Brain tumor research and treatment最新文献

{"title":"Massive Hyperostotic Meningioma En Plaque Mimicking Fibrous Dysplasia.","authors":"Ju In Park, Chang Kyu Park, Bong Jin Park, Seok Keun Choi","doi":"10.14791/btrt.2023.0027","DOIUrl":"10.14791/btrt.2023.0027","url":null,"abstract":"<p><p>The authors report an extremely rare case of a massive hyperostotic meningioma en plaque, which had characteristics of unique bony growth. A 34-year-old man presented with a palpable solid mass in the left cranial region that had gradually grown in size with a broad base on the calvarium for 8 years. Radiologically, the area involved by the mass ranged from the sphenoid bone to the frontal, parietal, temporal, and occipital bones. Three-dimensional CT revealed multiple growing spiculate features on the inner and outer cranial surface. Even though the radiologic features resembled fibrous dysplasia, it was histologically found to be a type of meningioma.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 4","pages":"271-273"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcome of the Brain Metastases in Peri-Rolandic Area: Comparison Between Surgery and Stereotactic Radiosurgery.","authors":"Jun Hyeok Jung, Kawngwoo Park, Eun Young Kim, Chan-Jong Yoo, Gi-Taek Yee, Woo-Kyung Kim, Dong-Won Shin","doi":"10.14791/btrt.2023.0032","DOIUrl":"10.14791/btrt.2023.0032","url":null,"abstract":"<p><strong>Background: </strong>Brain metastases of peri-Rolandic area is crucial as it directly impacts the quality of life for cancer patients. Surgery or stereotactic radiosurgery (SRS) is considered for peri-Rolandic brain metastases as for other brain metastases. However, the benefit of each treatment modality on functional outcome has not been clearly defined for this tumor. The purpose of this study is to compare the functional course of each treatment and to suggest an effective treatment for patients' quality of life.</p><p><strong>Methods: </strong>Fifty-two patients who had undergone SRS or surgery for brain metastasis confirmed by enhanced MRI were enrolled retrospectively. Overall survival (OS), progression free survival (PFS), and functional outcomes were estimated using the Kaplan-Meier method, univariate, multivariate analysis, and Cox proportional hazards regression.</p><p><strong>Results: </strong>Median OS and PFS were 13.3 months and 8.9 months in our study population. Treatment modalities were not significant factors for OS and PFS. Extracranial systemic cancer progression was significant factor for both parameters (<i>p</i>=0.030 for OS and <i>p</i>=0.040 for PFS). Median symptom improvement (improvement of at least 1 grade after surgery compared to preoperative state) time was significantly shorter in surgery group than in the SRS group (10.5 days vs. 37.5 days, <i>p</i>=0.034).</p><p><strong>Conclusion: </strong>Surgery for brain metastases can contribute to a positive quality of life for the remaining duration of the patient's life.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 4","pages":"246-253"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Intracranial Ewing Sarcoma With <i>EWSR1-FLI1</i> Gene Translocation Mimicking a Meningioma and a Multidisciplinary Therapeutic Approach: A Case Report and Systematic Review of Literatures.","authors":"Changjun Hyun, Yeonju Lee, Ho Kang, Hyun Joo Park, Koung Jin Suh, Byung Se Choi, Gheeyoung Choe, Chae-Yong Kim","doi":"10.14791/btrt.2023.0030","DOIUrl":"10.14791/btrt.2023.0030","url":null,"abstract":"<p><p>Ewing sarcoma and peripheral primitive neuroectodermal tumor (ES/pPNET) is an undifferentiated malignant tumor that is most prevalent in children and young adults and often radiologically mimics a meningioma. A 38-year-old female patient visited our hospital with complaints of right-sided tinnitus, right hemiparesis, and imbalance. She underwent preoperative imaging and was subsequently diagnosed as having a meningioma on the petrous ridge. After partial resection, <i>EWSR1-FLI1</i> gene fusion was confirmed, and she was diagnosed with ES/pPNET. The tumor was successfully treated using a multidisciplinary approach of adjuvant chemo- and radiotherapy. This case is noteworthy because it is an extremely rare case of an intracranial ES/pPNET, and it is worth sharing our clinical experience that the tumor was successfully treated through a multidisciplinary therapeutic approach even though complete resection was not achieved.