Clinical complementary medicine and pharmacology最新文献

{"title":"The Anti-parasitic Effect of Extract of Ceiba pentandra (L.) Gaertn Is Related to Its Anti-inflammatory, Analgesic and Anthelmintic Activities on Haemonchus contortus","authors":"Bogning Zangueu Calvin ,&nbsp;Alowanou Goue Géorcelin ,&nbsp;Belle Ebanda Kedi Phillipe ,&nbsp;Olounlade Abiodoun Pascal ,&nbsp;Magne Fongang Annie Laure ,&nbsp;Kojom Wanche Jacquy Joyce ,&nbsp;Nguemfo Edwige Laure ,&nbsp;Azebaze Anatole Guy Blaise ,&nbsp;Dongmo Alain Bertrand ,&nbsp;Hounzangbe-Adote Mawulé Sylvie","doi":"10.1016/j.ccmp.2023.100088","DOIUrl":"https://doi.org/10.1016/j.ccmp.2023.100088","url":null,"abstract":"<div><h3>Background</h3><p><em>Ceiba pentandra</em> is a medicinal plant used as alternative therapy to control parasitic nematodes in livestock.</p></div><div><h3>Objective</h3><p>This study aims to investigate anti-parasitic effect of aqueous stem back extract of <em>Ceiba pentandra</em> (L.) Gaertn through the evaluation of its anthelmintic, anti-inflammatory and analgesic activities.</p></div><div><h3>Methods</h3><p><em>In vitro</em>, the efficacy of aqueous extract (75 to 2400 µg·mL⁻¹) diluted in phosphate buffered saline (PBS) was tested against three stages of the life cycle of Haemonchus contortus through larval migration inhibition assay (LMIA), egg hatch assay (EHA), and adult worms motility inhibition assay (AMIA). <em>In vivo</em>, anti-inflammatory and antinociceptive properties of the aqueous extract (150 and 300 mg·kg⁻¹) was evaluated on rodent using phlogistic and algic chemicals.</p></div><div><h3>Results</h3><p>Significant inhibition activity (<em>P &lt;</em> 0.05) was obtained on EHA with the greatest inhibition of 46.63% obtained at 2400 µg·mL⁻¹. The plant treatment dramatically (<em>P &lt;</em> 0.05) inhibited L3 larval migration as compared to PBS. The highest inhibition rate was 53.33 % at 1200 µg·mL⁻¹. Adding of polyvinylpolyrrolidone (PVPP) to the extract significantly (<em>P &lt;</em> 0.01) reduced at 38.6% the activity of the plant extract on larval migration compared to extract without PVPP. The <em>Ceiba pentandra</em> extract reduced (<em>P &lt;</em> 0.05) worm motility after 24 h post exposure as compared to control. <em>In vitro</em>, aqueous extract significantly (<em>P &lt;</em> 0.05) inhibited the paw inflammation induced by carragenine, with a significant (<em>P &lt;</em> 0.05) reduction of the number of abdominal contortions induced by acetic acid to 41.11% at 300 mg·kg⁻¹ and the paw licking time induced by formaline in both phases to 57.22% and 63.59% at 300 mg·kg⁻¹ likened to control.</p></div><div><h3>Conclusions</h3><p><em>In vitro</em> results suggest that, this plant possess anti-parasitic properties. Antinociceptive and anti-inflammatory effects of <em>C. pentandra</em> can contribute to its anti- parasitic property.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"3 2","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49724341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrolithiasis: Insights into Biomimics, Pathogenesis, and Pharmacology","authors":"Aishwarya Tripurasundari Devi ,&nbsp;Rajini Nagaraj ,&nbsp;Ashwini Prasad ,&nbsp;Dhananjaya Bhadrapura Lakkappa ,&nbsp;Farhan Zameer ,&nbsp;Nagendra Prasad Mysore Nagalingaswamy","doi":"10.1016/j.ccmp.2022.100077","DOIUrl":"10.1016/j.ccmp.2022.100077","url":null,"abstract":"<div><h3>Background</h3><p>In the last decade, a varied prevalence of lifestyle-mediated health ailments ranging from infectious disorders to non-curable diseases has been observed. Globally the stone formation (lithiasis) in human kidneys has increased the trauma and economic burden. Furthermore, affordable rapid diagnosis, clinical trials, and therapeutics have to be addressed with newer holistic approaches.</p></div><div><h3>Objective</h3><p>The current comprehensive review attempts to study kidney stones using emerging translational, conventional, and non-conventional research models, which include prokaryotic and eukaryotic systems (<em>in vitro,</em> semi<em>-in vivo,</em> and <em>in vivo</em>).</p></div><div><h3>Methods</h3><p>The study eligibility criteria included systematic reviews and meta-analyses to explore various lithiatic models. Further, PubMed, PubMed Central, CINAHL Plus, Scopus, Web of Science, and EMBASE were used as data sources for the current study. A Measurement Tool to Assess Systematic Reviews (AMSTAR) was used.</p></div><div><h3>Results</h3><p>All curated literature from past 55 years (1967–2022) were considered for this review with keywords as \"Experimental models for human kidney stones\" AND \"Nephrolithasis\" AND \"Urolithasis\". A total of 765 abstracts were reviewed for inclusion with 414 selected for full-text review. A total of 47 studies were analyzed. Mean AMSTAR score of 6.96/11 (± 1.84) suggests moderate quality of the systematic reviews.