Communications medicine最新文献

{"title":"Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model.","authors":"Viktor Hartung, Philipp Gruschwitz, Anne Marie Augustin, Jan-Peter Grunz, Florian Kleefeldt, Dominik Peter, Süleyman Ergün, Johanna Günther, Teresa Reichl, Thomas Kampf, Martin Andreas Rückert, Stefan Herz, Volker Christian Behr, Thorsten Alexander Bley, Patrick Vogel","doi":"10.1038/s43856-025-00794-x","DOIUrl":"10.1038/s43856-025-00794-x","url":null,"abstract":"<p><strong>Background: </strong>Magnetic particle imaging (MPI) allows for radiation-free visualization of tracers without background signal. With the first human-sized interventional MPI scanner being recently developed, the aim of the present study was to test its performance for guiding of endovascular procedures in a realistic perfusion model.</p><p><strong>Methods: </strong>Three fresh-frozen cadaveric legs were prepared to establish continuous circulation in the superficial femoral artery via introducer sheaths in the inguinal and infragenicular region. To facilitate vessel visualization, a mixture of a MPI tracer (Resotran® or Perimag®) and X-ray contrast agent was injected under continuous extracorporeal perfusion and imaged simultaneously with MPI angiography and digital subtraction angiography (DSA) as reference.</p><p><strong>Results: </strong>The MPI scanner integrates seamlessly into the standard operating procedures in the angiography suite and simultaneous imaging with DSA and MPI is feasible. The MPI scanner detects a tracer bolus of 2 ml Perimag® or 1.5 ml Resotran®. Imaging results are consistent and reproducible in three cadaveric leg phantoms.</p><p><strong>Conclusion: </strong>This study demonstrates, that the recently developed human-sized MPI scanner facilitates reliable radiation-free image guidance for peripheral vascular interventions in the superficial femoral artery with a tracer approved for use in humans.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"75"},"PeriodicalIF":5.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission of alcohol use disorder following traumatic brain injury with focal orbitofrontal cortex hemorrhage: case report and network mapping.","authors":"Saarah Haque, Albert Bellmunt-Gil, Benjamin Davidson, Christian Lüscher, Michael D Fox, Juho Joutsa, Matthew J Burke","doi":"10.1038/s43856-025-00760-7","DOIUrl":"10.1038/s43856-025-00760-7","url":null,"abstract":"<p><strong>Background: </strong>The orbitofrontal cortex (OFC) and its role in the regulation of urges/compulsion has been identified as a critical component of circuit-based addiction models. Building on such models, it was recently shown that brain lesions disrupting addictive behavior can be mapped to a common brain circuit.</p><p><strong>Methods: </strong>We present a case of a 42-year-old woman with chronic treatment-refractory alcohol use disorder who experienced early remission following a traumatic brain injury (TBI) with focal left OFC intracerebral hemorrhage. Using a network mapping approach (normative connectome, n = 1000), functional connectivity was computed from the traced OFC lesion across all brain voxels.</p><p><strong>Results: </strong>The case lesion map topography converges on a brain lesion map previously described as disrupting addictive behavior, but with an inverse connectivity profile (spatial correlation r = -0.59). This spatial correlation is more negative than what would be expected by chance (permutation test 1-sided, p = 0.04) or by random lesion cases (1-sided, p < 0.001).</p><p><strong>Conclusions: </strong>Based on these results, we suggest that potentially just disrupting this brain network, regardless of the directionality, could facilitate remission. However, this case report cannot control for multiple psychosocial factors potentially impacting alcohol remission and caution is also needed for considering TBI as a mechanism for generating an isolated focal lesion. Overall, this case contributes to our understanding of circuit-based models of addictive behavior and could be useful in generating hypotheses for neuromodulatory treatment strategies.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"69"},"PeriodicalIF":5.