Brain, behavior, & immunity - health最新文献

筛选
英文 中文
The potential role of interleukin-6 in the association between inflammation and cognitive performance in obstructive sleep apnea 白细胞介素-6 在阻塞性睡眠呼吸暂停患者的炎症与认知能力之间的潜在作用
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-10-05 DOI: 10.1016/j.bbih.2024.100875
Mariana Fernandes , Matteo Spanetta , Giorgio Vetrugno , Marzia Nuccetelli , Fabio Placidi , Alessandro Castelli , Natalia Manfredi , Francesca Izzi , Giuseppina Laganà , Sergio Bernardini , Nicola Biagio Mercuri , Claudio Liguori
{"title":"The potential role of interleukin-6 in the association between inflammation and cognitive performance in obstructive sleep apnea","authors":"Mariana Fernandes ,&nbsp;Matteo Spanetta ,&nbsp;Giorgio Vetrugno ,&nbsp;Marzia Nuccetelli ,&nbsp;Fabio Placidi ,&nbsp;Alessandro Castelli ,&nbsp;Natalia Manfredi ,&nbsp;Francesca Izzi ,&nbsp;Giuseppina Laganà ,&nbsp;Sergio Bernardini ,&nbsp;Nicola Biagio Mercuri ,&nbsp;Claudio Liguori","doi":"10.1016/j.bbih.2024.100875","DOIUrl":"10.1016/j.bbih.2024.100875","url":null,"abstract":"<div><h3>Background</h3><div>Interleukin-6 (IL-6) represents one of the main molecules involved in inflammatory responses, which can be altered in either patients with cognitive impairment or obstructive sleep apnea (OSA). The present study aimed to evaluate serum IL-6 levels and cognitive performance in patients with severe OSA (Apnea-Hypopnea Index - AHI &gt;30/h).</div></div><div><h3>Methods</h3><div>Thirty patients with severe OSA were compared to 15 controls similar in age, sex, and Body Mass Index. All patients underwent a sleep medicine interview, including the Epworth Sleepiness Scale (ESS), a polygraphic cardiorespiratory recording, the Montreal Cognitive Assessment (MoCA), and a blood sample for serum IL-6 assessment.</div></div><div><h3>Results</h3><div>OSA patients presented higher IL-6 serum levels (Md = 7.38) than controls (Md = 2.20, p &lt; 0.001). Moreover, OSA patients showed lower MoCA (Md = 27.00) and higher ESS scores (Md = 8.00) than controls (Md = 30.00, p &lt; 0.001; Md = 4.00, p = 0.004, respectively). Higher IL-6 serum levels were associated with lower oxygen saturation parameters and MoCA scores.</div></div><div><h3>Conclusions</h3><div>This study documented an association between inflammation, featured by higher IL-6 serum levels, and both nocturnal hypoxemia and cognitive impairment in OSA patients. Therefore, the increase in IL-6 levels may represent the result of vascular damage and neuroinflammation due to intermittent nocturnal hypoxia and further causing neurocognitive dysfunction in OSA.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100875"},"PeriodicalIF":3.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying methamphetamine use predictors in HIV infection: Immune-dopaminergic signatures in peripheral leukocytes and the role of COMT genotype 识别艾滋病毒感染者使用甲基苯丙胺的预测因素:外周白细胞中的免疫多巴胺能特征和 COMT 基因型的作用
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-10-05 DOI: 10.1016/j.bbih.2024.100873
Liana V. Basova , Tera Riley , Donald Franklin , Violaine Delorme-Walker , Wei Ling Lim , Igor Grant , Scott L. Letendre , Jennifer E. Iudicello , Mariana Cherner , Ronald J. Ellis , Maria Cecilia Garibaldi Marcondes
{"title":"Identifying methamphetamine use predictors in HIV infection: Immune-dopaminergic signatures in peripheral leukocytes and the role of COMT genotype","authors":"Liana V. Basova ,&nbsp;Tera Riley ,&nbsp;Donald Franklin ,&nbsp;Violaine Delorme-Walker ,&nbsp;Wei Ling Lim ,&nbsp;Igor Grant ,&nbsp;Scott L. Letendre ,&nbsp;Jennifer E. Iudicello ,&nbsp;Mariana Cherner ,&nbsp;Ronald J. Ellis ,&nbsp;Maria Cecilia Garibaldi Marcondes","doi":"10.1016/j.bbih.2024.100873","DOIUrl":"10.1016/j.bbih.2024.100873","url":null,"abstract":"<div><div>The pursuit of translational biomarkers is complex due to the heterogeneous human pathophysiology, but critical for disease diagnosis, prognosis, monitoring therapeutic efficacy, and for patient stratification. In HIV-associated neurocognitive impairment (NCI), biomarkers that delineate the trajectory of neuropathogenesis and neurocognitive sequelae are critical, particularly