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 4","pages":"281-288"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Neurocognitive Impairment Following Chemoradiotherapy in Patients With High-Grade Glioma: Results of a Prospective Trial.","authors":"Prashasti Sharma,&nbsp;Partha Pratim Medhi,&nbsp;Apurba Kumar Kalita,&nbsp;Mouchumee Bhattacharyya,&nbsp;Jyotiman Nath,&nbsp;Gautam Sarma,&nbsp;Yanpothung Yanthan","doi":"10.14791/btrt.2023.0004","DOIUrl":"https://doi.org/10.14791/btrt.2023.0004","url":null,"abstract":"<p><strong>Background: </strong>High-grade gliomas (HGG) are highly fatal tumors despite advanced multimodality management. They are also associated with neurocognitive impairment, both due to disease pathology and treatment. We aimed to assess various risk factors responsible for neurocognitive decline in HGG patients undergoing adjuvant chemoradiation.</p><p><strong>Methods: </strong>Newly diagnosed HGG patients who underwent maximal safe resection were included. Patients received volumetric modulated arc therapy to a dose of 60 Gy in 30 fractions, along with concurrent temozolomide (TMZ) at a dose of 75 mg/m²/day orally; thereafter adjuvant TMZ (150-200 mg/m² for 5 days), given every 28 days for 6 to 8 cycles. The Mini-Mental State Examination questionnaire was used to measure cognitive impairment of each study patient at various time points. Cox regression model was used for univariate and multivariable analysis of data to establish possible risk factors.</p><p><strong>Results: </strong>Fifty-three patients were enrolled and analyzed. At a median follow-up of 15 months, 30 patients (56.6%) developed cognitive impairment, and 23 patients (43.4%) did not. On univariate analysis, HGG with WHO grade 4, glioblastoma and diffuse midline glioma histology, IDH-wild type, recursive partitioning analysis class IV/V, and only biopsy of primary tumor were significantly associated with neurocognitive impairment, but none of them were independent risk factors on multivariable analysis. Planning target volume and dose received by ipsilateral hippocampus were also significantly correlated with cognitive decline in HGG patients.</p><p><strong>Conclusion: </strong>Decline in neurocognitive functions in HGG patients is multifactorial and can be attributed to an amalgam of various tumor, patient, and treatment-related factors.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 3","pages":"183-190"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/3a/btrt-11-183.PMC10409617.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker.","authors":"Yu Jin Kim,&nbsp;Wooseok Choi,&nbsp;JeongMin Sim,&nbsp;Ju Won Ahn,&nbsp;JeongMan Park,&nbsp;Dongkil Kim,&nbsp;Ju-Yeon Jeong,&nbsp;Ji Min Lee,&nbsp;Kyunggi Cho,&nbsp;Jong-Seok Moon,&nbsp;Ju Hyung Moon,&nbsp;Kyoung Su Sung,&nbsp;Jaejoon Lim","doi":"10.14791/btrt.2023.0008","DOIUrl":"https://doi.org/10.14791/btrt.2023.0008","url":null,"abstract":"<p><strong>Background: </strong>Inflammasomes are key in the initiation of inflammatory responses and serve to defend the organism. However, when the immune system is imbalanced, these complexes contribute to tumor progression. The purpose of this study was to investigate the effect of non-canonical inflammasomes on glioma malignancy.</p><p><strong>Methods: </strong>We performed bioinformatics analysis to confirm the expression of canonical and non-canonical inflammasome-related molecules according to the degree of malignancy through immunohistochemical examination of glioma tissues obtained with patient consent from our institution.</p><p><strong>Results: </strong>Bioinformatics analysis confirmed that the expression levels of non-canonical inflammasome-related molecules were significantly higher in tumor tissues than in normal tissues, and they also increased according to malignancy, which adversely affected the survival rate. Furthermore, in gliomas, positive correlations were found between N-form gasdermin-D, a key molecule associated with the non-canonical inflammasome, and other related molecules, including NLRP3, caspase-1, caspase-4, and caspase-5. These results were verified by immunohistochemical examination of glioma tissues, and the expression levels of these molecules also increased significantly with increasing grade. In addition, the features of pyroptosis were confirmed.