</p></div><div><h3>Conclusion</h3><p>This review will empower clinicians, veterinarians, and researchers for a better understanding of the pathogenesis, causative factors, and prevalence of nephrolithiasis and urolithiasis and their associated mechanisms with rapid, reliable, and reproducible models. The findings of the study will aid in designing global healthcare policy and regional insurance for lithiatic disorders with effective therapeutics which will result in an increased quality of life, leading to better health and hygiene.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"3 2","pages":"Article 100077"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49012478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Antidiabetic Activity and Toxicological Properties of Hippocratea Velutina (Afzel.)","authors":"Farouk A. Oladoja ,&nbsp;Emmanuel S. Irokosu ,&nbsp;Marcus D. Ayoola ,&nbsp;Oyinloye O. Elijah ,&nbsp;Murtala A. Akanji ,&nbsp;Ogunleye T. Beatrice ,&nbsp;Odewo A. Samuel","doi":"10.1016/j.ccmp.2023.100080","DOIUrl":"10.1016/j.ccmp.2023.100080","url":null,"abstract":"<div><h3>Background</h3><p><em>Hippocratea velutina</em> (HV) is a novel plant folklorically used for lowering blood glucose, hence a potential source of new antidiabetic medication.</p></div><div><h3>Objective</h3><p>The study evaluated the anti-diabetic potentials of the methanol extract of <em>Hippocratea velutina</em> leaf and its toxicity profile in mice and rats.</p></div><div><h3>Methods</h3><p>Acute and subacute toxicity tests of the plant extract were carried out by using a modified OECD guideline. Its antidiabetic activity in streptozotocin-induced diabetic rats at 50, 150, and 300 mg/kg for 28 days was assayed, while glibenclamide (5 mg/kg) and distilled water were the positive and negative controls, respectively. Histopathological examination of vital organs was also carried out.</p></div><div><h3>Results</h3><p>Preliminary phytochemical screening of the leaf extract showed the presence of tannins, flavonoids, saponins, alkaloids, terpenoids, deoxy-sugars, and anthraquinones in HV. The extract had LD₅₀ greater than 2000 mg/kg in mice. It had no toxic effects on the haematological and biochemical components from blood samples collected but caused significant blood glucose level reduction in normal rats at 150 and 300 mg/kg. In streptozotocin-induced diabetic rats, the extract elicited a non–dose-dependent antidiabetic effect on day seven at all the tested doses, significantly higher than glibenclamide (10 mg/kg). However, on days 14, 21, and 28, the extract activity at all the tested doses and glibenclamide were comparable. The extract did not affect the liver, brain, kidney, and pancreas histology at 200 mg/kg but caused slight and severe effects on these organs at 400 and 800 mg/kg, respectively.</p></div><div><h3>Conclusion</h3><p>The study concluded that <em>Hippocratea velutina</em> possessed antihyperglycaemic activity and was non-toxic at low doses but could have deleterious effects to the liver and kidney at high concentrations.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"3 2","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48835842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism Research of Electroacupuncture Stimulation at Baihui and Zusanli in Cerebral Ischemia-reperfusion Injury Using RNA-Sequencing","authors":"Huanyuan Wang ,&nbsp;Xifa Xu ,&nbsp;Zekun Wang ,&nbsp;Gonglei Yue ,&nbsp;Bin Tang ,&nbsp;Qingchen Zhou ,&nbsp;Changzhen Gong ,&nbsp;Kaili Wang ,&nbsp;Guangzhong Du ,&nbsp;Yan Li","doi":"10.1016/j.ccmp.2023.100086","DOIUrl":"10.1016/j.ccmp.2023.100086","url":null,"abstract":"<div><h3>Background</h3><p>Electroacupuncture (EA) therapy, as a combination of electric stimulation and traditional acupuncture technology, is currently an important mean for treatment of ischemic stroke and post-stroke rehabilitation in China. Because of its remarkable therapeutic effect, it has been widely used in hospitals and clinic, however, the detailed mechanism remains unclear.</p></div><div><h3>Objective</h3><p>This research aims to comprehensively and systematically elucidate the mechanisms of EA treatment at the acupoints of Zusanli (ST36) and Baihui (GV20) on ischemic stroke.</p></div><div><h3>Methods</h3><p>In this study, EA was performed twice at onset of reperfusion and 20 h after reperfusion following cerebral ischemia-reperfusion (I/R) in middle cerebral artery occlusion (MCAO) rats, and transcriptomic changes of various molecules in ischemic hippocampal neurons of rats in Sham, I/R and EA groups were detected by RNA-Sequencing (RNA-Seq).