Clinical complementary medicine and pharmacology最新文献

{"title":"Network Pharmacology-based Strategy for Predicting Active Ingredients and Potential Targets of Cuscutae semen and Lycii fructus in Spermatogenic Dysfunction","authors":"Jianxiong Ma ,&nbsp;Siqi Guan ,&nbsp;Yutian Zhu ,&nbsp;Lei Dong ,&nbsp;Xiting Wang ,&nbsp;Wangqiang Chen ,&nbsp;Caifei Ding ,&nbsp;Bodong Lv ,&nbsp;Hongxuan Tong","doi":"10.1016/j.ccmp.2022.100057","DOIUrl":"10.1016/j.ccmp.2022.100057","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese Medicine (TCM) <em>Cuscutae semen</em> (SC, Tusizi from <em>Cuscuta chinensis</em> Lam.) and <em>Lycii fructus</em> (FL, Gouqi from <em>Lycium barbarum</em> L.), are also used as a herb pair (SC-FL) to treat various ailments, including spermatogenic dysfunction (SD), a disease responsible for low fertility in males.</p></div><div><h3>Objective</h3><p>Herein, we will further determine the bioactive components, component targets and partial molecular mechanisms of the herb pair for the treatment of SD.</p></div><div><h3>Methods</h3><p>We employed the traditional Chinese medicine systems pharmacology database in combination with Ultra high performance liquid chromatography (UHPLC) analysis to analyze the active ingredients of the SC-FL herbal pair and explore its possible targets and underlying mechanism in treatment of spermatogenic dysfunction (SD). Moreover, we used a Sprague-Dawley rat model, generated by using glucosides of <em>Tripterygium wilfordii</em> (GTW), to evaluate the effect of SC-FL and the underlying mechanism on SD and reliability of certain key targets and pathways obtained from the pharmacology analysis.</p></div><div><h3>Results</h3><p>We identified 56 active ingredients in SC-LF affecting 41 overlapping gene signals that influenced SD treatment outcomes. 262 Gene Ontology (GO) terms and 170 pathways were yielded under analyses of Gene Ontology, Kyoto Encyclopedia of Gene and Genome pathway from which we predicted that cell proliferation and apoptosis were the primary biological processes (BP) involved in the treatment of SD by SC-LF. The results showed that SC-FL treatment significantly improved the testicular organ coefficient along with sperm count and motility, while reduced testicular damage and testicular tissue cell apoptosis in SD model. Mechanistically, SC-FL significantly upregulated the expression levels of anti-apoptotic proteins AR and BCL2 and downregulated those of pro-apoptotic proteins BAD, BAX, cleaved caspase 3, and CASP3.</p></div><div><h3>Conclusion</h3><p>Collectively, these results indicated that SC-FL elicited a protective effect by potentially regulating apoptosis, thus suggesting that it will represent an effective reagent for male infertility.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 4","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371222000365/pdfft?md5=017160e813406d8fe47f72d2afc74562&pid=1-s2.0-S2772371222000365-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41923047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drimia calcarata Bulb Extracts Deactivate the PI3K Signalling Pathway in Cervical HPV-18 Positive HeLa Cells","authors":"Kagiso Laka ,&nbsp;Ladislaus Mdee ,&nbsp;Zukile Mbita","doi":"10.1016/j.ccmp.2022.100054","DOIUrl":"https://doi.org/10.1016/j.ccmp.2022.100054","url":null,"abstract":"<div><h3>Background</h3><p>The efficacy of <em>Drimia calcarata</em> against the human cervical cancer remains unexplored and less understood.</p></div><div><h3>Objective</h3><p>The present study focused on investigating the cytotoxic effect of <em>D. calcarata</em> bulb extracts on cervical cancer cells.</p></div><div><h3>Methods</h3><p>The growth inhibitory effects of <em>D. calcarata</em> extracts were determined using the MTT, Ki67 and PI3K Activation assays. Apoptosis induction was assessed using fluorescence microscopy, the Muse^Ⓡ Cell Analyser and gene expression analysis by RT-PCR. The cytotoxicity of the fractions was evaluated using MTT assay and the apoptosis induction using Muse^Ⓡ Cell Analyser.