Actas espanolas de psiquiatria最新文献

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Variables Associated with the Use of Psychotropic Medications by Brazilian University Students. 与巴西大学生使用精神药物相关的变量
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-12-01 DOI: 10.62641/aep.v52i6.1753
Cássia Regina Primila Cardoso Berti, Alice Milani Nespollo, Moises Kogien, Evelyn Kelly Das Neves Abreu, Samira Reschetti Marcon, Tatiane Lebre Dias
{"title":"Variables Associated with the Use of Psychotropic Medications by Brazilian University Students.","authors":"Cássia Regina Primila Cardoso Berti, Alice Milani Nespollo, Moises Kogien, Evelyn Kelly Das Neves Abreu, Samira Reschetti Marcon, Tatiane Lebre Dias","doi":"10.62641/aep.v52i6.1753","DOIUrl":"10.62641/aep.v52i6.1753","url":null,"abstract":"<p><strong>Background: </strong>University life is a phase of developing personal and professional skills, but it brings challenges such as distancing from family and supporting networks, difficulties with academic tasks, loneliness, new relationships, competitiveness, and social, socioeconomic, and psychological vulnerability, among others. These conditions can lead to the development of illnesses such as anxiety, depression, sleeping disorders, suicide, self-harming, and excessive drug use, including psychotropic medications. Therefore, this study aimed to evaluate the use of psychotropic medications and its association with sociodemographic, academic, behavioral, and health variables in Brazilian university students.</p><p><strong>Methods: </strong>A cross-sectional, quantitative research, with a sampling of 524 students from a Brazilian public Higher Education Institution (Federal University of Mato Grosso - UFMT). The collection took place from October 10th to December 30th, 2022. An online questionnaire was applied with sociodemographic and clinical questions-the General Anxiety Disorder Questionnaire-7 (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9). The data were descriptively and inferentially analyzed; in the descriptive analysis, the absolute (FA) and relative (FR) frequencies of each category investigated were presented; and for bi- and multivariate analyses, Poisson regression with robust estimation was used.</p><p><strong>Results: </strong>The participants were at the median age of 22 years old, the majority were female (69.7%), heterosexual (68.1%), with medium/high subjective social status (82.4%) and without being involved in a romantic relationship (54%). The prevalence of psychotropic medication use was 26.1%, considering that 17.5% was not prescribed by a medical professional. The most used class of medications was antidepressants (91 participants), followed by natural medicines (38 participants). Among the segments associated with the use of psychotropic drugs were female individuals, romantic relationships, perception of academic performance by postgraduate students, and previous diagnoses of mental or mood disorders (depression and anxiety).</p><p><strong>Conclusions: </strong>The results obtained highlight the importance of research on mental health among university students, especially regarding the use of psychotropic drugs, which must be monitored by a qualified professional. At the university, these data can be important for the development of policies aimed at health and life quality, in addition to contributing to the strengthening of national and international partnerships, and promoting the scientific production in the area.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 6","pages":"810-821"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease. 一种与液-液相分离诊断阿尔茨海默病相关的六基因标记。
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-12-01 DOI: 10.62641/aep.v52i6.1762
Chao Qiu, Hui Xu
{"title":"A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease.","authors":"Chao Qiu, Hui Xu","doi":"10.62641/aep.v52i6.1762","DOIUrl":"10.62641/aep.v52i6.1762","url":null,"abstract":"<p><strong>Background: </strong>Liquid-liquid phase separation (LLPS) has been increasingly recognized as a crucial mechanism in the pathogenesis of various neurodegenerative disorders, including Alzheimer's disease (AD). There remains a paucity of effective diagnostic biomarkers for this condition. This study aims to develop and validate a novel LLPS-related molecular signature to enhance the diagnostic accuracy and early detection of AD.