Brain disorders (Amsterdam, Netherlands)最新文献

{"title":"The prevalence of bruxism in children with profound intellectual and multiple disabilities; a systematic review and meta-analysis","authors":"","doi":"10.1016/j.dscb.2024.100131","DOIUrl":"10.1016/j.dscb.2024.100131","url":null,"abstract":"<div><h3>Introduction</h3><p>Bruxism is a repetitive masticatory muscle activity that may cause substantial morbidity and reduce the quality of life in children with profound intellectual and multiple disabilities. Assessment methods most commonly used were caregiver reporting and dental examination, This systematic review with meta-analysis aims to determine the prevalence of bruxism in children with profound intellectual and multiple disabilities and to describe the currently used assessment methods for bruxism in this population.</p></div><div><h3>Methods</h3><p>We conducted a systematic review and meta-analysis using a multi-component search strategy. We used a random effects model to calculate the prevalence and 95 % confidence intervals for each study, for all studies combined, and specifically for Rett syndrome (RS), cerebral palsy (CP), Down syndrome (DS), and “other disorders (primarily Angelman syndrome and Prader–Willi syndrome).”</p></div><div><h3>Results</h3><p>The prevalence for the entire group based on a random effects model was found to be 49 % (95 %CI 41–57 %) with high heterogeneity (<em>I</em>² = 93 %, <em>p</em> &lt; 0.01), for RS 74 % (95 %CI 53–88 %, <em>I</em>² = 84 %, <em>p</em> &lt; 0.01), CP 48 % (95 %CI 38–57 %, <em>I</em>² = 86 %, <em>p</em> &lt; 0.01), DS 40 % (95 %CI 33–47 %, <em>I</em>² = 60 %, <em>p</em> &lt; 0.01) and “other disorders” 40 % (95 %CI 18–67 %, <em>I</em>² = 98 %, <em>p</em> &lt; 0.01). The group prevalences were not equal, indicating a significant difference (<em>P</em>-value = 0.03), with a notably higher likelihood of RS.</p></div><div><h3>Conclusion</h3><p>We observed a five-fold increased likelihood of bruxism in children with profound intellectual and multiple disabilities. The disorder with the highest prevalence was Rett syndrome, with a seven-fold increased likelihood of bruxism. The increased likelihood of bruxism in this vulnerable group of children demands clinicians pay heed to this substantial morbidity.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"15 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000167/pdfft?md5=3374a6d6a2c82dde3d86517156ef617c&pid=1-s2.0-S2666459324000167-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging the role of trace minerals and vitamins in Alzheimer's disease","authors":"Kamaljeet ,&nbsp;Amandeep Kaur ,&nbsp;Lovekesh Singh","doi":"10.1016/j.dscb.2024.100139","DOIUrl":"https://doi.org/10.1016/j.dscb.2024.100139","url":null,"abstract":"<div><p>AD is the main contributor to dementia and one of the largest healthcare concerns of the twenty-first century. The principal components of plaques and tangles, respectively, amyloid-β (Aβ) and tau, have made molecular pathogenetic processes accessible, little is known about the disease's etiology and there are no proven treatments. Minerals known as trace elements or trace metals in very small amounts were found in living tissues. Although some metallic ions, such as iron and copper, are involved in oxidation–reduction processes in energy metabolism, trace elements often function as enzyme system catalysts. The major pathological markers of AD are Aβ plaques (_40–42) &amp; NF-tangles are associated with this disease. By examining various clinical &amp; preclinical studies have proven that Al causes memory impairment as well as oxidative stress that results in mitochondrial dysfunction via the nucleus and mitochondria dysfunction (complex-I, II, IV), which leads to a mechanistic understanding of aging and the etiology of neurodegenerative illnesses. Multi-targeted pharmaceutical evidence-based therapy may need to be combined with non-pharmacological approaches and/or lifestyle modifications to stop the pandemic of neurological disease in the elderly. Other markers like aging, illnesses, and apoptosis have a greater focus in the field of research on NDs in the future.