Cerebral cortex communications最新文献_第7页

Phasic stimulation in the nucleus accumbens enhances learning after traumatic brain injury. 脑外伤后伏隔核的阶段性刺激增强学习能力。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac016

Joshua P Aronson, Husam A Katnani, Anna Huguenard, Graham Mulvaney, Edward R Bader, Jimmy C Yang, Emad N Eskandar

{"title":"Phasic stimulation in the nucleus accumbens enhances learning after traumatic brain injury.","authors":"Joshua P Aronson, Husam A Katnani, Anna Huguenard, Graham Mulvaney, Edward R Bader, Jimmy C Yang, Emad N Eskandar","doi":"10.1093/texcom/tgac016","DOIUrl":"https://doi.org/10.1093/texcom/tgac016","url":null,"abstract":"Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Despite improvements in survival, treatments that improve functional outcome remain lacking. There is, therefore, a pressing need to develop novel treatments to improve functional recovery. Here, we investigated task-matched deep-brain stimulation of the nucleus accumbens (NAc) to augment reinforcement learning in a rodent model of TBI. We demonstrate that task-matched deep brain stimulation (DBS) of the NAc can enhance learning following TBI. We further demonstrate that animals receiving DBS exhibited greater behavioral improvement and enhanced neural proliferation. Treated animals recovered to an uninjured behavioral baseline and showed retention of improved performance even after stimulation was stopped. These results provide encouraging early evidence for the potential of NAc DBS to improve functional outcomes following TBI and that its effects may be broad, with alterations in neurogenesis and synaptogenesis.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 2","pages":"tgac016"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9070350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Predictive encoding of pure tones and FM-sweeps in the human auditory cortex. 人类听觉皮层中纯音和高频扫描的预测编码。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac047

Jasmin Stein, Katharina von Kriegstein, Alejandro Tabas

{"title":"Predictive encoding of pure tones and FM-sweeps in the human auditory cortex.","authors":"Jasmin Stein, Katharina von Kriegstein, Alejandro Tabas","doi":"10.1093/texcom/tgac047","DOIUrl":"https://doi.org/10.1093/texcom/tgac047","url":null,"abstract":"Expectations substantially influence perception, but the neural mechanisms underlying this influence are not fully understood. A prominent view is that sensory neurons encode prediction error with respect to expectations on upcoming sensory input. Although the encoding of prediction error has been previously demonstrated in the human auditory cortex (AC), previous studies often induced expectations using stimulus repetition, potentially confounding prediction error with neural habituation. These studies also measured AC as a single population, failing to consider possible predictive specializations of different AC fields. Moreover, the few studies that considered prediction error to stimuli other than pure tones yielded conflicting results. Here, we used functional magnetic resonance imaging (fMRI) to systematically investigate prediction error to subjective expectations in auditory cortical fields Te1.0, Te1.1, Te1.2, and Te3, and two types of stimuli: pure tones and frequency modulated (FM) sweeps. Our results show that prediction error is elicited with respect to the participants' expectations independently of stimulus repetition and similarly expressed across auditory fields. Moreover, despite the radically different strategies underlying the decoding of pure tones and FM-sweeps, both stimulus modalities were encoded as prediction error in most fields of AC. Altogether, our results provide unequivocal evidence that predictive coding is the general encoding mechanism in AC.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 4","pages":"tgac047"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10769199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Measuring "pain load" during general anesthesia. 测量全身麻醉时的“疼痛负荷”。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac019

Stephen Green, Keerthana Deepti Karunakaran, Delany Berry, Barry David Kussman, Lyle Micheli, David Borsook

