Brain and neuroscience advances最新文献

{"title":"'How does it make you feel?' Reclaiming subjectivity in neuroscience.","authors":"Estherina Trachtenberg, Ido Shalev, Nimrod Hertz-Palmor","doi":"10.1177/23982128251339567","DOIUrl":"https://doi.org/10.1177/23982128251339567","url":null,"abstract":"","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251339567"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimmunometabolic alterations and severity of depressive symptoms in people with HIV: An exploratory diffusion-weighted MRS study.","authors":"Arish Mudra Rakshasa-Loots, Goabaone Diteko, Nicholas G Dowell, Itamar Ronen, Jaime H Vera","doi":"10.1177/23982128251335792","DOIUrl":"https://doi.org/10.1177/23982128251335792","url":null,"abstract":"<p><p>Depression is associated with inflammation in the periphery and the central nervous system. People with HIV are at greater risk for depression, which may in part be driven by sustained neuroinflammation, although individuals with severe depression are often excluded from studies of HIV-related co-morbidities. In this exploratory study, we aimed to explore the neuroimaging signatures of severe and persistent depression among people with HIV. We enrolled N = 20 adults with HIV in Brighton, UK, of whom n = 11 had a Patient Health Questionnaire-9 (PHQ-9) score ⩾15 and a history of receiving antidepressant medication. We used diffusion-weighted magnetic resonance spectroscopy (DW-MRS), an emerging neuroimaging technique sensitive to neuroinflammation, to assess neurometabolite diffusion in the anterior cingulate cortex. Participants also underwent standard magnetic resonance spectroscopy (MRS) to assess neurometabolite concentrations in the anterior cingulate cortex, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess blood-brain barrier permeability in the whole brain and the thalamus. We observed a significant positive correlation between intracellular diffusion of creatine and depressive symptom severity (ρ = 0.46, p = 0.047). Increased creatine diffusion has previously been reported in conditions characterised by hypermetabolism and neuroinflammation, suggesting that worse depressive symptom severity in people with HIV may be correlated with neuroimmunometabolic alterations. Metabolite concentrations and blood-brain barrier permeability largely did not correlate with depressive symptom severity in this sample. In summary, we explored neuroimaging signatures of severe depression in people with HIV, including by applying diffusion-weighted magnetic resonance spectroscopy in this population. We report early evidence that worse depressive symptom severity in people with HIV may be correlated with neuroimmunometabolic dysfunction, evidenced by increased diffusion of creatine, likely reflecting hypermetabolism and neuroinflammation. Future research may aim to replicate these findings in larger and more diverse samples and compare the diffusion of neurometabolites between people with and without HIV living with severe depression.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251335792"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cortisol awakening response: Fact or fiction?","authors":"Clara Velazquez Sanchez, Jeffrey W Dalley","doi":"10.1177/23982128251327712","DOIUrl":"https://doi.org/10.1177/23982128251327712","url":null,"abstract":"<p><p>There has been significant discussion in recent years whether the increase in cortisol release that accompanies waking is dependent on the waking process itself or instead reflects a continuation of an underlying circadian rhythm. Establishing the origin or indeed existence of the so-called cortisol awakening response is important as disturbances in post-awakening cortisol secretion are associated with a range of stress-related disorders. The study reviewed in this article adopted an innovative in vivo microdialysis approach to measure tissue-free cortisol levels in 201 healthy volunteers before and after awakening in a home setting (Klaas et al., 2025). Rather surprisingly, the rate of increase in cortisol secretion did not change when participants awoke compared with the preceding hour when participants were asleep. However, considerable between-subject variability was observed, which was partly explained by sleep duration and the timing of waking relative to the previous morning. These findings highlight the complexity of the cortisol awakening response and summon caution in the interpretation of cortisol measurements based solely on post-awakening responses.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251327712"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological rehabilitation: A necessary next step in clinical psychiatry and neuroscience research.","authors":"Manuel Faria","doi":"10.1177/23982128251327253","DOIUrl":"https://doi.org/10.1177/23982128251327253","url":null,"abstract":"","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251327253"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From laboratory to life: Integrating diverse ways of knowing in mental health science.","authors":"James Downs","doi":"10.1177/23982128251327709","DOIUrl":"https://doi.org/10.1177/23982128251327709","url":null,"abstract":"","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251327709"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment.","authors":"Faissal Sharif, Catherine J Harmer, Miriam C Klein-Flügge, Huiling