Brain and neuroscience advances最新文献

First, breathe: Rethinking neuroscience engagement at Glastonbury festival. 首先，呼吸：重新思考格拉斯顿伯里音乐节的神经科学参与。

Brain and neuroscience advances Pub Date : 2026-04-13 eCollection Date: 2026-01-01 DOI: 10.1177/23982128261443571

Will Smith, Zoe Robbins

引用次数: 0

The BNA Festive Symposium 2025 - delivering neuroscience: From synapse to society. BNA节日研讨会2025 -传递神经科学：从突触到社会。

Brain and neuroscience advances Pub Date : 2026-04-02 eCollection Date: 2026-01-01 DOI: 10.1177/23982128261427975

Dana Abdulhafiz, Adeyinka Ruth Adeniran, Oluwatobi Ajewole, Limou Dembele, Constantinos Panayiotou, Karina Maria Piotrowska, Tijana Urosevic, Wanjia Yu, Kate Baker

引用次数: 0

The LOAD2 mouse model of late-onset alzheimer's disease exhibits an accelerated onset of locomotor and anxiety deficits. 迟发性阿尔茨海默病LOAD2小鼠模型显示运动和焦虑缺陷的加速发作。

Brain and neuroscience advances Pub Date : 2026-03-06 eCollection Date: 2026-01-01 DOI: 10.1177/23982128261430392

Shinwon Kang, Ashish Kadia, Junhui Wang, Rachael Ingram, Patrick Tidball, Fuzi Jin, Aram Abbasian, John Georgiou, Graham L Collingridge

{"title":"The LOAD2 mouse model of late-onset alzheimer's disease exhibits an accelerated onset of locomotor and anxiety deficits.","authors":"Shinwon Kang, Ashish Kadia, Junhui Wang, Rachael Ingram, Patrick Tidball, Fuzi Jin, Aram Abbasian, John Georgiou, Graham L Collingridge","doi":"10.1177/23982128261430392","DOIUrl":"https://doi.org/10.1177/23982128261430392","url":null,"abstract":"Late-onset alzheimer's disease is the most common form of dementia, and it arises from complex genetic and environmental interactions. Preclinical models that replicate the slow progression and long prodromal phase of late-onset alzheimer's disease are critical for identifying early therapeutic targets. The LOAD2 mouse model, developed on the C57BL/6J genetic background, integrates key late-onset alzheimer's disease genetic risk factors: APOE4, Trem2*R47H, and an App allele encoding humanised amyloid beta. This study aimed to characterise key disease-relevant phenotypes of LOAD2 mice during ageing. Behavioural assays were conducted on 18- and 24-month-old LOAD2 and age-matched C57BL/6J wild-type control mice. At 18 months, LOAD2 mice exhibited significantly reduced locomotor activity compared to wild-type controls. However, this difference was diminished at 24 months as wild-type mice displayed an age-related decline in total distance travelled. Similarly, anxiety-like behaviour was elevated in 18-month-old LOAD2 mice relative to wild-type controls, but this difference was no longer evident at 24 months due to increased anxiety levels in aged wild-type mice. In contrast, spatial working memory and associative fear learning were intact in both LOAD2 and wild-type mice at 18 and 24 months of age, indicating no age- or genotype-dependent deficits in these forms of memory. Both groups of mice performed equally poorly in novel object and novel location recognition tasks at both ages. Thus, compared to age-matched wild-type mice, LOAD2 mice exhibit early locomotor deficits and heightened anxiety, but not overt cognitive impairment beyond that of normal ageing. These phenotypes are reminiscent of prodromal symptoms of late-onset alzheimer's disease in humans.","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"10 ","pages":"23982128261430392"},"PeriodicalIF":0.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-visiting cognitive reserve: The importance of multiple brain measures. 重新审视认知储备：多重大脑测量的重要性。

Brain and neuroscience advances Pub Date : 2026-02-10 eCollection Date: 2026-01-01 DOI: 10.1177/23982128261422282