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000246/pdfft?md5=d181995ec4b99d94b09640e492b2be2c&pid=1-s2.0-S2666459324000246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variegate porphyria onset as neurovisceral manifestation and unusual sensory impairment distribution. Case report","authors":"Lucas Grobério Moulim de Moraes ,&nbsp;Caroline Colnago Demoner ,&nbsp;Amanda Ambrosini Cipriano ,&nbsp;Giselle Alves de Oliveira ,&nbsp;Raphael de Paula Doyle Maia ,&nbsp;Paula Zago Melo Dias ,&nbsp;Mariana Lacerda Reis Grenfell ,&nbsp;Renann Nunes Pirola ,&nbsp;Marcelo Ramos Muniz","doi":"10.1016/j.dscb.2024.100138","DOIUrl":"https://doi.org/10.1016/j.dscb.2024.100138","url":null,"abstract":"<div><p>Background: Acute hepatic porphyrias are heme metabolism disorders presenting with a broad clinical spectrum, including neurovisceral manifestations. Peripheral neuropathy is one of the most frequent complications in porphyrias and can correspond about 40 % of the neurovisceral manifestations, and it is mainly attributed to the ALA and PBG accumulation neurotoxicity. The hallmark of an acute porphyric attack is an acute motor axonal neuropathy accompanied by autonomic dysfunction. Sensory impairment is infrequent, and when present, it is classically described as the stocking-glove pattern or, more rarely, a “bathing suit” proximal distribution pattern. Objective: To report a variegate porphyria case in a young patient with unusual sensory manifestations. Methods: A 27-year-old man, previously healthy, present in context of possible arbovirus infeccion with severe abdominal pain, followed by dysautonomia due to orthostatic hypotension, change in urine color and, the emergence of sensory impairment in the trunk and proximal region of the four limbs about twenty days from onset. Dysestesia was severe and marked. Results: Positive clinical features and a urinary exposure test to sunlight corroborate in request genetic testing for acute hepatic porphyrias, with a positive mutation of the PPOX gene in heterozygosis. Discussion: Clinical manifestations with initial presentation of severe dysautonomia followed by sensory changes demarcate neurovisceral involvement of variegate porphyria, adopting an \"old-bathing-suit costume\" sensory pattern throughout its evolution.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000234/pdfft?md5=9d57dbcc9500ecd86464ceac2e3c9d5b&pid=1-s2.0-S2666459324000234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140906593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infrared free electron laser-irradiated polyleucine does not exert aggregates-induced aversive effects on mouse brain","authors":"Ayaka Mori ,&nbsp;Taichi Shiroishi ,&nbsp;Jun Fujioka ,&nbsp;Takashi Nakajima ,&nbsp;Shinichi Mitsui ,&nbsp;Hinaho Suginoma ,&nbsp;Yohei Kakuta ,&nbsp;Heishun Zen ,&nbsp;Kazuhiro Nakamura","doi":"10.1016/j.dscb.2024.100137","DOIUrl":"https://doi.org/10.1016/j.dscb.2024.100137","url":null,"abstract":"<div><p>Polyglutamine (polyQ) diseases are devastating neurological disorders that cannot be effectively treated. Repeat-associated non-AUG (RAN) translation has been documented in transcripts in polyQ diseases. RAN products include proteins with polyleucine (polyL) tracts. Similar to polyQ, polyL tends to aggregate, which is toxic to cells and mice. Irradiation with a free electron laser (FEL) tuned at mid-infrared wavelengths can dissociate polyQ aggregates in cultured cells. However, whether FEL dissociates the polyL is unclear. It is also unclear whether brain dysfunction caused by polyL aggregates in mice can be ameliorated by FEL irradiated polyL. Here, we show that FEL at approximately 6 μm can destroy polyL aggregates, as evidenced by scanning electron microscopy, atomic force microscopy, and dot blot analyses. Although polyL aggregates induced low viability and aberrant morphology of cultured astrocytes, FEL irradiated polyL exhibited mild defects. Likewise, the toxicity of polyL-containing microglia in vitro was ameliorated by FEL irradiation. In vivo, mice administered polyL aggregates in the cerebellum induced loss of Purkinje cells, which was ameliorated when FEL irradiated polyL was injected. These results justify the clearing of aggregates by approaches using molecular chaperones, laser irradiation, and ultrasound as a general therapeutic strategy to correct brain dysfunction by the RAN products.