{"title":"Measuring \"pain load\" during general anesthesia.","authors":"Stephen Green, Keerthana Deepti Karunakaran, Delany Berry, Barry David Kussman, Lyle Micheli, David Borsook","doi":"10.1093/texcom/tgac019","DOIUrl":"https://doi.org/10.1093/texcom/tgac019","url":null,"abstract":"Abstract Introduction Functional near-infrared spectroscopy (fNIRS) allows for ongoing measures of brain functions during surgery. The ability to evaluate cumulative effects of painful/nociceptive events under general anesthesia remains a challenge. Through observing signal differences and setting boundaries for when observed events are known to produce pain/nociception, a program can trigger when the concentration of oxygenated hemoglobin goes beyond ±0.3 mM from 25 s after standardization. Method fNIRS signals were retrieved from patients undergoing knee surgery for anterior cruciate ligament repair under general anesthesia. Continuous fNIRS measures were measured from the primary somatosensory cortex (S1), which is known to be involved in evaluation of nociception, and the medial polar frontal cortex (mPFC), which are both involved in higher cortical functions (viz. cognition and emotion). Results A ±0.3 mM threshold for painful/nociceptive events was observed during surgical incisions at least twice, forming a basis for a potential near-real-time recording of pain/nociceptive events. Evidence through observed true positives in S1 and true negatives in mPFC are linked through statistically significant correlations and this threshold. Conclusion Our results show that standardizing and observing concentrations over 25 s using the ±0.3 mM threshold can be an arbiter of the continuous number of incisions performed on a patient, contributing to a potential intraoperative pain load index that correlates with post-operative levels of pain and potential pain chronification.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 2","pages":"tgac019"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10339352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fetal blockade of nicotinic acetylcholine transmission causes autism-like impairment of biological motion preference in the neonatal chick. 胎儿对烟碱乙酰胆碱传递的阻断导致雏鸡生物运动偏好的自闭症样损伤。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac041

Toshiya Matsushima, Momoko Miura, Nina Patzke, Noriyuki Toji, Kazuhiro Wada, Yukiko Ogura, Koichi J Homma, Paola Sgadò, Giorgio Vallortigara

{"title":"Fetal blockade of nicotinic acetylcholine transmission causes autism-like impairment of biological motion preference in the neonatal chick.","authors":"Toshiya Matsushima, Momoko Miura, Nina Patzke, Noriyuki Toji, Kazuhiro Wada, Yukiko Ogura, Koichi J Homma, Paola Sgadò, Giorgio Vallortigara","doi":"10.1093/texcom/tgac041","DOIUrl":"https://doi.org/10.1093/texcom/tgac041","url":null,"abstract":"Several environmental chemicals are suspected risk factors for autism spectrum disorder (ASD), including valproic acid (VPA) and pesticides acting on nicotinic acetylcholine receptors (nAChRs), if administered during pregnancy. However, their target processes in fetal neuro-development are unknown. We report that the injection of VPA into the fetus impaired imprinting to an artificial object in neonatal chicks, while a predisposed preference for biological motion (BM) remained intact. Blockade of nAChRs acted oppositely, sparing imprinting and impairing BM preference. Beside ketamine and tubocurarine, significant effects of imidacloprid (a neonicotinoid insecticide) appeared at a dose ≤1 ppm. In accord with the behavioral dissociations, VPA enhanced histone acetylation in the primary cell culture of fetal telencephalon, whereas ketamine did not. VPA reduced the brain weight and the ratio of NeuN-positive cells (matured neurons) in the telencephalon of hatchlings, whereas ketamine/tubocurarine did not. Despite the distinct underlying mechanisms, both VPA and nAChR blockade similarly impaired imprinting to biological image composed of point-light animations. Furthermore, both impairments were abolished by postnatal bumetanide treatment, suggesting a common pathology underlying the social attachment malformation. Neurotransmission via nAChR is thus critical for the early social bond formation, which is hindered by ambient neonicotinoids through impaired visual predispositions for animate objects.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 4","pages":"tgac041"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10177854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The cortical N1 response to balance perturbation is associated with balance and cognitive function in different ways between older adults with and without Parkinson's disease. 在有和没有帕金森病的老年人中，皮层N1对平衡扰动的反应以不同的方式与平衡和认知功能相关。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac030

Aiden M Payne, J Lucas McKay, Lena H Ting

{"title":"The cortical N1 response to balance perturbation is associated with balance and cognitive function in different ways between older adults with and without Parkinson's disease.","authors":"Aiden M Payne, J Lucas McKay, Lena H Ting","doi":"10.1093/texcom/tgac030","DOIUrl":"https://doi.org/10.1093/texcom/tgac030","url":null,"abstract":"Mechanisms underlying associations between balance and cognitive impairments in older adults with and without Parkinson's disease are poorly understood. Balance disturbances evoke a cortical N1 response that is associated with both balance and cognitive abilities in unimpaired populations. We hypothesized that the N1 response reflects neural mechanisms that are shared between balance and cognitive function, and would therefore be associated with both balance and cognitive impairments in Parkinson's disease. Although N1 responses did not differ at the group level, they showed different associations with balance and cognitive function in the Parkinson's disease vs. control groups. In the control group, higher N1 amplitudes were correlated with lower cognitive set shifting ability and lower balance confidence. However, in Parkinson's disease, narrower N1 widths (i.e., shorter durations) were associated with greater parkinsonian motor symptom severity, lower balance ability and confidence, lower mobility, and lower overall cognitive function. Despite different relationships across populations, the present results suggest the N1 response reflects neural processes related to both balance and cognitive function. A better understanding of neural mechanisms linking balance and cognitive function could provide insight into associations between balance and cognitive decline in aging populations.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 3","pages":"tgac030"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10732308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Data-driven discovery of canonical large-scale brain dynamics. 数据驱动的典型大规模脑动力学发现。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac045