</p></div><div><h3>Results</h3><p>Both methanol extract (ME) and water extract (WE) showed safety against noncancerous KMST-6 and HEK-293 cells. The extracts exhibited anticancer activity against HeLa, with no significant cytotoxic effect against the Ca-Ski cells. The WE increased the Ki67 positive Ca-Ski population, while both ME and WE arrested HeLa cells at G2/M phase, and Ca-Ski cells in G0/G1 phase. AO/EB staining, Annexin V and Caspase 3/7 Activation revealed that the extracts significantly induced apoptosis in HeLa cells. In HeLa cells, the ME downregulated <em>TP53</em> variants, while WE upregulated both <em>TP53</em> variants in HeLa cells. Both extracts decreased the <em>STAT5A</em> and <em>STAT5B</em> mRNA expression in HeLa cells; however, these extracts upregulated cancer-promoting <em>STAT3</em> in Ca-Ski cells. Additionally, these extracts inactivated the PI3K signalling pathway in HeLa cells but not in Ca-Ski cells. The resistance of the Ca-Ski cells to the <em>D. calcarata</em> extracts may be due to the upregulation of <em>STAT3</em> and activated PI3K signalling pathway. The cytotoxicity and apoptosis induction in HeLa cells by <em>D. calcarata</em> extracts may be attributed to downregulation of <em>STAT5A</em> survival mechanisms. Water fractions 1, 2, 3 and 6 and methanol fractions 1 and 2 reduced cell viability of HeLa cells. Water fractions 2, 3 and 6 and methanol fractions 1 and 3 induced apoptosis, which was preceded by secondary necrosis. However, water fraction 1 and methanol fraction 2 led to most cells undergoing necrotic cell death. There are several compounds that can be credited with the anticancer activities of the ME and WE extracts since several fractions exhibited cytotoxicity against the HeLa cells.</p></div><div><h3>Conclusion</h3><p>These findings suggest that the <em>D. calcarata</em> extracts have anticancer activities, and thus, could be useful for therapeutic purposes against human HPV-18 positive gynaecologic cancers.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 4","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371222000353/pdfft?md5=7834f60262e9921076ba588e79dcfa21&pid=1-s2.0-S2772371222000353-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134668306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Trichoderma brevicompactum 31636 on Root Rot of Atractylodes macrocephala and the Fungal Community in the Rhizosphere Soil","authors":"Xingge Huang ,&nbsp;Xiaoning Yan ,&nbsp;Yunjia Tang ,&nbsp;Xiaofeng Yuan","doi":"10.1016/j.ccmp.2022.100025","DOIUrl":"10.1016/j.ccmp.2022.100025","url":null,"abstract":"<div><h3>Background</h3><p><em>Trichoderma brevicompactum</em> can control of plant diseases, but there are few studies about the control of root rot by <em>T. brevicompactum</em> 31636 and its biocontrol mechanism.</p></div><div><h3>Objective</h3><p>To explore the impact of <em>T. brevicompactum</em> 31636 on root rot and the structure of fungal communities of rhizosphere soil.</p></div><div><h3>Methods</h3><p>The effect of <em>T. brevicompactum</em> 31636 on controlling root rot was assessed, the growth of plants was observed by pot experiments, and the fungal structure was detected by high-throughput sequencing analysis.</p></div><div><h3>Results</h3><p>Compared with the CK (healthy plants) group, the plant height, fresh weight, and dry weight increased by 55.3%, 48.55% and 57.8%, respectively. While the concentration of atractylenolide I, II, III, and atractylone increased by 19.35%, 16.96%, 89.42% and 89.32%, respectively. The results of pot experiments indicated that <em>T. brevicompactum</em> 31636 could significantly improve the survival rate of <em>Atractylodes macrocephala</em>. The results of principal coordinates analysis (PCoA) showed that the sample of CK and Fo+Th (adding Fusdrium oxysporum before <em>T. brevicompactum</em> 31636) group on one side, and samples of Th and Fo group on the other. Furthermore, among the top 20 dominant fungi detected, the fungal genus with 1% increase of relative abundance included <em>Trichoderma</em> (1%), <em>Sordariomycetes</em> (1.5%), <em>Mortierella</em> (1.3%), <em>Penicillium</em> (1%), meanwhile the fungal genus with 1% decrease of relative abundance included <em>Fusarium</em> (30%) and <em>Pleosporales</em> (1%).</p></div><div><h3>Conclusion</h3><p>In summary, <em>T. brevicompactum</em> 31636 can control the root rot of <em>A. macrocephala</em> by regulating of the soil fungal community and inhibiting pathogen.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 4","pages":"Article 100025"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371222000079/pdfft?md5=a84e5294e18ff33f7d1d6a762766410b&pid=1-s2.0-S2772371222000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45022669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Yemeni Potash Alum as Hydrophilic Topical Preparations against Candidiasis and Aspergillosis","authors":"Moath Refat ,&nbsp;Anes A.M. Thabit ,&nbsp;Abdul-Rahman Maqboli ,&nbsp;Hesham Siddick ,&nbsp;Rafaʼa M. Al-Ghozee ,&nbsp;Abdul-baqi A. Thabet ,&nbsp;Manar Refat ,&nbsp;Aiman Saleh A. Mohammed ,&nbsp;Ahmed Al-Sabati ,&nbsp;Wu Xin'an","doi":"10.1016/j.ccmp.2022.100044","DOIUrl":"10.1016/j.ccmp.2022.100044","url":null,"abstract":"<div><h3>Background</h3><p>Skin and soft tissue infections are frequent. Candidiasis and Aspergillosis are the most common cutaneous fungal infections. Yemeni alum (Aluminium Potassium Sulphate) is a natural mineral with antifungal and antibacterial properties.