Brain disorders (Amsterdam, Netherlands)最新文献_第9页

Functional outcomes in adults following corpus callosotomy: A systematic review 成人胼胝体切开术后的功能结局：一项系统综述

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-12-15 DOI: 10.1016/j.dscb.2024.100176

Shriya Parekh , Deepa Anand Bapat

引用次数: 0

Cavernous sinus syndrome secondary to trigeminal nerve invasion by cutaneous squamous cell carcinoma: A case report and brief review 皮肤鳞状细胞癌侵犯三叉神经继发海绵窦综合征1例报告及简要回顾

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-12-06 DOI: 10.1016/j.dscb.2024.100175

Helena Alves de Andrade Ribeiro , Lucas Grobério Moulim de Moraes , David Jamil Hadad , Vitor Fiorin de Vasconcellos , Giselle Alves de Oliveira

{"title":"Cavernous sinus syndrome secondary to trigeminal nerve invasion by cutaneous squamous cell carcinoma: A case report and brief review","authors":"Helena Alves de Andrade Ribeiro , Lucas Grobério Moulim de Moraes , David Jamil Hadad , Vitor Fiorin de Vasconcellos , Giselle Alves de Oliveira","doi":"10.1016/j.dscb.2024.100175","DOIUrl":"10.1016/j.dscb.2024.100175","url":null,"abstract":"<div><h3>Objectives</h3><div>Cutaneous squamous cell carcinoma (cSCC) has a broad clinical spectrum, especially when it affects the head and neck. Given the possible presentations, there is perineural dissemination, with an unfavorable prognosis and involvement of less differentiated tumor cells. A possible outcome is cavernous sinus syndrome (CSS), which encompasses the cavernous sinus, an anatomical structure that includes the oculomotor, trochlear, abducens nerves and the V1 and V2 branches of the trigeminal nerve.</div></div><div><h3>Methods</h3><div>We present a 62-year-old white man who manifested unilateral progressive ptosis, binocular diplopia and supraorbital pain in the right eye.</div></div><div><h3>Results</h3><div>The relevant history of skin neoplasms on the head raised the diagnostic hypothesis. Neuroimaging evaluation demonstrated nerve infiltration of the trigeminal nerve with tumor expansion at the level of the ipsilateral cavernous sinus.</div></div><div><h3>Discussion</h3><div>The concomitance between cSCC and CSS correlates with the participation of the neural growth factor and the overexpression of programmed cell death protein 1 (PD-1), with dermatological and neurological manifestations. In this context, the standard treatment used is cemiplimab, an immunotherapy used in unresectable and metastatic tumors and recently emerging as neoadjuvant therapy in surgical cases. The present report illustrates the association of such entities with the use of the described monoclonal antibody.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"17 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of modified functional reach test in children with cerebral palsy aged 6–18 years: An observational cross-sectional study 6-18岁脑瘫儿童改良功能性伸手测验的可靠性：观察性横断面研究

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-11-06 DOI: 10.1016/j.dscb.2024.100172

