Brain and neuroscience advances最新文献

{"title":"Corrigendum to \"Basal Activation of Astrocytic Nrf2 in Neuronal Culture Media: Challenges and Implications for Neuron-Astrocyte Modelling\".","authors":"","doi":"10.1177/23982128261470929","DOIUrl":"https://doi.org/10.1177/23982128261470929","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/23982128251351360.].</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261470929"},"PeriodicalIF":0.0,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's Research UK Research Conference 2026.","authors":"Elizabeth M Simzer, Jamie A Elliott, Soraya Meftah, Sowmya Sekizar, Lauren F P Young, James H Catterson","doi":"10.1177/23982128261454415","DOIUrl":"10.1177/23982128261454415","url":null,"abstract":"<p><p>On 24-25 February 2026, Alzheimer's Research UK held its annual research conference at Manchester Central Convention Complex and online. The meeting brought together over 700 researchers spanning molecular biology, data science, clinical trials, prevention, and patient engagement. Over 2 days of plenaries, parallel sessions, and discussions, a clear message emerged: the field of dementia research is entering a new, more hopeful era. This report summarises a meeting that highlighted how dementia research is moving beyond the search for a single solution and instead embracing a multidimensional, collaborative framework for precision care.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261454415"},"PeriodicalIF":0.0,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13260779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It Takes a Village: Patient Satisfaction in a Specialized Atypical Parkinsonism Interdisciplinary Clinic.","authors":"Margaret Ivancic, Jessica Shurer, Hailey Daly, Nina Browner, Miriam Sklerov","doi":"10.1177/23982128261456452","DOIUrl":"10.1177/23982128261456452","url":null,"abstract":"<p><strong>Background & objectives: </strong>Atypical parkinsonism syndromes (multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS)) are life-limiting neurodegenerative disorders with complex motor and nonmotor symptoms. A person-centered, coordinated, multidisciplinary approach may provide optimal care. Interdisciplinary care models in complex neurologic diseases are shown to improve disease outcomes. It is unknown whether specialized interdisciplinary care benefits people with atypical parkinsonism. Our study sought to determine patient satisfaction with a specialized atypical parkinsonism interdisciplinary clinic.</p><p><strong>Methods: </strong>A retrospective, cross-sectional analysis was conducted of anonymous satisfaction surveys from patients who attended the UNC atypical parkinsonism interdisciplinary clinic from 10/2017-3/2024. The survey was divided into four subcategories - Services, Results, Clinicians, and Overall Experience. Responses were converted to numerical values for statistical analysis. Linear regression was used to determine predictors of overall experience scores. Qualitative data was analyzed and categorized into themes.</p><p><strong>Results: </strong>51.4% of all clinic attendees were diagnosed with PSP, 36.5% with MSA, and 9.5% with CBS. 39 of 74 (52.7%) satisfaction surveys were completed. Survey responses indicated high levels of satisfaction across all categories. Responses in the services category were the strongest predictor of variability in overall experience scores. Common themes from qualitative data were expressions of gratitude and constructive feedback.</p><p><strong>Discussion: </strong>We report high patient satisfaction ratings in this first investigation of patient-centered outcomes in specialized interdisciplinary clinics for atypical parkinsonism. Future investigations focused on quality of life and care partner burden will provide additional insights for best care practices for people living with atypical parkinsonisms.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261456452"},"PeriodicalIF":0.0,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First, breathe: Rethinking neuroscience engagement at Glastonbury festival.","authors":"Will Smith, Zoe Robbins","doi":"10.1177/23982128261443571","DOIUrl":"10.1177/23982128261443571","url":null,"abstract":"","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261443571"},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The <i>BNA</i> Festive Symposium 2025 - delivering neuroscience: From synapse to society.","authors":"Dana Abdulhafiz, Adeyinka Ruth Adeniran, Oluwatobi Ajewole, Limou Dembele, Constantinos Panayiotou, Karina Maria Piotrowska, Tijana Urosevic, Wanjia Yu, Kate Baker","doi":"10.1177/23982128261427975","DOIUrl":"10.1177/23982128261427975","url":null,"abstract":"<p><p>The <i>BNA</i>'s winter research meeting took place high above the City of London at Canary Wharf, an inspiring setting to consider new perspectives. The central theme was <i>'delivery'</i>, focusing on translation of fundamental neuroscience into effective therapies. The event targeted three main questions: How can therapies be effectively delivered to the brain? How might 'meaningful intervention' be realised for patients? How might hope be maintained for people with neurological and psychiatric disorders? Several interlocking ideas and debates emerged, circling around a central concern of how to move from molecular promise to effective and equitable real-world change for patients.