong>Conclusions: </strong>Findings from this study enhance our understanding of the plasmid backgrounds of mcr-9 and mcr-10, their associated antimicrobial resistance gene carriage and co-occurrence. This knowledge may be critical to inform scalable and effective public health interventions aimed at preserving the efficacy of colistin.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"399"},"PeriodicalIF":5.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying a systems thinking approach to evaluating the effectiveness of Africa's foodborne disease surveillance systems.","authors":"Cecilie Thystrup, Tosin Ogunbiyi, Tine Hald","doi":"10.1038/s43856-025-01115-y","DOIUrl":"10.1038/s43856-025-01115-y","url":null,"abstract":"<p><strong>Background: </strong>Foodborne diseases (FBDs) pose a large public health challenge worldwide, particularly in low- and middle-income countries (LMICs), where limited infrastructure, weak regulatory frameworks, and insufficient cross-sector collaboration hinder effective surveillance and prevention. While previous efforts in Africa have focused on risk identification and management training, these approaches often fail to consider the interconnected nature of risk factors, transmission routes, and systemic barriers. As a result, interventions have had limited impact. Addressing this issue requires a systems approach that accounts for the biological, social, and economic complexities of FBD surveillance.</p><p><strong>Methods: </strong>We applied the \"Five Phase Process of Systems Thinking and Modelling\" approach to identify and address the key challenges of implementing effective FBD surveillance systems in Africa. Using leverage point analysis, we identified leverage points with the potential to strengthen the system. We developed and analyzed five scenarios to evaluate the system's performance under various configurations of these leverage points.</p><p><strong>Results: </strong>Our approach identifies 33 elements and behaviors that are connected in a systems map through balancing and reinforcing feedback loops. We identify three deep leverage points with the potential to strengthen the system: Public trust, compliance with food safety practices, and data sharing. Among the scenarios assessed, scenario 5, characterized by high levels of public trust, compliance, and data sharing, is determined as the optimal strategy.</p><p><strong>Conclusions: </strong>By targeting these elements, countries can pave the way for more effective, sustainable, and culturally appropriate interventions that are critical for improving food safety and overall public health outcomes in these regions. Achieving Scenario 5 will require targeted investments in infrastructure, regulatory support, and public engagement. This study provides actionable insights for policymakers seeking to enhance FBD surveillance systems, contributing to stronger food safety and public health in Africa.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"397"},"PeriodicalIF":5.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities.","authors":"Yana Hrytsenko, Brian W Spitzer, Heming Wang, Suzanne M Bertisch, Kent D Taylor, Olga Garcia-Bedoya, Alberto R Ramos, Martha L Daviglus, Linda C Gallo, Carmen R Isasi, Jianwen Cai, Qibin Qi, Carmela Alcántara, Susan Redline, Tamar Sofer","doi":"10.1038/s43856-025-01107-y","DOIUrl":"10.1038/s43856-025-01107-y","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA), and other sleep disorders, are associated with increased risk of developing diabetes mellitus (DM). We examined whether sleep disorders influence the genetic risk of developing diabetes in Hispanic/Latino individuals.</p><p><strong>Methods: </strong>We developed Type 2 Diabetes (T2D) polygenic risk score (T2D-PRS) useful in admixed Hispanic/Latino individuals. We estimated the association of the T2D-PRS with cross-sectional (n = 12,342) and incident (n = 6965) DM in the Hispanic Community Health Study/Study of Latinos (ages 18-76, 50.9% female). We conducted a mediation analysis with T2D-PRS as an exposure, incident DM as an outcome, and OSA as a mediator. Additionally, we performed Mendelian randomization (MR) analysis to assess the causal relationship between T2D and OSA.</p><p><strong>Results: </strong>Here, we show that a 1 standard deviation increase in T2D-PRS has DM adjusted odds ratio (OR) = 2.67, 95% CI [2.40; 2.97] and a higher incident DM rate (incident rate ratio (IRR) = 2.02, 95% CI [1.75; 2.33]). In a stratified analysis based on OSA severity categories the associations are stronger in individuals with mild OSA compared to those with moderate to severe OSA. Mediation analysis suggests that OSA mediates the T2D-PRS association with DM. In two-sample MR analysis, T2D has a causal effect on OSA, OR = 1.03, 95% CI [1.01; 1.05], and OSA has a causal effect on T2D, with OR = 2.34, 95% CI [1.59; 3.44].