Brain, behavior, & immunity - health最新文献

{"title":"Acute and chronic nasal inflammation induces lymphangiogenesis in the olfactory mucosa in mice","authors":"Suzuho Komaki ,&nbsp;Ryuichi Imai ,&nbsp;Yuzuki Sugimoto ,&nbsp;Rei Settsu ,&nbsp;Aki Obara ,&nbsp;Atsuyoshi Shimada ,&nbsp;Robert Dantzer ,&nbsp;Geoffroy Laumet ,&nbsp;Fumiaki Imamura ,&nbsp;Sanae Hasegawa-Ishii","doi":"10.1016/j.bbih.2025.101119","DOIUrl":"10.1016/j.bbih.2025.101119","url":null,"abstract":"<div><h3>Background</h3><div>Lymphangiogenesis, the formation of new lymphatic vessels, is primarily driven by VEGF-C-mediated activation of VEGFR-3 and plays a critical role in immune regulation and tissue repair. Although lymphangiogenesis has been well documented in various inflamed tissues, its occurrence and spatiotemporal characteristics in the olfactory mucosa during nasal inflammation remain poorly understood. To address this, we investigated the localization and development of lymphatic vessels in a mouse model of both acute and chronic nasal inflammation.</div></div><div><h3>Methods</h3><div>Acute inflammation was induced by intranasal administration of lipopolysaccharide (LPS; 10 μg per nostril) in 8-week-old male mice, with saline-treated mice as controls. Behavioral tests were conducted at 24 and 48 h post-administration. Nasal tissues were collected at multiple time points up to four weeks. Cytokine expression was analyzed by quantitative RT-PCR, and VEGF levels were quantified using ELISA. Immune cell infiltration and lymphatic vessel localization were assessed histologically using markers such as Lyve-1, VEGFR-3, and Prox-1. For the chronic inflammation model, mice received unilateral intranasal LPS or saline administration three times per week for 10 weeks, followed by histological analysis of lymphatic remodeling.</div></div><div><h3>Results</h3><div>Mice showed transient reduction in food and water intake and body weight, some aspects of sickness behavior within 24 h, but did not display depression-like phenotypes at 24 and 48 h post-LPS, as measured by duration of immobility in the tail suspension test and forced swim test, and percent sucrose volume consumed in the sucrose preference test. LPS treatment induced a sustained inflammatory response, with elevated pro- and anti-inflammatory cytokine expression persisting for up to two weeks. Immune cell infiltration and lymphangiogenesis were localized to specific areas of the olfactory mucosa, particularly the inner regions of the first and second turbinates. These inflammatory hotspots exhibited increased expression of lymphatic markers, primarily due to proliferation of lymphatic endothelial cells. VEGF-C and VEGF-A levels were significantly upregulated following LPS treatment. In the chronic model, lymphangiogenesis became more widespread throughout the olfactory mucosa, and was accompanied by dense infiltration of CD11b + immune cells.</div></div><div><h3>Conclusions</h3><div>Nasal inflammation induces region-specific lymphangiogenesis during the acute phase, likely driven by local proliferation of lymphatic endothelial cells. Under chronic inflammatory conditions, both inflammation and lymphangiogenesis expand across the olfactory mucosa. Further studies are needed to elucidate the underlying molecular mechanisms and to determine the functional relevance of olfactory lymphangiogenesis.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101119"},"PeriodicalIF":3.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the neuroendocrine and psychological effects of acute everolimus administration in healthy male participants","authors":"Lucie Jacquet ,&nbsp;Anna Lena Friedel ,&nbsp;Elisa Orth ,&nbsp;Nathalie Reiser ,&nbsp;Tina Hörbelt-Grünheidt ,&nbsp;Sophie Wiczoreck ,&nbsp;Oliver Witzke ,&nbsp;Manfred Schedlowski ,&nbsp;Marie Jakobs","doi":"10.1016/j.bbih.2025.101120","DOIUrl":"10.1016/j.bbih.2025.101120","url":null,"abstract":"<div><div>Previous experimental studies have shown that immunosuppressive mechanistic target of rapamycin inhibitors can induce neuropsychological changes, such as anxiety and depression, in healthy rodents. Furthermore, psychiatric