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261427975"},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The LOAD2 mouse model of late-onset alzheimer's disease exhibits an accelerated onset of locomotor and anxiety deficits.","authors":"Shinwon Kang, Ashish Kadia, Junhui Wang, Rachael Ingram, Patrick Tidball, Fuzi Jin, Aram Abbasian, John Georgiou, Graham L Collingridge","doi":"10.1177/23982128261430392","DOIUrl":"10.1177/23982128261430392","url":null,"abstract":"<p><p>Late-onset alzheimer's disease is the most common form of dementia, and it arises from complex genetic and environmental interactions. Preclinical models that replicate the slow progression and long prodromal phase of late-onset alzheimer's disease are critical for identifying early therapeutic targets. The LOAD2 mouse model, developed on the C57BL/6J genetic background, integrates key late-onset alzheimer's disease genetic risk factors: <i>APOE4</i>, <i>Trem2</i>*R47H, and an <i>App</i> allele encoding humanised amyloid beta. This study aimed to characterise key disease-relevant phenotypes of LOAD2 mice during ageing. Behavioural assays were conducted on 18- and 24-month-old LOAD2 and age-matched C57BL/6J wild-type control mice. At 18 months, LOAD2 mice exhibited significantly reduced locomotor activity compared to wild-type controls. However, this difference was diminished at 24 months as wild-type mice displayed an age-related decline in total distance travelled. Similarly, anxiety-like behaviour was elevated in 18-month-old LOAD2 mice relative to wild-type controls, but this difference was no longer evident at 24 months due to increased anxiety levels in aged wild-type mice. In contrast, spatial working memory and associative fear learning were intact in both LOAD2 and wild-type mice at 18 and 24 months of age, indicating no age- or genotype-dependent deficits in these forms of memory. Both groups of mice performed equally poorly in novel object and novel location recognition tasks at both ages. Thus, compared to age-matched wild-type mice, LOAD2 mice exhibit early locomotor deficits and heightened anxiety, but not overt cognitive impairment beyond that of normal ageing. These phenotypes are reminiscent of prodromal symptoms of late-onset alzheimer's disease in humans.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261430392"},"PeriodicalIF":0.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-visiting cognitive reserve: The importance of multiple brain measures.","authors":"Richard N Henson","doi":"10.1177/23982128261422282","DOIUrl":"10.1177/23982128261422282","url":null,"abstract":"<p><p>The term 'cognitive reserve' broadly refers to better-than-expected cognitive abilities in old age, presumed to reflect environmental/lifestyle factors earlier in life. This commentary addresses the question of what determines 'better than expected' cognition; specifically, whether cognitive reserve can be 'explained away' by considering multiple brain measurements. Using simulations, I show that, once one allows for multiple brain properties related to cognition, differential maintenance of those properties can reproduce the clinical picture associated with cognitive reserve. Using real data, I then show that white-matter microstructure and functional connectivity explain significant additional variance in fluid intelligence beyond grey-matter volume (at least cross-sectionally), supporting the importance of measuring multiple brain properties. Using multimodal, longitudinal data to identify changes in those brain properties that are especially important for changes in cognition will help decide which interventions are most likely to be effective at maintaining cognition in old age.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261422282"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing oligodendrocyte and myelin alterations following absence seizures in a rat model of <i>GRIN2B</i> neurodevelopmental disorder.","authors":"Zita Francsics, Eleni Tsoukala, Katerina Hristova, Alfredo Gonzalez-Sulser, Lida Zoupi","doi":"10.1177/23982128251405032","DOIUrl":"10.1177/23982128251405032","url":null,"abstract":"<p><p>Neuronal activity can modulate myelination throughout life, influencing circuit function and behaviour. Pathological changes in neuronal activity have been associated with myelin remodelling in a rat model of idiopathic absence seizures, raising the question of whether this represents a common mechanism underlying absence epilepsy. Here we examined oligodendrocyte populations and myelin architecture in a rat model of <i>GRIN2B</i> neurodevelopmental disorder, a rare and severe condition that is frequently accompanied by absence seizures. Using histology and 3D imaging, we report that despite robust seizure-like activity in this model, there was no evidence of changes in oligodendrocyte lineage cell populations, overall myelin content, or node of Ranvier organization. These results contrast with prior reports of seizure-associated myelin modulation, indicating that seizure-induced myelin plasticity may not be a uniform feature across all models of absence seizures. Our findings indicate that such adaptations may depend on additional factors including seizure burden and timing, highlighting the need for further analysis to determine when and how myelin plasticity contributes to absence epilepsy.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251405032"},"PeriodicalIF":0.0,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12719588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cambridge neuroscience symposium: Interventions and recovery.","authors":"Katherine R Birditt, Alasdair Coles, Amy Doyle, Bayan Hijazi, Ailie G McWhinnie, Thomas Pritchard, Ewan St John Smith","doi":"10.1177/23982128251406340","DOIUrl":"10.1177/23982128251406340","url":null,"abstract":"<p><p>On 10-11 September 2025, the Cambridge Neuroscience Interdisciplinary Research Centre held its eighth biennial symposium on the topic of <i>Interventions and Recovery</i>. The meeting saw basic and clinical neuroscientists come together from Cambridge and beyond to discuss the latest advancements in cell and gene therapies, pharmaceutical innovations and cutting-edge neurotechnology aimed at addressing neurological diseases. Here, we provide a summary of the meeting, which shined a light on reasons to be optimistic for the future of treating conditions of the nervous system.</p>","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251406340"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12708998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neurobiological rationale for improving paternity leave in academia and beyond.","authors":"Paul G Anastasiades, Valentina Mosienko, Antonia Tzemanaki","doi":"10.1177/23982128251401757","DOIUrl":"10.1177/23982128251401757","url":null,"abstract":"","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251401757"},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12701226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}