</p><p><strong>Conclusions: </strong>These results support a causal association between OSA and DM, with OSA mediating up to 4.7% of the genetic risk for DM. OSA treatment may reduce DM prevalence.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"398"},"PeriodicalIF":5.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durability of next-generation self-replicating RNA vaccine RBI-4000: a phase 1, randomized open label clinical trial.","authors":"Christian J Maine, Gaelle Picarda, Shigeki J Miyake-Stoner, Brandon Essink, Guillermo Somodevilla, Jessica Sparks, Andrew J Geall, Nathaniel S Wang, Zelanna Goldberg, Parinaz Aliahmad","doi":"10.1038/s43856-025-01147-4","DOIUrl":"10.1038/s43856-025-01147-4","url":null,"abstract":"<p><strong>Background: </strong>The benefits of mRNA-based platforms, such as rapid response and simplified manufacturing, may be overshadowed by lack of durable protective immunity compared to traditional vaccine technologies targeting certain pathogens. Self-replicating RNA has the potential to induce durable immune responses at lower doses than traditional mRNA. A recent Phase 1 clinical trial showed that a self-replicating RNA vaccine encoding rabies, RBI-4000, was able to show de novo immunogenicity at all doses tested, specifically 0.1, 1, and 10 micrograms in a prime-boost regimen or a single 10 microgram dose (NCT06048770).</p><p><strong>Methods: </strong>Here, we report the secondary outcome of the Phase 1 study, durability of immune responses elicited by RBI-4000, as assessed by the presence of the rabies virus neutralizing antibody response, up to 8 months post immunization. We compare long term immunogenicity of RBI-4000 to a commercial comparator, an inactivated viral vaccine RabAvert, using several statistical models with a post-hoc analysis. The trial was performed at two sites in the United States enrolling 89 healthy volunteers aged 18-45.</p><p><strong>Results: </strong>Individual rabies virus neutralizing antibody titers, above the benchmark seropositivity, were detected out to 8 months in all study cohorts. Statistical decay modeling showed that RBI-4000 induces rabies virus neutralizing antibodies with similar or improved durability compared to RabAvert.</p><p><strong>Conclusions: </strong>We report the first durability data from a head-to-head study of an optimized self-replicating RNA vaccine for rabies that elicits sustained immune responses compared to a commercial comparator that uses a traditional vaccine technology.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"392"},"PeriodicalIF":5.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries.","authors":"Moneeza K Siddiqui, Theo Dupuis, Ranjit Mohan Anjana, Adem Y Dawed, Margherita Bigossi, Sundararajan Srinivasan, Sam Hodgson, Ebenezer Tolu Adedire, Alasdair Taylor, Jebarani Saravanan, Ambra Sartori, David Davtian, Radha Venkatesan, Alison McNeilly, James Cantley, Rohini Mathur, Naveed Sattar, Sarah Finer, Ewan R Pearson, Rajendra Pradeepa, Viswanathan Mohan, Colin N A Palmer, Andrew A Brown, Ana Viñuela","doi":"10.1038/s43856-025-01076-2","DOIUrl":"10.1038/s43856-025-01076-2","url":null,"abstract":"<p><strong>Background: </strong>Individuals of South and East Asian ancestry have a higher risk of type 2 diabetes, often driven by insulin deficiency due to impaired beta-cell function. The transcription factor XBP1 supports beta-cell survival by reducing cellular stress, but its role in diabetes risk and glucose regulation remains unclear. This study aimed to evaluate the impact of XBP1 expression on diabetes risk, beta-cell function, glycaemic traits, and treatment response across ancestries.</p><p><strong>Methods: </strong>We performed colocalisation analyses to test whether XBP1 expression in pancreatic islets and type 2 diabetes share causal variants. A lead variant regulating XBP1 expression was identified and analysed in two South Asian cohorts from India to assess associations with beta-cell function and glucose levels. We further assessed glycaemic control using HbA1c in cohorts of British South Asians and white Europeans. We examined the effect of the variant on drugs designed to improve insulin secretion.