</p><p><strong>Methods: </strong>LLPS-related genes were identified from online databases and subjected to bioinformatic analyses, including protein-protein interaction (PPI) network analysis and least absolute shrinkage and selection operator (LASSO) regression. Based on the optimal LLPS-related genes, a diagnosis risk model was constructed, and the diagnostic ability was evaluated using a receiver operator characteristic (ROC) curve. To elucidate the biological functions of the identified LLPS-related genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted.</p><p><strong>Results: </strong>A total of 149 LLPS-related genes were screened, which were found to be involved in functions related to oxidative stress, apoptosis, and cancer progression. The 149 genes were refined to six optimal candidates through PPI network analysis and LASSO regression: Activator of HSP90 ATPase Activity 1 (AHSA1), Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2 (EIF2AK2), Heat Shock Protein Family A (Hsp70) Member 4 (HSPA4), Notch Receptor 1 (NOTCH1), Superoxide Dismutase 1 (SOD1), and Thioredoxin (TXN). Based on the six optimal genes, a diagnostic risk model was constructed, and the diagnostic ability was verified to be promising in AD both in training, internal validation, and two external validation datasets, with area under ROC curve (AUC) above 0.8. Furthermore, significant correlations were observed between the expression of these genes and tumor immune cell infiltration.</p><p><strong>Conclusions: </strong>A six-gene diagnosis model was constructed and verified to exhibit robust diagnostic ability in AD.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 6","pages":"759-768"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professional Responsibility of Psychologists in the Field of Mental Health in Spain. 西班牙心理健康领域心理学家的职业责任。
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-12-01 DOI: 10.62641/aep.v52i6.1819
José Manuel Bertolín-Guillén, Andrés Porcel-Torrens, Francisca Cantero-Araque, Yolanda Morant-Luján
{"title":"Professional Responsibility of Psychologists in the Field of Mental Health in Spain.","authors":"José Manuel Bertolín-Guillén, Andrés Porcel-Torrens, Francisca Cantero-Araque, Yolanda Morant-Luján","doi":"10.62641/aep.v52i6.1819","DOIUrl":"10.62641/aep.v52i6.1819","url":null,"abstract":"<p><p>In Spain and many other countries, psychotherapy training is heterogeneous and not very evidence-based. This contribution addresses related ethical, normative and legal issues with the aim of clarification, as well as certain relevant aspects of psychological work in the field of mental and behavioural health in Spain. It will analyse professional responsibility and possible intrusiveness in the clinical-psychological field. The authors have scrutinised national legislation along with PubMed/Medline content, as well as a wide variety of scientific papers collected using the search engines Google Scholar and Scientific Electronic Library Online. For clinical psychologists and psychiatric doctors, when appropriate, it is their professional responsibility to choose among the various and sometimes conflicting interventions proposed as the most appropriate or priority psychotherapies. Psychotherapy, as a treatment, although not regulated, should only be undertaken by health personnel who are suitably qualified in mental health with the guarantee of the State, at least in Spain. This would probably help to mitigate the perennial crisis of replication in psychology, particularly as applied to mental health. Likewise, it is a relevant and popular issue, antagonistic to intrusiveness, that any common intervention of interpersonal psychic help should be considered therapeutic, or preferably be undertaken by personnel with a degree in psychology. There is no mandatory psychotherapeutic standard for clinical psychologists and psychiatrists, nor is there an official common international system of accreditation in clinical psychology outside Spain. In the field of mental health, any intervening psychologist, like any medical doctor, is ethically and legally responsible for their actions, omissions and consequences.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 6","pages":"843-853"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Adverse Effects of Anxiety and Depression on Pregnant Women with Hypothyroidism in Late Pregnancy. 焦虑和抑郁对妊娠晚期甲状腺功能减退症孕妇的不良影响。
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-10-01 DOI: 10.62641/aep.v52i5.1644
Jun Ma, Wenjing He, Chengfang Fan, Jianying Duan, Jiaming Wu, Cuijing Zhang, Yi Peng
