Brain tumor research and treatment最新文献

{"title":"Meningioma With Partial and Spontaneous Regression of Peritumoral Edema on Long-Term Follow Up.","authors":"Bo-Seob Kim,&nbsp;Tae-Young Jung,&nbsp;Kyung-Sub Moon,&nbsp;In-Young Kim,&nbsp;Shin Jung","doi":"10.14791/btrt.2022.0040","DOIUrl":"https://doi.org/10.14791/btrt.2022.0040","url":null,"abstract":"<p><p>Spontaneous regression of meningioma is rarely observed. We report a one person of an incidentally diagnosed meningioma with a spontaneous regression. The 73-year-old female patient without symptoms showed the right sphenoid meningioma with peritumoral edema. The meningioma was incidentally diagnosed and followed up by MRI for 10 years. The tumor shrank with a decrease of edema on T2 MRI. The initial volume of 58.59 cm³, regressed to 37.16 cm³.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 4","pages":"275-278"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2e/30/btrt-10-275.PMC9650118.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40673061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaplastic Meningioma: Clinical Characteristics, Prognostic Factors and Survival Outcome.","authors":"Dong Ok Seo,&nbsp;Sang Woo Song,&nbsp;Young-Hoon Kim,&nbsp;Chang-Ki Hong,&nbsp;Jeong Hoon Kim","doi":"10.14791/btrt.2022.0030","DOIUrl":"https://doi.org/10.14791/btrt.2022.0030","url":null,"abstract":"<p><strong>Background: </strong>Anaplastic meningioma is very rare and is generally known to have a poor prognosis. However, due to its rarity, the relationship between clinical prognosis and prognostic factors is not clear. We analyzed the prognostic factors influencing survival outcomes of patients with anaplastic meningioma. Moreover, we analyzed on the progression pattern and the response to treatment about anaplastic meningioma.</p><p><strong>Methods: </strong>Retrospective review of 48 patients with diagnosis of World Health Organization (WHO) grade 3 meningioma was performed. According to diagnosis type, primary anaplastic meningioma was included in 28 cases and secondary anaplastic meningioma in 20 cases. Gross total resection was performed in 36 patients (75.0%), and 32 patients (66.7%) received adjuvant radiotherapy after tumor resection with confirmed WHO grade 3 meningioma. Kaplan-Meier survival curve and Cox proportional hazards modeling were used for outcome analysis.</p><p><strong>Results: </strong>The median progression-free survival (PFS) and overall survival (OS) were 13.9 months (95% confidence interval [CI], 8.8 to 19.1) and 56.9 months (95% CI, 24.1 to 89.7), respectively. Adjuvant radiotherapy was a robust prognostic factor for PFS and OS. Extent of resection and diagnosis type which appeared to be significant prognostic factors in univariate analysis were failed to prove statistical significance in multivariate analysis.</p><p><strong>Conclusion: </strong>Adjuvant radiotherapy is an essential treatment arm in patients with anaplastic meningiomas. Stereotactic radiosurgery seems to play an important role as a salvage treatment. But chemotherapy seems to have limited efficacy. Because of the disseminated nature of the disease, further investigations to improve survival outcome are needed.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 4","pages":"244-254"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/31/btrt-10-244.PMC9650123.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes of Endoscopic Endonasal Versus Transcranial Resections of Adult Craniopharyngioma: A Meta-Analysis.","authors":"Wardah Rafaqat,&nbsp;Mohammad Hamza Bajwa,&nbsp;Meher Angez,&nbsp;Syed Ather Enam","doi":"10.14791/btrt.2022.0014","DOIUrl":"https://doi.org/10.14791/btrt.2022.0014","url":null,"abstract":"<p><strong>Background: </strong>The endoscopic endonasal approach (EEA) has been gaining popularity for resection of adult craniopharyngiomas. However, the safety and effectiveness of the procedure in comparison to the traditional transcranial approach (TCA) remains unestablished as previous reviews are outdated.</p><p><strong>Methods: </strong>A literature search without language restriction was conducted in PubMed, Cochrane database, and Web of Science from conception to July 9, 2021. Cohort studies and case series that compared EEA with TCA and assessed postoperative complications, recurrence, and 30-day mortality were included. Articles, where data for adult populations could not be extracted or calculated, were excluded. Article selection and data extraction in a predesigned data extraction form were conducted in duplicate. Pooled participant data were included in a random-effects model.