Communications medicine最新文献

{"title":"Association of leukocyte composition ratios from blood methylation with cancer mortality outcomes.","authors":"Ziwen Fan, Dominic Edelmann, Zitong Zhao, Bruno Christian Köhler, Michael Hoffmeister, Hermann Brenner","doi":"10.1038/s43856-025-01132-x","DOIUrl":"10.1038/s43856-025-01132-x","url":null,"abstract":"<p><strong>Background: </strong>Leukocyte composition ratios derived from blood genome-wide methylation (DNAm-derived LCRs), reflecting systemic inflammation, remain unclear in relation to various mortality outcomes.</p><p><strong>Methods: </strong>We performed an epigenome-wide analysis to identify the association of DNAm-derived LCRs with all-cause mortality, cancer-specific mortality, and lung-cancer-specific mortality in a large prospective cohort study with 17 years follow-up.</p><p><strong>Results: </strong>Strong associations of multiple LCRs are seen for all mortality outcomes. The neutrophil-to-B-cell ratio was strongly associated with all-cause mortality (HR per SD increase, 1.20; 95% CI, 1.10-1.31), the neutrophil-to-lymphocyte ratio with cancer-specific mortality (HR, 1.28; 1.11-1.49), and the lymphocyte-to-monocyte ratio with lung-cancer-specific mortality (HR, 0.53; 0.38-0.75). The consistency of HR estimations across 11-year, 14-year, and 17-year follow-ups reinforces these findings. Several LCRs show stronger associations in females and younger participants.</p><p><strong>Conclusions: </strong>Our study identifies DNAm-derived LCRs as particularly useful measures for quantifying cancer mortality risk over long-term follow-ups exceeding a decade.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"411"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine concentrations in people with eating disorders: A comprehensive updated systematic review and meta-analysis.","authors":"Johanna L Keeler, Charlotte Bovenberg, Hubertus Himmerich, Janet Treasure, Ben Carter, Ulrike Schmidt, Bethan Dalton","doi":"10.1038/s43856-025-01122-z","DOIUrl":"10.1038/s43856-025-01122-z","url":null,"abstract":"<p><strong>Background: </strong>Prior research has found altered levels of cytokines in people with eating disorders (EDs). This study is an update of a previous meta-analysis, including longitudinal analyses and machine learning heterogeneity analyses (MetaForest).</p><p><strong>Methods: </strong>This pre-registered ( https://osf.io/g6d3f ) systematic review and meta-analysis following PRISMA guidelines assessed studies from four databases (PubMed, Web of Science, MEDLINE, PsycINFO) reporting cytokine concentrations in people with EDs until 10^th November 2024. Random-effects models were utilised for all meta-analyses.</p><p><strong>Results: </strong>Twenty-four new studies are incorporated, resulting in a total of 43 studies included in meta-analyses. Interleukin (IL)-6 and IL-15 are higher, and IL-7 lower, in anorexia nervosa (AN) compared with controls. When controlling for outliers, tumour necrosis factor (TNF)-α, IL-1β, IL-4, IL-8, IL-10, interferon (IFN)-γ, monocyte chemoattractant protein (MCP) and transforming growth factor (TGF)-β are similar between AN and controls. Longitudinally, IL-6 is lower in AN at follow-up compared to baseline, although this may be an artefact of publication bias. TNF-α and IL-1β do not change longitudinally. There are largely no differences in IL-6 and TNF-α in bulimia nervosa (BN) and there are insufficient studies to perform meta-analyses for binge eating disorder or other EDs.</p><p><strong>Conclusions: </strong>In acute AN, concentrations of IL-6 and IL-15 are elevated and IL-7 is decreased, with preliminary but unconclusive evidence for small decreases in IL-6 over the course of weight restoration. Other cytokines considered to have broadly pro-inflammatory functions are not increased in AN. In BN, there is little evidence for increases in pro-inflammatory cytokines, but the evidence base is limited.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"408"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental low-dose bisphenol A exposure leads to extensive transcriptome female masculinization and male feminization later in life.","authors":"Thomas Lind, Linda Dunder, Margareta H Lejonklou, P Monica Lind, Håkan Melhus, Lars Lind","doi":"10.1038/s43856-025-01119-8","DOIUrl":"10.1038/s43856-025-01119-8","url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA) is an endocrine disruptor, and exposure to low doses in utero has been associated with the development of metabolic diseases. Previous studies have suggested that bone marrow (BM) may be particularly susceptible to BPA exposure.