Juan Piccinini, Gustavo Deco, Morten Kringelbach, Helmut Laufs, Yonatan Sanz Perl, Enzo Tagliazucchi

{"title":"Data-driven discovery of canonical large-scale brain dynamics.","authors":"Juan Piccinini, Gustavo Deco, Morten Kringelbach, Helmut Laufs, Yonatan Sanz Perl, Enzo Tagliazucchi","doi":"10.1093/texcom/tgac045","DOIUrl":"https://doi.org/10.1093/texcom/tgac045","url":null,"abstract":"Human behavior and cognitive function correlate with complex patterns of spatio-temporal brain dynamics, which can be simulated using computational models with different degrees of biophysical realism. We used a data-driven optimization algorithm to determine and classify the types of local dynamics that enable the reproduction of different observables derived from functional magnetic resonance recordings. The phase space analysis of the resulting equations revealed a predominance of stable spiral attractors, which optimized the similarity to the empirical data in terms of the synchronization, metastability, and functional connectivity dynamics. For stable limit cycles, departures from harmonic oscillations improved the fit in terms of functional connectivity dynamics. Eigenvalue analyses showed that proximity to a bifurcation improved the accuracy of the simulation for wakefulness, whereas deep sleep was associated with increased stability. Our results provide testable predictions that constrain the landscape of suitable biophysical models, while supporting noise-driven dynamics close to a bifurcation as a canonical mechanism underlying the complex fluctuations that characterize endogenous brain activity.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 4","pages":"tgac045"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10378469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neurons in inferior temporal cortex are sensitive to motion trajectory during degraded object recognition. 在物体识别退化过程中，下颞叶皮层神经元对运动轨迹非常敏感。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac034

Diana C Burk, David L Sheinberg

{"title":"Neurons in inferior temporal cortex are sensitive to motion trajectory during degraded object recognition.","authors":"Diana C Burk, David L Sheinberg","doi":"10.1093/texcom/tgac034","DOIUrl":"https://doi.org/10.1093/texcom/tgac034","url":null,"abstract":"Our brains continuously acquire sensory information and make judgments even when visual information is limited. In some circumstances, an ambiguous object can be recognized from how it moves, such as an animal hopping or a plane flying overhead. Yet it remains unclear how movement is processed by brain areas involved in visual object recognition. Here we investigate whether inferior temporal (IT) cortex, an area known for its relevance in visual form processing, has access to motion information during recognition. We developed a matching task that required monkeys to recognize moving shapes with variable levels of shape degradation. Neural recordings in area IT showed that, surprisingly, some IT neurons responded stronger to degraded shapes than clear ones. Furthermore, neurons exhibited motion sensitivity at different times during the presentation of the blurry target. Population decoding analyses showed that motion patterns could be decoded from IT neuron pseudo-populations. Contrary to previous findings, these results suggest that neurons in IT can integrate visual motion and shape information, particularly when shape information is degraded, in a way that has been previously overlooked. Our results highlight the importance of using challenging multifeature recognition tasks to understand the role of area IT in naturalistic visual object recognition.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 3","pages":"tgac034"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9316303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pattern learning reveals brain asymmetry to be linked to socioeconomic status. 模式学习揭示大脑不对称与社会经济地位有关。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac020

Timm B Poeppl, Emile Dimas, Katrin Sakreida, Julius M Kernbach, Ross D Markello, Oliver Schöffski, Alain Dagher, Philipp Koellinger, Gideon Nave, Martha J Farah, Bratislav Mišić, Danilo Bzdok