</p></div><div><h3>Results</h3><p>Thus, we detected 18 significantly different genes related to atherosclerosis (AS), with their functions associated with lipid metabolism, thrombosis, monocytes and vascular smooth muscle cells. And, we detected 10 significantly different genes related to oxidative stress and apoptosis and 10 significantly different genes related to calcium overload and excitatory amino acids release. Also, we detected 19 significantly different genes related to blood-brain barrier (BBB) and 22 significantly different genes related to inflammatory response.</p></div><div><h3>Conclusion</h3><p>In conclusion, EA can play a role in treating ischemic stroke through a variety of mechanisms, affecting atherosclerosis, oxidative stress, apoptosis, calcium overload, excitatory amino acids release, blood-brain barrier (BBB) and inflammatory response.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"3 2","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43064508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic Potential of African Medicinal Plants in Diabetic and Non-Diabetic Human Subjects: A Review","authors":"Aminu Mohammed","doi":"10.1016/j.ccmp.2023.100081","DOIUrl":"10.1016/j.ccmp.2023.100081","url":null,"abstract":"<div><p>Africa is blessed with several plants and marine organisms used to treat various diseases including diabetes. The folkloric use of some of these plants in treating diabetes has been documented in various databases and publications, and validated using various diabetes models. However, most of the investigations on African medicinal plants as antidiabetic agents are not taken beyond proof-of-concept stage. Besides, limited number of clinical trials were conducted to validate the efficacy in humans and the few available clinical studies have not been critically reviewed. Therefore, this review is intended to document the antidiabetic potential of African medicinal plants investigated in human subjects as well their safety implications. Relevant articles were harvested from the major scientific databases (Scopus, PubMed, and Google Scholar). According to the present search, eighteen (18) African medicinal plants and one herbal formulation were the only plants investigated for antidiabetic activity in humans. The plants showed no noticeable toxicity throughout the study period. Interestingly, all the 18 plant species were traditionally used to treat diabetes in various parts of Africa. Despite variations in the study period and dosages used, <em>Laportea ovalifolia</em> (Schumach. &amp; Thonn.) Chew. (Urticaceae) and <em>Momordica charantia</em> L. (Cucurbitaceae) were the most effective as they reduced fasting blood glucose by &gt;50% after 10 days and 4 weeks treatment periods, respectively. The available information revealed that African medicinal plants especially <em>L. ovalifolia</em> and <em>M. charantia</em> should be subjected to phase III clinical trial, aimed at getting the natural product-based antidiabetic drugs from Africa.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"3 2","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48952466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Effects of Heat Stress and PM2.5 Exposure on Glucose Metabolism and Hepatic Insulin Signaling","authors":"Weijia Gu ,&nbsp;Ziwei Cai ,&nbsp;Ruiqing Wang ,&nbsp;Mianhua Zhong ,&nbsp;Lung-Chi Chen ,&nbsp;Lu Zhang ,&nbsp;Rucheng Chen ,&nbsp;Ran Li ,&nbsp;Li Qin ,&nbsp;Qinghua Sun ,&nbsp;Cuiqing Liu","doi":"10.1016/j.ccmp.2022.100042","DOIUrl":"https://doi.org/10.1016/j.ccmp.2022.100042","url":null,"abstract":"<div><h3>Background</h3><p>Heatwave events occur more frequently, accompanied by a significant increase in the ambient concentration of fine particulate matter (PM_2.5). Epidemiological and experimental studies have suggested that heat stress or PM_2.5 exposure would impair glucose homeostasis and insulin sensitivity.</p></div><div><h3>Objective</h3><p>To explore the joint effects of heat stress and PM_2.5 exposure on glucose metabolism and hepatic insulin pathway.</p></div><div><h3>Methods</h3><p>C57BL/6 mice were randomly divided into filtered air (FA) group, fine particulate matter (PM) group, filtered air combined with heat stress (FH) group, and PM combined with heat stress (PH) group. Mice were exposed to PM for a total of 6 weeks, and heat stress combined with PM exposure was applied at the 5th and 6th weeks via a whole-body exposure system. Systemic glucose homeostasis, insulin sensitivity, and circulating inflammatory cytokines were examined. HSP72 expression and insulin signaling in the liver were measured.