Communications medicine最新文献

{"title":"Salivary gland tissue chip screening identifies candidate radioprotective drugs.","authors":"Lindsay R Piraino, Chiao Yun Chen, Jared A Mereness, Paul M Dunman, Catherine E Ovitt, Danielle S W Benoit, Lisa A DeLouise","doi":"10.1038/s43856-025-01136-7","DOIUrl":"https://doi.org/10.1038/s43856-025-01136-7","url":null,"abstract":"<p><strong>Background: </strong>Most head and neck cancer patients treated with ionizing radiation loose salivary gland function. Patients with decreased saliva have trouble eating, speaking and are predisposed to oral infections and tooth decay. Amifostine is the only FDA approved drug to prevent radiation-induced hyposalivation. However, it has intolerable side-effects that limit its use, motivating the discovery of alternative therapeutics.</p><p><strong>Methods: </strong>We leveraged our salivary gland tissue chip platform for high-content drug discovery that we developed using submandibular gland tissue from female SKH1 hairless mice, backcrossed 6 generations with C57BL/6 J mice. We developed in-chip assays to quantify reduced glutathione and cellular senescence, which are accepted biomarkers of radiation damage. We validated radioprotection using WR-1065, the active form of Amifostine and tested other reported radioprotective drugs including Edaravone, Tempol, N-acetylcysteine, Rapamycin, Ex-Rad, and Palifermin. Next, a Selleck Chemicals library of FDA-approved drugs was screened for radioprotection. Lead hits were tested in mouse models.</p><p><strong>Results: </strong>We identify 25 candidate compounds and down-select them using EC50 values and published pharmacologic data. This lead us to test Phenylbutazone (an anti-inflammatory), Enoxacin (a fluoroquinolone antibiotic), and Doripenem (a carbapenem antibiotic) for in vivo radioprotection in mice. Results confirm that these three drugs exhibit radioprotection equivalent to Amifostine but with superior EC50 values, ranging from 140 to 6900-fold lower values.</p><p><strong>Conclusions: </strong>This body of work demonstrates the development and validation of assays using a tissue chip platform for high-content drug screening and the successful discovery and in vivo validation of candidate radioprotective drugs with non-antioxidant primary modes of action. These results point to possible unknown mechanisms of radioprotection. These drugs can be developed to improve radioprotection efficacy and clinical administration without adverse side-effects.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"420"},"PeriodicalIF":5.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing a publicly accessible automated machine learning platform to enable diagnosis before tumor surgery.","authors":"Farideh Hosseinzadeh, George Liu, Esmond Tsai, Ahmad Mahmoudi, Angela Yang, Dayoung Kim, Maxime Fieux, Lirit Levi, Soraya Abdul-Hadi, Nithin D Adappa, Jeremiah A Alt, Khaled A Altartoor, Norbert Banyi, Megana Challa, Rakesh Chandra, Michael T Chang, Philip G Chen, Do-Yeon Cho, Camila Rios de Choudens, Naweed Chowdhury, Clariliz Munet Colon, John M DelGaudio, Anthony Del Signore, Christina Dorismond, Daniel Dutra, Shaun Edalati, Thomas S Edwards, Jose Busquets Ferriol, Mathew Geltzeiler, Christos Georgalas, Satish Govindaraj, Jessica W Grayson, David A Gudis, Richard J Harvey, Austin Heffernan, Peter H Hwang, Alfred Marc Iloreta, Nicolaus D Knight, Michael A Kohanski, David K Lerner, Argyro Leventi, Lik Hang Lee, Rory Lubner, Chengetai Mahomva, Conner Massey, Edward D McCoul, Jayakar V Nayak, Ezra Pak-Harvey, James N Palmer, Vivek C Pandrangi, Alkis J Psaltis, Joseph Raviv, Peta Sacks, Ray Sacks, Madeleine Schaberg, Ethan Soudry, Auddie Sweis, Andrew Thamboo, Justin H Turner, Steve X Wang, Sarah K Wise, Bradford A Woodworth, Peter-John Wormald, Zara M Patel","doi":"10.1038/s43856-025-01134-9","DOIUrl":"https://doi.org/10.1038/s43856-025-01134-9","url":null,"abstract":"<p><strong>Background: </strong>In benign tumors with potential for malignant transformation, sampling error during pre-operative biopsy can significantly change patient counseling and surgical planning. Sinonasal inverted papilloma (IP) is the most common benign soft tissue tumor of the sinuses, yet it can undergo malignant transformation to squamous cell carcinoma (IP-SCC), for which the planned surgery could be drastically different. Artificial intelligence (AI) could potentially help with this diagnostic challenge.</p><p><strong>Methods: </strong>CT images from 19 institutions were used to train the Google Cloud Vertex AI platform to distinguish between IP and IP-SCC. The model was evaluated on a holdout test dataset of images from patients whose data were not used for training or validation. Performance metrics of area under the curve (AUC), sensitivity, specificity, accuracy, and F1 were used to assess the model.