{"title":"The Adverse Effects of Anxiety and Depression on Pregnant Women with Hypothyroidism in Late Pregnancy.","authors":"Jun Ma, Wenjing He, Chengfang Fan, Jianying Duan, Jiaming Wu, Cuijing Zhang, Yi Peng","doi":"10.62641/aep.v52i5.1644","DOIUrl":"https://doi.org/10.62641/aep.v52i5.1644","url":null,"abstract":"<p><strong>Background: </strong>Maternal depression and anxiety during pregnancy are significant public health concerns commonly reported worldwide among pregnant women. This study aimed to investigate the impact of anxiety and depression on thyroid function, pregnancy outcomes, and sleep quality among pregnant women with hypothyroidism in the later stages of pregnancy.</p><p><strong>Methods: </strong>Eighty cases of pregnant women with hypothyroidism in late pregnancy who were treated at Zhangjiakou First Hospital from January 2021 to October 2023 were selected for this retrospective study. The pregnant women in late pregnancy were divided into four groups according to the scores on the Hospital Anxiety and Depression Scale (HADS): control group with 20 cases, anxiety group with 18 cases, depression group with 22 cases, and anxiety-depression group with 20 cases. A comparison was made among the four groups regarding general information of pregnant women in late pregnancy, HADS scale scores, levels of free thyroxine (FT4, FT3), thyroid-stimulating hormone (TSH), occurrence of adverse pregnancy outcomes, and sleep quality at different time periods.</p><p><strong>Results: </strong>There was no statistically significant difference in comparing general information among the four groups of pregnant women in late pregnancy (p > 0.05). There were statistically significant differences in HADS depression and HADS anxiety scores (p < 0.05), levels of FT4, FT3, TSH in pregnant women in late pregnancy postpartum (p < 0.05), occurrence of adverse pregnancy outcomes (p < 0.05), and comparison of sleep quality of pregnant women in late pregnancy at 1, 3, and 5 months of follow-up among the groups (F = 5.735, 23.930, 11.573, p < 0.05).</p><p><strong>Conclusion: </strong>Anxiety and depression significantly impact thyroid function, pregnancy outcomes, and sleep quality in pregnant women with hypothyroidism in late pregnancy, which is detrimental to the health of pregnant women in late pregnancy. Therefore, necessary interventions are needed.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 5","pages":"625-631"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Associated Factors of Depressive Symptoms among Older Adults in the Philippines. 菲律宾老年人抑郁症状的患病率和相关因素。
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-10-01 DOI: 10.62641/aep.v52i5.1686
Supa Pengpid, Karl Peltzer
{"title":"Prevalence and Associated Factors of Depressive Symptoms among Older Adults in the Philippines.","authors":"Supa Pengpid, Karl Peltzer","doi":"10.62641/aep.v52i5.1686","DOIUrl":"https://doi.org/10.62641/aep.v52i5.1686","url":null,"abstract":"<p><strong>Background: </strong>Depressive symptoms may increase with age, potentially influenced by sociodemographic characteristics, stressors and support, health status, and health behaviour. It is unclear if this is the case among older adults in the Philippines. Therefore, the aim of this study is to estimate the prevalence and associated factors of depressive symptoms among older adults in the Philippines.</p><p><strong>Methods: </strong>In all, 5209 items of cross-sectional nationally representative data from older adults (≥60 years) participating in the 2018 Longitudinal Study on Ageing and Health in the Philippines (LSAHP) were analysed. Depressive symptoms were assessed using the 11-item 3-response category Center for Epidemiological Studies Depression (CES-D) Scale.</p><p><strong>Results: </strong>The overall prevalence of depressive symptoms was 32.1%, with 25.6% among older men and 36.5% among older women. In the final adjusted models, overall, widowed (Adjusted Odds Ratio (AOR): 1.52, 95% Confidence Interval (CI): 1.00 to 2.30), hunger (AOR: 2.22, 95% CI: 1.40 to 3.51), living alone (AOR: 1.61, 95% CI: 1.00 to 2.59), not satisfied with present life (AOR: 2.04, 95% CI: 1.09 to 3.81), body pain (AOR: 2.39, 95% CI: 1.73 to 3.31), and insomnia (AOR: 1.69, 95% CI: 1.24 to 2.31) were positively associated, while working (AOR: 0.55, 95% CI: 0.37 to 0.80) was negatively associated with depressive symptoms. In addition, among men, older age (80 years and above) (AOR: 1.95, 95% CI: 1.06 to 3.58), unmet healthcare needs (AOR: 2.19, 95% CI: 1.07 to 4.47), and hearing difficulty (AOR: 2.41, 95% CI: 1.06 to 5.52) were positively associated poor childhood health (AOR: 0.12, 95% CI: 0.04 to 0.36), while social network (AOR: 0.94, 95% CI: 0.90 to 0.99) was negatively associated. Among women, loss of bladder control (AOR: 1.69, 95% CI: 1.03 to 2.77) was positively associated with depressive symptoms.