Brazilian journal of cardiovascular surgery最新文献

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Survival Analysis in Adult Heart Transplantation: Correspondence. 成人心脏移植的生存分析:对应。
Brazilian journal of cardiovascular surgery Pub Date : 2025-07-02 DOI: 10.21470/1678-9741-2024-0310
Hinpetch Daungsupawong, Viroj Wiwanitkit
{"title":"Survival Analysis in Adult Heart Transplantation: Correspondence.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.21470/1678-9741-2024-0310","DOIUrl":"https://doi.org/10.21470/1678-9741-2024-0310","url":null,"abstract":"","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 5","pages":"e20240310"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Between Science and Humanity: The Journey of Paulo Évora. 科学与人文之间:保罗之旅Évora。
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-30 DOI: 10.21470/1678-9741-2025-0902
André Luppi, Henrique Murad
{"title":"Between Science and Humanity: The Journey of Paulo Évora.","authors":"André Luppi, Henrique Murad","doi":"10.21470/1678-9741-2025-0902","DOIUrl":"https://doi.org/10.21470/1678-9741-2025-0902","url":null,"abstract":"","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 3","pages":"e20250902"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Systemic Microcirculatory Vessel Density in the Early Postoperative Period of Heart Valve Surgery: an Observational Study. 心脏瓣膜手术术后早期系统微循环血管密度的评价:一项观察性研究。
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-18 DOI: 10.21470/1678-9741-2024-0039
Marcos Vinícius Fernandes, Andrea de Lorenzo, Eduardo Tibiriça
{"title":"Evaluation of Systemic Microcirculatory Vessel Density in the Early Postoperative Period of Heart Valve Surgery: an Observational Study.","authors":"Marcos Vinícius Fernandes, Andrea de Lorenzo, Eduardo Tibiriça","doi":"10.21470/1678-9741-2024-0039","DOIUrl":"10.21470/1678-9741-2024-0039","url":null,"abstract":"<p><strong>Introduction: </strong>The present study evaluated systemic microcirculatory alterations occurring in the early postoperative period of cardiopulmonary bypass-assisted heart valve surgery compared to preoperative parameters through noninvasive point-of-care microcirculatory imaging of the sublingual area using incident dark field imaging.</p><p><strong>Methods: </strong>This was a single-center cross-sectional observational study that included 23 patients aged 49 ± 13 years. Sublingual microcirculatory density and perfusion were evaluated using a handheld camera based on incident dark field imaging before surgery and in the early postoperative period.</p><p><strong>Results: </strong>The total number of capillary vessels (1029 ± 13, P=0.0006), total length of capillary vessels (29.4 ± 3.2 mm, P=0.0005), and capillary vessel density (16.8 ± 1.8 mm/mm2, P=0.0005) were all higher after surgery. On the other hand, the total number of noncapillary vessels (85 ± 34, P=0.05), total length of noncapillary vessels (1.9 ± 0.8 mm, P=0.07), and noncapillary vessel density (1.1 ± 0.5 mm/mm2, P=0.07) were similar before and after surgery. The total number of capillary vessels was higher after surgery (1109 ± 92) in patients who received milrinone infusion (P=0.002) but not in patients who did not receive milrinone (986 ± 129, P=0.05).</p><p><strong>Conclusion: </strong>After cardiac valve surgery, there was an improvement in microvascular parameters concerning capillary vessels and in the total number of microvessels. Moreover, significant positive correlations were found between the use of milrinone and these parameters. The study demonstrated the usefulness of handheld cameras for bedside evaluation of the microcirculation.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e20240039"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Treatment of Pulmonary Artery Angiosarcoma - A Ten-Year Experience. 肺动脉血管肉瘤的外科治疗-十年经验。
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-18 DOI: 10.21470/1678-9741-2023-0441
Alexander Edemskiy, Oksana Vasiltseva, Elena Kliver, Natalya Novikova, Dmitry Sirota, Alexander Chernyavskiy