Abhijeet Arun Deshmukh, Mayuri Anil Tijare, Maneesha Shrikrishna Deshpande

{"title":"Reliability of modified functional reach test in children with cerebral palsy aged 6–18 years: An observational cross-sectional study","authors":"Abhijeet Arun Deshmukh, Mayuri Anil Tijare, Maneesha Shrikrishna Deshpande","doi":"10.1016/j.dscb.2024.100172","DOIUrl":"10.1016/j.dscb.2024.100172","url":null,"abstract":"<div><h3>Background</h3><div>Balance in sitting plays an important role among children with cerebral palsy. The modified functional reach test(mFRT) is reliable tool to evaluate both static and dynamic sitting balance among children but the reliability of mFRT has not been proven among cerebral palsy children.</div></div><div><h3>Objective</h3><div>To find the reliability of mFRT(forward reach, left lateral and right lateral reach), cerebral palsy children.</div></div><div><h3>Methods and Material</h3><div>An observational cross-sectional study on 90 children with cerebral palsy aged 6-to-18 years was randomly selected. The children reached forward and at both the lateral directions. Three successive trials of forward reach and lateral reaches with the child sitting with feet shoulder width apart were performed and the mean of 3 trials was calculated. Reliability of mFRT test in all the directions (forward, left and right lateral) was found out.</div></div><div><h3>Results</h3><div>Reliability of mFRT test was found out in all the directions. The values of reach in age groups were compared. The genders were compared with the mFRT. GMFCS levels were compared with mFRT. BMI was correlated with mFRT.</div></div><div><h3>Discussion</h3><div>This study found excellent intra rater reliability(test-retest reliability) of mFRT in children with cerebral palsy aged 6–18years, in all directions; forward reach test <em>r</em> = 0.996, left lateral reach test <em>r</em> = 0.974, right lateral reach test <em>r</em> = 0.988. This test can be used to evaluate the dynamic sitting balance of children with cerebral palsy of age 6–18 years in both genders.</div></div><div><h3>Conclusions</h3><div>The mFRT has excellent intra rater-reliability among cerebral palsy children of 6–18 years.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of oleanolic acid against secondary cascades of traumatic brain injury in mice 齐墩果酸对小鼠脑外伤继发级联的神经保护作用

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-11-01 DOI: 10.1016/j.dscb.2024.100173

Hemlata , Sunil Sharma , Neeru Vasudeva , Tanuj Hooda

{"title":"Neuroprotective effects of oleanolic acid against secondary cascades of traumatic brain injury in mice","authors":"Hemlata , Sunil Sharma , Neeru Vasudeva , Tanuj Hooda","doi":"10.1016/j.dscb.2024.100173","DOIUrl":"10.1016/j.dscb.2024.100173","url":null,"abstract":"<div><h3>Introduction</h3><div>Traumatic Brain Inury (TBI) is a neurodegenerative disorder. Oleanolic acid (OA) is a pentacyclic triterpenoid showed a large number of neuroprotective effects such as anti-alziermer, anti-ischemic etc.</div></div><div><h3>Objectives</h3><div>In the present investigation an effort has been made to evaluate the neuroprotective effect of OA and molecular mechanism is involved in TBI.</div></div><div><h3>Methods</h3><div>Weight drop model has been utilized to induce moderate TBI and assess the neuroprotective effect of OA at the doses 50 mg/kg and 100 mg/kg intraperitoneally (i.p.) in mice. After 30 min of injury, OA was administered. The neuroprotective effect of OA was observed after 24 h and 21 days of drug administration. Neurological behaviour (neurological score, open field test, beam walk and morris water maze test) were assessed before sacrifice the animal at different time interval. Oxidative stress (MDA, CAT, GSH, SOD and Nitrite), neuro-inflammatory cytokines (NF-ĸB, TNF-α, IL-6 and IL-1β and mitochondrial dysfunction were evaluated.</div></div><div><h3>Results</h3><div>OA at both the doses significantly improved the neurological behaviours as compared to vehicle treated group. OA also showed significant anti-oxidant and anti-inflammatory effect via regulated the oxidative stress (MDA, CAT, and GSH) and inflammatory cytokines (TNF-α, IL-6, NF-ĸB and IL-1β) on 24 h and 21st day of injury. OA significantly reduced the mitochondrial dysfunction by regulated various complex enzyme activity.</div></div><div><h3>Conclusion</h3><div>OA can be potentially considered as a neuroprotective compound for therapeutic management of TBI.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migraine and epilepsy frontiers, new challenges in its understanding: A case report 偏头痛与癫痫的前沿，认识偏头痛的新挑战：病例报告

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-10-19 DOI: 10.1016/j.dscb.2024.100170