</p><p><strong>Conclusion: </strong>This study identified the potential of non-canonical inflammasomes as aggressiveness markers for gliomas and presented a perspective for improving glioma treatment.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 3","pages":"191-203"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/1e/btrt-11-191.PMC10409615.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Applications of 3D Printing and Standardization Issues.","authors":"Kyu Won Shim","doi":"10.14791/btrt.2023.0001","DOIUrl":"https://doi.org/10.14791/btrt.2023.0001","url":null,"abstract":"<p><p>The three-dimensional (3D) printing itself is not a novel technology, it is more than 30 years old. Stereolithographic (SLA) technology has been used as the first and popular technology for medical application of 3D printing. Since 1991 <i>Radiology</i> and <i>Plastic Surgery</i> have published articles about SLA for rapid prototyping anatomical 3D models. Medical applications of 3D printing have been popularizing and stabilizing so far. Implantable medical devices such as metal or absorbable implants, surgical guide systems, prosthesis and orthosis, and 3D anatomical models for normal or diseased anatomy have been developing and expanding its markets so far. There are many obstacles, such as insurance, authorization as a medical device, and lack of standards technology for further expansion of medical applications. Many technical specifications and guidelines for authorization as medical device have been published by regulatory bodies from many countries. Even though international standards for 3D printing have been developing more and more, there have been few standards for medical application of 3D printing. In this harsh environment academia, company, research institute, regulatory bodies, and government have been doing good job for the development of 3D printing industry.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 3","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/a2/btrt-11-159.PMC10409621.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10325337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Immediate Postoperative Prolactin Measurement in Female Prolactinoma Patients: Predicting Long-Term Remission After Complete Tumor Removal.","authors":"Gi Yeop Lee,&nbsp;Sun Ho Kim,&nbsp;Eui Hyun Kim","doi":"10.14791/btrt.2023.0023","DOIUrl":"https://doi.org/10.14791/btrt.2023.0023","url":null,"abstract":"<p><strong>Background: </strong>Transsphenoidal surgery is one of the important treatment options in the management of prolactinomas; however, complete resection of the tumor does not always lead to endocrinological remission. While many studies have investigated preoperative factors associated with surgical outcome, little has been known about the relationship between postoperative factors and long-term surgical outcomes; moreover, there is no consistency in results. The aim of this study was to demonstrate the reliability of immediate postoperative prolactin levels as predictors of long-term outcomes.</p><p><strong>Methods: </strong>A total of 105 female patients who underwent complete removal of their histologically confirmed prolactinomas were included, and their medical records were retrospectively reviewed. To evaluate the predictability of immediate postoperative prolactin levels for long-term remission, prolactin levels were measured at 2, 6, 12, 18, 24, 48, and 72 h after surgery.</p><p><strong>Results: </strong>From the 105 included patients, 95 (90.5%) and 10 (9.5%) belonged to the remission and non-remission groups, respectively. A significant difference was observed in the prolactin level measured 6 h after surgery between the remission and non-remission groups, and this difference stayed apparent until 72 h after surgery. We derived a cut-off value for every postoperative time point that showed a significant relationship with disease remission.</p><p><strong>Conclusion: </strong>Our study suggests that immediate postoperative measurement of prolactin levels is a reliable predictor of long-term remission and can contribute to early identification of patients who require adjuvant treatment after surgery.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 3","pages":"204-209"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/b0/btrt-11-204.PMC10409623.