</p></div><div><h3>Objective</h3><p>This study aimed to confirm Yemeni alum's antifungal effectiveness against selected fungal strains and develop useful topical formulations.</p></div><div><h3>Methods</h3><p>Using different alum concentrations, we prepared twenty-three formulations, including four non-adjusted aqueous solutions, eight adjusted pH aqueous solutions, eight glycerite solutions, and three Oil/Water cream formulations. Then, we examined the antifungal activity against the suggested fungus. The animal skin irritation test evaluated the local skin sensitivity reactions that might happen upon using the formulations we prepared on the intact animal's skin. Additionally, this study also included six weeks of stability testing to estimate the expected shelf life (t90) of the selected formulations.</p></div><div><h3>Results</h3><p>Alum exerted antifungal effect against Candida albicans, Aspergillus niger, and Aspergillus flavus. The animal's skin was not irritated by any of the formulations examined. The 5% alum aqueous solution and the 10% alum Oil/Water cream exhibited promising results among all tested formulations. The approximate formulation's shelf-lives (t90) were 2 and 1.52 years with alum content (%) ranging between 105.75% to 106.02%, respectively.</p></div><div><h3>Conclusion</h3><p>Based on the results we found, 10% alum Oil/Water cream is a promising formulation for large-scale manufacture.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 4","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371222000250/pdfft?md5=5ae09929ebe3c8421bac196394d438dd&pid=1-s2.0-S2772371222000250-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46814356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Effect of COVID-19 Pandemic on Cancer Patients and its Treatment: A Systematic Review","authors":"Mohammad Ali ,&nbsp;Shahid Ud Din Wani ,&nbsp;Mubashir Hussain Masoodi ,&nbsp;Nisar Ahmad Khan ,&nbsp;H.G. Shivakumar ,&nbsp;Riyaz M. Ali Osmani ,&nbsp;Khalid Ahmed Khan","doi":"10.1016/j.ccmp.2022.100041","DOIUrl":"10.1016/j.ccmp.2022.100041","url":null,"abstract":"<div><h3>Background</h3><p>At a global level, the COVID-19 disease outbreak has had a major impact on health services and has induced disruption in routine care of health institutions, exposing cancer patients to severe risks. To provide uninterrupted tumor treatment throughout a pandemic lockdown is a major obstacle. Coronavirus disease (COVID-19) and its causative virus, SARS-CoV-2, stance considerable challenges for the management of oncology patients. COVID-19 presents particularly severe respiratory and systemic infection in aging and immunosuppressed individuals, including patients with cancer.</p></div><div><h3>Objective</h3><p>In the present review, we focused on emergent evidence from cancer sufferers that have been contaminated with COVID-19 and cancer patients who were at higher risk of severe COVID-19, and indicates that anticancer treatment may either rise COVID-19 susceptibility or have a duple therapeutic impact on cancer as well as COVID-19; moreover, how SARS-CoV-2 infection impacts cancer cells. Also, to assess the global effect of the COVID-19 disease outbreak on cancer and its treatment.</p></div><div><h3>Methods</h3><p>A literature survey was conducted using PubMed, Web of Science (WOS), Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and VIral Protein domain DataBase (VIP DB) between Dec 1, 2019 and Sep 23, 2021, for studies on anticancer treatments in patients with COVID-19. The characteristics of the patients, treatment types, mortality, and other additional outcomes were extracted and pooled for synthesis.</p></div><div><h3>Results</h3><p>This disease has a huge effect on sufferers who have cancer(s). Sufferers of COVID-19 have a greater percentage of tumor diagnoses than the rest of the population. Likewise, cancer and highest proportion is lung cancer sufferers are more susceptible to COVID-19 constriction than the rest of the population.