</p><p><strong>Results: </strong>Here we show CT image data from 958 patients and 41099 individual images that were labeled to train and validate the deep learning image classification model. The model demonstrated a 95.8 % sensitivity in correctly identifying IP-SCC cases from IP, while specificity was robust at 99.7 %. Overall, the model achieved an accuracy of 99.1%.</p><p><strong>Conclusions: </strong>A deep automated machine learning model, created from a publicly available artificial intelligence tool, using pre-operative CT imaging alone, identified malignant transformation of inverted papilloma with excellent accuracy.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"419"},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmaceutical and biomedical challenges for crew autonomy in health preservation during future exploration missions.","authors":"Gianni Ciofani, Tiziano Bandiera, Alberto Corsini, Marco Crescenzi, Massimo De Vittorio, Silvia Mari, Eugenio Martinelli, Monica Monici, Sara Piccirillo, Marco Narici, Francesca Ferranti","doi":"10.1038/s43856-025-01128-7","DOIUrl":"https://doi.org/10.1038/s43856-025-01128-7","url":null,"abstract":"<p><p>Human space missions beyond Low Earth Orbit (LEO), such as to the Moon and Mars, will require increased crew autonomy in health management, due to communication delays and limited resupply. These missions pose unique biomedical challenges, including radiation exposure, altered gravity, and prolonged isolation, which can affect physiology and compromise available treatments. This review examines current efforts in pharmaceutical and biomedical strategies to support health preservation during long-duration missions. We discuss technologies needed to assure drug stability and storage, also considering potential modifications of pharmacokinetics in space, and the potential of nanotechnologies, physical therapies, and in-situ manufacturing. Non-pharmacological tools for diagnostics, trauma care, and tissue regeneration are highlighted for their promise in enhancing medical self-sufficiency. These advances are not only critical for ensuring mission success and crew safety beyond LEO, yet may also translate to healthcare solutions in remote or underserved Earth settings.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"418"},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A One Health framework for global and local stewardship across the antimicrobial lifecycle.","authors":"Bruce M Altevogt, Philip Taylor, Holy Teneg Akwar, David W Graham, Lesley A Ogilvie, Erin Duffy, Sabiha Y Essack","doi":"10.1038/s43856-025-01090-4","DOIUrl":"10.1038/s43856-025-01090-4","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) is a One Health challenge, affecting human and animal health, plants and the environment. It has significant impacts on population health, food security and economies of all countries. AMR is a complex problem that requires broad One Health stewardship from local to global levels, encompassing infection prevention together with stewardship across the six stages of the antimicrobial lifecycle, i.e., (1) research and development, (2) production, (3) registration evaluation and market authorization, (4) selection, procurement and supply, (5) appropriate and prudent use and (6) disposal, as outlined by the World Health Organization (WHO), the Food and Agriculture Organization (FAO), and the World Organization for Animal Health (WOAH). This requires the stewardship of innovation, access, use and disposal. Such end-to-end stewardship will individually and collectively help to maintain the efficacy of existing and new antimicrobials for the optimal management and prevention of infections in humans, animals, and plants while protecting the environment. This Perspective proposes a comprehensive One Health stewardship framework that spans the entire antimicrobial lifecycle-from innovation to disposal-across humans, animals, plants, and the environment as One Health sectors. By embedding stewardship principles at all levels, the framework aims to preserve antimicrobial efficacy, mitigate resistance, and safeguard global health, animal health food security, and ecosystems.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"414"},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in peripheral blood and cognitive performance after nonconcussive head impacts in elite female soccer players.","authors":"Martin Cente, Janka Perackova, Pavol Peracek, Marek Majdan, Igor Toth, Martin Mikulic, Jozef Hanes, Marian Spajdel, Patrik Sivco, Michaela Skrabanova, Rostislav Skrabana, Igor Jurisica, Peter Filipcik","doi":"10.1038/s43856-025-01127-8","DOIUrl":"10.1038/s43856-025-01127-8","url":null,"abstract":"<p><strong>Background: </strong>Exposure to repetitive head impacts (RHI) has been shown to be associated with cognitive impairment and markers of neurodegeneration in professional male soccer players. However, data on the effects of RHI in female players are very limited. In this exploratory study, we investigated changes in blood biomarkers along with the cognitive status of elite female soccer players and compared the effect of RHI with outcomes in male players.