Jorge Sinche-Flores

{"title":"Migraine and epilepsy frontiers, new challenges in its understanding: A case report","authors":"Jorge Sinche-Flores","doi":"10.1016/j.dscb.2024.100170","DOIUrl":"10.1016/j.dscb.2024.100170","url":null,"abstract":"<div><div>The relationship between migraine and epilepsy has been recognized since the 20th century. Currently, both pathologies share several characteristics, from molecular and electrophysiological mechanisms to their similarity in clinical symptoms and response to treatment. This is a case report of an 11-year-old male patient who presented with focal epilepsy at the age of 8 years. One year later, he developed episodes of migraine without aura followed by seizures with a frequency of 1–2 times per month, with headache duration ranging from 10 min to 6 h. At age 11, he also presented other episodes in which the headache occurred after the epileptic event and other episodes in which the headache was present both before and after the epileptic seizure. An interictal EEG study and an EEG study during a migraine attack showed the presence of high-voltage theta activity and bilateral temporo-parieto-occipital spikes with a greater expression in the right cerebral hemisphere. To our knowledge, this is the first report of an atypical presentation of migraine without aura and epileptic seizure. This case opens new challenges in the search for understanding between both pathologies.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platform for the radiomics analysis of brain regions: The case of Alzheimer's disease and metabolic imaging 脑区放射组学分析平台：阿尔茨海默病和代谢成像案例

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-10-16 DOI: 10.1016/j.dscb.2024.100168

Ramin Rasi, Albert Guvenis, Alzheimer's Disease Neuroimaging Initiative

{"title":"Platform for the radiomics analysis of brain regions: The case of Alzheimer's disease and metabolic imaging","authors":"Ramin Rasi, Albert Guvenis, Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.dscb.2024.100168","DOIUrl":"10.1016/j.dscb.2024.100168","url":null,"abstract":"<div><h3>Objective</h3><div>This study introduces a PET-based platform for brain radiomics analysis. We automatically identify key brain regions and features associated with Alzheimer's disease (AD), enabling more accurate diagnosis and staging compared to using predefined regions.</div></div><div><h3>Methods</h3><div>To create an integrated platform that covers all the phases of radiomics, we obtained FDG-PET images of 549 individuals from the ADNI database. We used FastSurfer to segment the brain into 95 regions. We then obtained 120 features for each of the 95 ROIs. We employed eight feature selection methods to select and analyze the features. We finally utilized nine different classifiers on the 20 most significant features extracted.</div></div><div><h3>Results</h3><div>For all three predictions AD vs. cognitively normal (CN), AD vs. mild cognitive impairments (MCI), and CN vs. MCI the Random Forest (RF) classifier with LASSO demonstrated the highest accuracy with an AUC of 0.976 for AD vs CN, AUC=0.917 for AD vs MCI, and AUC=0.877 for MCI vs CN. This is the highest performance that we encountered compared to the studies in the literature. Three subregions hippocampus, entorhinal, and amygdala could then be identified as critical.</div></div><div><h3>Conclusion</h3><div>A brain radiomics platform can enable an efficient, standardized, and optimally accurate AD and MCI diagnosis from FDG PET images by using an automated pipeline. The three regions identified as having the highest discriminating power confirm the findings of previous clinical research results on AD. While the focus was AD in this study, the platform can potentially be used to address other brain conditions.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights 重新审视 mpox：对大脑的隐形攻击和新的生物医学研究见解

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-10-16 DOI: 10.1016/j.dscb.2024.100169