conditions including anxiety have been reported in transplant patients and healthy subjects receiving the mechanistic target of rapamycin inhibitor everolimus. Thus, the present study aimed to further investigate the potentially dose-dependent neuroendocrine and psychological adverse side effects of acute everolimus intake in healthy male subjects. To this end, P70S6 kinase and Akt expression and phosphorylation in peripheral mononuclear blood cells as well as plasma and saliva cortisol, plasma noradrenaline and plasma dehydroepiandrosterone sulfate have been evaluated via western blotting and ELISA. State anxiety and depression have been assessed using questionnaires. Administering 2.5 mg of everolimus four times significantly increased blood peak levels. Additionally, acute everolimus intake led to decreased P70S6 kinase and slightly increased Akt phosphorylation, while protein expression remained unregulated. However, no effects on neuroendocrine parameters including cortisol, noradrenaline and dehydroepiandrosterone sulfate have been reported. Consistent with these findings, acute everolimus administration had no impact on psychological parameters, such as anxiety and depression. Overall, the present study demonstrated that the acute administration of 2.5 mg everolimus in healthy men does not lead to neuroendocrine or psychological adverse side effects. However, as other studies have reported neuroendocrine alterations as well as anxiety- and depression-like symptoms at lower everolimus doses, these findings should be further verified to determine whether everolimus induces psychiatric side effects in a dose-dependent manner.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101120"},"PeriodicalIF":3.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Break free from cognitive impairment: The magic of exercise-induced molecules","authors":"Wenbo Liu ,&nbsp;Hui Zhang ,&nbsp;Qiuting Zeng ,&nbsp;Wenlan Cai ,&nbsp;Yunfeng Rui ,&nbsp;Jie Sun","doi":"10.1016/j.bbih.2025.101117","DOIUrl":"10.1016/j.bbih.2025.101117","url":null,"abstract":"","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101117"},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverted “u-shaped” association of cold-water immersion frequency with mental health and upper respiratory tract infection: a cross-sectional study","authors":"Jan Czarnecki ,&nbsp;Łukasz Mokros","doi":"10.1016/j.bbih.2025.101118","DOIUrl":"10.1016/j.bbih.2025.101118","url":null,"abstract":"<div><h3>Introduction</h3><div>Evidence for a link between cold-water immersion (CWI) and health benefits remains scarce. The aim of this study was to verify whether CWI and its frequency is associated with mental health indices, duration of upper respiratory tract infection (URTI) and duration of sick leave (SL) taken due to URTI.</div></div><div><h3>Methods</h3><div>Data on N = 732 polar plungers and N = 501 controls was collected via the Internet in June 2022. The following self-reported methods were included: 28-item General Health Questionnaire (GHQ-28) comprising four subscales (somatic symptoms, anxiety and insomnia, social dysfunction, and depressive symptoms), URTI and SL durations were represented as a number of days. The statistical analysis involved analysis of covariance and linear regression controlled for confounding variables: sex, age, multimorbidity, temperament and mindfulness.</div></div><div><h3>Results</h3><div>Polar plungers declared better mental health status, shorter URTIs and SLs. The increase in frequency of CWI up to twice per week was associated with a decrease in general mental health index (effect size sR = −0.164), shortening of URTIs (sR = −0.144), and SLs (sR = −0.145). Further increase in the frequency was linked to worsening of the results. CWIs twice per week were related to the shortest URTIs (B = −4.431, p &lt; 0.001), shortest SLs (B = −2.606, p &lt; 0.001), and lowest depressive symptoms score (B = −1.057, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Regular performance of CWI may be related to better mental health, and immunity against URTI in a dose-related manner. These relationships resembled an inverted u-shaped curve and were independent of confounding parameters. Further studies are required to determine whether CWI could be a cost-effective health intervention.