{"title":"Pattern learning reveals brain asymmetry to be linked to socioeconomic status.","authors":"Timm B Poeppl, Emile Dimas, Katrin Sakreida, Julius M Kernbach, Ross D Markello, Oliver Schöffski, Alain Dagher, Philipp Koellinger, Gideon Nave, Martha J Farah, Bratislav Mišić, Danilo Bzdok","doi":"10.1093/texcom/tgac020","DOIUrl":"https://doi.org/10.1093/texcom/tgac020","url":null,"abstract":"Socioeconomic status (SES) anchors individuals in their social network layers. Our embedding in the societal fabric resonates with habitus, world view, opportunity, and health disparity. It remains obscure how distinct facets of SES are reflected in the architecture of the central nervous system. Here, we capitalized on multivariate multi-output learning algorithms to explore possible imprints of SES in gray and white matter structure in the wider population (n ≈ 10,000 UK Biobank participants). Individuals with higher SES, compared with those with lower SES, showed a pattern of increased region volumes in the left brain and decreased region volumes in the right brain. The analogous lateralization pattern emerged for the fiber structure of anatomical white matter tracts. Our multimodal findings suggest hemispheric asymmetry as an SES-related brain signature, which was consistent across six different indicators of SES: degree, education, income, job, neighborhood and vehicle count. Hence, hemispheric specialization may have evolved in human primates in a way that reveals crucial links to SES.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 2","pages":"tgac020"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9916715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Academic achievements and brain volume development in children and adolescents. 儿童和青少年的学习成绩和脑容量发育。

Cerebral cortex communications Pub Date : 2022-01-01 DOI: 10.1093/texcom/tgac048

Teruo Hashimoto, Yutaka Matsuzaki, Susumu Yokota, Ryuta Kawashima

{"title":"Academic achievements and brain volume development in children and adolescents.","authors":"Teruo Hashimoto, Yutaka Matsuzaki, Susumu Yokota, Ryuta Kawashima","doi":"10.1093/texcom/tgac048","DOIUrl":"https://doi.org/10.1093/texcom/tgac048","url":null,"abstract":"Children are expected to acquire both basic and numeric skills. Achievement of higher levels of reading, writing, arithmetic, and vocabulary are favorable and desirable. The relationship between each literacy skill and neural development has been investigated; however, association between brain development and the 4 literacy skills has not been examined. This longitudinal, structural, neuroimaging study explored the contribution of higher academic achievement in reading, writing, arithmetic, and vocabulary to neural development. The brain volumes of children and adolescents aged 9-16 years were measured in the first test. Approximately 2.6 years later, the brain volumes and 4 academic achievement scores of 77 participants were measured in the second test. Changes in the gray matter volume in the left fusiform gyrus were associated with vocabulary scores, whereas those in the left striatum were associated with arithmetic scores. The reading and writing scores showed no statistically significant relationship with changes in brain volume. The current vocabulary score correlated with current gray matter volume, while brain volumes in the first test showed no association with any achievement scores. These results suggest that academic achievement may modulate brain plasticity in various ways.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":"3 4","pages":"tgac048"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microstructural Properties of Human Brain Revealed by Fractional Anisotropy Can Predict the After-Effect of Intermittent Theta Burst Stimulation. 分数各向异性揭示的人脑微观结构特性可以预测间歇性θ波脉冲刺激的后效。

Cerebral cortex communications Pub Date : 2021-12-15 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgab065

Ikko Kimura, Hiroki Oishi, Masamichi J Hayashi, Kaoru Amano

{"title":"Microstructural Properties of Human Brain Revealed by Fractional Anisotropy Can Predict the After-Effect of Intermittent Theta Burst Stimulation.","authors":"Ikko Kimura, Hiroki Oishi, Masamichi J Hayashi, Kaoru Amano","doi":"10.1093/texcom/tgab065","DOIUrl":"https://doi.org/10.1093/texcom/tgab065","url":null,"abstract":"Intermittent theta burst stimulation (iTBS) delivered by transcranial magnetic stimulation (TMS) produces a long-term potentiation-like after-effect useful for investigations of cortical function and of potential therapeutic value. However, the iTBS after-effect over the primary motor cortex (M1) as measured by changes in motor evoked potential (MEP) amplitude exhibits a largely unexplained variability across individuals. Here, we present evidence that individual differences in white matter (WM) and gray matter (GM) microstructural properties revealed by fractional anisotropy (FA) predict the magnitude of the iTBS-induced after-effect over M1. The MEP amplitude change in the early phase (5-10 min post-iTBS) was associated with FA values in WM tracts such as right superior longitudinal fasciculus and corpus callosum. By contrast, the MEP amplitude change in the late phase (15-30 min post-iTBS) was associated with FA in GM, primarily in right frontal cortex. These results suggest that the microstructural properties of regions connected directly or indirectly to the target region (M1) are crucial determinants of the iTBS after-effect. FA values indicative of these microstructural differences can predict the potential effectiveness of repetitive TMS for both investigational use and clinical application.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgab065"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2