Brain and neuroscience advances最新文献

Brain and Neuroscience Advances - 2024 in review.

Brain and neuroscience advances Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251317305

Kate Baker

引用次数: 0

Under pressure: UK preclinical neuroscience at a crossroads.

Brain and neuroscience advances Pub Date : 2025-02-04 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251314616

Mark E Walton, Catherine M Abbott, Laura A Ajram, Narender Ramnani, Tara L Spires-Jones

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No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching.

Brain and neuroscience advances Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251314577

Petar P Raykov, Jessica Daly, Simon E Fisher, Else Eising, Linda Geerligs, Chris M Bird

{"title":"No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching.","authors":"Petar P Raykov, Jessica Daly, Simon E Fisher, Else Eising, Linda Geerligs, Chris M Bird","doi":"10.1177/23982128251314577","DOIUrl":"10.1177/23982128251314577","url":null,"abstract":"Apolipoprotein E ε4 is a major genetic risk factor for Alzheimer's disease, and some apolipoprotein E ε4 carriers show Alzheimer's disease-related neuropathology many years before cognitive changes are apparent. Therefore, studying healthy apolipoprotein E genotyped individuals offers an opportunity to investigate the earliest changes in brain measures that may signal the presence of disease-related processes. For example, subtle changes in functional magnetic resonance imaging functional connectivity, particularly within the default mode network, have been described when comparing healthy ε4 carriers to ε3 carriers. Similarly, very mild impairments of episodic memory have also been documented in healthy apolipoprotein E ε4 carriers. Here, we use a naturalistic activity (movie watching), and a marker of episodic memory encoding (transient changes in functional magnetic resonance imaging activity and functional connectivity around so-called 'event boundaries'), to investigate potential phenotype differences associated with the apolipoprotein E ε4 genotype in a large sample of healthy adults. Using Bayes factor analyses, we found strong evidence against existence of differences associated with apolipoprotein E allelic status. Similarly, we did not find apolipoprotein E-associated differences when we ran exploratory analyses examining: functional system segregation across the whole brain, and connectivity within the default mode network. We conclude that apolipoprotein E genotype has little or no effect on how ongoing experiences are processed in healthy adults. The mild phenotype differences observed in some studies may reflect early effects of Alzheimer's disease-related pathology in apolipoprotein E ε4 carriers.","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251314577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The map and the territory: Why diversity advances neuroscience. 地图和领域：为什么多样性促进神经科学的发展。

Brain and neuroscience advances Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI: 10.1177/23982128241309691

Alexis Deighton MacIntyre

引用次数: 0

Why does research matter to psychiatrists? 为什么研究对精神科医生很重要？

Brain and neuroscience advances Pub Date : 2025-01-11 eCollection Date: 2025-01-01 DOI: 10.1177/23982128241305866

Lindsey I Sinclair, Laura Ajram, Gertrude Seneviratne, Derek Tracy, Hugo Critchley

引用次数: 0

Review of the gastric physiology of disgust: Proto-nausea as an under-explored facet of the gut-brain axis. 恶心的胃生理学综述：原恶心是肠脑轴的一个未被充分探索的方面。

Brain and neuroscience advances Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1177/23982128241305890

Sameer N B Alladin, Ruth Judson, Poppy Whittaker, Angela S Attwood, Edwin S Dalmaijer