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000222/pdfft?md5=b7af97ff4f1cf53cdaf3e38650bf2ee4&pid=1-s2.0-S2666459324000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140902078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent exposure to light and traffic noise pollution augments behavioral deficits in rats: Protective effect of curcumin","authors":"Sonal Sharma ,&nbsp;Jiten Singh ,&nbsp;Dinesh Kumar ,&nbsp;Mandeep Kumar Arora ,&nbsp;Ashok Jangra","doi":"10.1016/j.dscb.2024.100136","DOIUrl":"10.1016/j.dscb.2024.100136","url":null,"abstract":"<div><p>The current study was aimed to explore the effect of light and traffic noise pollution exposure on behavioral and neurochemical deficits in adult male Wistar rats. We hypothesized that exposure to these pollutants alone or in combination may cause behavioral deficits in rats. Animals were allocated into different groups and were exposed to either varying light cycles (150 lx-5 lx, 14:10 h) or traffic noise with sound level 100 dBA for 6 h/day or both for 28 days. Concurrently, Curcumin (100 mg/kg; per oral; 28 days) was administered in varying light cycles and noise exposed animal groups to study the preventive effect. After the exposure time, the Morris water maze test, elevated plus maze test, novel object recognition test, locomotor activity test, and forced swimming test were conducted. The neurobehavioral results suggested that only combined exposure of light and noise pollution markedly impaired the learning as well as spatial and reference memory in rats. Furthermore, we found significant anxiety (less no. of open arm entries in EPM) and depressive-like behavior (increased immobility time) in light or/and traffic noise pollution exposed group animals in comparison to normal control groups. Curcumin treatment significantly prevented the behavioral anomalies in combined light and noise exposed rats. Furthermore, our results revealed augmentation of acetylcholinesterase, oxidative stress markers and interleukin (IL)-1β in the hippocampal region of noise and light-exposed groups which were markedly ameliorated by curcumin. In conclusion, our results suggest that curcumin significantly modulates light and noise pollution exposed behavioral and neurochemical anomalies in rats.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000210/pdfft?md5=f374ff54b646a0191a4e7e9362fc006e&pid=1-s2.0-S2666459324000210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of rehabilitation duration in patients with intracerebral hemorrhage","authors":"Subhan Ahmed ,&nbsp;Evan Liu ,&nbsp;Hely D. Nanavati ,&nbsp;Chen Lin","doi":"10.1016/j.dscb.2024.100133","DOIUrl":"https://doi.org/10.1016/j.dscb.2024.100133","url":null,"abstract":"<div><h3>Background and Purpose</h3><p>No consensus exists on the ideal duration of rehabilitation in patients with intracerebral hemorrhage (ICH). The aim of this study is to identify demographic and clinical characteristics associated with rehabilitation duration (RD) in patients with ICH during hospitalization.</p></div><div><h3>Methods</h3><p>This retrospective study followed consecutive patients admitted to a tertiary care center between 2016 and 2019 with primary diagnosis of ICH. The primary outcome, RD was calculated by adding the total number of therapy (speech, occupational, and physical) minutes received during admission, divided by the hospital length of stay. Variables abstracted included demographic and clinical characteristics (ICH score, neurosurgical procedure). Multiple linear regression models were used to measure adjusted association between select predictors and mean RD.</p></div><div><h3>Results</h3><p>A total of 316 ICH patients (62.5 ± 15.9 years, 49 % White) were included in the final analysis. Compared to Whites, other racial minorities (β= -9.017, <em>p</em> = 0.002) received rehabilitation therapy for a significantly shorter duration in the adjusted model. Age was significantly associated with having higher RD (β=0.320, <em>p</em> &lt; 0.001). Patients with lobar ICH (β= -7.486, <em>p</em> = 0.014) had significantly shorter RD compared to deep. ICH score was significantly associated with having a lower RD (β= -8.624, <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Age, race, ICH score, and location were significantly associated with RD. Non-White patients had significantly shorter RD, indicating a potential racial disparity in the rehabilitation of patients with ICH.