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramaximal Resection for Glioblastoma: Redefining the Extent of Resection Criteria and Its Impact on Survival.","authors":"Tae Hoon Roh,&nbsp;Se-Hyuk Kim","doi":"10.14791/btrt.2023.0012","DOIUrl":"https://doi.org/10.14791/btrt.2023.0012","url":null,"abstract":"<p><p>Glioblastomas (GBMs) are the most common and aggressive primary brain tumors, and despite advances in treatment, prognosis remains poor. The extent of resection has been widely recognized as a key factor affecting survival outcomes in GBM patients. The surgical principle of \"maximal safe resection\" has been widely applied to balance tumor removal and neurological function preservation. Historically, T1-contrast enhanced (T1CE) extent of resection has been the focus of research; however, the \"supramaximal resection\" concept has emerged, advocating for even greater tumor resection while maintaining neurological function. Recent studies have demonstrated potential survival benefits associated with resection beyond T1CE extent in GBMs. This review explores the developing consensus and newly established criteria for \"supramaximal resection\" in GBMs, with a focus on T2-extent of resection. Systematic reviews and meta-analyses on supramaximal resection are summarized, and the Response Assessment in Neuro-Oncology (RANO) resect group classification for extent of resection is introduced. The evolving understanding of the role of supramaximal resection in GBMs may lead to improved patient outcomes and more objective criteria for evaluating the extent of tumor resection.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 3","pages":"166-172"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/5b/btrt-11-166.PMC10409622.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10325336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yesterdays, Todays, and Tomorrows-Korean Society for Pediatric Neuro-Oncology<sup />.","authors":"Se Hoon Kim","doi":"10.14791/btrt.2023.0018","DOIUrl":"https://doi.org/10.14791/btrt.2023.0018","url":null,"abstract":"<p><p>In 2022, in celebration of the 20th anniversary of the Korean Society for Pediatric Neuron-Oncology (KSPNO), a commemorative meeting was held with former and current members. At the meeting, there was a special lecture for the retrospect of the Emeritus Professor Thad Ghim, one of the founders and the 1st president (2002-2003) of KSPNO. He celebrated the history and development of the KSPNO, along with the vision of our society. Especially he appreciated the efforts and endeavors of our senior members. In 2001, we started as \"Korean Pediatric Neuro-Oncological Study Group.\" The next year, we changed our name to \"Korean Society for Pediatric Neuro-Oncology (KSPNO).\" KSPNO emphasized the multidisciplinary approach to patient care. These efforts were strengthened by \"The National Cancer Moonshot Initiative\" since 2005. Now our society goes forward together with \"National Cancer Treatment Guideline Project and Childhood Cancer and Rare Disease Control Group Project.\" After all, we do not exist for ourselves, but for our sick children.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 3","pages":"177-182"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/05/btrt-11-177.PMC10409624.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Nontuberculous Mycobacterial Abscess Mimicking Brain Tumor in an Immunocompetent Patient.","authors":"Junho Jung,&nbsp;Ilyoung Shin,&nbsp;Younghee Choi","doi":"10.14791/btrt.2023.0019","DOIUrl":"https://doi.org/10.14791/btrt.2023.0019","url":null,"abstract":"<p><p>Nontuberculous mycobacteria (NTM) is a type of bacteria that typically infects the pulmonary system, and NTM-central nervous system (CNS) infection, which occurs in the brain, is a very rare disease. A 64-year-old female patient presented with seizures as the main symptom and was found to have a mass of less than 1 cm in the right temporal lobe with accompanying edema. Although diseases such as tumor metastasis and parasitic cyst were suspected, the patient underwent a surgical resection, and NTM-CNS infection with abscess was diagnosed through biopsy. Antibiotic treatment was initiated after surgery, and the patient has been followed up without any significant symptoms. In this report, we review a rare case of NTM-CNS infection and discuss the understanding and treatment of this disease.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"11 3","pages":"219-222"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/b8/btrt-11-219.PMC10409619.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}