</p></div><div><h3>Conclusion</h3><p>Sufferers who have both COVID-19 and tumor have a considerably elevated death risk than single COVID-19 positive patients overall. During the COVID-19 pandemic, there was a reduction in the screening of cancer and detection, and also deferral of routine therapies, which may contribute to an increase in cancer mortality there in future.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 4","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10327974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Marrow-derived Mesenchymal Stem Cells Promote Microglia/Macrophage M2 Polarization and Enhance Neurogenesis in the Acute and Chronic Stages after Ischemic Stroke","authors":"Yan Yang,&nbsp;Hangyang Bao,&nbsp;Huaqian Jin,&nbsp;Lin Li,&nbsp;Yan Fang,&nbsp;Cuicui Ren,&nbsp;Jun Wang,&nbsp;Lisheng Chu","doi":"10.1016/j.ccmp.2022.100040","DOIUrl":"10.1016/j.ccmp.2022.100040","url":null,"abstract":"<div><h3>Background</h3><p>Ischemic stroke has been regarded as a major cause of disability and death around the world due to limited effective therapies. Accumulating evidence have shown that although microglia are polarized to an anti-inflammatory M2 phenotype in the early stage of ischemia, they transform progressively into a proinflammatory M1 phenotype. Bone marrow-derived mesenchymal stem cells (BMSCs) may be used to treat ischemic injury through regulating the poststroke inflammatory response. However, the mechanism by which BMSCs can treat ischemic stroke remains unclarified.</p></div><div><h3>Objective</h3><p>This study aimed to investigate whether BMSCs shift M1-to-M2 phenotype transformation of microglia/macrophages and enhance neurogenesis in a rat transient middle cerebral artery occlusion (tMCAO) model.</p></div><div><h3>Methods</h3><p>Ninety-minute tMCAO was applied to the rats, followed by reperfusion. BMSCs were transplanted into the rats via intravenous injection at 24 h after tMCAO. After being randomly divided into the sham group, the MCAO group, and the BMSCs group, the rats’ behavior was assessed at 1, 3, 7, and 14 days following tMCAO. qRT-PCR, double-immunofluorescence staining, and Western blot were performed at 3 and 14 days after tMCAO to determine M1/M2 polarization of microglia/macrophages. Neurogenesis was examined by double-immunofluorescence staining at 14 days after tMCAO. Expression of brain-derived neurotrophic factor (BDNF) was measured on the protein level by immunofluorescence staining at 3 and 14 days after tMCAO.</p></div><div><h3>Results</h3><p>We found that BMSCs treatment promoted the recovery of neurological function after tMCAO, inhibited the expression of TNFα, iNOS and CD16/32, which are markers of M1 microglia/macrophage, and enhanced the expression of IL10, TGFβ and CD206 that are markers of M2 microglia/macrophage. Moreover, BMSCs treatment promoted neurogenesis and M2-derived BDNF expression after tMCAO.</p></div><div><h3>Conclusion</h3><p>It is indicated by the results that BMSCs modulate neuroinflammation and enhance neurogenesis, which could be due to transforming microglia/macrophages from the M1 polarization state towards M2 in a rat tMCAO model.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 4","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371222000213/pdfft?md5=ed1bc5b0432974765b9a446bcf9ae961&pid=1-s2.0-S2772371222000213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46761531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERCUTANEOUS ENDOSCOPIC GASTROSTOMY (LITERATURE REVIEW)","authors":"A. Guseynov, T. Guseynov","doi":"10.12737/2409-3750-2022-8-3-29-33","DOIUrl":"https://doi.org/10.12737/2409-3750-2022-8-3-29-33","url":null,"abstract":"Percutaneous endoscopic gastrostomy is the most common method for long-term enteral nutrition in patients with organic and functional diseases of the esophagus, with severe neurogenic oropharyngeal dysphagia as a result of acute cerebral circulatory disorders, oropharyngeal cancer, severe facial injuries, etc. \u0000The advantages of endoscopic surgery are the minimally invasive nature and speed of the intervention, an insignificant percentage of postoperative complications. \u0000The review article analyzes data on the relevance of the problem, indications and contraindications, technique of execution, complications of percutaneous endoscopic gastrostomy. \u0000Measures aimed at minimizing risks during this operation, including correction of the general condition and concomitant somatic diseases in patients, a thorough assessment of the risk of surgery, which have the greatest impact on the immediate results of the operation, are