</p><p><strong>Results: </strong>The search yielded 227 articles, from which eight cohort studies containing 11,395 patients were included (EEA: 6,614 patients, TCA: 4,781 patients). Six studies were good quality and two were fair quality according to the Newcastle Ottawa Scale. There were significantly higher rates of cerebrospinal fluid leak (risk ratio [RR]=0.23, 95% confidence interval [CI] 0.17-0.32, <i>p</i><0.00001, I²=0%) and lower rates of postoperative hypopituitarism (RR=1.40, 95% CI 1.30-1.51, <i>p</i><0.00001, I²=0%), hydrocephalus (RR=6.95, 95% CI 5.78-8.36, <i>p</i><0.00001, I²=0%), visual impairment (RR=1.52, 95% CI 1.34-1.73, <i>p</i><0.00001, I²=0%), and 30-day mortality (RR=5.63, 95% CI 3.87-8.19, <i>p</i><0.00001, I²=0%) after EEA. Non-significant lower rates of postoperative diabetes insipidus (RR=1.12, 95% CI 0.78-1.61, <i>p</i>=0.53, I²=85%) and recurrence of tumor (RR=2.69, 95% CI 0.35-20.81, <i>p</i>=0.34, I²=47%) were seen after EEA.</p><p><strong>Conclusion: </strong>EEA may be associated with reduced postoperative hypopituitarism, hydrocephalus, visual impairment, and 30-day mortality and higher rates of cerebrospinal fluid leak. These findings do not account for differences in tumor size and extension between the EEA and TCA cohorts. Further research on patients with comparable tumor characteristics is required to fully assess outcomes.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 4","pages":"226-236"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/45/btrt-10-226.PMC9650119.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Microangiopathy Mimicking a High-Grade Glioma in Old Age: A Case Report.","authors":"Young Min Kwon,&nbsp;Song-Hee Han,&nbsp;Kyoung Su Sung,&nbsp;Young Jin Song","doi":"10.14791/btrt.2022.0021","DOIUrl":"https://doi.org/10.14791/btrt.2022.0021","url":null,"abstract":"<p><p>Cerebral microangiopathy (CM) has become a common disease related to improved neuroimaging modalities and an increased life expectancy. Intracerebral tumor-like mass lesions have rarely been reported in cases of cerebral amyloid angiopathy (CAA) in elderly patients. However, tumor-like mass lesions from CM without amyloid deposits have rarely been reported. These two angiopathies may have different pathogeneses and neuroimaging characteristics. Herein, we present the case of an 83-year-old man with CM mimicking a high-grade glioma. We described the possible pathogenesis and different neuroimaging features of CM compared to CAA.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 3","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/f7/btrt-10-195.PMC9353164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Metastases in Appendiceal Cancer: Comprehensive Review and Report of Rare Medullary Carcinoma Histology.","authors":"Charles Mackel,&nbsp;Harry Rosenberg,&nbsp;Hemant Varma,&nbsp;Rafael Vega,&nbsp;Martina Stippler","doi":"10.14791/btrt.2022.0019","DOIUrl":"https://doi.org/10.14791/btrt.2022.0019","url":null,"abstract":"<p><p>Appendiceal cancer is an extremely rare malignancy, and its metastatic spread to the brain is even more unusual. We describe a 47-year-old female who presented with a rare cerebral appendiceal carcinoma metastasis, a case that is further remarkable for representing the first histologic diagnosis of primary medullary carcinoma in the appendix. Based on a comprehensive review of the English literature using PubMed, Embase, and Google Scholar, only six other cases of cerebral appendiceal metastases have been described.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 3","pages":"200-205"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/b0/btrt-10-200.PMC9353166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments.","authors":"Jaehyun Ahn,&nbsp;Christopher Shin,&nbsp;Yeo Song Kim,&nbsp;Jae-Sung Park,&nbsp;Sin-Soo Jeun,&nbsp;Stephen Ahn","doi":"10.14791/btrt.2022.0010","DOIUrl":"https://doi.org/10.14791/btrt.2022.0010","url":null,"abstract":"<p><p>Over the last two decades, numerous studies have investigated the presence of human cytomegalovirus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few researchers have suggested the potential benefits of cytotoxic T lymphocyte or dendritic cell-based vaccines for recurrent or newly diagnosed glioblastoma patients, several studies did not at all agree with the existence of CMV in glioblastoma cells. In this review, we summarized the conflicting results and issues about the detection of CMV in glioblastoma or glioma patients. We also provided the clinical data of published and unpublished clinical trials using CMV-specific immunotherapy for glioblastomas.