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101118"},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astroglia-mediated neuroinflammation as a putative mechanism of neurological outcomes in COVID-19? Insights from a Brazilian cohort","authors":"Ethiane Segabinazi ,&nbsp;Fernando R. Tocantins ,&nbsp;Talita Glaser ,&nbsp;Tamires Maglio ,&nbsp;Nathalia C. Oliveira ,&nbsp;Andrelissa Gorete Castanha ,&nbsp;Fabiele Baldino Russo ,&nbsp;Paulo Emílio Corrêa Leite ,&nbsp;Anita Brito ,&nbsp;Camila Vieira Molina ,&nbsp;Gabriela Prado Paludo ,&nbsp;Raquel de Oliveira Souza ,&nbsp;Simone Ravena Maia Alves ,&nbsp;Marielton dos Passos Cunha ,&nbsp;Henning Ulrich ,&nbsp;Edison Luiz Durigon ,&nbsp;Paola Minoprio ,&nbsp;Patricia C.B. Beltrão-Braga","doi":"10.1016/j.bbih.2025.101115","DOIUrl":"10.1016/j.bbih.2025.101115","url":null,"abstract":"<div><div>NeuroCOVID-19 has emerged as a significant global health concern, presenting a wide spectrum of neurological manifestations, including headaches, brain fog and anosmia. While mounting evidence indicates that SARS-CoV-2 infection compromises central nervous system (CNS) function, the precise processes underlying these effects remain incompletely understood. Although neurons have been extensively studied, astrocytes – critical regulators of brain homeostasis - have been largely overlooked in this context. In this study, we position astrocytes as central players in the neuropathological landscape of neuroCOVID-19, challenging their traditionally supportive role. We evaluated the frequent neurological symptoms in a Brazilian cohort of COVID-19 patients and investigated whether SARS-CoV-2 infection of cortical astrocytes induces neuroinflammation, glutamatergic imbalance, vasoregulatory disruption, and apoptosis as likely pathogenic processes. Among 162 COVID-19-positive patients, headache (53.09 %), brain fog (42.15 %), and anosmia (38.72 %) were the most commonly reported symptoms. Using human-induced pluripotent stem cell (hiPSC)-derived astrocytes, we found that SARS-CoV-2 infection promotes a pronounced pro-inflammatory response, evidenced by elevated levels of IL-6, IL-15, and IL-4 in the culture supernatant. Infected astrocytes also showed reduced mRNA expression of <em>KLK1</em> and <em>EAAT1</em>, key genes involved in vasodilation and glutamate clearance, respectively. Additionally, a significant increase in cleaved caspase-3-positive cells indicated enhanced apoptosis. Overall, these findings demonstrate that SARS-CoV-2 disrupts astrocyte homeostatic functions, leading to neuroinflammation, excitatory neurotransmission dysregulation, and cell death that may, hypothetically, underlie the neurological sequelae of COVID-19. By reframing astrocytes as active protagonists, this study highlights their essential role in CNS vulnerability. It also suggests potential targets for the future investigation in the development of therapies against the neurological complications of COVID-19.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101115"},"PeriodicalIF":3.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in functional connectivity analyzed using MREG in patients with suspected autoimmune psychosis spectrum syndromes","authors":"Katharina von Zedtwitz ,&nbsp;Ludger Tebartz van Elst ,&nbsp;Isabelle Matteit ,&nbsp;Andrea Schlump ,&nbsp;Thomas Lange ,&nbsp;Kimon Runge ,&nbsp;Judith Weiser ,&nbsp;Kathrin Nickel ,&nbsp;Katharina Domschke ,&nbsp;Harald Prüss ,&nbsp;Alexander Rau ,&nbsp;Marco Reisert ,&nbsp;Simon J. Maier ,&nbsp;Bernd Feige ,&nbsp;Dominique Endres","doi":"10.1016/j.bbih.2025.101111","DOIUrl":"10.1016/j.bbih.2025.101111","url":null,"abstract":"<div><h3>Introduction</h3><div>In NMDA-R encephalitis, which is typically accompanied by psychotic symptoms, conventional magnetic resonance imaging (MRI) is often normal, despite widespread alterations in functional connectivity. This is the first functional connectivity study in psychiatric patients with suspected autoimmune psychosis (AP) spectrum syndromes.