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low responsiveness of machine learning models to critical or deteriorating health conditions.","authors":"Tanmoy Sarkar Pias, Sharmin Afrose, Moon Das Tuli, Ipsita Hamid Trisha, Xinwei Deng, Charles B Nemeroff, Danfeng Daphne Yao","doi":"10.1038/s43856-025-00775-0","DOIUrl":"10.1038/s43856-025-00775-0","url":null,"abstract":"<p><strong>Background: </strong>Machine learning (ML) based mortality prediction models can be immensely useful in intensive care units. Such a model should generate warnings to alert physicians when a patient's condition rapidly deteriorates, or their vitals are in highly abnormal ranges. Before clinical deployment, it is important to comprehensively assess a model's ability to recognize critical patient conditions.</p><p><strong>Methods: </strong>We develop multiple medical ML testing approaches, including a gradient ascent method and neural activation map. We systematically assess these machine learning models' ability to respond to serious medical conditions using additional test cases, some of which are time series. Guided by medical doctors, our evaluation involves multiple machine learning models, resampling techniques, and four datasets for two clinical prediction tasks.</p><p><strong>Results: </strong>We identify serious deficiencies in the models' responsiveness, with the models being unable to recognize severely impaired medical conditions or rapidly deteriorating health. For in-hospital mortality prediction, the models tested using our synthesized cases fail to recognize 66% of the injuries. In some instances, the models fail to generate adequate mortality risk scores for all test cases. Our study identifies similar kinds of deficiencies in the responsiveness of 5-year breast and lung cancer prediction models.</p><p><strong>Conclusions: </strong>Using generated test cases, we find that statistical machine-learning models trained solely from patient data are grossly insufficient and have many dangerous blind spots. Most of the ML models tested fail to respond adequately to critically ill patients. How to incorporate medical knowledge into clinical machine learning models is an important future research direction.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"62"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor positioning systems provide insight into emergency department systems enabling proposal of designs to improve workflow.","authors":"Marius Huguet, Canan Pehlivan, François Ballereau, Antoine Dodane-Loyenet, Franck Fontanili, Thierry Garaix, Youri Yordanov, Vincent Augusto, Karim Tazarourte, Abdesslam Redjaline","doi":"10.1038/s43856-025-00793-y","DOIUrl":"10.1038/s43856-025-00793-y","url":null,"abstract":"<p><strong>Background: </strong>In this study, we implemented an indoor positioning system to track the activities of healthcare professionals during their shifts in an emergency department, aiming to gain a better understanding of the emergency care production process.</p><p><strong>Methods: </strong>An ultrawideband-based tracking system was used in an experiment at the emergency department of Le Corbusier Hospital in Firminy, France. Over a 46-day period, healthcare professionals, including assistant nurses, nurses, doctors, and managers, wore a sensor to record their location within the emergency department. We analyzed a substantial amount of quasi-real-time data to objectively assess physicians' time allocation and movement patterns and their correlation with the emergency department's occupancy. Additionally, we developed a user recognition algorithm (i.e., random forest classifier) capable of detecting the job category of the participant wearing the sensor.</p><p><strong>Results: </strong>The proportion of time spent on care-related activities ranges from 26% to 39% for doctors. In contrast, this share reaches approximately half of the time for triage nurses and intensive care unit nurses. The burden of non-care-related activities appears to be largely induced by the time spent on administrative duties and transit. For doctors, the share of non-care-related activities is found to be correlated with the occupancy level. The hourly distance walked by nurses (except triage nurses) is found to increase with occupancy, while for doctors, the walking distance remains invariant to patient load. The random forest classifier predicts job categories with 96% accuracy.