</p><p><strong>Methods: </strong>In a cohort study, elite female soccer players (age 16-41 years) performed training without heading the ball (n = 36) and training including heading (n = 30). Athletes were evaluated for the parameters of physical activity (heart rate) and neuropsychological testing (focused attention and cognitive flexibility) before and 1 h after each training. The levels of plasma tau, pTau₁₈₁, pTau₂₁₇ and microRNAs were determined at four timepoints: before training, 1 h, 24 h, and 48 h after each training session. Parameters in females were compared with control male players (n = 32).</p><p><strong>Results: </strong>The levels of tau, pTau₁₈₁ and pTau₂₁₇ are significantly increased in the plasma of female soccer players 1 hour after physical exercise (tau, 1.4-fold; pTau₁₈₁, 1.3-fold; pTau₂₁₇, 1.2-fold) and repetitive head impacts (tau, 1.2-fold; pTau₁₈₁, 1.3-fold; pTau₂₁₇, 1.3-fold) compared to pre-training levels. The ratio of pTau₁₈₁ to tau fold change is significantly higher 1 hour after heading and remains elevated specifically in the heading group even after 48 h. The analysis of deregulated microRNAs in plasma reveals enrichment of neuroprotective pathways after heading training. Female soccer players show worse cognitive functions after heading compared to exercise and also compared to male soccer players.</p><p><strong>Conclusions: </strong>RHIs may lead to acute disbalance of tau and phosphorylated tau in plasma, and are associated with short-term decline in cognitive performance and neuroprotective pathways in elite female soccer players. The sexual dimorphism in response to RHI may reflect biological risk factors potentially relevant to the different degree of susceptibility to neurological disorders in females and males in later life.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"417"},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early pandemic HIV-1 integration site preferences differ across anatomical sites.","authors":"Hinissan P Kohio, Hannah O Ajoge, Emile A Barua, Neel R Vajaria, Isaac K F Wu, Macon D Coleman, Sean K Tom, Frank van der Meer, John Gill, Deirdre Church, Paul Beck, Christopher Power, Guido van Marle, Stephen D Barr","doi":"10.1038/s43856-025-01146-5","DOIUrl":"10.1038/s43856-025-01146-5","url":null,"abstract":"<p><strong>Background: </strong>HIV-1 persists in the body even when treatment suppresses viral replication. This persistence is due in part to the virus integrating into the DNA of infected cells. While it is known that HIV-1 can integrate into many different tissues, it remains unclear whether integration patterns differ across anatomical sites. This study investigated how the location and characteristics of HIV-1 integration sites vary across distinct tissues in people living with HIV-1 subtype B during the early years of the pandemic, before modern treatment was widely available.</p><p><strong>Methods: </strong>Integration site data were obtained from matched samples from the esophagus, blood, stomach, duodenum, and colon, and from unmatched brain tissue. We evaluated how frequently the virus integrated near different genomic features, including gene regions, repetitive elements, and predicted DNA structures, and compared integration patterns across tissues and individuals.</p><p><strong>Results: </strong>We show that integration site patterns differ by tissue. In brain tissue, HIV integrates less frequently into genes and more frequently into specific repetitive elements and accessible regions of DNA. We also find that integration near unusual DNA shapes varies by tissue, and that certain integration hotspots are shared while others are unique. Genes involved in HIV-1-related diseases are frequently targeted across tissues.</p><p><strong>Conclusions: </strong>This study reveals that HIV-1 integration patterns are shaped by the tissue environment. These findings suggest that the long-term persistence of HIV-1 depends in part on tissue-specific integration site features, with potential implications for disease risk and treatment strategies.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"405"},"PeriodicalIF":5.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating direct electrical stimulation with brain connectivity predicts lesion-induced language impairment and recovery.","authors":"Ludovico Coletta, Paolo Avesani, Luca Zigiotto, Martina Venturini, Luciano Annicchiarico, Laura Vavassori, Sharna D Jamadar, Emma X Liang, Justine Y Hansen, Bratislav Misic, Sam Ng, Hugues Duffau, Silvio Sarubbo","doi":"10.1038/s43856-025-01121-0","DOIUrl":"10.1038/s43856-025-01121-0","url":null,"abstract":"<p><strong>Background: </strong>Neurological conditions account for millions of deaths per year and induce long-lasting cognitive impairments. The disruption of structural brain networks predicts the emergence of cognitive impairments in stroke cases, but the role of the white matter in modeling longitudinal behavioral trajectories in glioma patients is understudied.