</div></div><div><h3>Methods</h3><div>Twenty-eight patients with suspected AP spectrum syndromes who were selected according to the concept of autoimmune psychiatric syndromes (APS) and 28 matched healthy controls (HCs) were examined with ultrafast functional MRI using magnetic resonance encephalography (MREG). Patients were positive for either well-characterized or novel central nervous system antibodies or well-characterized systemic antibodies with autoimmune brain involvement. MREG data were processed using “Analysis of Functional NeuroImages” (AFNI) with the “Functional And Tractographic Connectivity Analysis AFNI toolbox” to analyze connectivity across 170 regions, yielding an analysis of 5995 evaluable connectivities.</div></div><div><h3>Results</h3><div>After correction for multiple testing, functional connectivity between the left middle cingulate/paracingulate gyri and the right insula (p_adj = 0.025) was significantly reduced in the patient group compared to HCs. Exploratory analyses revealed widespread global functional connectivity alterations in 226 of all connections (corresponding to 3.8 %). Notably, of these altered connections, 99 % showed reduced connectivity, while 1 % showed hyperconnectivity. The medial pulvinar of the left thalamus emerged as the most disconnected hub with altered connectivity to 33 other regions. Overall, 46 % of all analyzed regions exhibited at least one altered functional connectivity, with 19 % of hubs located in the cerebellum, 11 % in the frontal brain, and 9 % in the thalami. After correction for multiple comparisons, increased connectivity between the left insula and the left superior temporal gyrus correlated with the Beck Depression Inventory scores (p_adj = 0.043).</div></div><div><h3>Discussion</h3><div>Patients with suspected AP spectrum syndromes exhibit altered insular functional connectivity associated with the severity of depressive symptoms. Broader changes identified via hypothesis-generating analyses highlighted major hubs in the cerebellum, frontal brain, and thalamus. These findings suggest that functional MRI may serve as an additional tool for detecting patients with AP/APS. Future studies in more homogeneous autoimmune-mediated patient groups may help delineate specific connectivity signatures in functional networks.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101111"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High dietary phosphate intake induces anxiety in normal male mice","authors":"Pavel Yanev ,&nbsp;Thomas A. Ujas ,&nbsp;Han-Kyul Kim ,&nbsp;Teppei Fujikawa ,&nbsp;Noriyoshi Isozumi ,&nbsp;Eiichiro Mori ,&nbsp;Jadwiga Turchan-Cholewo ,&nbsp;Connor Stuart ,&nbsp;Rowan Sturgill ,&nbsp;Shari G. Birnbaum ,&nbsp;Ann M. Stowe ,&nbsp;Wanpen Vongpatanasin","doi":"10.1016/j.bbih.2025.101112","DOIUrl":"10.1016/j.bbih.2025.101112","url":null,"abstract":"<div><h3>Background</h3><div>Diet is increasingly recognized as an important risk factor for mental health. Inorganic phosphate (Pi) is currently used as a flavor enhancer or preservative at an unregulated amount in the western diet despite evidence that excessive dietary Pi intake associates with metabolic and cardiovascular disorders. The impact of high Pi on brain function remains poorly understood. This study aimed to evaluate the effects of chronic consumption of high dietary phosphate on behavior, neurovascular health, and neuroimmune populations, and cortical gene expression in key brain regions associated with emotional regulation.</div></div><div><h3>Methods</h3><div>Adult C57BL/6 male mice were fed either a normal phosphate (NP) or high phosphate (HP) diet for 12 weeks. Behavioral assessments included the open field test (OFT) and fear conditioning. Histological analyses assessed neuronal densities and vascularization. Flow cytometry quantified brain-resident immune cell populations and microglia. Unbiased analysis of hippocampal gene expression was performed using RNA sequencing (RNA-Seq).