Abhimanyu Thakur

{"title":"Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights","authors":"Abhimanyu Thakur","doi":"10.1016/j.dscb.2024.100169","DOIUrl":"10.1016/j.dscb.2024.100169","url":null,"abstract":"<div><div>The recent global outbreak of mpox virus (MPXV) infections has reignited interest in this zoonotic disease, mpox. As of August 2024, mpox continues to pose significant global health challenges, with ongoing transmission in Africa, the Americas, and Europe. This article examines the neurological implications of MPXV infection, synthesizing current research to provide biomedical insights into the virus's potential impact on the central nervous system (CNS). The neuroinvasive potential of MPXV and the rare but serious complication of encephalomyelitis have been discussed. The article explores advances in mpox research, including insights from animal models such as dogs, squirrels, and mice. Further. the application of bioinformatics and machine learning techniques for enhanced mpox detection and potential therapeutics for mpox and related neurological complications have discussed. The article also addresses the current state of mpox vaccines, existing resources, and future directions for vaccine development. By examining the molecular characteristics of MPXV, its mechanisms of cellular invasion, and its effects beyond cutaneous manifestations, this article provides a comprehensive overview of the current understanding of mpox neurological implications. Eventually, the major research priorities and potential strategies for mitigating the neurological impact of MPXV infections have been highlighted in the context of ongoing global health challenges.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the potential: Woodfordia fruticosa Kurz in Alzheimer's disease management - A concise review 挖掘潜力：库尔兹木芙蓉（Woodfordia fruticosa Kurz）在阿尔茨海默病治疗中的应用--简明综述

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-10-16 DOI: 10.1016/j.dscb.2024.100171

Sanjukta Sen , Shreyasi Meur , Gouranga Nandi , Dipanjan Karati

{"title":"Unlocking the potential: Woodfordia fruticosa Kurz in Alzheimer's disease management - A concise review","authors":"Sanjukta Sen , Shreyasi Meur , Gouranga Nandi , Dipanjan Karati","doi":"10.1016/j.dscb.2024.100171","DOIUrl":"10.1016/j.dscb.2024.100171","url":null,"abstract":"<div><div>Alzheimer's disease (AD), a progressive neurodegenerative disorder, epitomizes the intricate interplay between genetic predisposition and molecular pathology, resulting in the relentless deterioration of neuronal structures within the brain. Characterized by the formation of amyloid-beta plaques and tau protein tangles, this condition disrupts synaptic connections, leading to profound cognitive impairment. The utilization of medicinal herbs in the treatment of AD has garnered considerable attention within scientific research due to their potential neuroprotective and therapeutic properties. The World Health Organization has long noted and brought to the attention of many countries the growing public interest in medicinal plants and their products to cure various disorders, including AD due to their potential neuroprotective properties. The ethnomedicinal relevance of the plant <em>Woodfordia fruticosa</em> Kurtz has been reflected in the art of Ayurveda and India's traditional healing system, which reveals its widespread use in Ayurvedic treatments. Numerous chemical compounds found in <em>Woodfordia fruticosa</em> (WF) have been shown to be biologically active against the predisposing factors of AD. The flower extract of WF is particularly effective in inhibiting key enzymes like AChE and BuChE that are involved in AD, while its leaf and stem extracts also contribute to this effect. <em>In vivo</em> studies demonstrate that the flower extract can reverse memory impairment and reduce elevated enzyme levels in animal models. This review highlights the comprehensive potential of <em>Woodfordia fruticosa</em> Kurz in AD management, the multifaceted activities of WF, spanning enzyme inhibition, cholinesterase inhibition, and neuroprotection, underscore its promise as a natural therapeutic agent for AD.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percheron Artery Stroke and Reperfusive therapies: A systematic review and meta-analysis 佩尔切隆动脉中风与再灌注疗法：系统回顾和荟萃分析

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-10-15 DOI: 10.1016/j.dscb.2024.100167

Giulio Papiri , Emanuele Puca , Matteo Marcucci , Cristina Paci , Donatella Petritola , Stefania Bifolchetti , Sandro Sanguigni , Fabio Di Marzio , Gabriella Cacchiò , Giordano D'Andreamatteo , Claudia Cagnetti