considering confounders such as substance use, including Methamphetamine (METH). METH use is a significant health concern among persons living with HIV (PWH), aggravating cognitive deficits and neuroinflammation despite of antiretrovirals, introducing elements in the microenvironment that are fundamentally differerent in relation to non-METH users, such as high levels of dopamine (DA) affecting HIV-innate immune targets. Yet, current biomarkers do not detect these differences. We hypothesized that predefined DA-induced signatures detectable in peripheral blood leukocytes, can distinguish HIV+ METH users compared to HIV-negative or PWH that are non METH users. The elevated expression of CD8A, CREBBP, CCL5, and combinations of dopaminergic pathway transcripts clustered METH users with detectable CSF viral load and major depressive disorder (MDD), indicating neuroimmune-mechanistic links. Cathecol-o-methyltransferase (COMT) gene polymorphisms affecting DA metabolism improved the identification of PWH using METH with biomarkers. The results indicate that underlying immunedopaminergic mechanisms provide signatures and genotypes that can identify PWH that are METH users and their attributes.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100873"},"PeriodicalIF":3.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammation and depression: A study protocol to dissect pathogenetic mechanisms in the onset, comorbidity and treatment response 炎症与抑郁症:剖析发病、合并症和治疗反应的病理机制的研究方案
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-10-05 DOI: 10.1016/j.bbih.2024.100886
Catia Scassellati , Nadia Cattane , Francesco Benedetti , Tiziana Borsello , Giuseppe Cicala , Massimo Gennarelli , Patrizia Genini , Alessandro Gialluisi , Arianna Giani , Licia Iacoviello , Alessandra Minelli , Edoardo Spina , Benedetta Vai , Erika Vitali , Annamaria Cattaneo
{"title":"Inflammation and depression: A study protocol to dissect pathogenetic mechanisms in the onset, comorbidity and treatment response","authors":"Catia Scassellati ,&nbsp;Nadia Cattane ,&nbsp;Francesco Benedetti ,&nbsp;Tiziana Borsello ,&nbsp;Giuseppe Cicala ,&nbsp;Massimo Gennarelli ,&nbsp;Patrizia Genini ,&nbsp;Alessandro Gialluisi ,&nbsp;Arianna Giani ,&nbsp;Licia Iacoviello ,&nbsp;Alessandra Minelli ,&nbsp;Edoardo Spina ,&nbsp;Benedetta Vai ,&nbsp;Erika Vitali ,&nbsp;Annamaria Cattaneo","doi":"10.1016/j.bbih.2024.100886","DOIUrl":"10.1016/j.bbih.2024.100886","url":null,"abstract":"<div><div>About one third of patients suffering from Major Depressive Disorder (MDD) do not respond to any antidepressant medications and 75% experience relapses and general health deterioration. Importantly, inflammation can contribute to such negative outcomes, as well as to cause depression in patients who have been exposed to adverse childhood experiences and/or to viral infections, including COVID-19. Depressed patients also have an increased risk for developing comorbidities, such as cardio-metabolic dysfunctions, where inflammatory alterations, again, play a role in connecting MDD and these comorbid conditions.</div><div>Here, we present our study protocol funded by the Italian Ministry of Health in the context of the PNRR call (M6/C2_CALL 2022; Project code: PNRR-MAD-2022-12375859). The project aims to clarify the role of inflammation: i) in the onset of depression in association with environmental factors; ii) in the mechanisms associated with treatment response/resistance; iii) in depression and its comorbidity. To reach all these aims, we will perform biochemical, transcriptomic, genetic variants analyses on inflammatory/immune genes, pharmacokinetics and machine learning techniques, taking advantage of different human cohorts (adolescent depressed patients exposed to childhood trauma; adult depressed patients; treatment resistant depression patients; both prevalent and incident depression cases identified within a large population cohort). Moreover, we will use <em>in vitro</em> models (primary cultures of astrocytes, neurons and microglia) treated with pro-inflammatory or stressful challenges and preventive compounds to clarify the underlying mechanisms.</div><div>This 2-years project will increase the knowledge on the role of inflammation in the prevention and treatment of MDD and in comorbid disorders, and it will also provide experimental evidence for the development of novel targets and tools for innovative personalized intervention strategies.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100886"},"PeriodicalIF":3.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammation and cognitive performance in elite athletes: A cross-sectional study 精英运动员的炎症与认知能力:横断面研究