{"title":"Surgical Treatment of Pulmonary Artery Angiosarcoma - A Ten-Year Experience.","authors":"Alexander Edemskiy, Oksana Vasiltseva, Elena Kliver, Natalya Novikova, Dmitry Sirota, Alexander Chernyavskiy","doi":"10.21470/1678-9741-2023-0441","DOIUrl":"10.21470/1678-9741-2023-0441","url":null,"abstract":"<p><strong>Introduction: </strong>Pulmonary artery angiosarcoma is a rare and extremely severe tumor. Our study summarizes the clinical data of patients treated for pulmonary artery angiosarcoma over the period of 2010-2020.</p><p><strong>Methods: </strong>We retrospectively analyzed cases of surgical treatment of patients with diagnosis of pulmonary artery angiosarcoma at our center. Data of operative findings, short-term follow-up, and the long-term results were reviewed where available.</p><p><strong>Results: </strong>The 30-day mortality rate was six (67%) out of nine patients. Three (33%) patients were discharged. Data on pulmonary vascular resistance in the earlyand long-term postoperative periods were assessed if possible. Certain computed tomography signs have been identified that can be used to suspect pulmonary artery angiosarcoma and make a differential diagnosis with chronic thromboembolic pulmonary hypertension.</p><p><strong>Conclusion: </strong>The surgical treatment of choice is pneumonectomy with contralateral pulmonary endarterectomy. Oncological vigilance regarding angiosarcoma in occlusive-stenotic lesions of the pulmonary artery is extremely important. Patients' assessment must be carried out in an expert cardiothoracic surgery center with the involvement of an oncological crew.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e20230441"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technical Performance Score: A Robust Predictor of Morbidity Following the Norwood Procedure at a Developing Country Institution. 技术性能评分:发展中国家机构诺伍德手术后发病率的可靠预测指标。
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-18 DOI: 10.21470/1678-9741-2024-0442
Davi Freitas Tenório, Leonardo Augusto Miana, João Guilherme Vidal Meyer, Eric Shih Katsuyama, Christian Ken Fukunaga, Aida Luiza Ribeiro Turquetto, Luiza Patrick Amato, Marcelo Biscegli Jatene, Fabio B Jatene
{"title":"Technical Performance Score: A Robust Predictor of Morbidity Following the Norwood Procedure at a Developing Country Institution.","authors":"Davi Freitas Tenório, Leonardo Augusto Miana, João Guilherme Vidal Meyer, Eric Shih Katsuyama, Christian Ken Fukunaga, Aida Luiza Ribeiro Turquetto, Luiza Patrick Amato, Marcelo Biscegli Jatene, Fabio B Jatene","doi":"10.21470/1678-9741-2024-0442","DOIUrl":"10.21470/1678-9741-2024-0442","url":null,"abstract":"<p><strong>Introduction: </strong>The Norwood operation has transformed the approach to hypoplastic left heart syndrome and its variants. Given the complexity of this procedure, postoperative residual injuries are prevalent.</p><p><strong>Objective: </strong>To evaluate the impact of significant residual injuries on clinical outcomes and mortality in Norwood procedure patients at a high-volume tertiary center in a developing nation using the technical performance score (TPS).</p><p><strong>Methods: </strong>This single-center, retrospective study included patients who underwent the Norwood procedure between December 2018 and February 2023. Data on demographics, echocardiograms, complications, intensive care unit stay, and mortality were collected. Logistic regression and linear analyses assessed the impact of TPS on outcomes.</p><p><strong>Results: </strong>Of 69 patients, nine (13%) were excluded due to incomplete echocardiographic data, leaving 60 (87%) for TPS classification. Among them, 28 (47%) were male. TPS classification was as follows: 40 (66%) in class 1 (excellent), five (8.3%) in class 2 (adequate), and 15 (25%) in class 3 (inadequate), indicating significant residual lesions or need for reintervention. The 30-day mortality rate was 21.6%, increasing to 41.6% before the next stage. In TPS class 3, 30-day mortality was 33% vs. 17% in classes 1 and 2 (P = 0.27). Interstage mortality was 60% in class 3 compared to 35% in other groups (P = 0.13). Major complications were significantly higher in TPS class 3 (93% vs. 55.5%, P = 0.04).</p><p><strong>Conclusion: </strong>TPS effectively predicts major complications post-Norwood and serves as a valuable tool for improving patient outcomes.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e20240442"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Systemic Immune-Inflammation Index on Prognosis in Non-Functional Mitral Regurgitation Patients Undergoing Isolated Mitral Valve Replacement. 全身免疫炎症指数对非功能性二尖瓣返流患者行孤立二尖瓣置换术预后的影响。
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-18 DOI: 10.21470/1678-9741-2023-0362
Busra Temel Yuksel, Mehmet Isık, Omer Tanyeli, Serkan Yıldırım, Niyazi GOrmus