</p><p><strong>Methods: </strong>Here, we investigate how developmental exposure to low levels of BPA affects the BM transcriptome and the blood metabolic profile in Fischer 344 rats later in life. We compare these effects to those observed in human metabolic syndrome (MetS) using a population-based cohort.</p><p><strong>Results: </strong>The results show an unexpectedly extensive sex-biased effect on the BM transcriptome from a BPA dose approximately eight times lower than the recent temporary European Food Safety Authority (EFSA) human tolerable daily intake (TDI) and a higher dose considered safe in 2015. BPA exposure induces sex-specific changes in gene expression, progressing toward a hypometabolic cancer-like state in females and a hypermetabolic autoimmunity-like state in males, with a blood metabolic profile that significantly overlaps with human MetS in a cross-sectional study.</p><p><strong>Conclusions: </strong>We conclude that developmental low-dose BPA exposure might induce metabolic syndrome specifically in males, possibly by affecting T cell activity in a sex-specific manner. Our study provides biologically plausible and convincing evidence for significant effects from low-dose BPA exposure, supporting the substantial lowering of the human BPA TDI by EFSA based on its critical effects on T cells.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"410"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical and transcatheter aortic valve replacement after orthotopic heart transplantation: a case series.","authors":"Luise Roehrich, Hristian Hinkov, Christoph Knosalla, Felix Hennig, Christoph Klein, Marian Kukucka, Nicolas Merke, Laurenz Kopp Fernandes, Isabell Anna Just, Sascha Ott, Henryk Dreger, Volkmar Falk, Axel Unbehaun, Felix Schoenrath","doi":"10.1038/s43856-025-01151-8","DOIUrl":"10.1038/s43856-025-01151-8","url":null,"abstract":"<p><strong>Background: </strong>Aortic valve dysfunction is a rare but relevant long-term complication after orthotopic heart transplantation (HTX). Treatment options include surgical (SAVR) and transcatheter (TAVR) aortic valve replacement, but evidence is limited to the level of case reports.</p><p><strong>Methods: </strong>A total of 2054 patients underwent HTX between 1986 and 2023 at the Deutsches Herzzentrum der Charité, Berlin, Germany, 16 of them underwent aortic valve replacement (SAVR, N = 7; TAVR, N = 9) after HTX. In this case series we report on the outcomes of these 16 patients (age 29-73 years).</p><p><strong>Results: </strong>Isolated aortic valve regurgitation occurs in 5 (31%) patients (TAVR N = 1, SAVR N = 4), while 11 patients (69%) suffer from aortic valve stenosis. Severe pre-procedural heart failure is present in 38% of the patients. Thirty-day mortality is 0%, in-hospital mortality is N = 2 (22%) patients due to sepsis, both patients were severely decompensated prior to TAVR. An uneventful postoperative course occurs in 8 (50%) patients, the patient's functional status improves in 12 (75%) cases.</p><p><strong>Conclusion: </strong>TAVR is the increasingly preferred treatment for aortic valve dysfunction after heart transplantation, but SAVR is a feasible alternative for individuals who are ineligible for TAVR. Further information is needed on the appropriate procedural timing in these high-risk patients.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"412"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing telemedicine and task-sharing to improve access to psychotherapy for perinatal populations.","authors":"Nicole Andrejek, Zoë Lea, Abigail Cussons, Shelly Sandeep, Cindy-Lee Dennis, Laura M La Porte, Simone N Vigod, Richard K Silver, Samantha Meltzer-Brody, Daisy R Singla","doi":"10.1038/s43856-025-01099-9","DOIUrl":"10.1038/s43856-025-01099-9","url":null,"abstract":"<p><strong>Background: </strong>The Scaling Up Maternal Mental healthcare by Increasing access to Treatment (SUMMIT) trial (ClinicalTrials.gov: NCT04153864) examined two solutions to improving access to psychotherapy for perinatal populations: telemedicine and task-sharing with non-specialist providers (individuals without prior specialized training or experience in delivering mental healthcare). The SUMMIT trial showed that telemedicine and non-specialist-delivered psychotherapy were non-inferior to treatment delivered in-person or by a specialist mental health provider. Our aim was to conduct an implementation assessment of task-sharing and telemedicine to inform best practices when providing access to psychotherapy treatment for perinatal patients in real world healthcare settings.