</div></div><div><h3>Results</h3><div>HP-fed mice exhibited increased anxiety-like behaviors compared to NP-fed controls, as indicated by increased thigmotaxis (i.e., more time close to the walls and, consequently, less time spent in the central area, HP: 164 ± 61 vs. NP: 215 ± 54 s, <em>P</em> = 0.03) in the OFT and increased time freezing regardless of stimulus type during fear conditioning. Neuronal density is significantly decreased in the hypothalamus of HP-fed mice (21.9 % ± 4.5 % vs. 16.4 ± 2.9 %, <em>P</em> = 0.02) but without concomitant differences in brain vascularization. Immunophenotyping showed that HP-diet significantly reduced TCRβ⁺ T cells and NK1.1⁺ NK cells (both <em>P</em> &lt; 0.05), suggesting diet-induced alterations in neuroimmune homeostasis. RNA-Seq identified significant alterations in gene expression in the hippocampus, including upregulation of Neat1 and Stat3 and downregulation of Igf2, which are implicated in stress regulation, neurodegeneration, synaptic plasticity and immune system pathways.</div></div><div><h3>Conclusions</h3><div>Collectively, this study highlights that habitual consumption of high dietary phosphate in mice may induce chronic anxiety<em>,</em> accompanied by significant changes in the neuronal and brain-resident immune populations. The data point to a potential link between dietary Pi, neuroinflammation, and the pathogenesis of anxiety and depression in otherwise healthy young male mice. Given the prevalence of phosphate additives in processed foods, these findings have important public health implications supporting the regulation of Pi in the food industry.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101112"},"PeriodicalIF":3.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of exosomes in the pathogenesis and treatment of coronary heart disease with depression and/or anxiety","authors":"Jiecheng Huang ,&nbsp;Ying Piao ,&nbsp;Xin Jiang ,&nbsp;Jingjin Liu","doi":"10.1016/j.bbih.2025.101113","DOIUrl":"10.1016/j.bbih.2025.101113","url":null,"abstract":"<div><div>Coronary heart disease (CHD) patients have been found to also possess high anxiety and depression rates, which have been considered as significant risk factors for the disease. One possible underlying biological mechanism behind anxiety/depression being associated with CHD may be exosomes, extracellular vesicles produced by cells throughout the body. These exosomes contain various proteins and miRNAs that could exert a variety of physiological and pathological effects. However, the precise role they play in CHD with anxiety/depression has still not been fully elucidated. In this review, we summarized the current research on exosome involvement in the pathogenesis of CHD with anxiety/depression, particularly focusing on inflammatory responses, neuroendocrine signaling, sympathetic nervous system (SNS) regulation, platelet activation, and endothelial injury. In particular, for inflammatory responses, exosomes have been associated with increased pro-inflammatory cytokine release, such as interleukin (IL)-1β, while for neuroendocrine signaling, the miRNAs miR-135a-5p and miR-320a have been implicated in increasing glucocorticoid signaling. As for SNS regulation, exosome miRNAs are involved in downregulating Nrf2, leading to increased sympathetic nerve excitation, while inhibiting exosome production counteracts platelet activation, in turn lowering thrombosis risk for CHD. Endothelial dysfunction could be promoted by exosomes carrying miR-155. On the other hand, exosome contents exert beneficial effects that could be used for treatment strategies, such as miR-1246 alleviating hypoxia-induced myocardial tissue damage, as well as miR-188–3p lowering nigrostriatal autophagy. Overall, identifying the roles that exosomes play in CHD with concurrent anxiety/depression pathogenesis, as well as potential alleviation, may be greatly beneficial for formulating effective treatment strategies.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101113"},"PeriodicalIF":3.