</p><p><strong>Conclusions: </strong>Indoor tracking systems offer additional perspectives for enhancing the understanding of emergency department systems. The technology tested in this study demonstrates its potential to quantify physicians' time allocation and movements.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"72"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023.","authors":"Miaomiao Xie, Yanyan Zhang, Kaichao Chen, Ning Dong, Hongwei Zhou, Yonglu Huang, Congcong Liu, Edward Wai-Chi Chan, Sheng Chen, Rong Zhang","doi":"10.1038/s43856-025-00748-3","DOIUrl":"10.1038/s43856-025-00748-3","url":null,"abstract":"<p><strong>Background: </strong>Development of polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a severe challenge to public health. Here we aimed to perform a retrospective study of prevalence and molecular characteristics of polymyxin-resistant CRKP strains.</p><p><strong>Methods: </strong>4455 clinical CRKP strains from 18 provinces in China during 2000 to 2023 were collected. Polymyxin-resistant CRKP strains were subjected to antimicrobial susceptibility testing, whole genome sequencing and bioinformatic analysis. Molecular mechanisms underlying the polymyxin resistance in CRKP were analyzed.</p><p><strong>Results: </strong>Here we show that polymyxin-resistant CRKP emerge initially in 2014, prevalence of such strains then increase steadily over the years, reaching a rate of 9.86% in 2023. In total, 112 polymyxin-resistant CRKP isolates are identified. Antimicrobial susceptibility tests show that all polymyxin-resistant CRKP are resistant to commonly used antibiotics, yet most isolates remain susceptible only to ceftazidime-avibactam and tigecycline. Predominant polymyxin resistance mechanism in CRKP is mutations in mgrB (59/112), which commonly involves disruption of mgrB by insertion of elements such as ISKpn26 (20/59), IS903B (14/59), and ISKpn14 (9/59). Phylogenetic analysis reveals frequent clonal dissemination of polymyxin-resistant CRKP within the same hospital and even among different hospitals in neighboring provinces. pLVPK-like virulence plasmids are detected in 46 isolates, such strains are therefore categorized as polymyxin and carbapenem-resistant hypervirulent K. pneumoniae which may cause infections with high mortality.</p><p><strong>Conclusions: </strong>Our results highlight frequent clonal transmission of polymyxin-resistant CRKP within hospitals. Continuous surveillance of polymyxin resistance among CRKP should be implemented to prevent further dissemination of such strains in clinical settings in China.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"73"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UK Biobank data demonstrate long-term exposure to floods is a risk factor for incident dementia.","authors":"Yao Wu, Rongbin Xu, Danijela Gasevic, Zhengyu Yang, Pei Yu, Bo Wen, Yanming Liu, Guowei Zhou, Yan Zhang, Jiangning Song, Hong Liu, Shanshan Li, Yuming Guo","doi":"10.1038/s43856-025-00771-4","DOIUrl":"10.1038/s43856-025-00771-4","url":null,"abstract":"<p><strong>Background: </strong>Flooding has emerged as the most prevalent natural disaster, impacting billions of individuals worldwide. However, the long-term effects of flooding exposure on dementia remain unclear.</p><p><strong>Methods: </strong>With a nested case-control design, a risk-set sampling method was used to match cases and controls. Annual cumulative flooding exposure was calculated for each participant. The associations between flooding exposure and incident dementia were assessed using conditional logistic regression models.</p><p><strong>Results: </strong>Here we show that the risk of flood-related incident dementia is the strongest in the current year and diminished over a span of 6 years. In the fully adjusted model, the cumulative odds ratios (OR) are 1.28 (95% confidence interval [CI]: 1.25-1.31) for any dementia, 1.44 (95% CI: 1.36-1.53) for Alzheimer's disease and 1.65 (95% CI: 1.48-1.83) for vascular dementia, associated with per unit increase in annual cumulative flooding exposure over lag 0-6 years. Participants under the age of 65 years (OR: 1.39, 95% CI: 1.33-1.46) and female participants (OR: 1.41, 95% CI: 1.33-1.49) exhibit a higher risk of incident dementia compared to those aged 65 years and older (OR: 1.25, 95% CI: 1.21-1.28) and male participants (OR: 1.26, 95% CI: 1.23-1.30), respectively. Similar effect estimates are observed in the stratified analyses of Alzheimer's disease according to genetic factors.