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-10-05 DOI: 10.1016/j.bbih.2024.100872
Kati Wiedenbrüg , Laura Will , Lukas Reichert , Sebastian Hacker , Claudia Lenz , Karen Zentgraf , Markus Raab , Karsten Krüger
{"title":"Inflammation and cognitive performance in elite athletes: A cross-sectional study","authors":"Kati Wiedenbrüg ,&nbsp;Laura Will ,&nbsp;Lukas Reichert ,&nbsp;Sebastian Hacker ,&nbsp;Claudia Lenz ,&nbsp;Karen Zentgraf ,&nbsp;Markus Raab ,&nbsp;Karsten Krüger","doi":"10.1016/j.bbih.2024.100872","DOIUrl":"10.1016/j.bbih.2024.100872","url":null,"abstract":"<div><div>Functional cognition is relevant for athletic success and interdependent with physical exercise, yet despite repeatedly demonstrated inflammatory responses to physical training, there are no studies addressing the relationship between cognition and inflammation in athletes. The aim of this study was to investigate the relationship between cognitive performance and selected inflammatory, and further physiological biomarkers in elite athletes. Data from 350 elite athletes regarding cognitive performance (processing speed, selective attention, working memory, cognitive flexibility), systemic inflammatory markers, metabolic hormones, growth factors, tissue damage markers, and micronutrients (e.g., ferritin, 25-OH-vitamin D), as well as physiological, subjective ratings of recovery and stress were analysed by correlative and multiple regression analyses. Results show that across all athletes variance in processing speed, selective attention, and working memory, could be best explained through a combination of metabolic hormones with physiological and psychological indicators of stress, and in cognitive flexibility through vitamin D levels. Only for the subgroup of athletes from closed-skill sports, the ratio TNF-α:IL-10 significantly contributed to explanation of variance in working memory and cognitive flexibility. In general, found correlations point to the importance of inflammatory balance and sufficient long-term nutrient supply for unaffected cognitive performance.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100872"},"PeriodicalIF":3.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Extension to the stress-buffering model: Timing of support across the lifecourse 压力缓冲模式的扩展:在整个生命过程中提供支持的时机
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-10-04 DOI: 10.1016/j.bbih.2024.100876
Phoebe H. Lam
{"title":"An Extension to the stress-buffering model: Timing of support across the lifecourse","authors":"Phoebe H. Lam","doi":"10.1016/j.bbih.2024.100876","DOIUrl":"10.1016/j.bbih.2024.100876","url":null,"abstract":"<div><div>Children and adolescents exposed to severe stressors exhibit poorer health across the lifespan. However, decades of research evaluating the Stress-Buffering model suggests that social support can attenuate stressors' negative impacts. Psychoneuroimmunology research in this area has shifted from asking whether support buffers stress to when and why support would succeed (or fail) to confer protection. This article takes a lifecourse perspective and proposes that timing of support may shape support's protective value by defining the type of protection that is provided and its operating mechanisms. Specifically, it considers three temporal scenarios: support that occurs during, after, or before stressor exposure. When support intervenes at the same developmental stage as the stressor (concurrent support), buffering effects occur wherein support prevents the development of intermediary mechanisms that reflect or increase disease risk; when support is present at a developmental stage