</p><p><strong>Methods: </strong>In this current study, we examined barriers and facilitators of task-sharing and telemedicine-delivered psychotherapy from a multistakeholder perspective (N = 105). We interviewed perinatal participants (n = 70) who received psychotherapy and specialist or non-specialist providers (n = 35) who delivered psychotherapy in the SUMMIT trial. We conducted an inductive thematic analysis.</p><p><strong>Results: </strong>Our results show many facilitators of telemedicine across all stakeholder groups, including alleviating childcare needs through convenience, flexibly, and increased accessibility. Although perinatal participants and providers express that there are some benefits of in-person delivery (e.g., seeing physical cues and minimizing privacy concerns), we find that there are more barriers than facilitators of in-person psychotherapy. Regarding task-sharing, perinatal participants who received treatment from non-specialist and specialist providers report the same facilitators at similar rates, including capacity for active listening and empathy.</p><p><strong>Conclusions: </strong>Our implementation assessment shows that telemedicine and task-sharing are acceptable, feasible, and patient-centred solutions to improve access to evidence-based psychotherapies across healthcare settings.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"406"},"PeriodicalIF":5.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, pathological and molecular characteristics of patients with disease recurrence despite pathologic response to neoadjuvant ipilimumab plus nivolumab in stage III melanoma.","authors":"Judith M Versluis, Huma Shehwana, Robert Elens, Alexander M Menzies, Irene L M Reijers, Petros Dimitriadis, Nigel G Maher, Astrid M M van der Veldt, Ellen Kapiteijn, Annegien Broeks, Richard A Scolyer, Bart A van de Wiel, Alexander C J van Akkooi, Ton N Schumacher, Georgina V Long, Christian U Blank","doi":"10.1038/s43856-025-01118-9","DOIUrl":"10.1038/s43856-025-01118-9","url":null,"abstract":"<p><strong>Background: </strong>Pathologic response has been shown to be strongly associated with long-term event-free survival after neoadjuvant ipilimumab plus nivolumab in stage III melanoma. Only a small proportion of patients developed disease recurrence after initial pathologic response, making conclusions with statistically significant data challenging. However, the homogeneity of population of patients with stage III melanoma might augment the ability to identify immune resistance mechanisms.</p><p><strong>Methods: </strong>To test if recurrence could be due to true tumor immune evasion or due to insufficient persistence of the immune pressure, 10/140 patients with pathologic response after neoadjuvant ipilimumab plus nivolumab with disease recurrence were identified within the OpACIN, OpACIN-neo, and PRADO trials.</p><p><strong>Results: </strong>Compared to their counterparts without recurrence, clinical characteristics are different regarding sex, age, BRAF mutation status, depth of pathologic response and frequency of immune-related endocrinopathies. Immune activation-related gene expressions are increased at recurrence after major pathologic response (MPR), but not after pathologic partial response (pPR), and TCR diversity nor clonality are different between baseline and recurrence for both MPR and pPR.</p><p><strong>Conclusions: </strong>No genetic changes explaining tumor immune evasion are found. We propose that disease recurrence may potentially be explained by diminishing of the initial therapy-induced immune response, but not due to genetic changes in the tumor cells mediating immune evasion.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"407"},"PeriodicalIF":5.