</p><p><strong>Methods: </strong>We analyzed 486 intracranial brain stimulations from 297 patients (age range 37-40, male ratio 53-64% depending on the functional categories) along with functional and structural brain connectivity data from over 1750 healthy individuals, to create a network mapping method able to identify the neural substrate causally involved in language production. We tested the validity of our procedure by (i) quantifying the spatial correspondence between white matter metabolic and hemodynamic spontaneous activity, measured via resting-state functional Magnetic Resonance Imaging and [18 F]-fluorodeoxyglucose functional Positron Emission Tomography (respectively); (ii) predicting unseen intracranial stimulations points; (iii) modeling the severity of stroke-induced aphasia (n = 105) and the longitudinal recovery of language abilities in glioma patients (n = 42, 3 timepoints).</p><p><strong>Results: </strong>We show that spontaneous white matter hemodynamic oscillations map into metabolic fluctuations. We also demonstrate that the integration of patient-specific intracranial stimulation points and normative human connectivity data (i) is predictive of unseen stimulation points; (ii) provides better estimates than total lesion volume in predicting the severity of stroke-induced aphasia symptoms; (iii) models post-operative language recovery trajectories better than state-of-the-art clinical measures in glioma patients.</p><p><strong>Conclusions: </strong>This work presents a data-driven and neurobiologically grounded tool for modeling cognitive and neurological impairments in terms of network disruption, demonstrating improved precision over existing approaches.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"416"},"PeriodicalIF":5.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the response to immunotherapy from gene expression data in HER2-negative breast cancer.","authors":"Caterina A M La Porta, Ornella Garrone, Marco Merlano, Stefano Zapperi","doi":"10.1038/s43856-025-01131-y","DOIUrl":"10.1038/s43856-025-01131-y","url":null,"abstract":"<p><strong>Background: </strong>The addition of immunotherapy in the neoadjuvant setting is showing promising results for HER2- and triple-negative breast cancer patients, but pathological complete response is observed only in a fraction of patients. The aim of the present work was to investigate if ARIADNE, an algorithmic strategy to analyze gene expression data from bioptic samples based on epithelial-mesenchymal phenotypes, can predict the response to immunotherapy in HER2- patients.</p><p><strong>Methods: </strong>We considered gene expression data for HER2-breast cancer patients treated with pembrolizumab in addition to chemotherapy (n = 69) and with chemotherapy alone (n = 179) from the I-SPY 2 trial. We stratified patients in two risk groups (low/high risk) according to the score of the ARIADNE algorithm and studied an additional cytokine signature. To better understand the significance of our results, we studied the interactions among genes in the PD-L1 pathway and analyzed single-cell data from TNBC patients treated with pembrolizumab.</p><p><strong>Results: </strong>Our results show that ARIADNE predicts differential response to immunotherapy: the high-risk group has a pathological complete response (pCR) rate of 26% as compared with 62% for the low-risk group (OR 4.7, with 1.68-11.32 95% CI and p < 0.01). We also find significant correlations between a cytokine score and the rate of pCR. The ability of ARIADNE to predict pCR is associated with regulatory activity within the PD-L1 pathway. Comparison between ARIADNE and other immunological genomic signatures shows no correlations. The study of single-cell data showed that patients responding to immunotherapy display a larger number of exhausted T-cells than non-responders.</p><p><strong>Conclusions: </strong>Our analysis shows that ARIADNE is predictive of the response to immunotherapy, but not to chemotherapy, in HER2- patients.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"415"},"PeriodicalIF":5.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update of a prediction model for postoperative shoulder stiffness after arthroscopic rotator cuff repair.","authors":"Thomas Stojanov, Soheila Aghlmandi, Andreas Marc Müller, Philipp Moroder, Alexandre Lädermann, Cornelia Baum, Laurent Audigé","doi":"10.1038/s43856-025-01125-w","DOIUrl":"10.1038/s43856-025-01125-w","url":null,"abstract":"<p><strong>Background: </strong>Arthroscopic rotator cuff repair (ARCR) is a common procedure, and postoperative shoulder stiffness (POSS) is one of its most frequent adverse events, potentially necessitating individualized therapy. Our objectives were to update and internally validate a model predicting the occurrence of POSS for patients undergoing an ARCR.