Richard N Henson

引用次数: 0

Assessing oligodendrocyte and myelin alterations following absence seizures in a rat model of GRIN2B neurodevelopmental disorder. 评估GRIN2B神经发育障碍大鼠模型中缺失癫痫后少突胶质细胞和髓磷脂的改变。

Brain and neuroscience advances Pub Date : 2025-12-21 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251405032

Zita Francsics, Eleni Tsoukala, Katerina Hristova, Alfredo Gonzalez-Sulser, Lida Zoupi

{"title":"Assessing oligodendrocyte and myelin alterations following absence seizures in a rat model of GRIN2B neurodevelopmental disorder.","authors":"Zita Francsics, Eleni Tsoukala, Katerina Hristova, Alfredo Gonzalez-Sulser, Lida Zoupi","doi":"10.1177/23982128251405032","DOIUrl":"10.1177/23982128251405032","url":null,"abstract":"Neuronal activity can modulate myelination throughout life, influencing circuit function and behaviour. Pathological changes in neuronal activity have been associated with myelin remodelling in a rat model of idiopathic absence seizures, raising the question of whether this represents a common mechanism underlying absence epilepsy. Here we examined oligodendrocyte populations and myelin architecture in a rat model of GRIN2B neurodevelopmental disorder, a rare and severe condition that is frequently accompanied by absence seizures. Using histology and 3D imaging, we report that despite robust seizure-like activity in this model, there was no evidence of changes in oligodendrocyte lineage cell populations, overall myelin content, or node of Ranvier organization. These results contrast with prior reports of seizure-associated myelin modulation, indicating that seizure-induced myelin plasticity may not be a uniform feature across all models of absence seizures. Our findings indicate that such adaptations may depend on additional factors including seizure burden and timing, highlighting the need for further analysis to determine when and how myelin plasticity contributes to absence epilepsy.","PeriodicalId":72444,"journal":{"name":"Brain and neuroscience advances","volume":"9 ","pages":"23982128251405032"},"PeriodicalIF":0.0,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12719588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cambridge neuroscience symposium: Interventions and recovery. 剑桥神经科学研讨会：干预和恢复。

Brain and neuroscience advances Pub Date : 2025-12-15 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251406340

Katherine R Birditt, Alasdair Coles, Amy Doyle, Bayan Hijazi, Ailie G McWhinnie, Thomas Pritchard, Ewan St John Smith

引用次数: 0

The neurobiological rationale for improving paternity leave in academia and beyond. 在学术界及其他领域改善陪产假的神经生物学原理。

Brain and neuroscience advances Pub Date : 2025-12-12 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251401757

Paul G Anastasiades, Valentina Mosienko, Antonia Tzemanaki

引用次数: 0

The UK National Mouse Genetics Network: Translating genetic findings using preclinical mouse models to better understand neurodevelopmental, neuropsychiatric and neurodegenerative disorders. 英国国家小鼠遗传学网络：利用临床前小鼠模型翻译遗传发现，以更好地理解神经发育、神经精神和神经退行性疾病。

Brain and neuroscience advances Pub Date : 2025-11-30 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251383973

Sevda T Boyanova, Nicholas E Clifton, Karolina Dec, Michal M Milczarek, Anthony R Isles

引用次数: 0

The power of public engagement: Reflections on bring your own brain 2025. 公众参与的力量：带来你自己的大脑2025的反思。

Brain and neuroscience advances Pub Date : 2025-11-20 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251398905

Susannah C Walker

引用次数: 0

Connecting neuroscience research advances with clinical insights: Reflections from an NHS clinician in pain services. 连接神经科学研究进展与临床见解：反映从一个NHS临床医生在疼痛服务。

Brain and neuroscience advances Pub Date : 2025-10-31 eCollection Date: 2025-01-01 DOI: 10.1177/23982128251380422

Catriona Drew

引用次数: 0