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000180/pdfft?md5=6f0ab20a467ab42d8031d350079d6139&pid=1-s2.0-S2666459324000180-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of diabetes mellitus on the development of psychiatric and neurological disorders","authors":"Olivia Kelly,&nbsp;Jillian Sullivan,&nbsp;Natalie Carris,&nbsp;Samantha Geci,&nbsp;Athena Martinez,&nbsp;Varvara Liashenko,&nbsp;James Colvin,&nbsp;Emily Misko,&nbsp;Gary Vanderlaan,&nbsp;He Liu,&nbsp;Prasad S. Dalvi","doi":"10.1016/j.dscb.2024.100135","DOIUrl":"https://doi.org/10.1016/j.dscb.2024.100135","url":null,"abstract":"<div><p>Diabetes mellitus (DM) is a chronic condition resulting from insulin deficiency or systemic insulin resistance. In this disorder, either the pancreatic β-cells are unable to produce enough insulin, or the secreted insulin is ineffective to overcome the peripheral or central insulin resistance. Over time, glucose metabolism becomes dysregulated, resulting in overt DM characterized by hyperglycemia and chronic systemic inflammation. This research review explores the connections and potential correlations between DM and various psychiatric and neurological disorders, including major depressive disorder (MDD), Parkinson's disease (PD), and Alzheimer's disease (AD). While no claims of direct causation can be made, DM does show significant correlations and associations with MDD, PD, and AD. Each of these conditions shows some overlap among risk factors, biological pathways, mechanisms, and therapeutic approaches with DM. Interestingly, depending on the factor, DM can influence the progression of MDD, PD and AD, and vice versa. This review of pathophysiological pathways and molecular events associated with these disorders allows for further investigation into establishing connections between each of these conditions.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000209/pdfft?md5=f5e0f0a8e08cea5d277d0bc5df94c882&pid=1-s2.0-S2666459324000209-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYNE1 gene mutation: A recessive ataxic syndrome presenting with weakness and muscle atrophy. A case report","authors":"Lucas Grobério Moulim de Moraes,&nbsp;Caroline Colnago Demoner,&nbsp;Giselle Alves de Oliveira,&nbsp;Raphael de Paula Doyle Maia,&nbsp;Paula Zago Melo Dias,&nbsp;Mariana Lacerda Reis Grenfell,&nbsp;Renann Nunes Pirola,&nbsp;Marcelo Ramos Muniz","doi":"10.1016/j.dscb.2024.100134","DOIUrl":"https://doi.org/10.1016/j.dscb.2024.100134","url":null,"abstract":"<div><h3>Background</h3><p>Autosomal recessive spinocerebellar ataxia type 8 (SCAR8) is a rare neurodegenerative disease that can be manifest in a wide spectrum from ataxias and motoneuron syndromes.</p></div><div><h3>Objective</h3><p>To report a case of mutation in the SYNE1 gene with predominant motoneuron disease signs.</p></div><div><h3>Methods</h3><p>Index case medical report and literature review.</p></div><div><h3>Results</h3><p>A 32-year-old woman onset with pyramidal and lower motoneuron signs and symptoms during the second decade of life, with marked dysarthria showing associated cerebellar pattern. Clinical investigation with electroneuromyography showed chronic preganglionic disease and brain MRI showed cerebellar atrophy. Genetic testing confirmed pathogenic mutation in homozygosity in the SYNE1 gene.</p></div><div><h3>Conclusions</h3><p>Rare neurological condition that may be associated with signs of impairment of the pyramidal pathway and second motoneuron (amyotrophic lateral sclerosis-like syndrome), in addition to cerebellar ataxia in insidious course.