{"title":"Percheron Artery Stroke and Reperfusive therapies: A systematic review and meta-analysis","authors":"Giulio Papiri , Emanuele Puca , Matteo Marcucci , Cristina Paci , Donatella Petritola , Stefania Bifolchetti , Sandro Sanguigni , Fabio Di Marzio , Gabriella Cacchiò , Giordano D'Andreamatteo , Claudia Cagnetti","doi":"10.1016/j.dscb.2024.100167","DOIUrl":"10.1016/j.dscb.2024.100167","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Percheron Artery Stroke, affecting bilateral paramedian thalamic structures, accounts for 0.1–0.4 % of all acute ischemic strokes. Little is known about disability or mortality outcomes in patients receiving intravenous thrombolysis (IVT) or endovascular treatment (EVT), therefore a systematic review was carried out.</div></div><div><h3>Methods</h3><div>A systematic search of Pubmed, Embase and Scopus databases for all kind of studies regarding Percheron Artery Stroke was performed. The review is registered in INPLASY (202410059). In total, 1895 papers were screened; 197 studies were included, consisting exclusively in case reports, retrospective series and conference abstracts. Data from 448 patients were analyzed in logistic regression.</div></div><div><h3>Results</h3><div>Both IVT (OR<sub>IVT</sub> = 3.08; 95 % CI 1.4 – 6.7; <em>p</em> = 0.005) and EVT (OR<sub>EVT</sub> = 5.77; 95 % CI 1.69 – 19.7; <em>p</em> = 0.005) were associated with reduced disability, as well as exclusive thalamic involvement (OR = 3.24; CI 2.1 – 5.1; <em>p</em> < 0.001) and higher Glasgow Coma Scale score (GCS) on admission (OR = 1.2; 95 % CI 1.12 – 1.28; <em>p</em> < 0.001). GCS (OR = 0.73, 95 % CI 0.63 – 0.82; <em>p</em> < 0.001) and exclusive thalamic involvement (OR = 0.36; 95 % CI 0.16 – 0.74; <em>p</em> = 0.005) were associated with lesser mortality, while IVT displayed a non-significant trend towards reduced mortality (OR<sub>IVT</sub> = 0.13; 95 % CI 0.01 – 1.04; <em>p</em> = 0.056).</div></div><div><h3>Conclusion</h3><div>The present work, albeit summarizing data coming from low quality sources, suggests an association between both EVT/IVT and better outcomes in paramedian bilateral thalamic strokes.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the role of structural connectivity in the individuals with moderate hearing loss 研究结构连接在中度听力损失患者中的作用

Brain disorders (Amsterdam, Netherlands) Pub Date : 2024-10-08 DOI: 10.1016/j.dscb.2024.100165

AHM Ruhul Quddus , Mst Shahnaj Pervin , Artyom Zinchenko , Md Mamun Al Amin

{"title":"Investigating the role of structural connectivity in the individuals with moderate hearing loss","authors":"AHM Ruhul Quddus , Mst Shahnaj Pervin , Artyom Zinchenko , Md Mamun Al Amin","doi":"10.1016/j.dscb.2024.100165","DOIUrl":"10.1016/j.dscb.2024.100165","url":null,"abstract":"<div><div>Hearing loss has been identified as a risk factor for cognitive decline. The processing of auditory information relies on a well-connected neuronal network. Previous studies have found white matter abnormalities in individuals with hearing loss, but the structural connectivity and microstructural properties of white matter in individuals with moderate hearing loss remain unclear.</div><div>To examine the integrity of white matter, identify vulnerable structural connectivity, and assess network topology, we examined major white matter tracts in elderly individuals with moderate hearing loss (MHL) (>30 dB) and compared them to age-matched controls with good hearing (GH).</div><div>We observed that the fractional anisotropy of the right corticospinal tract and left superior longitudinal fasciculus – parietal was higher in subjects with MHL. Additionally, we identified a disrupted network centered on the left putamen in MHL, involving eight brain regions. Network topology analysis showed reduced betweenness centrality and small-world network in MHL. Interestingly, the fractional anisotropy of the forceps major tract and left uncinate tracts were correlated with hearing status.</div><div>Our findings suggest that MHL is associated with putamen-centered disruptions in structural connectivity. The increased fractional anisotropy of the right corticospinal tract may be a compensatory mechanism, as it projects fibers to the right putamen. Overall, these results provide valuable insights into the impact of hearing loss on white matter integrity and may inform the development of new treatments to prevent its progression.</div></div>","PeriodicalId":72447,"journal":{"name":"Brain disorders (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0