Tan","doi":"10.1177/23982128251322241","DOIUrl":"10.1177/23982128251322241","url":null,"abstract":"<p><p>Mental disorders pose a significant global burden and constitute a major cause of disability worldwide. Despite strides in treatment, a substantial number of patients do not respond adequately, underscoring the urgency for innovative approaches. Traditional non-invasive brain stimulation techniques show promise, yet grapple with challenges regarding efficacy and specificity. Variations in mechanistic understanding and reliability among non-invasive brain stimulation methods are common, with limited spatial precision and physical constraints hindering the ability to target subcortical areas often implicated in the disease aetiology. Novel techniques such as transcranial ultrasonic stimulation and temporal interference stimulation have gained notable momentum in recent years, possibly addressing these shortcomings. Transcranial ultrasonic stimulation (TUS) offers exceptional spatial precision and deeper penetration compared with conventional electrical and magnetic stimulation techniques. Studies targeting a diverse array of brain regions have shown its potential to affect neuronal excitability, functional connectivity and symptoms of psychiatric disorders such as major depressive disorder. Nevertheless, challenges such as target planning and addressing acoustic interactions with the skull must be tackled for its widespread adoption in research and potentially clinical settings. Similar to transcranial ultrasonic stimulation, temporal interference (TI) stimulation offers the potential to target deeper subcortical areas compared with traditional non-invasive brain stimulation, albeit requiring a comparatively higher current for equivalent neural effects. Promising yet still sparse research highlights TI's potential to selectively modulate neuronal activity, showing potential for its utility in psychiatry. Overall, recent strides in non-invasive brain stimulation methods like transcranial ultrasonic stimulation and temporal interference stimulation not only open new research avenues but also hold potential as effective treatments in psychiatry. However, realising their full potential necessitates addressing practical challenges and optimising their application effectively.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251322241"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Brain and Neuroscience Advances</i> - 2024 in review.","authors":"Kate Baker","doi":"10.1177/23982128251317305","DOIUrl":"10.1177/23982128251317305","url":null,"abstract":"","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251317305"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under pressure: UK preclinical neuroscience at a crossroads.","authors":"Mark E Walton, Catherine M Abbott, Laura A Ajram, Narender Ramnani, Tara L Spires-Jones","doi":"10.1177/23982128251314616","DOIUrl":"10.1177/23982128251314616","url":null,"abstract":"<p><p>Graphical Abstract.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251314616"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching.","authors":"Petar P Raykov, Jessica Daly, Simon E Fisher, Else Eising, Linda Geerligs, Chris M Bird","doi":"10.1177/23982128251314577","DOIUrl":"10.1177/23982128251314577","url":null,"abstract":"<p><p>Apolipoprotein E ε4 is a major genetic risk factor for Alzheimer's disease, and some apolipoprotein E ε4 carriers show Alzheimer's disease-related neuropathology many years before cognitive changes are apparent. Therefore, studying healthy apolipoprotein E genotyped individuals offers an opportunity to investigate the earliest changes in brain measures that may signal the presence of disease-related processes. For example, subtle changes in functional magnetic resonance imaging functional connectivity, particularly within the default mode network, have been described when comparing healthy ε4 carriers to ε3 carriers. Similarly, very mild impairments of episodic memory have also been documented in healthy apolipoprotein E ε4 carriers. Here, we use a naturalistic activity (movie watching), and a marker of episodic memory encoding (transient changes in functional magnetic resonance imaging activity and functional connectivity around so-called 'event boundaries'), to investigate potential phenotype differences associated with the apolipoprotein E ε4 genotype in a large sample of healthy adults. Using Bayes factor analyses, we found strong evidence against existence of differences associated with apolipoprotein E allelic status. Similarly, we did not find apolipoprotein E-associated differences when we ran exploratory analyses examining: functional system segregation across the whole brain, and connectivity within the default mode network. We conclude that apolipoprotein E genotype has little or no effect on how ongoing experiences are processed in healthy adults. The mild phenotype differences observed in some studies may reflect early effects of Alzheimer's disease-related pathology in apolipoprotein E ε4 carriers.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251314577"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The map and the territory: Why diversity advances neuroscience.","authors":"Alexis Deighton MacIntyre","doi":"10.1177/23982128241309691","DOIUrl":"https://doi.org/10.1177/23982128241309691","url":null,"abstract":"","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128241309691"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}