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000192/pdfft?md5=7dc68cf165382397f368eccc7d4e03c2&pid=1-s2.0-S2666459324000192-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting molecular mechanisms underlying treatment efficacy and resistance in DIPG: A review of current and future strategies","authors":"Kaoutar Bentayebi ,&nbsp;Rim El Aked ,&nbsp;Oumaima Ezzahidi ,&nbsp;Alae Bekkouri Alami ,&nbsp;Sara Louati ,&nbsp;Mouna Ouadghiri ,&nbsp;Tarik Aanniz ,&nbsp;Saaïd Amzazi ,&nbsp;Lahcen Belyamani ,&nbsp;Azzedine Ibrahimi ,&nbsp;Keittisak Suwan ,&nbsp;Amin Hajitou ,&nbsp;Rachid Eljaoudi","doi":"10.1016/j.dscb.2024.100132","DOIUrl":"10.1016/j.dscb.2024.100132","url":null,"abstract":"<div><p>Diffuse intrinsic pontine glioma (DIPG) presents a significant challenge in paediatric neuro-oncology due to its aggressive nature and limited treatment options. Typically affecting children aged 5–10 years, DIPG patients have a poor prognosis, with a median survival of less than 1 year. The inoperable nature of DIPG hinders comprehensive molecular analysis, presenting a critical obstacle. Despite scientific advancements, treatment options are limited, and prognosis remains poor, particularly for paediatric patients. This review provides a comprehensive examination of the current landscape of DIPG research, addressing key aspects of diagnosis, molecular understanding, treatment modalities, and emerging therapeutic strategies. The review navigates the complexities of DIPG heterogeneity, emphasizing the need for nuanced approaches in therapeutic interventions. Clinical trials exploring combinations of radiation, chemotherapy, and novel agents, including anti-angiogenic drugs and immunotherapy, are discussed, shedding light on potential avenues of hope. Common genomic alterations in TP53, PDGFRA, and ACVR1 are explored as potential therapeutic targets. Gene therapy, with a focus on immunostimulatory approaches, is under investigation in clinical trials to address the infiltrative nature of DIPG. This review aims to offer a comprehensive overview of the current state of DIPG research, highlighting challenges, advancements, and future directions in the pursuit of effective therapeutic strategies for this devastating paediatric brain tumour.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000179/pdfft?md5=5a82c2b0676d2d8d3d4640ead7966ec6&pid=1-s2.0-S2666459324000179-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted language training combined with transcranial direct current therapy for Wernicke aphasia in the sequelae stage: A case report","authors":"Juan Yang ,&nbsp;Huozhong Yuan","doi":"10.1016/j.dscb.2024.100130","DOIUrl":"https://doi.org/10.1016/j.dscb.2024.100130","url":null,"abstract":"<div><h3>Objective</h3><p>To observe the effects of combining targeted language training with transcranial direct current stimulation (tDCS) on speech rehabilitation in senile stroke patients with Wernicke's aphasia in the sequelae stage.</p></div><div><h3>Methods</h3><p>A patient with Wernicke's aphasia caused by stroke, 15 months prior, was successively treated with regimen A (targeted language training), regimen B (L-Wernicke area tDCS + targeted language training), and regimen C (R-Wernicke area tDCS + targeted language training) for a total of 3 weeks, with a 2-day washout period between each regimen. The accuracy of spontaneous speech, auditory word-picture matching, visual word-picture matching, retelling, graph-reading writing, and graph-reading naming items was evaluated and compared before treatment and 3 weeks after treatment with regimens A, B, and C.</p></div><div><h3>Results</h3><p>After 3 weeks of the regimen A treatment, there was no significant improvement in each evaluation item. After 3 weeks of treatment with regimen B, the patient's spontaneous speech slightly improved, but the expression remained meaningless. Visual word-graph matching was slightly improved, but auditory word-graph matching was not. After 3 weeks of treatment with regimen C, the spontaneous speech of the patient's increased significantly, and the correct rates of auditory word-graph matching, visual word-graph matching, retelling, and picture reading and writing were significantly improved compared with those before treatment and after 3 weeks of treatment with regimens A and B (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>Targeted language training combined with tDCS stimulation of the non-dominant Wernicke's area can improve spontaneous speech, auditory word-picture matching, visual word-picture matching, retelling, and picture reading and writing ability in elderly patients with Wernicke's aphasia after stroke, thus promoting speech rehabilitation.</p></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666459324000155/pdfft?md5=29cf974e9479b0d16b0c9e580cc82cba&pid=1-s2.0-S2666459324000155-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}