{"title":"Effect of Systemic Immune-Inflammation Index on Prognosis in Non-Functional Mitral Regurgitation Patients Undergoing Isolated Mitral Valve Replacement.","authors":"Busra Temel Yuksel, Mehmet Isık, Omer Tanyeli, Serkan Yıldırım, Niyazi GOrmus","doi":"10.21470/1678-9741-2023-0362","DOIUrl":"10.21470/1678-9741-2023-0362","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of preoperative and postoperative systemic immune-inflammation index (SII) values on early prognosis in patients with nonfunctional mitral regurgitation etiology undergoing isolated mitral valve replacement (MVR).</p><p><strong>Methods: </strong>A total of 176 patients with isolated MVR performed from 2015 to 2021 were retrospectively investigated. The platelet, lymphocyte, and neutrophil counts were measured, and SII, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) values were calculated preoperatively and on the first and fourth days postoperatively. The correlations with postoperative 30-day early-term prognosis and mortality were investigated.</p><p><strong>Results: </strong>Mean age of the patients was 55.4 years, 69.9% were female, and 30.1% were male. At 30-day follow-up, 9% (n = 16) of patients died. There were significant positive correlations observed between age (P < 0.001), preoperative NLR (P = 0.003), preoperative SII (P = 0.02), and postoperative fourth day NLR (P < 0.001) values with 30-day mortality. Receiver operating characteristic analysis identified that age + preoperative SII (P < 0.001), age + preoperative NLR (P < 0.001), and age + postoperative fourth day NLR (P = 0.001) combinations were significant predictive factors for 30-day mortality. There was a significant positive correlation between postoperative fourth day SII value with intensive care unit (ICU) admission duration (P < 0.001, Ρ = 0.308).</p><p><strong>Conclusion: </strong>For non-functional, isolated MVR patients, preoperative and postoperative fourth day SII and NLR values were found to provide an idea about 30-day prognosis. Additionally, patients with high postoperative fourth day SII values were observed to have longer ICU stays.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e20230362"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Effects of Blood Cardioplegia and Del Nido Cardioplegia on Postoperative Intensive Care Needs, Drainage, and Renal Functions in Patients Undergoing Isolated Coronary Artery Bypass. 血停搏与Del Nido停搏对孤立冠状动脉搭桥术后重症监护需求、引流及肾功能影响的比较
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-04 DOI: 10.21470/1678-9741-2024-0237
Yaşar Sarıgol, Serkan Yıldırım, Mehmet Işık, Omer Tanyeli, Yuksel Dereli, Erdal Ege, Niyazi Gormuş
{"title":"Comparison of the Effects of Blood Cardioplegia and Del Nido Cardioplegia on Postoperative Intensive Care Needs, Drainage, and Renal Functions in Patients Undergoing Isolated Coronary Artery Bypass.","authors":"Yaşar Sarıgol, Serkan Yıldırım, Mehmet Işık, Omer Tanyeli, Yuksel Dereli, Erdal Ege, Niyazi Gormuş","doi":"10.21470/1678-9741-2024-0237","DOIUrl":"10.21470/1678-9741-2024-0237","url":null,"abstract":"<p><strong>Objective: </strong>A variety of cardioplegia techniques with different components are implemented to ensure myocardial protection, in addition to keeping the operationa field immobile and free of blood during cardiac surgery. The implemented cardioplegia has unwanted negative effects on other end organs. In this study, our aim was to compare the effects of Del Nido cardioplegia and blood cardioplegia solutions on postoperative intensive care duration, drainage, and renal functions for patients undergoing cardiopulmonary bypass and bypass graft operations.</p><p><strong>Methods: </strong>Selections were made from patients undergoing elective bypass graft operations in our clinic from January 1, 2022 to December 31, 2023. Patients were randomly selected, retrospectively assessed, and divided into two groups - De Nido group (Group 1) and blood cardioplegia group (Group 2). Comparisons were made between these groups in terms of intensive care duration, drainage, and renal functions.</p><p><strong>Results: </strong>The study included 120 patients. The Del Nido cardioplegia group included 60 patients, with 60 patients in the blood cardioplegia group. Comparisons between the groups found that the aortic cross-clamping duration was significantly high in Group 1 (P = 0.014). The noradrenaline dose given to Group 1 was high (P = 0.004). In terms of renal injury, significant degree of elevation was present in Group 1 (P = 0.027). The longer aortic cross-clamping duration in Group 1 may be assessed as a determinant factor for noradrenaline dose and acute kidney injury.</p><p><strong>Conclusion: </strong>This study concluded that it willbe appropriate to choose the cardioplegia method by performing broader meta-analysis studies and minimizing limiting factors.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e20240237"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the Fate of the Internal Mammary Vein in CABG Similar to that of the Saphenous Vein? CABG中乳腺内静脉的命运与隐静脉相似吗?
