Brain and neuroscience advances最新文献

{"title":"BNA 2021 Festival of Neuroscience Poster abstracts","authors":"J. E. Haley, A. Mehta, C. Abbott","doi":"10.1177/23982128211035062","DOIUrl":"https://doi.org/10.1177/23982128211035062","url":null,"abstract":"As part of the engagement programme for FENS2020 in Glasgow, and to mark the centenary of the founding of the Cajal Institute in Madrid in 1920, we embarked on creating what we believe could be the world's largest Cajal-related embroidery! Consisting of 81 separate panels representing 9 different neuron/astrocyte illustrations by Santiago Ramón y Cajal, this embroidery project was intended to engage neuroscientists, embroiderers, artists and crafters. Launched in February 2020, the project immediately had challenges to overcome as the world went into a covid-19 pandemic lockdown. Whilst not its original intended purpose, the Cajal Embroidery Project, was found by many of our contributors to be a source of tranquility and connection during a chaotic and isolating period. It brought people together, virtually, to share progress of their work, seek advice or materials and find out more about Cajal and the project. The pandemic resulted in the FENS Forum moving online, so we produced a short film featuring the embroideries, the process, and the contributor's feelings about the project. This was made available as one of their Open Theatre slots. Our project has continued and, to date, we have received 77 embroideries from 64 contributors in 7 countries. The final four panels are due for completion in January 2021 and we will join all the panels together during Spring 2021 (pandemic permitting!). The project has already generated exciting outcomes - a short article in BNA Bulletin and a published 'In Context' piece in Lancet Neurology. During 2021, the embroideries are featuring on Lancet Neurology front covers, to accompany 'Focal point' commentaries. Plus, they will form the inaugural exhibition at the Dott Gallery within the new Division of Clinical Neurosciences building, Edinburgh. Communal crafting projects have been used by groups of women for centuries to make often beautiful but utilitarian objects. These projects have traditionally existed in the domestic sphere but we have successfully harnessed the same skills to engage not just the participants (who happened to all be women) but a wider, global community in understanding the history of neuroscience. The Cajal Embroidery Project: celebrating neuroscience, Mehta A. et al, Lancet Neurol. 2020;19: 979 Statistical statement: Although this project clearly involves replicants (n=9 of each image), embroideries, being an artistic expression, are not usually amenable to delivering measurable data. In addition, the end output is, by design, an n of 1. The authors feel, therefore, that statistical analysis is not appropriate or possible for this particular project. Communal crafting projects have been used by groups of women for centuries to make often beautiful but utilitarian objects. These projects have traditionally existed in the domestic sphere but we have successfully harnessed the same skills to engage not just the participants (who happened to all be women) but a wider, global community in un","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/23982128211035062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45722891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.","authors":"Ethan G Dutcher, E A Claudia Pama, Mary-Ellen Lynall, Shahid Khan, Menna R Clatworthy, Trevor W Robbins, Edward T Bullmore, Jeffrey W Dalley","doi":"10.1177/2398212820978049","DOIUrl":"10.1177/2398212820978049","url":null,"abstract":"<p><p>Repeated maternal separation is the most widely used pre-clinical approach to investigate the relationship between early-life chronic stress and its neuropsychiatric and physical consequences. In this systematic review, we identified 46 studies that conducted repeated maternal separation or single-episode maternal separation and reported measurements of interleukin-1b, interleukin-6, interleukin-10, tumour necrosis factor-alpha, or microglia activation and density. We report that in the short-term and in the context of later-life stress, repeated maternal separation has pro-inflammatory immune consequences in diverse tissues. Repeated maternal separation animals exhibit greater microglial activation and elevated pro-inflammatory cytokine signalling in key brain regions implicated in human psychiatric disorders. Notably, repeated maternal separation generally has no long-term effect on cytokine expression in any tissue in the absence of later-life stress. These observations suggest that the elevated inflammatory signalling that has been reported in humans with a history of early-life stress may be the joint consequence of ongoing stressor exposure together with potentiated neural and/or immune responsiveness to stressors. Finally, our findings provide detailed guidance for future studies interrogating the causal roles of early-life stress and inflammation in disorders such as major depression.