</p></div><div><h3>Results</h3><p>Glucose tolerance and insulin sensitivity were impaired in response to heat stress, accompanied by lessened hepatic GLUT2 expression and inhibited insulin signaling pathway. No synergistic effects of heat stress and PM_2.5 exposure on glucose homeostasis were observed, while heat-upregulated HSP72 expression was attenuated with accumulated TNFα induced by further PM_2.5 exposure.</p></div><div><h3>Conclusion</h3><p>Heat stress combined with PM_2.5 exposure induced TNFα, which could inhibit heat-elevated hepatic HSP72 expression. Elevated circulating TNFα impaired hepatic insulin signaling and GLUT2 expression. Then, glucose homeostasis was perturbed, and insulin action was impaired.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"3 2","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49737500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL CASE SYSTEMIC SCLERODERMA A MIDDLE-AGED WOMAN","authors":"M. Demin, O. Avdeeva","doi":"10.12737/2409-3750-2023-9-1-22-26","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-1-22-26","url":null,"abstract":"Systemic scleroderma is a rare chronic disease characterized by the development of diffuse fibrosis, pathological changes in the skin, blood vessels, joints and internal organs. \u0000The article presents a clinical case of a patient with systemic scleroderma with such obvious manifestations of skin and vascular lesions as sclerodactyly, masking of the face, \"purse-string mouth\", Raynaud's syndrome, as well as lesions of the joints, muscles, immunological disorders, the development of steroid osteoporosis with multiple fractures","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"36 12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87333580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIAC ARRHYTHMIA IN PATIENTS AFTER CORONAVIRUS INFECTION: FEATURES OF THE COURSE AND THERAPY","authors":"I. Sergunina, V. Malygina, E. Golubeva","doi":"10.12737/2409-3750-2023-9-1-27-30","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-1-27-30","url":null,"abstract":"This paper presents data on the peculiarities of the course and treatment of rhythm disturbances in patients who have suffered a coronavirus infection in the cardiology department of the CHM \"KB RZD-Medicine\" in Tula. Among all patients who underwent therapy in a specialized cardiology department for various kinds of arrhythmias for the period from 2020 to 2022, 72% of rhythm disturbances occurred after COVID-19. \u0000The most common arrhythmic consequences of coronavirus infection are supraventricular and ventricular extrasystole, paroxysmal form of supraventricular tachycardia and atrial fibrillation. Based on the analysis of the data obtained by us, it was revealed that complex treatment with the use of beta-blockers, cardioprotectors, sedatives, antiarrhythmic agents of class I and III has the greatest effectiveness.","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79333444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LONG COVID SYNDROME","authors":"S.Yu. Kuznecova, E. Belyaeva","doi":"10.12737/2409-3750-2023-9-1-31-32","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-1-31-32","url":null,"abstract":"Clinical observations of polymorbid patients with Long Covid syndrome in real clinical practice are presented. Treatment options for patients with lung, muscle, cardiovascular and nervous system damage, immuno-inflammatory syndrome are proposed.","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73996144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The debut of systemic lupus erythematosus during pregnancy","authors":"O. Dvornikova, E. Belyaeva","doi":"10.12737/2409-3750-2023-9-1-35-40","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-1-35-40","url":null,"abstract":"For a long time, systemic lupus erythematosus remains an insufficiently studied problem of rheumatology, the factors influencing the development and progression of the disease are not clear. The hormonal factor remains one of the possible triggers in the development of the disease in predisposed individuals. The course of pregnancy in patients with systemic lupus erythematosus is always associated with multiple risks. The onset of the disease during pregnancy often leads to the death of the fetus and the threat to the life of the mother. At the present stage, thanks to the possibilities of modern diagnostics and treatment, the prognosis for the life and health of both mother and fetus has improved. A case of the development of systemic lupus erythematosus during pregnancy and successful therapy with corticosteroids and belimumab is presented.","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75229917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}