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-04 DOI: 10.21470/1678-9741-2023-0332
Luis Roberto Palma Dallan, Luis Alberto Oliveira Dallan, Antonio Neves, Omar Asdrubal Vilca Mejia, Luiz Augusto Ferreira Lisboa, Fabio B Jatene
{"title":"Is the Fate of the Internal Mammary Vein in CABG Similar to that of the Saphenous Vein?","authors":"Luis Roberto Palma Dallan, Luis Alberto Oliveira Dallan, Antonio Neves, Omar Asdrubal Vilca Mejia, Luiz Augusto Ferreira Lisboa, Fabio B Jatene","doi":"10.21470/1678-9741-2023-0332","DOIUrl":"10.21470/1678-9741-2023-0332","url":null,"abstract":"","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e20230332"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diaphragm Dysfunction After Cardiac Surgery. 心脏手术后膈肌功能障碍。
Brazilian journal of cardiovascular surgery Pub Date : 2025-06-04 DOI: 10.21470/1678-9741-2023-0239
Tim Somers, Sandy Iskander, Ad F T M Verhagen, Wilson W L Li
{"title":"Diaphragm Dysfunction After Cardiac Surgery.","authors":"Tim Somers, Sandy Iskander, Ad F T M Verhagen, Wilson W L Li","doi":"10.21470/1678-9741-2023-0239","DOIUrl":"10.21470/1678-9741-2023-0239","url":null,"abstract":"<p><strong>Introduction: </strong>Diaphragm elevation is commonly seen after cardiac surgery, mostly due to phrenic nerve injury. However, only historical data is available on the incidence of diaphragm elevation and its consequences during recovery.</p><p><strong>Objective: </strong>We aim to provide contemporary insights into the incidence of diaphragm dysfunction in patients undergoing cardiac surgery and its effect on postoperative outcomes.</p><p><strong>Methods: </strong>Records of all patients undergoing cardiac surgery through sternotomy between 2015 and 2016 at the Radboud University MedicalCentre were retrospectively reviewed. Diaphragm position and elevation were evaluated on available chest radiography. Right-sided diaphragm elevation was defined as the right diaphragm being > 3.0 cm above the left diaphragm; left-sided diaphragm elevation was defined as < 0.5 cm below or above the level of the right diaphragm.</p><p><strong>Results: </strong>A total of 1510 patients have undergone cardiac surgery through sternotomy during the study period, of which 1316 patients were included in the final analysis. Of these 1316 patients, 13% (n = 179) had pre-existing diaphragm elevation, 27% (n = 351) had a new diaphragm elevation postoperative-y, and 60% (n = 786) had no diaphragm elevation. No statistically significant differences were found between the groups in the occurrence of postoperative (pulmonary) complications or mortality. Of patients who developed new diaphragm elevation postoperatively, 65% recovered in the follow-up period.</p><p><strong>Conclusion: </strong>New postoperative diaphragm elevation occurs in 27% of patients undergoing cardiac surgery. However, new postoperative diaphragm elevation is not associated with a higher incidence of postoperative complications and spontaneous recovery is seen in most patients.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e20230239"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pioneer of Cardiothoracic Surgery - the Brazilian Northeast Heart Transplant Program. 心胸外科的先驱-巴西东北心脏移植项目。
Brazilian journal of cardiovascular surgery Pub Date : 2025-05-30 DOI: 10.21470/1678-9741-2024-0128
Ricardo de, José Teles de, José Wanderley, Mozart Augusto Soares de, José Glauco Lobo, José Ricardo Lagreca de
{"title":"A Pioneer of Cardiothoracic Surgery - the Brazilian Northeast Heart Transplant Program.","authors":"Ricardo de, José Teles de, José Wanderley, Mozart Augusto Soares de, José Glauco Lobo, José Ricardo Lagreca de","doi":"10.21470/1678-9741-2024-0128","DOIUrl":"10.21470/1678-9741-2024-0128","url":null,"abstract":"<p><p>This review highlights the pivotal milestones in the development of cardiac transplantation and related techniques. Beginning with Alexis Carrel's pioneering work on vascular anastomosis and organ preservation, the narrative progresses through groundbreaking achievements such as John Gibbon's invention of the heart-lung machine in 1953 and James Hardy's daring chimpanzee-to-human heart transplant in 1964. The story culminates in Christiaan Barnard's historic human heart transplant in 1967 and Euryclides Zerbini's leadership in bringing this innovation to Brazil in 1968. Key advancements include the development of orthotopic heart transplantation techniques by Richard Lower and Norman Shumway and the resurgence of heart transplants following the introduction of cyclosporine in 1983, which revolutionized organ rejection management. The collaborative Programa Nordeste de Transplante Cardíaco, initiated in 1986, exemplifies regional innovation in overcoming logistical and financial barriers in Brazil. Recent progress, such as the first successful xenotransplantation using a genetically modified pig heart in 2022, underscores ongoing efforts to address donor shortages and improve transplant outcomes. This narrative is a testament to human ingenuity and perseverance in offering life-saving solutions to end-stage heart disease.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 4","pages":"e2024128"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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