{"title":"Review of the gastric physiology of disgust: Proto-nausea as an under-explored facet of the gut-brain axis.","authors":"Sameer N B Alladin, Ruth Judson, Poppy Whittaker, Angela S Attwood, Edwin S Dalmaijer","doi":"10.1177/23982128241305890","DOIUrl":"10.1177/23982128241305890","url":null,"abstract":"Humans feel visceral disgust when faced with potential contaminants like bodily effluvia. The emotion serves to reject potentially contaminated food and is paired with proto-nausea: alterations in gastric rhythm in response to disgust. Here, we offer a narrative synthesis of the existing literature on the effects of disgust on the stomach as measured through electrogastrography, a non-invasive technique that measures stomach activity with electrodes placed on the abdominal skin surface. After identifying and assessing 368 studies for eligibility and inclusion based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses process, we reviewed a final sample of only 10 articles that employed electrogastrography to assess gastric responses to unpleasant stimuli, including disgust elicitors. Reviewed findings illustrate that changes in gastric rhythm are associated with negatively valenced emotions, and most reliably with visceral disgust elicitors. This rhymes with recent evidence for a causal role of gastric state in reductions in visceral disgust avoidance. Because limitations in the reviewed body of work come from the low number of studies and relatively small sample sizes, we strongly encourage studies of proto-nausea in designs with higher statistical power, ideally paired with experimental manipulations of gastric state.","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"8 ","pages":"23982128241305890"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From neurophobia to neurophilia: Fostering confidence and passion for neurology in medical students. 从神经恐惧症到神经癖：培养医学生对神经学的信心和热情。

Brain and neuroscience advances Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI: 10.1177/23982128241307148

Amna Ali, Paul Stephen Hubbard, Muzuki Ueda

引用次数: 0

Are all neuroscience degrees the same? A comparison of undergraduate neuroscience degrees across the United Kingdom. 所有的神经科学学位都一样吗？英国神经科学本科学位的比较。

Brain and neuroscience advances Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI: 10.1177/23982128241307585

Isabel M Logan, Charlotte Mosley, Thomas Malcomson, Emma Yhnell

引用次数: 0

Centralising a loss of consciousness to the central medial thalamus. 将意识丧失集中到中央内侧丘脑。

Brain and neuroscience advances Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1177/23982128241306549

Florence Rawlings-Mortimer, Jeffrey W Dalley

引用次数: 0

Genetically modified animals as models of neurodevelopmental conditions: A review of systematic review reporting quality. 将转基因动物作为神经发育状况的模型：系统综述报告质量回顾。

Brain and neuroscience advances Pub Date : 2024-10-18 eCollection Date: 2024-01-01 DOI: 10.1177/23982128241287279

Emma Wilson, Gillian Currie, Malcolm Macleod, Peter Kind, Emily S Sena

{"title":"Genetically modified animals as models of neurodevelopmental conditions: A review of systematic review reporting quality.","authors":"Emma Wilson, Gillian Currie, Malcolm Macleod, Peter Kind, Emily S Sena","doi":"10.1177/23982128241287279","DOIUrl":"10.1177/23982128241287279","url":null,"abstract":"Using genetically modified animals to model neurodevelopmental conditions helps better our understanding of biology underlying these conditions. Animal research has unique characteristics not shared with clinical research, meaning systematic review methods must be adapted to this context. We aim to evaluate the quantity, characteristics, and reporting quality of systematic reviews which synthesise research using genetically modified animals to model neurodevelopmental conditions. On 23 January 2023, we searched PubMed, Embase, and the Web of Science Core Collection to identify systematic reviews of genetic neurodevelopmental condition animal research where the modified gene was one in a list of 102 genes associated with neurodevelopmental conditions identified through large-scale exome sequencing or Fmr1, Mecp2, or Ube3a. Two independent reviewers screened studies based on full text and assessed the reporting quality of relevant reviews using an adapted version of the PRISMA checklist (PRISMA-Pre). Twelve review publications met our criteria. We found mixed levels of reporting: items such as identifying the publication as a systematic review in the title, search strategies, and funding sources being well reported, and others such as protocol registration and data sharing less well reported. We also identified 19 review registrations via PROSPERO, most of which remain unpublished after their anticipated end dates. Systematic reviews are limited by lack of reporting. Increased awareness of reporting guidelines may help authors increase the transparency and reproducibility, and therefore the reliability, of their systematic reviews.","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"8 ","pages":"23982128241287279"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0