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 3","pages":"135-143"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/e7/btrt-10-135.PMC9353163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40683295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptomeningeal Spread at the Diagnosis of Glioblastoma Multiforme: A Case Report and Literature Review.","authors":"Cheolwon Jang,&nbsp;Byung-Kyu Cho,&nbsp;Sung Hwan Hwang,&nbsp;Hyung Jin Shin,&nbsp;Sang Hoon Yoon","doi":"10.14791/btrt.2022.0013","DOIUrl":"https://doi.org/10.14791/btrt.2022.0013","url":null,"abstract":"<p><p>Approximately two-thirds of glioblastoma (GBM) patients progress to leptomeningeal spread (LMS) within two years. While 90% of LMS cases are diagnosed during the progression and/or recurrence of GBM (defined as secondary LMS), LMS presentation at the time of GBM diagnosis (defined as primary LMS) is very rare. ¹⁸F-fluorodeoxy glucose positron emission tomography computed tomography (¹⁸F-FDG PET/CT) study helps to diagnose the multifocal spread of the malignant primary brain tumor. Our patient was a 31-year-old man with a tumorous lesion located in the right temporal lobe, a wide area of the leptomeninges, and spinal cord (thoracic 5/6, and lumbar 1 level) involvement as a concurrent manifestation. After the removal of the right temporal tumor, the clinical status progressed rapidly, showing signs of increased intracranial pressure and hydrocephalus caused by LMS. He underwent a ventriculoperitoneal shunt a week after craniotomy. During management, progression of cord compression, paraplegia, bone marrow suppression related to radiochemotherapy, intercurrent infections, and persistent ascites due to peritoneal metastasis of the LMS through the shunt system was observed. The patient finally succumbed to the disease nine months after the diagnosis of simultaneous GBM and LMS. The overall survival of primary LMS with GBM in our case was nine months, which is shorter than that of secondary LMS with GBM. The survival period after the diagnosis of LMS did not seem to be significantly different between primary and secondary LMS. To determine the prognostic effect and difference between primary and secondary LMS, further cooperative studies with large-volume data analysis are warranted.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 3","pages":"183-189"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/05/btrt-10-183.PMC9353161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Update on Neurosurgical Management of Brain Metastasis.","authors":"Jihwan Yoo,&nbsp;Hun Ho Park,&nbsp;Seok-Gu Kang,&nbsp;Jong Hee Chang","doi":"10.14791/btrt.2022.0023","DOIUrl":"https://doi.org/10.14791/btrt.2022.0023","url":null,"abstract":"<p><p>Brain metastasis (BM), classified as a secondary brain tumor, is the most common malignant central nervous system tumor whose median overall survival is approximately 6 months. However, the survival rate of patients with BMs has increased with recent advancements in immunotherapy and targeted therapy. This means that clinicians should take a more active position in the treatment paradigm that passively treats BMs. Because patients with BM are treated in a variety of clinical settings, treatment planning requires a more sophisticated decision-making process than that for other primary malignancies. Therefore, an accurate prognostic prediction is essential, for which a graded prognostic assessment that reflects next-generation sequencing can be helpful. It is also essential to understand the indications for various treatment modalities, such as surgical resection, stereotactic radiosurgery, and whole-brain radiotherapy and consider their advantages and disadvantages when choosing a treatment plan. Surgical resection serves a limited auxiliary function in BM, but it can be an essential therapeutic approach for increasing the survival rate of specific patients; therefore, this must be thoroughly recognized during the treatment process. The ultimate goal of surgical resection is maximal safe resection; to this end, neuronavigation, intraoperative neuro-electrophysiologic assessment including evoked potential, and the use of fluorescent materials could be helpful. In this review, we summarize the considerations for neurosurgical treatment in a rapidly changing treatment environment.