</p><p><strong>Results: </strong>XBP1 expression colocalises with diabetes risk in East Asians but not in white Europeans, and lower expression is associated with higher risk of diabetes. The lead SNP of the eQTL (rs7287124) is more common in East (65%) and South Asians (50%) compared to white Europeans (25%). rs7287124 is associated with lower beta-cell function using HOMA-B (P = 5 × 10^-3, n = 470). In trans-ancestry meta-analyses rs7287124 is associated with 4.32 mmol/mol (95% CI: 2.60-6.04, P = 8 × 10^-7) higher HbA1c. In individuals with young, non-obese onset diabetes, the trans-ancestry effect is 6.41 mmol/mol (P = 2 × 10^-4). Variant carriers show impaired response to sulphonylureas.</p><p><strong>Conclusions: </strong>XBP1 expression is associated with diabetes risk with particular value in under-represented populations at risk of young, non-obese onset diabetes.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"396"},"PeriodicalIF":5.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical ophthalmic anesthetics for corneal abrasions: findings from a Cochrane systematic review and meta-analysis.","authors":"Louis Leslie, Su-Hsun Liu, Irene C Kuo","doi":"10.1038/s43856-025-00979-4","DOIUrl":"10.1038/s43856-025-00979-4","url":null,"abstract":"<p><strong>Background: </strong>Despite potential benefit, outpatient use of topical ophthalmic anesthetics can result in poor healing, infection, scar, and blindness. An unbiased analysis of randomized controlled trials (RCTs) is needed to examine their effectiveness and safety compared with placebo or other treatments for corneal abrasions.</p><p><strong>Methods: </strong>Cochrane Central Register of Controlled Trials, MEDLINE, Embase.com, Latin American and Caribbean Health Sciences, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform were searched on February 10, 2023, without restriction on language or publication date. The published review protocol served as registration.</p><p><strong>Results: </strong>Systematic review and meta-analysis of nine RCTs describing 314 participants with post-traumatic abrasions and 242 participants with post-surgical abrasions, with a median study length of 7 days (interquartile range, 7-14), show no evidence of a difference in pain control between anesthetics and placebo at 24 h in post-trauma cases. Self-reported pain at 24 h is reduced with anesthetics plus topical nonsteroid anti-inflammatory drug in post-surgical participants (mean difference [MD], -5.72 on a 10-point scale; 95% CI, -7.35 to -4.09; 1 RCT; 30 participants) and at 48 h with anesthetics alone in post-trauma participants (MD, -5.68; 95% CI, -6.38 to -4.98; 1 RCT; 111 participants). Anesthetics are associated with 37% increased risk of non-healing defects (risk ratio, 1.37; 95% CI, 0.78 to 2.42; 3 RCTs; 221 post-trauma participants). All evidence is of very low certainty. Over 50% of trials have an overall high risk of bias.</p><p><strong>Conclusions: </strong>Available evidence is insufficient to support outpatient use of topical anesthetics for corneal abrasions with respect to pain, re-epithelialization, and complication risk.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"393"},"PeriodicalIF":5.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"War impact on antimicrobial resistance and bacteriological profile of wound infections in Ukraine.","authors":"Viktoriia M Holubnycha, Olena V Kholodylo","doi":"10.1038/s43856-025-01056-6","DOIUrl":"10.1038/s43856-025-01056-6","url":null,"abstract":"<p><strong>Background: </strong>Infections and antimicrobial resistance are among the main public health issues in the countries affected by war. This study evaluates war's impact on wound microbiome and antimicrobial resistance distribution among patients treated in Ukrainian civilian hospitals.</p><p><strong>Methods: </strong>The patients with combat wounds were treated in the civilian hospitals located in the Northeast of Ukraine from January to April 2024. The wound samples were examined. The isolated microorganisms were identified with further investigation of antimicrobial resistance profiles.</p><p><strong>Results: </strong>Here we show the data obtained from the examination of seventy-three wounded soldiers. Wound infections are associated with severe trauma and the middle age of patients. Bacteria were isolated in 56.16% samples with a predominance of gram-negative bacilli. The most frequent isolates are A. baumannii (36%), E. faecalis (12%), and B. cereus (12%). The frequency of multidrug resistance is 84.6%. Each isolated species has a certain sensitivity profile to antibiotics. The number of multidrug-resistant strains among gram-negative bacteria is higher than among gram-positive ones.</p><p><strong>Conclusions: </strong>This study shows the dominance of gram-negative bacilli in military personnel with a higher frequency of multidrug-resistant isolates. These complicate the healing process and promote the spread of multidrug-resistant strains within healthcare settings.