</p><p><strong>Conclusion: </strong>One in three older adults participating in this study exhibited depressive symptoms. Sociodemographic factors, stressors, and health status factors were positively associated, and support factors were negatively associated with depressive symptoms.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 5","pages":"705-715"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Intersection between Tryptophan-Kynurenine Pathway Metabolites and Immune Inflammation, Hormones, and Gut Microbiota in Perinatal Depression. 围产期抑郁症中色氨酸-犬尿氨酸途径代谢物与免疫炎症、激素和肠道微生物群之间的交集
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-10-01 DOI: 10.62641/aep.v52i5.1748
Huiyan Liu, Kuangyi Zhu, Cheng Yang
{"title":"The Intersection between Tryptophan-Kynurenine Pathway Metabolites and Immune Inflammation, Hormones, and Gut Microbiota in Perinatal Depression.","authors":"Huiyan Liu, Kuangyi Zhu, Cheng Yang","doi":"10.62641/aep.v52i5.1748","DOIUrl":"https://doi.org/10.62641/aep.v52i5.1748","url":null,"abstract":"<p><p>Perinatal depression is a prevalent mental disorder among pregnant women, characterized by sleep disturbances, appetite changes, negative emotions, cognitive impairment, and suicidal or homicidal tendencies. These symptoms severely compromise personal well-being, disrupt family life, and burden society. Early detection and intervention are thus crucial. The tryptophan-kynurenine (TRP-KYN) pathway is central to the inflammatory hypothesis of depression and has gained significant attention in perinatal depression research. This pathway encompasses numerous metabolic enzymes and neuroactive metabolites that interact with other physiological systems, influencing neurotransmitter synthesis and neuronal development. Through these interactions, the TRP-KYN pathway exerts psychotropic effects. This article reviews the key metabolites and enzymes of the TRP-KYN pathway and examines its intersection with immune inflammation, hormones, and gut microbiota.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 5","pages":"733-740"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effectiveness and Safety Analysis of Duloxetine in Treating Comorbid Depression in Parkinson's Disease: A Retrospective Study. 度洛西汀治疗帕金森病合并抑郁症的有效性和安全性分析:一项回顾性研究
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-10-01 DOI: 10.62641/aep.v52i5.1634
Zhuoqun Wang, Jing Tian, Weixin Dai, Na Zhang, Jianglin Wang, Zhanyu Li
{"title":"The Effectiveness and Safety Analysis of Duloxetine in Treating Comorbid Depression in Parkinson's Disease: A Retrospective Study.","authors":"Zhuoqun Wang, Jing Tian, Weixin Dai, Na Zhang, Jianglin Wang, Zhanyu Li","doi":"10.62641/aep.v52i5.1634","DOIUrl":"https://doi.org/10.62641/aep.v52i5.1634","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms, including depression, which significantly impacts the quality of life of affected individuals. This study aims to investigate the real-world effectiveness and safety of duloxetine in treating comorbid depression in patients with Parkinson's disease and to compare its outcomes with traditional treatment approaches.</p><p><strong>Methods: </strong>This study included adult patients diagnosed with Parkinson's disease combined with depression from December 2020 to December 2023. Based on the use of duloxetine, the cohort was divided into a traditional treatment group and a duloxetine group (traditional treatment combined with duloxetine). Patients with incomplete medical records, concurrent antidepressant therapy, or major psychiatric or neurological disorders were excluded. Retrospective data, including demographic information, treatment adherence, and various assessment scores, were collected from medical records by trained research staff.</p><p><strong>Results: </strong>In total, 106 patients were analyzed, with 50 patients receiving traditional treatment and 56 patients receiving duloxetine. The duloxetine group exhibited significantly lower scores than the traditional treatment group in the Unified PD Rating Scale (p = 0.015), Hamilton Depression Rating Scale (p = 0.013), Beck Depression Inventory (p = 0.031), Parkinson's disease Questionnaire-39 (p = 0.006), and Clinical Global Impression-Improvement (p < 0.001) scores. In motor function assessment, the duloxetine group demonstrated improvements in kinetic tremor scores (p = 0.017), gait speed (p < 0.001), Timed Up and Go Test performance (p < 0.001), dyskinesia severity (p = 0.017), and rigidity (p = 0.019) compared to the traditional treatment group. Additionally, the duloxetine group exhibited better cognitive function across various assessments, including the Symbol Digit Modalities Test (p = 0.024), Stroop Color-Word Test (p = 0.048), and Montreal Cognitive Assessment (p = 0.024).