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-stage large language model framework for extracting suicide-related social determinants of health.","authors":"Song Wang, Yishu Wei, Haotian Ma, Max Lovitt, Kelly Deng, Yuan Meng, Zihan Xu, Jingze Zhang, Yunyu Xiao, Ying Ding, Xuhai Xu, Joydeep Ghosh, Yifan Peng","doi":"10.1038/s43856-025-01114-z","DOIUrl":"10.1038/s43856-025-01114-z","url":null,"abstract":"<p><strong>Background: </strong>Understanding social determinants of health (SDoH) factors contributing to suicide incidents is crucial for early intervention and prevention. However, data-driven approaches to this goal face challenges such as long-tailed factor distributions, analyzing pivotal stressors preceding suicide incidents, and limited model explainability.</p><p><strong>Methods: </strong>We present a multi-stage large language model framework to enhance SDoH factor extraction from unstructured text. Our approach was compared to other state-of-the-art language models (i.e., pre-trained BioBERT and GPT-3.5-turbo) and reasoning models (i.e., DeepSeek-R1). We also evaluated how the model's explanations help people annotate SDoH factors more quickly and accurately. The analysis included both automated comparisons and a pilot user study.</p><p><strong>Results: </strong>We show that our proposed framework demonstrates performance boosts in the overarching task of extracting SDoH factors and in the finer-grained tasks of retrieving relevant context. Additionally, we show that fine-tuning a smaller, task-specific model achieves comparable or better performance with reduced inference costs. The multi-stage design not only enhances extraction but also provides intermediate explanations, improving model explainability.</p><p><strong>Conclusions: </strong>Our approach improves both the accuracy and transparency of extracting suicide-related SDoH from unstructured texts. These advancements have the potential to support early identification of individuals at risk and inform more effective prevention strategies.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"404"},"PeriodicalIF":5.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revascularization strategy for left main coronary artery disease comparing percutaneous coronary intervention versus coronary artery bypass grafting.","authors":"Ryaan El-Andari, Jimmy Kang, Nicholas Fialka, Yongzhe Hong, Finlay A McAlister, Jeevan Nagendran, Jayan Nagendran","doi":"10.1038/s43856-025-01098-w","DOIUrl":"10.1038/s43856-025-01098-w","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery bypass grafting(CABG) has long been the preferred treatment for left main coronary artery disease(LMCAD), although percutaneous coronary intervention(PCI) has been increasingly utilized. Despite numerous investigations seeking to identify the optimal revascularization strategy for LMCAD, limitations in sample size or follow-up duration have hindered definitive conclusions. Herein, we compare the long-term outcomes up to 14 years after CABG or PCI for patients with LMCAD.</p><p><strong>Methods: </strong>Data was retrospectively collected from a provincial database. The inclusion criteria is patients ≥18 years old, with LMCAD, and revascularization with CABG or PCI. The primary outcome is all-cause mortality. Secondary outcomes are any rehospitalization, myocardial infarction (MI), stroke, or repeat revascularization. Outcomes are adjusted for age, sex, and clinical comorbidities. The average age of the patients was 67 ± 9 years for the CABG patients and 71 ± 11 years for the PCI patients. 84.7% of the CABG patients and 71.5% of the PCI patients were male.</p><p><strong>Results: </strong>5580 patients are identified with LMCAD between 2009 and 2018. 1706 patients (1180 CABG; 526 PCI) are included in the final analysis and followed until March 31, 2023. Rates of mortality at longest follow-up of 14 years are 40.0% for CABG and 58.4% for PCI (adjusted hazard ratio(aHR) 0.58, 95% confidence interval(CI) 0.48-0.70, p < 0.001). Rates of MI (10.7% vs 22.3%, aHR 0.40, 95% CI 0.29-0.55, p < 0.001) and repeat revascularization (5.4%vs16.3%, aHR 0.25, 95% CI 0.18-0.36, p < 0.001) favor CABG over PCI.</p><p><strong>Conclusions: </strong>Patients with LMCAD undergoing CABG experience significant benefit over PCI in terms of long-term mortality, MI, and required repeat revascularization. These finding suggest CABG should remain the preferred revascularization strategy for patients with LMCAD and acceptable surgical risk. Future studies should explore evolving PCI techniques and their impact on long-term outcomes.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"402"},"PeriodicalIF":5.