before stressor exposure (prior support), banking effects occur such that support intervenes indirectly by fortifying the individual with resilience-promoting characteristics that in turn prevents the development of intermediary mechanisms; finally, when support arrives at a developmental stage after stressor exposure (later support), counteracting effects occur such that support offsets the impacts of intermediary mechanisms on diseases. It further posits that a match between timing of support and the linkage of interest (e.g., the stressor-mechanism path vs. the mechanism-disease path) is necessary for successful protection. The present paper discusses these postulations, reviews nascent evidence, and proposes future directions.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100876"},"PeriodicalIF":3.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation 生命早期的肥胖环境整合了免疫代谢和表观遗传特征,对神经炎症起着调节作用
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-10-02 DOI: 10.1016/j.bbih.2024.100879
Perla Ontiveros-Ángel , Julio David Vega-Torres , Timothy B. Simon , Vivianna Williams , Yaritza Inostroza-Nives , Nashareth Alvarado-Crespo , Yarimar Vega Gonzalez , Marjory Pompolius , William Katzka , John Lou , Fransua Sharafeddin , Ike De la Peña , Tien Dong , Arpana Gupta , Chi T. Viet , Marcelo Febo , Andre Obenaus , Aarti Nair , Johnny D. Figueroa
{"title":"Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation","authors":"Perla Ontiveros-Ángel ,&nbsp;Julio David Vega-Torres ,&nbsp;Timothy B. Simon ,&nbsp;Vivianna Williams ,&nbsp;Yaritza Inostroza-Nives ,&nbsp;Nashareth Alvarado-Crespo ,&nbsp;Yarimar Vega Gonzalez ,&nbsp;Marjory Pompolius ,&nbsp;William Katzka ,&nbsp;John Lou ,&nbsp;Fransua Sharafeddin ,&nbsp;Ike De la Peña ,&nbsp;Tien Dong ,&nbsp;Arpana Gupta ,&nbsp;Chi T. Viet ,&nbsp;Marcelo Febo ,&nbsp;Andre Obenaus ,&nbsp;Aarti Nair ,&nbsp;Johnny D. Figueroa","doi":"10.1016/j.bbih.2024.100879","DOIUrl":"10.1016/j.bbih.2024.100879","url":null,"abstract":"<div><div>Childhood overweight/obesity is associated with stress-related psychopathology, yet the pathways connecting childhood obesity to stress susceptibility are poorly understood. We employed a systems biology approach with 62 adolescent Lewis rats fed a Western-like high-saturated fat diet (WD, 41% kcal from fat) or a control diet (CD, 13% kcal from fat). A subset of rats underwent a 31-day model of predator exposures and social instability (PSS). Effects were assessed using behavioral tests, DTI (diffusion tensor imaging), NODDI (neurite orientation dispersion and density imaging), 16S rRNA gene sequencing for gut microbiome profiling, hippocampal microglia analysis, and targeted gene methylation. Parallel experiments on human microglia cells (HMC3) examined how palmitic acid influences cortisol-related inflammatory responses.</div><div>Rats exposed to WD and PSS exhibited deficits in sociability, increased fear/anxiety-like behaviors, food consumption, and body weight. WD/PSS altered hippocampal microstructure (subiculum, CA1, dentate gyrus), and microbiome analysis showed a reduced abundance of members of the phylum <em>Firmicutes</em>. WD/PSS synergistically promoted neuroinflammatory changes in hippocampal microglia, linked with microbiome shifts and altered <em>Fkbp5</em> expression/methylation. In HMC3, palmitate disrupted cortisol responses, affecting morphology, phagocytic markers, and cytokine release, partially mediated by FKBP5.</div><div>This study identifies gene-environment interactions that influence microglia biology and may contribute to the connection between childhood obesity and stress-related psychopathology later in life.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100879"},"PeriodicalIF":3.7,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural and immune interactions linking early life stress and anhedonia 将早期生活压力和失乐症联系起来的神经和免疫相互作用
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-09-30 DOI: 10.1016/j.bbih.2024.100881
Rachel Deanna Phillips