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic immune dysregulation in severe mental illness: Exaggerated innate and attenuated adaptive immune responses following SARS-CoV-2 vaccination","authors":"Tim Rietberg ,&nbsp;Kawtar El Abdellati ,&nbsp;Alexandre Lucas ,&nbsp;Margot Lemarinier ,&nbsp;Steven Fried ,&nbsp;Jean-Romain Richard ,&nbsp;Ryad Tamouza ,&nbsp;Violette Coppens ,&nbsp;Manuel Morrens ,&nbsp;Marion Leboyer ,&nbsp;Livia De Picker","doi":"10.1016/j.bbih.2025.101114","DOIUrl":"10.1016/j.bbih.2025.101114","url":null,"abstract":"<div><h3>Background</h3><div>Immune dysregulation in severe mental illness (SMI) is usually characterised using static measurements. As such, how the immune system of SMI patients responds to real-world challenges remains largely unknown. Prior studies suggest that patients may exhibit an exaggerated innate and attenuated adaptive immune response, but in vivo studies are lacking.</div></div><div><h3>Objectives</h3><div>This study aimed to assess immune responses to SARS-CoV-2 vaccination in SMI patients compared to non-psychiatric controls (NPCs). We investigated post-vaccination changes in cytokine and antibody levels, their associations, and secondary measures including tryptophan-kynurenine pathway metabolites and psychiatric symptoms.</div></div><div><h3>Methods</h3><div>We collected blood samples of 72 SMI patients and 127 NPCs before and after the first and second vaccine dose administrations to quantify cytokines (IL1β, IL6, IL8, IL10) and anti-SARS-CoV-2 antibodies (Spike, S1, S2, S1RBD, Nucleocapsid). We used linear mixed models to assess whether post-vaccination changes in biomarker levels differ between SMI patients and NPCs, and to evaluate associations among biomarkers.</div></div><div><h3>Results</h3><div>SMI patients showed significantly greater increases in IL1β (F(394.3) = 30.03, <em>P</em>_<em>FDR</em> &lt; 0.001) and IL8 (F(384.4) = 15.28, <em>P</em>_<em>FDR</em> = 0.005) levels following the first vaccine dose and smaller increases in Spike (F(508.7) = 8.58, <em>P</em>_<em>FDR</em> = 0.005), S1 (F(506.9) = 19.76, <em>P</em>_<em>FDR</em> &lt; 0.0001) and S2 (F(507.8) = 20.96, <em>P</em>_<em>FDR</em> &lt; 0.0001) antibody levels after two vaccine doses when compared to NPCs. Higher cytokine levels were associated with lower antibody response in SMI patients.</div></div><div><h3>Conclusion</h3><div>Our findings provide in vivo evidence for exaggerated innate and attenuated adaptive immune responses to vaccination in SMI patients. The study underscores the need for longitudinal, experimental approaches in immunopsychiatry to better characterise the dynamic dysregulation of both the innate and the adaptive immune system in this population.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101114"},"PeriodicalIF":3.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory predictors of Post-COVID fatigue","authors":"A. Nuber-Champier ,&nbsp;G. Breville ,&nbsp;P. Voruz ,&nbsp;I. Jacot de Alcântara ,&nbsp;P.H. Lalive ,&nbsp;G. Allali ,&nbsp;L. Benzakour ,&nbsp;K.-O. Lövblad ,&nbsp;O. Braillard ,&nbsp;M. Nehme ,&nbsp;M. Coen ,&nbsp;J. Serratrice ,&nbsp;J.-L. Reny ,&nbsp;J. Pugin ,&nbsp;I. Guessous ,&nbsp;B.N. Landis ,&nbsp;A. Cionca ,&nbsp;F. Assal ,&nbsp;J.A. Péron","doi":"10.1016/j.bbih.2025.101109","DOIUrl":"10.1016/j.bbih.2025.101109","url":null,"abstract":"<div><div>The biological mechanisms underlying objective and subjective fatigue in post-COVID syndrome remain unclear. This study investigates whether immune responses during the acute phase of SARS-CoV-2 infection predict fatigue dimensions 6–9 months post-infection. We analyzed serum immune markers from 54 hospitalized patients (mean age: 58.69 ± 10.90 yrs; female: 31 %) and assessed their association with chronic fatigue using general linear mixed models. Elevated levels of IL-1RA, IFNγ, TNFα, and monocyte percentage during acute infection predicted increased physical and total fatigue. Additionally, higher TNFα levels (r = −0.40, <em>p</em> = .019) correlated with reduced awareness of cognitive fatigue. These findings highlight the role of acute inflammation in the persistence of post-COVID fatigue.</div></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"49 ","pages":"Article 101109"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}