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and MRI markers for acute vs chronic temporomandibular disorders using a machine learning and deep neural networks.","authors":"Yeon-Hee Lee, Seonggwang Jeon, Do-Hoon Kim, Q-Schick Auh, Jeong-Hoon Lee, Yung-Kyun Noh","doi":"10.1038/s43856-025-01081-5","DOIUrl":"10.1038/s43856-025-01081-5","url":null,"abstract":"<p><strong>Background: </strong>Exploring the transition from acute to chronic temporomandibular disorders (TMD) remains challenging due to the multifactorial nature of the disease. This study aims to identify clinical, behavioral, and imaging-based predictors that contribute to symptom chronicity in patients with TMD.</p><p><strong>Methods: </strong>We enrolled 239 patients with TMD (161 women, 78 men; mean age 35.60 ± 17.93 years), classified as acute ( < 6 months) or chronic ( ≥ 6 months) based on symptom duration. TMD was diagnosed according to the Diagnostic Criteria for TMD (DC/TMD Axis I). Clinical data, sleep-related variables, and temporomandibular joint magnetic resonance imaging (MRI) were collected. MRI assessments included anterior disc displacement (ADD), joint space narrowing, osteoarthritis, and effusion using 3 T T2-weighted and proton density scans. Predictors were evaluated using logistic regression and deep neural networks (DNN), and performance was compared.</p><p><strong>Results: </strong>Chronic TMD is observed in 51.05% of patients. Compared to acute cases, chronic TMD is more frequently associated with TMJ noise (70.5%), bruxism (31.1%), and higher pain intensity (VAS: 4.82 ± 2.47). They also have shorter sleep and higher STOP-Bang scores, indicating greater risk of obstructive sleep apnea. MRI findings reveal increased prevalence of ADD (86.9%), TMJ-OA (82.0%), and joint space narrowing (88.5%) in chronic TMD. Logistic regression achieves an AUROC of 0.7550 (95% CI: 0.6550-0.8550), identifying TMJ noise, bruxism, VAS, sleep disturbance, STOP-Bang≥5, ADD, and joint space narrowing as significant predictors. The DNN model improves accuracy to 79.49% compared to 75.50%, though the difference is not statistically significant (p = 0.3067).</p><p><strong>Conclusions: </strong>Behavioral and TMJ-related structural factors are key predictors of chronic TMD and may aid early identification. Timely recognition may support personalized strategies and improve outcomes.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"401"},"PeriodicalIF":5.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding sexually dimorphic proteomic landscapes in the context of aging and mortality.","authors":"Zhihao Jin, Bingying Du, Xuehao Jiao, Zhengsheng Gu, Tianren Wang, Li Cao, Xiaoying Bi, Lei Yuan, Bo Peng, Yanxia Rao","doi":"10.1038/s43856-025-01113-0","DOIUrl":"10.1038/s43856-025-01113-0","url":null,"abstract":"<p><strong>Background: </strong>Aging-associated changes are major contributors to the onset and progression of chronic diseases. Different aging clocks have been developed to assess biological aging, demonstrating their utility in predicting mortality, diagnosing disease, and evaluating the efficacy of antiaging interventions. However, the protein profile underlying the accelerating or decelerating rates of aging, hidden behind aging clocks, remains poorly understood.</p><p><strong>Method: </strong>Based on the UK Biobank (n = 53, 013; age range 39-71 years; 53.9% men and 46.1% women), we built a proteomic-based aging clock, ProteAge, and assessed its performance in predicting all-cause mortality. Sex-specific aging trajectories and aging rate-associated proteins (ARPs) were identified.</p><p><strong>Results: </strong>ProteAge reveals distinct aging trajectories for males and females, with females exhibiting more nonlinear changes in the aging rate than males do. We identify hundreds of accelerating and decelerating aging rate proteins (ARPs) in both sexes. Given the critical role of mortality prediction in aging and longevity research, we identify a subset of mortality-aging-associated proteins among ARPs, with a total of 1 protein in females but 172 in males. Furthermore, the protective and risk factors in both sexes are identified based on these ARPs.</p><p><strong>Conclusions: </strong>These findings highlight sexually-dimorphic proteomic changes associated with aging and mortality, offering insights into the biological mechanisms underlying aging and longevity.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"403"},"PeriodicalIF":5.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}