{"title":"Neural and immune interactions linking early life stress and anhedonia","authors":"Rachel Deanna Phillips","doi":"10.1016/j.bbih.2024.100881","DOIUrl":"10.1016/j.bbih.2024.100881","url":null,"abstract":"<div><div>Early experiences of stress and adversity are associated with blunted reward sensitivity and altered reward learning. Meanwhile, anhedonia is characterized by impairments in reward processing, including motivation, effort, and pleasure. Early life stress (ELS) and anhedonia share psychological, behavioral, and neurobiological correlates, and the system-level interactions that give rise to anhedonia have yet to be fully appreciated. The proposed framework uses a multilevel, multisystem approach to aid in understanding neural-immune interactions that link ELS and anhedonia. The interactions linking anhedonia and ELS presented here include reduced reward sensitivity, alterations in hypothalamic-pituitary-adrenal (HPA) axis response, elevated inflammatory cytokines or physiological markers of stress, and blunted reward circuitry functioning along the mesocorticolimbic pathway. The clinical implications and areas for future research are also discussed. Ultimately, this research may inform the development of more specific and individualized treatments for anhedonia.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100881"},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nerve agent exposure and physiological stress alter brain microstructure and immune profiles after inflammatory challenge in a long-term rat model of Gulf War Illness 在长期海湾战争病大鼠模型中,神经毒剂暴露和生理应激改变了炎症挑战后的大脑微结构和免疫特征
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-09-30 DOI: 10.1016/j.bbih.2024.100878
Chia-Hsin Cheng , Yi Guan , Vidhi P. Chiplunkar , Farzad Mortazavi , Maria L. Medalla , Kimberly Sullivan , James P. O'Callaghan , Bang-Bon Koo , Kimberly A. Kelly , Lindsay T. Michalovicz
{"title":"Nerve agent exposure and physiological stress alter brain microstructure and immune profiles after inflammatory challenge in a long-term rat model of Gulf War Illness","authors":"Chia-Hsin Cheng ,&nbsp;Yi Guan ,&nbsp;Vidhi P. Chiplunkar ,&nbsp;Farzad Mortazavi ,&nbsp;Maria L. Medalla ,&nbsp;Kimberly Sullivan ,&nbsp;James P. O'Callaghan ,&nbsp;Bang-Bon Koo ,&nbsp;Kimberly A. Kelly ,&nbsp;Lindsay T. Michalovicz","doi":"10.1016/j.bbih.2024.100878","DOIUrl":"10.1016/j.bbih.2024.100878","url":null,"abstract":"<div><div>Gulf War Illness (GWI) is a disorder experienced by many veterans of the 1991 Gulf War, with symptoms including fatigue, chronic pain, respiratory and memory problems. Exposure to toxic chemicals during the war, such as oil well fire smoke, pesticides, physiological stress, and nerve agents, is thought to have triggered abnormal neuroinflammatory responses that contribute to GWI. Previous studies have examined the acute effects of combined physiological stress and chemical exposures using GWI rodent models and presented findings related to neuroinflammation and changes in diffusion magnetic resonance imaging (MRI) measures, suggesting a neuroimmune basis for GWI. In the current study, using <em>ex vivo</em> MRI, cytokine mRNA expression, and immunohistological analyses of brain tissues, we examined the brain structure and immune function of a chronic rat model of GWI. Our data showed that a combination of long-term corticosterone treatment (to mimic high physiological stress) and diisopropyl fluorophosphate exposure (to mimic sarin exposure) primed the response to subsequent systemic immune challenge with lipopolysaccharide resulting in elevations of multiple cytokine mRNAs, an increased activated glial population, and disrupted brain microstructure in the cingulate cortex and hippocampus compared to control groups. Our findings support the critical role of neuroinflammation, dysregulated glial activation, and their relationship to disrupted brain microstructural integrity in the pathophysiology of <span>GWI</span> and highlight the unique consequences of long-term combined exposures on brain biochemistry and structural connectivity.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100878"},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What can the psychoneuroimmunology of yoga teach us about depression's psychopathology? 瑜伽的心理神经免疫学对抑郁症的精神病理学有何启示?