</p><p><strong>Conclusions: </strong>This study provides robust epidemiological evidence supporting the link between floods and an increased risk of dementia. These findings enhance the understanding of the long-term consequences of flood exposure.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"71"},"PeriodicalIF":5.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced reproductive potential in young healthy women with hereditary breast and/or ovarian cancer syndrome.","authors":"Giovanna Sighinolfi, Giovanni Grandi, Elena Barbieri, Marta Venturelli, Claudia Piombino, Chiara Melotti, Rebecca Lippi Bruni, Riccardo Costantini Cuoghi, Roberto D'Amico, Matteo Lambertini, Fedro A Peccatori, Elena Tenedini, Massimo Dominici, Laura Cortesi, Antonio La Marca, Angela Toss","doi":"10.1038/s43856-025-00788-9","DOIUrl":"10.1038/s43856-025-00788-9","url":null,"abstract":"<p><strong>Background: </strong>Young, healthy women carrying a pathogenic or likely pathogenic variant (P/LPV) in genes configuring the hereditary breast and/or ovarian cancer (HBOC) syndrome face several non-oncological issues. Among these, the implications on fertility are not yet entirely understood.</p><p><strong>Methods: </strong>Aiming to explore the ovarian reserve in young, healthy women with HBOC syndrome, we conducted a monocentric, prospective, observational cohort trial between January 2020 and September 2023. Eighty-seven healthy women aged less than 42 years with a P/LPV in HBOC predisposition genes were enrolled: 32 BRCA1 P/LPV carriers, 47 BRCA2 P/LPV carriers, and 8 carriers of P/LPV in other genes (TP53, RAD50, CHECK2, RAD51D, PALB2, ATM). AMH levels and antral follicular count (AFC) were evaluated as fertility biomarkers.</p><p><strong>Results: </strong>No significant differences in demographic characteristics or mean levels of AMH or in AFC are observed between BRCA1 and BRCA2 P/LPV carriers. The distribution of AMH values is significantly lower compared to the general population (p = 0.019). The significant decrease in AMH levels is mostly ascribable to BRCA1 P/LPV carriers (p = 0.03). Both in the overall population and in BRCA1/2 P/LPV carriers, AFC decreases faster compared to those reported in the nomogram.</p><p><strong>Conclusions: </strong>A consistent trend for reduced reproductive potential in young, healthy women with HBOC syndrome is observed, particularly in BRCA1 P/LPV carriers. These findings need to be confirmed by larger studies including also women carrying P/LPV in other HBOC syndrome-related genes.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"70"},"PeriodicalIF":5.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Des-γ-carboxy Prothrombin in hepatocellular carcinoma post-operative recurrence risk evaluation.","authors":"Xinting Pan, Yang Zhou, Zhenli Li, Pengfei Guo, Jianyang Zeng, Xiuqing Dong, En Hu, Liman Qiu, Zhixiong Cai, Geng Chen, Xiaolong Liu","doi":"10.1038/s43856-025-00784-z","DOIUrl":"10.1038/s43856-025-00784-z","url":null,"abstract":"<p><strong>Background: </strong>While the value of Des-γ-carboxy prothrombin in hepatocellular carcinoma diagnosis has been widely acknowledged, whether or how Des-γ-carboxy prothrombin could be used in recurrence evaluation remains largely unexplored.</p><p><strong>Methods: </strong>We performed a multicenter retrospective analysis including an Exploration Cohort (1074 patients, 5133 Des-γ-carboxy prothrombin measurements) and a Validation Cohort (263 patients, 612 Des-γ-carboxy prothrombin measurements) to investigate whether Des-γ-carboxy prothrombin could evaluate patients' prognosis. We introduced the Des-γ-carboxy prothrombin dynamic rate as a normalized quantitative measurement of Des-γ-carboxy prothrombin dynamic change. Des-γ-carboxy prothrombin dynamic rates were further applied in a high-risk liver cirrhosis patient cohort (PreCar Cohort, 542 liver cirrhosis patients, 2023 Des-γ-carboxy prothrombin measurements).