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 3","pages":"164-171"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/81/btrt-10-164.PMC9353165.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Huge Radiation-Induced Cavernous Hemangioma Following Stereotactic Radiosurgery for Meningioma: A Case Report.","authors":"Sang Hwa Lee,&nbsp;Kyung Hwan Kim,&nbsp;Han-Joo Lee,&nbsp;Hyon-Jo Kwon,&nbsp;Seung-Won Choi,&nbsp;Seon-Hwan Kim,&nbsp;Hyeon-Song Koh,&nbsp;Jin-Young Youm","doi":"10.14791/btrt.2022.0020","DOIUrl":"https://doi.org/10.14791/btrt.2022.0020","url":null,"abstract":"<p><p>Radiation-induced cavernous hemangiomas (RICHs) have been increasingly reported as a late complication after conventional radiotherapy. RICH after stereotactic radiosurgery (SRS) is extremely rare and the few cases have been reported to demonstrate their properties. A 72-year-old female patient presented with progressive neurologic deficits. She underwent tumor surgery for meningioma 13 years ago and two times of SRS for treating a residual tumor. Newly-developed mass was 4.3 cm-sized heterogeneously enhancing mass with severe cerebral edema. She underwent surgical resection and the histologic examinations revealed organized hematoma. Finally, it was diagnosed as a RICH following SRS based on radiological and histological findings and a history of multiple radiosurgeries. Clinical, radiological, and histological features of a RICH following SRS were discussed in this report.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 3","pages":"190-194"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/4d/btrt-10-190.PMC9353168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Outcomes and Predictors for Recurrence of Surgically Treated Brain Metastasis From Non-Small Cell Lung Cancer.","authors":"Joonho Byun,&nbsp;Jong Hyun Kim,&nbsp;Moinay Kim,&nbsp;Seungjoo Lee,&nbsp;Young-Hoon Kim,&nbsp;Chang Ki Hong,&nbsp;Jeong Hoon Kim","doi":"10.14791/btrt.2022.0016","DOIUrl":"https://doi.org/10.14791/btrt.2022.0016","url":null,"abstract":"<p><strong>Background: </strong>There are numerous factors to consider in deciding whether to undergo surgical treatment for brain metastasis from lung cancer. Herein, we aimed to analyze the survival outcome and predictors of recurrence of surgically treated brain metastasis from non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>A total of 197 patients with brain metastasis from NSCLC who underwent microsurgery were included in this study.</p><p><strong>Results: </strong>A total of 114 (57.9%) male and 83 (42.1%) female patients with a median age of 59 years (range, 27-79) was included in this study. The median follow-up period was 22.7 (range, 1-126) months. The 1-year and 2-year overall survival (OS) rates of patients with brain metastasis secondary to NSCLC were 59% and 43%, respectively. The 6-month and 1-year progression-free survival (PFS) rates of local recurrence were 80% and 73%, respectively, whereas those of distant recurrence were 84% and 63%, respectively. <i>En-bloc</i> resection of tumor resulted in better PFS for local recurrence (1-year PFS: 79% vs. 62%, <i>p</i>=0.02). Ventricular opening and direct contact between the tumor and the subarachnoid space were not associated with distal recurrence and leptomeningeal seeding. The difference in PFS of local recurrence according to adjuvant resection bed irradiation was not significant. Moreover, postoperative whole-brain irradiation did not show a significant difference in PFS of distant recurrence. In multivariate analysis, only <i>en-bloc</i> resection was a favorable prognostic factor for local recurrence. Contrastingly, multiple metastasis was a poor prognostic factor for distant recurrence.</p><p><strong>Conclusion: </strong><i>En-bloc</i> resection may reduce local recurrence after surgical resection. Ventricular opening and contact between the tumor and subarachnoid space did not show a statistically significant result for distant recurrence and leptomeningeal seeding. Multiple metastasis was only meaningful factor for distant recurrence.</p>","PeriodicalId":72453,"journal":{"name":"Brain tumor research and treatment","volume":"10 3","pages":"172-182"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/51/btrt-10-172.PMC9353167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40671367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}