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"394"},"PeriodicalIF":5.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UK Biobank study of the association between circadian syndrome and cardio-kidney events or all-cause mortality.","authors":"Hong-Juan Yang, Hong Shu, Rui Chen, Qian Hou, Jia-Xin Huang, Rong-Chong Huang, Jian-Jun Li, Li-Chan Tao","doi":"10.1038/s43856-025-01064-6","DOIUrl":"10.1038/s43856-025-01064-6","url":null,"abstract":"<p><strong>Background: </strong>Circadian syndrome (CircS) has demonstrated a strong association with the occurrence of cardiovascular disease (CVD), as well as chronic kidney disease (CKD). However, the association of CircS with cardiac-kidney events (CKE) or even mortality is unknown. This study was to evaluate whether CircS was related with CKE or all-cause mortality.</p><p><strong>Methods: </strong>This prospective study analyzed data from 295,378 participants in the UK Biobank (UKB) cohort. CircS was characterized by the components of metabolic syndrome (MetS), along with short sleep and depression. We applied Cox regression analyses to examine the associations between CircS and composite outcome of CKE or all-cause mortality.</p><p><strong>Results: </strong>Among the 295,378 included participants (median age, 58 years; 55.7% female), we find that 28,027 primary outcome events are recorded during a median follow-up of 13.6 years. Findings reveal that CircS (hazard ratio [HR] 1.379; 95% confidence interval [CI] 1.319-1.441) demonstrates a significant positive association with the primary outcome. With the increase in CircS score, the risk of the primary outcome also increases. Among the seven components, depression (HR 1.518; 95% CI 1.426-1.616) emerges as the strongest contributing factor. Furthermore, we also find that CircS is a significant risk factor for CKE (HR 1.143; 95% CI 1.044-1.251) and has a greater impact on CKE with CVD-first and CKE with renal failure.</p><p><strong>Conclusions: </strong>CircS is strongly linked to increased CKE and all-cause mortality risk, highlighting the need for greater clinical focus on this syndrome. This correlation also provides theoretical support for the cardiovascular-kidney-metabolic syndrome concept.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"395"},"PeriodicalIF":5.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.","authors":"Chunxia Li, Yanli Li, Lizhu Liu, Ruimin You, Bingbing Fan, Jiali Lv, Dingyun You, Zhenhui Li, Tao Zhang","doi":"10.1038/s43856-025-01133-w","DOIUrl":"10.1038/s43856-025-01133-w","url":null,"abstract":"<p><strong>Background: </strong>Existing literature on serum cholinesterase (ChE) in cancer prognosis have predominantly evaluated preoperative levels, ignoring serial ChE measurements during postoperative follow-up.</p><p><strong>Methods: </strong>5925 patients undergoing curative resection for stage I-III non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and gastric cancer (GC) were retrospectively included. Patients were divided into persistently normal, normalized, lowered and persistently low perioperative ChE patterns, as well as longitudinal ChE trajectories identified by the latent class growth mixed model (LCGMM). The associations of ChE dynamic changes with overall survival (OS) and recurrence-free survival (RFS) were evaluated.</p><p><strong>Results: </strong>Postoperative ChE emerged as an independent prognostic factor, event after accounting for preoperative levels. Perioperative ChE stratification revealed divergent survival outcomes: the persistently normal group (82.5%) demonstrated 8.6% higher 5-year OS rate than the lowered group (73.9%), while the normalized group (73.3%) had 13.9% higher 5-year OS rate than the persistently low group (59.4%). LCGMM identified three distinct longitudinal trajectories: slow-rising (5-year OS rate: 79.7%; reference group), rising-decreasing (5-year OS rate: 64.8%; adjusted HR: 1.50, 95% CI: 1.14 to 1.99) and decreasing-rising (5-year OS rate: 58.1%; adjusted HR: 2.33, 95% CI: 1.69 to 3.22). Consistent results were observed for RFS as well. Furthermore, stratified analyses confirmed statistically significant associations of ChE dynamic changes with prognosis across all histological subtypes.</p><p><strong>Conclusions: </strong>A routine follow-up measurement of postoperative ChE was recommended to improve individualized management of cancer patients.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"391"},"PeriodicalIF":5.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}