identified.","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80035980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of injectable collagen in osteoarthritis in multimorbid patients","authors":"E. Belyaeva, A. Fatenko, Sof'ya Kuznetsova","doi":"10.12737/2409-3750-2022-8-3-40-44","DOIUrl":"https://doi.org/10.12737/2409-3750-2022-8-3-40-44","url":null,"abstract":"It has been established that osteoarthritis (OA) refers to diseases with high comorbidity. According to available data, OA is most often combined with arterial hypertension (AH) and other cardiovascular diseases (CVD). The combination of OA and CVD causes certain difficulties when choosing drug therapy. Traditionally, with pain syndrome, the choice falls on NSAIDs, since this allows in most cases to get a quick response to treatment. However, the use of NSAIDs may be accompanied by an increase in average blood pressure by 5 mm Hg or more in patients with arterial hypertension (AH) and significantly reduces the antihypertensive effectiveness of beta-blockers and ACE inhibitors. Symptomatic effect of the use of symptom-modifying drugs of delayed action (SYSADOA - Symptomatic slow acting drugs for osteoarthritis) develops approximately 8-12 weeks after the start of administration. Limitations in the use of NSAIDs in patients with OA and CVD due to increased cardiovascular risk and a long waiting period for the onset of the effect when using drugs of the SYSADOA group dictate the need to search for new approaches in the treatment of OA, on the one hand, with rapid effectiveness, and on the other - meeting all the requirements of cardiovascular safety. It is known that local injection therapy with the use of different groups of drugs has high efficiency in OA: glucocorticosteroids (GCS), hyaluronic acid, chondroitin, etc. Currently, microinduction collagen preparations with a high safety profile have joined them. Special attention in OA deserves the drug Plexatron, which has in its composition a type 1 tropocollagen with a molecular weight of 300 kD and calcium phosphate 1 mcg, and is intended for intra-articular and periarticular administration. Injectable collagen preparations are capable of inducing the regeneration of damaged collagen fibers by stimulating the migration of fibroblasts to the sites of damage, the release of growth factors and the activation of a key enzyme for the induction of endogenous collagen synthesis - lysine hydroxylase","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83711712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperuricemia as a component of metabolic syndrome and a risk factor for comorbid conditions","authors":"F. Karabaeva, E. Belyaeva","doi":"10.12737/2409-3750-2022-8-3-19-28","DOIUrl":"https://doi.org/10.12737/2409-3750-2022-8-3-19-28","url":null,"abstract":"A sufficient number of scientific papers have been accumulated on the association of hyperuricemia with cardiovascular diseases and their consequences (stroke and myocardial infarction), metabolic syndrome, arterial hypertension, insulin resistance, type 2 diabetes mellitus, chronic kidney disease, lipid metabolism disorders, atrial fibrillation. The association of GU with an increased risk of mortality is shown. Pathogenetic connections between the components of the metabolic syndrome have been established.","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89964049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIOPSY METHODS IN DIAGNOSTICS BREAST DISEASES","authors":"A. Guseynov","doi":"10.12737/2409-3750-2022-8-3-11-18","DOIUrl":"https://doi.org/10.12737/2409-3750-2022-8-3-11-18","url":null,"abstract":"The article provides information on the use of various biopsy methods in the diagnosis of breast diseases. \u0000A biopsy followed by morphological examination of the material is the basis for both the primary diagnosis of pathology and differential diagnosis of various focal formations and changes in breast tissue, among which breast cancer is of the greatest clinical importance. \u0000Biopsy methods used in clinical practice include excision, incision and puncture technology, allowing to obtain material for both cytological and histological examination. \u0000The article examines in detail the advantages and disadvantages of thin- and thick-needle aspiration biopsy, soge (trepan) biopsy, fusion biopsy, vacuum aspiration biopsy, stereotactic biopsy, indications and contraindications to to conduct them.","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85090946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}