</p><p><strong>Results: </strong>Here, we show a post-operative decrease of Des-γ-carboxy prothrombin in the Exploration Cohort, making the Des-γ-carboxy prothrombin threshold in diagnosis unsuitable for prognosis, while Des-γ-carboxy prothrombin dynamic rates significantly associate with recurrence risk. Categorizing patients based on Des-γ-carboxy prothrombin dynamic rates and final concentrations shows that patients negative for both exhibit the best median recurrence-free survival and patients positive for both show the worst median recurrence-free survival. Patients with consistently positive status have a significantly lower median recurrence-free survival compared to those whose status reverted to negative. These findings are validated in the Validation Cohort. Furthermore, the Des-γ-carboxy prothrombin dynamic rates in the PreCar Cohort can identify an additional 28% of cirrhosis patients progressing to hepatocellular carcinoma.</p><p><strong>Conclusions: </strong>These results expand on the clinical utilization of the hepatocellular carcinoma diagnosis biomarker, Des-γ-carboxy prothrombin, by proposing a quantification measurement of Des-γ-carboxy prothrombin dynamics to monitor hepatocellular carcinoma recurrence. This measurement is not limited in prognosis but can also improve the sensitivity of early hepatocellular carcinoma screening.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"65"},"PeriodicalIF":5.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral microbiome diversity associates with carotid intima media thickness in middle-aged male subjects.","authors":"Ramin Akhi, Anton Lavrinienko, Miia Hakula, Leo Tjäderhane, Rasmus Hindström, Antti Nissinen, Chunguang Wang, Juha Auvinen, Arja M Kullaa, Pekka Ylöstalo, Tuula Salo, Kari Kaikkonen, Janne J Koskimäki, Sohvi Hörkkö","doi":"10.1038/s43856-025-00773-2","DOIUrl":"10.1038/s43856-025-00773-2","url":null,"abstract":"<p><strong>Background: </strong>Although there have been significant advancements in reducing the burden of cardiovascular disease (CVD) by modifying traditional CVD risk factors, substantial risks persist, particularly among male subjects who exhibit heightened susceptibility to atherosclerosis. In this context, we aim to study the link between oral microbiome and carotid intima media thickness (cIMT).</p><p><strong>Methods: </strong>The Northern Finland Birth Cohort of 1966 (mean age 46 years, n = 869) underwent an extensive health examination, including the measurement of cIMT. The oral microbiome was also investigated using high-throughput 16S rRNA gene sequencing.</p><p><strong>Results: </strong>Here we show that oral microbiome diversity links with atherosclerosis risk factors, namely smoking, glycemic balance, low-grade inflammation, and periodontitis. After excluding CVD-influencing factors (n = 339), oral microbiome genera (p = 0.030), Shannon index (p = 0.001), β-diversity Bray-Curtis (p < 0.001), and Jaccard (p < 0.001) are associated with cIMT in males, but not in the female sub-cohort. Furthermore, in the male sub-cohort (n = 131), the genera Prevotella, Megasphaera, and Veillonella associate positively with cIMT, while Absconditabacteria, Capnocytophaga, Gemella, Fusobacterium, Neisseria, Aggregatibacter, Tannerella, Treponema, Cardiobacterium, and Bacteroidales associate inversely with cIMT. We examine the involvement of serum total immunoglobulins and antibodies to phosphorylcholine (PCho) and malondialdehyde-acetaldehyde LDL (MAA-LDL) with cIMT. Subjects with high cIMT have lower levels of serum total IgA (p = 0.009), IgA to PCho (p = 0.017), and IgG to PCho (p = 0.008). The relative abundance of cIMT-associated genera correlates with serum IgA antibodies.</p><p><strong>Conclusions: </strong>This middle-aged birth cohort study shows that male oral microbiome diversity links to cIMT, suggesting a potential sex-specific interaction between the oral microbiome and atherosclerosis.</p>","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"66"},"PeriodicalIF":5.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the challenge of antimicrobial resistance.","authors":"Timothy M Rawson, Luke Sp Moore, Mohammed Lamorde","doi":"10.1038/s43856-025-00758-1","DOIUrl":"10.1038/s43856-025-00758-1","url":null,"abstract":"","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":"5 1","pages":"67"},"PeriodicalIF":5.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}