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820978049"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38821546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striatal and hippocampal contributions to flexible navigation in rats and humans.","authors":"Christoffer J Gahnstrom, Hugo J Spiers","doi":"10.1177/2398212820979772","DOIUrl":"10.1177/2398212820979772","url":null,"abstract":"<p><p>The hippocampus has been firmly established as playing a crucial role in flexible navigation. Recent evidence suggests that dorsal striatum may also play an important role in such goal-directed behaviour in both rodents and humans. Across recent studies, activity in the caudate nucleus has been linked to forward planning and adaptation to changes in the environment. In particular, several human neuroimaging studies have found the caudate nucleus tracks information traditionally associated with that by the hippocampus. In this brief review, we examine this evidence and argue the dorsal striatum encodes the transition structure of the environment during flexible, goal-directed behaviour. We highlight that future research should explore the following: (1) Investigate neural responses during spatial navigation via a biophysically plausible framework explained by reinforcement learning models and (2) Observe the interaction between cortical areas and both the dorsal striatum and hippocampus during flexible navigation.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820979772"},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38803997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cytokines in modulating learning and memory and brain plasticity.","authors":"Julie-Myrtille Bourgognon, Jonathan Cavanagh","doi":"10.1177/2398212820979802","DOIUrl":"10.1177/2398212820979802","url":null,"abstract":"<p><p>Cytokines are proteins secreted in the central nervous system by neurons, microglia, astrocytes and infiltrating peripheral immune cells under physiological and pathological conditions. Over the last 20 years, a growing number of reports have investigated the effects of these molecules on brain plasticity. In this review, we describe how the key cytokines interleukin 1β, interleukin 6 and tumour necrosis factor α were found to support long-term plasticity and learning and memory processes in physiological conditions. In contrast, during inflammation where cytokines levels are elevated such as in models of brain injury or infection, depression or neurodegeneration, the effects of cytokines are mostly detrimental to memory mechanisms, associated behaviours and homeostatic plasticity.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820979802"},"PeriodicalIF":0.0,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38795427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological coding of space and time in the hippocampus, entorhinal cortex, and retrosplenial cortex.","authors":"Andrew S Alexander, Jennifer C Robinson, Holger Dannenberg, Nathaniel R Kinsky, Samuel J Levy, William Mau, G William Chapman, David W Sullivan, Michael E Hasselmo","doi":"10.1177/2398212820972871","DOIUrl":"10.1177/2398212820972871","url":null,"abstract":"<p><p>Neurophysiological recordings in behaving rodents demonstrate neuronal response properties that may code space and time for episodic memory and goal-directed behaviour. Here, we review recordings from hippocampus, entorhinal cortex, and retrosplenial cortex to address the problem of how neurons encode multiple overlapping spatiotemporal trajectories and disambiguate these for accurate memory-guided behaviour. The solution could involve neurons in the entorhinal cortex and hippocampus that show mixed selectivity, coding both time and location. Some grid cells and place cells that code space also respond selectively as time cells, allowing differentiation of time intervals when a rat runs in the same location during a delay period. Cells in these regions also develop new representations that differentially code the context of prior or future behaviour allowing disambiguation of overlapping trajectories. Spiking activity is also modulated by running speed and head direction, supporting the coding of episodic memory not as a series of snapshots but as a trajectory that can also be distinguished on the basis of speed and direction. Recent data also address the mechanisms by which sensory input could distinguish different spatial locations. Changes in firing rate reflect running speed on long but not short time intervals, and few cells code movement direction, arguing against path integration for coding location. Instead, new evidence for neural coding of environmental boundaries in egocentric coordinates fits with a modelling framework in which egocentric coding of barriers combined with head direction generates distinct allocentric coding of location. The egocentric input can be used both for coding the location of spatiotemporal trajectories and for retrieving specific viewpoints of the environment. Overall, these different patterns of neural activity can be used for encoding and disambiguation of prior episodic spatiotemporal trajectories or for planning of future goal-directed spatiotemporal trajectories.