</p><p><strong>Methods: </strong>We prospectively enrolled 973 patients undergoing primary ARCR included in the ARCR_Pred dataset. A two-round Delphi survey with 53 surgeons established a consensus definition of POSS within 6 months postoperatively and a ranking of candidate prognostic factors. Treating surgeons estimated POSS risk immediately after surgery. We externally validated an existing POSS model and developed updated multivariable logistic regression models using complete-case and multiple imputed datasets.</p><p><strong>Results: </strong>We achieved a high consensus (88%) on the POSS definition among 44 responding shoulder surgeons, who also ranked the prognostic relevance of 71 factors for the prediction of POSS. The newly developed ARCR_Pred-POSS included 7 factors (age, acromiohumeral distance, symptom duration, baseline external rotation, active baseline abduction, baseline Oxford Shoulder Score, and surgery duration) and demonstrated superior discrimination (AUC = 0.735) and calibration (slope = 1.022) compared to the original POSS model (AUC = 0.581, slope = 0.508). Surgeons tended to overestimate the risk of POSS in their patients (AUC = 0.563, slope = 1.241).</p><p><strong>Conclusions: </strong>These findings support the continued development of prediction models and provide valuable outputs for optimizing surgical timing, indications, and personalized rehabilitation.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"413"},"PeriodicalIF":5.4,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of electroconvulsive therapy on hippocampal longitudinal axis and its association with cognitive side effects.","authors":"Olga Therese Ousdal, Miklos Argyelan, Maarten Laroy, Amit Anand, Filip Bouckaert, Joan A Camprodon, Marta Cano, Narcis Cardoner, Udo Dannlowski, Annemiek Dols, Louise Emsell, Randall Espinoza, Kaat Hebbrecht, René Hurlemann, Martin Jorgensen, Maximillian Kiebs, Taishiro Kishimoto, Katherine L Narr, Pia Nordanskog, Nils Opel, Ronny Redlich, Didi Rhebergen, Alexander Sartorius, Didier Schrijvers, Pascal Sienaert, Carles Soriano-Mas, Akihiro Takamiya, Freek Ten Doesschate, Indira Tendolkar, Mikel Urretavizcaya, Linda van Diermen, Philip van Eijndhoven, Guido van Wingen, Jeroen van Waarde, Mathieu Vandenbulcke, Joey Verdijk, Benjamin S C Wade, Yrondi Antoine, Njål Brekke, Joan Prudic, Shawn McClintock, Ute Kessler, Hauke Bartsch, Ketil Odegaard, Jan Haavik, Åsa Hammar, Christopher Abbott, Leif Oltedal","doi":"10.1038/s43856-025-01120-1","DOIUrl":"10.1038/s43856-025-01120-1","url":null,"abstract":"<p><strong>Background: </strong>Electroconvulsive therapy (ECT)-mediated hippocampal volumetric increase is consistently reported, though its clinical relevance remains debated. This study evaluates if ECT-related cognitive side effects are associated with regional volumetric changes along the hippocampal longitudinal axis.</p><p><strong>Methods: </strong>Longitudinal T1-weighted MRI scans in 435 patients (54.0 ± 15.0 years, 261 female) with major depression from the Global ECT-MRI Research Collaboration (GEMRIC) were used to measure changes in right global and longitudinal axis hippocampal subdivisions (head, body, tail) from baseline to post-treatment. Cognitive side effects were evaluated using pre-to-post treatment changes in two different verbal fluency tests available for 124 patients. Electric field modelling was applied to explore whether the regional hippocampal electric field strength related to individual changes in cognitive performance.</p><p><strong>Results: </strong>Global hippocampal enlargement is observed pre-to-post ECT (p_FDR < 0.001), but enlargement of the hippocampal head significantly exceeds the volumetric change in the hippocampal body and tail (p_FDR < 0.001). Volumetric expansion of the hippocampal body and tail significantly associates with reduced verbal fluency scores (p_FDR< 0.05). Moreover, volumetric reduction of the hippocampal tail at 6 months post-ECT associates with improved cognitive performance (p_FDR < 0.05, N = 24). Finally, patients performing worse on verbal fluency tests following treatment have greater electric field during ECT in the right hippocampal body (p_uncorrected < 0.05).</p><p><strong>Conclusions: </strong>The findings support that cognitive performance following ECT relates to macrostructural changes in the posterior cognitive hippocampus. Thus, there may be a threshold of ECT induced posterior hippocampal volumetric change, beyond which cognitive side effects occur.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"409"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}