</p><p><strong>Conclusion: </strong>Duloxetine is associated with superior efficacy in improving motor and non-motor symptoms, overall clinical status, and cognitive function. These findings support the potential utility of duloxetine as a comprehensive treatment option for comorbid depression in Parkinson's disease.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 5","pages":"607-615"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights and Reflections on Cognitive Behavioural and Dialectical Behavioural Therapies for Adolescent Self-Harm and Suicidal Behavior. 对认知行为疗法和辩证行为疗法治疗青少年自残和自杀行为的见解和思考。
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-10-01 DOI: 10.62641/aep.v52i5.1815
Guilherme Nobre Nogueira
{"title":"Insights and Reflections on Cognitive Behavioural and Dialectical Behavioural Therapies for Adolescent Self-Harm and Suicidal Behavior.","authors":"Guilherme Nobre Nogueira","doi":"10.62641/aep.v52i5.1815","DOIUrl":"10.62641/aep.v52i5.1815","url":null,"abstract":"<p><p>No abstract present.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 5","pages":"748-749"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calycosin-7-O-β-D-Glucoside Ameliorates Palmitate-Induced Lipid Accumulation in HT22 Cells. 萼萼苷-7-O-β-D-葡萄糖苷可改善棕榈酸酯诱导的 HT22 细胞脂质积累。
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-10-01 DOI: 10.62641/aep.v52i5.1723
Yanming Xu, Dalong Li, Ao Xue, Jiaming Gu, Yifan Ren, Siyu Zhu, Xia Lei, Jianxin Liu, Jihui Zhao, Fang Geng, Ning Zhang
{"title":"Calycosin-7-O-β-D-Glucoside Ameliorates Palmitate-Induced Lipid Accumulation in HT22 Cells.","authors":"Yanming Xu, Dalong Li, Ao Xue, Jiaming Gu, Yifan Ren, Siyu Zhu, Xia Lei, Jianxin Liu, Jihui Zhao, Fang Geng, Ning Zhang","doi":"10.62641/aep.v52i5.1723","DOIUrl":"https://doi.org/10.62641/aep.v52i5.1723","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of Alzheimer's disease (AD) is complex. Recent research suggests that AD patients have early disorders in brain cholesterol metabolism. Cholesterol and its derivatives accumulate in neurons, leading to p-Tau overproduction and synaptic dysfunction, initiating AD progression. Calycosin-7-O-β-D-glucoside (CG), a distinctive constituent of Astragali Radix, holds a representative position. Many clinical trials have demonstrated that CG can attenuate cerebral ischemia/reperfusion injury and preserve the structural integrity of the blood-brain barrier. However, whether CG alleviates tau-mediated neurodegeneration by increasing cholesterol efflux after lipid accumulation remains unexplored.</p><p><strong>Methods: </strong>Ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) and multivariate data analysis were employed to investigate metabolic changes in HT22 cells induced by sodium palmitate following 24 hours of CG treatment. The potential therapeutic mechanisms of CG on AD were further examined through Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis.</p><p><strong>Results: </strong>Metabolomic analysis characterized 24 potential biomarkers, revealing that CG could ameliorate cholesterol metabolic pathways. The results of cell experiments revealed that CG can increase the expression of enzyme cholesterol 24-hydroxylase (CYP46A1) (p < 0.05) and the level of 24 hydroxycholesterol (24-OHC) (p < 0.05), reduce the expression of p-Tau (Thr231)/Tau (p < 0.01), inhibit the formation of lipid droplets.</p><p><strong>Conclusion: </strong>CG may inhibit the accumulation of cholesterol and its derivatives in neurons by affecting the CYP46A1-CE-Tau axis, offering a potential therapeutic strategy for AD.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"52 5","pages":"641-652"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Reliability, Dimensions, and Variance of Young's Internet Addiction Test by Applying it to Adolescents at the National Psychiatric Hospital in Costa Rica. 通过对哥斯达黎加国家精神病医院的青少年进行测试,评估杨氏网络成瘾测试的可靠性、维度和方差。
IF 1 4区 医学
Actas espanolas de psiquiatria Pub Date : 2024-10-01 DOI: 10.62641/aep.v52i5.1845
José A Martín Herrero, Karla Fernández Mora, Antonio Molina Fernández
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