Alana Smith, C. Cropp, G. Vidal, Elizabeth K Pritchard, Jennifer B. Cordero, Claire L. Simpson, A. Starlard-Davenport
{"title":"Prevalence of the UGT1A1*28 promoter polymorphism and breast cancer risk among African American women in Memphis, TN.","authors":"Alana Smith, C. Cropp, G. Vidal, Elizabeth K Pritchard, Jennifer B. Cordero, Claire L. Simpson, A. Starlard-Davenport","doi":"10.9777/CHD.2019.1015","DOIUrl":"https://doi.org/10.9777/CHD.2019.1015","url":null,"abstract":"Inherited variations in UDP-glucuronosyltransferase 1A1 (UGT1A1) are associated with an increased breast cancer risk in women of African ancestry. The UGT1A1*28 promoter polymorphism is characterized by the presence of 7 TA repeats in the TATA box sequence and results in reduced UGT1A1 gene expression and enzymatic activity. In this study, we investigated associations between the UGT1A1*28 polymorphism and breast cancer risk among African American (AA) women in Memphis, Tennessee, a city with increased breast cancer mortality rates among AA women. Saliva was collected from 352 AA women, including breast cancer cases (n=82) and controls (n=270) between June 2016 to June 2017. DNA was isolated and sequenced for the UGT1A1*28 polymorphism. The odds ratio for cases with the low UGT1A1 activity alleles (TA)7/8 repeat genotypes versus 5/5, 5/6, and 6/6 genotypes was 1.46 [95% CI, 0.65-3.31; P = 0.36] in premenopausal women and 1.10 (95% CI, 0.52-2.38; P = 0.79) in postmenopausal women. Further analysis of TCGA RNA-seq data showed that UGT1A1 mRNA was significantly lower among estrogen receptor (ER)-negative breast cancers from AA as compared to non-Hispanic white women with ER-negative breast cancer. Larger epidemiological studies are needed to determine the functional consequence of the UGT1A1*28 polymorphism on breast cancer risk in AA women.","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"3 1","pages":"e1-e12"},"PeriodicalIF":0.0,"publicationDate":"2019-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45254998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of Community Health Needs Assessment for Increasing Awareness and Reducing Disparities","authors":"A. Caron, Joseph Jaeger, M. Bar-on, K. Andolsek","doi":"10.1007/978-3-030-12771-8_56","DOIUrl":"https://doi.org/10.1007/978-3-030-12771-8_56","url":null,"abstract":"","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75230687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensitization as the First Step: The Horatio Alger Exercise","authors":"Varun U. Shetty, S. Mostade","doi":"10.1007/978-3-030-12771-8_58","DOIUrl":"https://doi.org/10.1007/978-3-030-12771-8_58","url":null,"abstract":"","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87056158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health Disparities and Social Determinants of Health","authors":"Sarah Shick, I. Adebambo, A. Perzynski","doi":"10.1007/978-3-030-12771-8_2","DOIUrl":"https://doi.org/10.1007/978-3-030-12771-8_2","url":null,"abstract":"","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77188149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discussion Guide for Health Disparities Case Narratives","authors":"I. Adebambo, A. Perzynski, Sarah Shick","doi":"10.1007/978-3-030-12771-8_55","DOIUrl":"https://doi.org/10.1007/978-3-030-12771-8_55","url":null,"abstract":"","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77463694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health Disparities: Weaving a New Understanding Through Case Narratives","authors":"A. Perzynski, Sarah Shick, I. Adebambo","doi":"10.1007/978-3-030-12771-8","DOIUrl":"https://doi.org/10.1007/978-3-030-12771-8","url":null,"abstract":"","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"82 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77079932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhixin Wang, Sarah Dilley, HyounKyoung G Park, Alfred A Bartolucci, Chenguang Wang, Warner K Huh, Sejong Bae
{"title":"Regional Disparities in Ovarian Cancer in the United States.","authors":"Zhixin Wang, Sarah Dilley, HyounKyoung G Park, Alfred A Bartolucci, Chenguang Wang, Warner K Huh, Sejong Bae","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to investigate the association between geographic regions and ovarian cancer disparities in the United States. Data from the Surveillance, Epidemiology, and End Results (SEER) Program was used to identify women diagnosed with ovarian cancer. 18 registries were divided into two groups: South region and US14 region. Chi-Square tests were used to compare proportions, the logistic regression model to evaluate the association between 5-year survival and other variables, and the Cox proportional hazards model to estimate hazard ratios. The South region had a lower incidence rate than the US14 region (12.0 vs. 13.4 per 100,000), and a lower 5-year observed survival rate (37.5% vs. 39.8%). White women living in the US14 region had the best overall survival, compared to white women living in the South region, and black women living in both regions. Women in the South region were less likely to have insurance (6.6% vs. 2.7%, p<0.0001) and surgery (73.4% vs. 76.2%, p<0.0001). Women living in the South were 1.4 times more likely to die after five years of diagnosis than women living in the US14 region. The data confirmed regional disparities in ovarian cancer in the United States, showing women living in the South region were disadvantaged in ovarian cancer survival regardless of race, black or white. Future research focusing on the identification of contributing factors to regional disparity in ovarian cancer is necessary to develop practical approaches to improve health outcomes related to this lethal disease.</p>","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"3 ","pages":"e1-e12"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034285/pdf/nihms-1034640.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25582259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Notch as an Immunologic Basis of Cancer Disparities.","authors":"Portia LaLiah Thomas, Anil Shanker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Inter-individual differences due to racial/ethnic backgrounds may alter host immunity responsible for the cancer immunosurveillance and elimination, leading to disparate cancer incidence and relapse. One basis of disparity in tumor incidence, progression or therapeutic outcomes could lie in the components of Notch intercellular communication system, which provide instructive signals for a variety of pathways regulating cell commitment and differentiation including context-dependent lymphocyte polarization in tumor microenvironment. Notch signaling in hematopoietic cells is perturbed by tumor growth for its advantage, and there are indications that differences in Notch components could underlie poor cancer prognosis in certain populations. Here, we discuss the oncogenic and immunologic aspects of Notch, which should inform on cancer health disparities and therapeutic outcomes.</p>","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"3 ","pages":"e1-e10"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278364/pdf/nihms-1554334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39189922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guidelines for Health Disparities Case Narratives Workshops","authors":"A. Perzynski, I. Adebambo","doi":"10.1007/978-3-030-12771-8_54","DOIUrl":"https://doi.org/10.1007/978-3-030-12771-8_54","url":null,"abstract":"","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"168 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78705970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Growing Old in a New World","authors":"T. Said, H. Gill","doi":"10.1007/978-3-030-12771-8_38","DOIUrl":"https://doi.org/10.1007/978-3-030-12771-8_38","url":null,"abstract":"","PeriodicalId":72512,"journal":{"name":"Cancer health disparities","volume":"33 1-2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78203894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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