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820972871"},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/76/10.1177_2398212820972871.PMC7708714.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38351909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions.","authors":"Steven L Poulter,&nbsp;Yutaka Kosaki,&nbsp;David J Sanderson,&nbsp;Anthony McGregor","doi":"10.1177/2398212820972599","DOIUrl":"https://doi.org/10.1177/2398212820972599","url":null,"abstract":"<p><p>We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two distinctive objects in each of the right-angled corners. In a different room, rats were then placed into a rectangular arena with two identical copies of one of the two objects from the exploration phase, one in each of the two adjacent right-angled corners that were separated by a long wall. Time spent exploring these two objects was recorded as a measure of recognition memory. Since both objects were in different locations with respect to the room (different between exploration and test phases) and the global geometry (also different between exploration and test phases), differential exploration of the objects must be a result of initial habituation to the object relative to its local geometric context. The results indicated an impairment in processing the local geometric features of the environment for both hippocampus and dorsolateral striatum lesioned rats compared with sham-operated controls, though a control experiment showed these rats were unimpaired in a standard object recognition task. The dorsolateral striatum has previously been implicated in egocentric route-learning, but the results indicate an unexpected role for the dorsolateral striatum in processing the spatial layout of the environment. The results provide the first evidence that lesions to the hippocampus and dorsolateral striatum impair spontaneous encoding of local environmental geometric features.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820972599"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2398212820972599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38681218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediabetes and working memory in older adults.","authors":"Gilda E Ennis,&nbsp;Ursula Saelzler,&nbsp;Guillermo E Umpierrez,&nbsp;Scott D Moffat","doi":"10.1177/2398212820961725","DOIUrl":"https://doi.org/10.1177/2398212820961725","url":null,"abstract":"<p><p>Insulin sensitivity, pancreatic β-cell function, fasting glucose, and 2-h post-load glucose were related to cognition in cognitively healthy nondiabetic older adults. Thirty-five adults (⩾65 years) underwent a 2-h oral glucose tolerance test and cognitive testing. Seventeen had normal glucose tolerance and 18 had intermediate hyperglycaemia or prediabetes (World Health Organization criteria). Fasting glucose and 2-h post-load glucose and oral glucose tolerance test-derived measures of β-cell function (oral disposition index) and insulin sensitivity were analysed as predictors of four cognitive domains: verbal episodic memory, verbal fluency, executive function, and working memory. The prediabetes group had significantly worse working memory performance than the normal glucose tolerance group. Controlling for age and education, decreased oral disposition index, and increased 2-h post-load glucose were significantly related to worse working memory performance. Prediabetes may worsen working memory in healthy older adults. Reduced pancreatic β-cell function should be investigated as a contributor to age-related cognitive decline.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820961725"},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2398212820961725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38517183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.","authors":"Richard N Henson,&nbsp;Sana Suri,&nbsp;Ethan Knights,&nbsp;James B Rowe,&nbsp;Rogier A Kievit,&nbsp;Donald M Lyall,&nbsp;Dennis Chan,&nbsp;Else Eising,&nbsp;Simon E Fisher","doi":"10.1177/2398212820961704","DOIUrl":"https://doi.org/10.1177/2398212820961704","url":null,"abstract":"Polymorphisms in the apolipoprotein E (APOE) gene have been associated with individual differences in cognition, brain structure and brain function. For example, the ε4 allele has been associated with cognitive and brain impairment in old age and increased risk of dementia, while the ε2 allele has been claimed to be neuroprotective. According to the ‘antagonistic pleiotropy’ hypothesis, these polymorphisms have different effects across the lifespan, with ε4, for example, postulated to confer benefits on cognitive and brain functions earlier in life. In this stage 2 