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-09-30 DOI: 10.1016/j.bbih.2024.100877
Carola Chiarpenello, Katja Brodmann
{"title":"What can the psychoneuroimmunology of yoga teach us about depression's psychopathology?","authors":"Carola Chiarpenello,&nbsp;Katja Brodmann","doi":"10.1016/j.bbih.2024.100877","DOIUrl":"10.1016/j.bbih.2024.100877","url":null,"abstract":"<div><div>Depression, the most prevailing mental health condition, remains untreated in over 30% of patients. This cluster presents with sub-clinical inflammation. Investigations trialling anti-inflammatory medications had mixed results. The lack of results may result from inflammation's complexity and targeting only a few of depression's abnormal pathways. Mind-body therapies' biological and neuro-imaging studies offer valuable insights into depression psychopathology. Interestingly, mind-body therapies, like yoga, reverse the aberrant pathways in depression. These aberrant pathways include decreased cognitive function, interoception, neuroplasticity, salience and default mode networks connectivity, parasympathetic tone, increased hypothalamic-pituitary-adrenal (HPA) axis activity, and metabolic hyper/hypofunction. Abundant evidence found yogic techniques improving self-reported depressive symptoms across various populations. Yoga may be more effective in treating depression in conjunction with pharmacological and cognitive therapies. Yoga's psychoneuroimmunology teaches us that reducing allostatic load is crucial in improving depressive symptoms. Mind-body therapies promote parasympathetic tone, downregulate the HPA axis, reduce inflammation and boost immunity. The reduced inflammation promotes neuroplasticity and, subsequently, neurogenesis. Improving interoception resolves the metabolic needs prediction error and restores homeostasis. Additionally, by improving functional connectivity within the salience network, they restore the dynamic switching between the default mode and central executive networks, reducing rumination and mind-wandering. Future investigations should engineer therapies targeting the mechanisms mentioned above. The creation of multi-disciplinary health teams offering a combination of pharmacological, gene, neurofeedback, behavioural, mind-body and psychological therapies may treat treatment-resistant depression.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"42 ","pages":"Article 100877"},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifestyle score is associated with cellular immune profiles in healthy Tanzanian adults 生活方式评分与坦桑尼亚健康成年人的细胞免疫特征有关
IF 3.7
Brain, behavior, & immunity - health Pub Date : 2024-09-20 DOI: 10.1016/j.bbih.2024.100863
Jeremia J. Pyuza , Marloes M.A.R. van Dorst , Koen Stam , Linda Wammes , Marion König , Vesla I. Kullaya , Yvonne Kruize , Wesley Huisman , Nikuntufya Andongolile , Anastazia Ngowi , Elichilia R. Shao , Alex Mremi , Pancras C.W. Hogendoorn , Sia E. Msuya , Simon P. Jochems , Wouter A.A. de Steenhuijsen Piters , Maria Yazdanbakhsh
{"title":"Lifestyle score is associated with cellular immune profiles in healthy Tanzanian adults","authors":"Jeremia J. Pyuza ,&nbsp;Marloes M.A.R. van Dorst ,&nbsp;Koen Stam ,&nbsp;Linda Wammes ,&nbsp;Marion König ,&nbsp;Vesla I. Kullaya ,&nbsp;Yvonne Kruize ,&nbsp;Wesley Huisman ,&nbsp;Nikuntufya Andongolile ,&nbsp;Anastazia Ngowi ,&nbsp;Elichilia R. Shao ,&nbsp;Alex Mremi ,&nbsp;Pancras C.W. Hogendoorn ,&nbsp;Sia E. Msuya ,&nbsp;Simon P. Jochems ,&nbsp;Wouter A.A. de Steenhuijsen Piters ,&nbsp;Maria Yazdanbakhsh","doi":"10.1016/j.bbih.2024.100863","DOIUrl":"10.1016/j.bbih.2024.100863","url":null,"abstract":"<div><div>Immune system and vaccine responses vary across geographical locations worldwide, not only between high and low-middle income countries (LMICs), but also between rural and urban populations within the same country. Lifestyle factors such as housing conditions, exposure to microorganisms and parasites and diet are associated with rural-and urban-living. However, the relationships between these lifestyle factors and immune profiles have not been mapped in detail. Here, we profiled the immune system of 100 healthy Tanzanians living across four rural/urban areas using mass cytometry. We developed a lifestyle score based on an individual's household assets, housing condition and recent dietary history and studied the association with cellular immune profiles. Seventeen out of 80 immune cell clusters were associated with living location or lifestyle score, with eight identifiable only using lifestyle score. Individuals with low lifestyle score, most of whom live in rural settings, showed higher frequencies of NK cells, plasmablasts, atypical memory B cells, T helper 2 cells, regulatory T cells and activated CD4<sup>+</sup> T effector memory cells expressing CD38, HLA-DR and CTLA-4. In contrast, those with high lifestyle score, most of whom live in urban areas, showed a less activated state of the immune system illustrated by higher frequencies of naïve CD8<sup>+</sup> T cells. Using an elastic net machine learning model, we identified cellular immune signatures most associated with lifestyle score. Assuming a link between these immune profiles and vaccine responses, these signatures may inform us on the cellular mechanisms underlying poor responses to vaccines, but also reduced autoimmunity and allergies in low- and middle-income countries.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"41 ","pages":"Article 100863"},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信