of the Registered Report – https://osf.io/bufc4, we report the results from the cognitive and brain measures in the Cambridge Centre for Ageing and Neuroscience cohort (www.cam-can.org). We investigated the antagonistic pleiotropy hypothesis by testing for allele-by-age interactions in approximately 600 people across the adult lifespan (18–88 years), on six outcome variables related to cognition, brain structure and brain function (namely, fluid intelligence, verbal memory, hippocampal grey-matter volume, mean diffusion within white matter and resting-state connectivity measured by both functional magnetic resonance imaging and magnetoencephalography). We found no evidence to support the antagonistic pleiotropy hypothesis. Indeed, Bayes factors supported the null hypothesis in all cases, except for the (linear) interaction between age and possession of the ε4 allele on fluid intelligence, for which the evidence for faster decline in older ages was ambiguous. Overall, these pre-registered analyses question the antagonistic pleiotropy of APOE polymorphisms, at least in healthy adults.","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820961704"},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2398212820961704","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38517185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used.","authors":"Pierre-Yves Jacob,&nbsp;Tiffany Van Cauter,&nbsp;Bruno Poucet,&nbsp;Francesca Sargolini,&nbsp;Etienne Save","doi":"10.1177/2398212820953004","DOIUrl":"https://doi.org/10.1177/2398212820953004","url":null,"abstract":"<p><p>The entorhinal-hippocampus network plays a central role in navigation and episodic memory formation. To investigate these interactions, we examined the effect of medial entorhinal cortex lesions on hippocampal place cell activity. Since the medial entorhinal cortex is suggested to play a role in the processing of self-motion information, we hypothesised that such processing would be necessary for maintaining stable place fields in the absence of environmental cues. Place cells were recorded as medial entorhinal cortex-lesioned rats explored a circular arena during five 16-min sessions comprising a baseline session with all sensory inputs available followed by four sessions during which environmental (i.e. visual, olfactory, tactile) cues were progressively reduced to the point that animals could rely exclusively on self-motion cues to maintain stable place fields. We found that place field stability and a number of place cell firing properties were affected by medial entorhinal cortex lesions in the baseline session. When rats were forced to rely exclusively on self-motion cues, within-session place field stability was dramatically decreased in medial entorhinal cortex rats relative to SHAM rats. These results support a major role of the medial entorhinal cortex in processing self-motion cues, with this information being conveyed to the hippocampus to help anchor and maintain a stable spatial representation during movement.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820953004"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2398212820953004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38516750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(2<i>S</i>,6<i>S</i>)- and (2<i>R</i>,6<i>R</i>)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice.","authors":"Heather Kang,&nbsp;Pojeong Park,&nbsp;Muchun Han,&nbsp;Patrick Tidball,&nbsp;John Georgiou,&nbsp;Zuner A Bortolotto,&nbsp;David Lodge,&nbsp;Bong-Kiun Kaang,&nbsp;Graham L Collingridge","doi":"10.1177/2398212820957847","DOIUrl":"https://doi.org/10.1177/2398212820957847","url":null,"abstract":"<p><p>The ketamine metabolite (2<i>R</i>,6<i>R</i>)-hydroxynorketamine has been proposed to have rapid and persistent antidepressant actions in rodents, but its mechanism of action is controversial. We have compared the ability of (<i>R,S</i>)-ketamine with the (2<i>S</i>,6<i>S</i>)- and (2<i>R</i>,6<i>R</i>)-isomers of hydroxynorketamine to affect the induction of <i>N</i>-methyl-d-aspartate receptor-dependent long-term potentiation in the mouse hippocampus. Following pre-incubation of these compounds, we observed a concentration-dependent (1-10 μM) inhibition of long-term potentiation by ketamine and a similar effect of (2<i>S</i>,6<i>S</i>)-hydroxynorketamine. At a concentration of 10 μM, (2<i>R</i>,6<i>R</i>)-hydroxynorketamine also inhibited the induction of long-term potentiation. These findings raise the possibility that inhibition of <i>N</i>-methyl-d-aspartate receptor-mediated synaptic plasticity is a site of action of the hydroxynorketamine metabolites with respect to their rapid and long-lasting antidepressant-like effects.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"4 ","pages":"2398212820957847"},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2398212820957847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38516751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}