Brain & spine最新文献

{"title":"Prognostication or predestination?","authors":"José Pedro Lavrador, Savvas Vlachos","doi":"10.1016/j.bas.2024.102793","DOIUrl":"https://doi.org/10.1016/j.bas.2024.102793","url":null,"abstract":"","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 102793"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424000493/pdfft?md5=5a5f9fc44804f9a596972a48bfc48264&pid=1-s2.0-S2772529424000493-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140328772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical tightrope: Navigating neuro-ethics in brain computer interface (BCI) technology","authors":"Allah Yar Yahya Khan, Ammar Anjum, Haseeb Mehmood Qadri (Dr)","doi":"10.1016/j.bas.2024.102800","DOIUrl":"https://doi.org/10.1016/j.bas.2024.102800","url":null,"abstract":"","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 102800"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424000560/pdfft?md5=70f55a8c1ad7c44e72aed5cf7dedab5c&pid=1-s2.0-S2772529424000560-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140342511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revitalizing neurosurgical frontiers: The EANS frontiers in neurosurgery committee's strategic framework","authors":"Aaron Lawson McLean ,&nbsp;Ignazio G. Vetrano ,&nbsp;Anna C. Lawson McLean ,&nbsp;Alfredo Conti ,&nbsp;Patrick Mertens ,&nbsp;Michael Müther ,&nbsp;Jakob Nemir ,&nbsp;Simone Peschillo ,&nbsp;Antonio Santacroce ,&nbsp;Can Sarica ,&nbsp;Constantin Tuleasca ,&nbsp;Cesare Zoia ,&nbsp;Jean Régis ,&nbsp;EANS Frontiers in Neurosurgery Committee","doi":"10.1016/j.bas.2024.102794","DOIUrl":"https://doi.org/10.1016/j.bas.2024.102794","url":null,"abstract":"<div><h3>Introduction</h3><p>The field of neurosurgery faces challenges with the increasing involvement of other medical specialties in areas traditionally led by neurosurgeons. This paper examines the implications of this development for neurosurgical practice and patient care, with a focus on specialized areas like pain management, peripheral nerve surgery, and stereotactic radiosurgery.</p></div><div><h3>Research question</h3><p>To assess the implications of the expanded scope of other specialties for neurosurgical practice and to consider the response of the EANS Frontiers in Neurosurgery Committee to these challenges.</p></div><div><h3>Materials and methods</h3><p>Analysis of recent trends in neurosurgery, including the shift in various procedures to other specialties, demographic challenges, and the emergence of minimally invasive techniques. This analysis draws on relevant literature and the initiatives of the Frontiers in Neurosurgery Committee.</p></div><div><h3>Results</h3><p>We explore a possible decrease in neurosurgical involvement in certain areas, which may have implications for patient care and access to specialized neurosurgical interventions. The Frontiers in Neurosurgery Committee's role in addressing these concerns is highlighted, particularly in terms of training, education, research, and networking for neurosurgeons, especially those early in their careers.</p></div><div><h3>Discussion and conclusion</h3><p>The potential decrease in neurosurgical involvement in certain specialties warrants attention. This paper emphasizes the importance of carefully considered responses by neurosurgical societies, such as the EANS, to ensure neurosurgeons continue to play a vital role in managing neurological diseases. Emphasis on ongoing education, integration of minimally invasive techniques, and multidisciplinary collaboration is essential for maintaining the field's competence and quality in patient care.</p></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 102794"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277252942400050X/pdfft?md5=493589aab9b4a8d28af20563039cc3da&pid=1-s2.0-S277252942400050X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of uncertainty of PRx time trends","authors":"Erta Beqiri ,&nbsp;Michal M. Placek ,&nbsp;Ka Hing Chu ,&nbsp;Joseph Donnelly ,&nbsp;Giada Cucciolini ,&nbsp;Virginia Motroni ,&nbsp;Claudia A. Smith ,&nbsp;Marek Czosnyka ,&nbsp;Peter Hutchinson ,&nbsp;Peter Smielewski","doi":"10.1016/j.bas.2024.102795","DOIUrl":"https://doi.org/10.1016/j.bas.2024.102795","url":null,"abstract":"<div><h3>Introduction</h3><p>PRx can be used as surrogate measure of Cerebral Autoregulation (CA) in traumatic brain injury (TBI) patients. PRx can provide means for individualising cerebral perfusion pressure (CPP) targets, such as CPPopt. However, a recent Delphi consensus of clinicians concluded that consensus could not be reached on the accuracy, reliability, and validation of any current CA assessment method.</p></div><div><h3>Research question</h3><p>We aimed to quantify the short-term uncertainty of PRx time-trends and to relate this to other physiological measurements.</p></div><div><h3>Material and methods</h3><p>Intracranial pressure (ICP), arterial blood pressure (ABP), end-tidal CO₂ (EtCO₂) high-resolution recordings of 911 TBI patients were processed with ICM + software. Hourly values of metrics that describe the variability within modalities derived from ABP, ICP and EtCO₂, were calculated for the first 24h of neuromonitoring. Generalized additive models were used to describe the time trend of the variability in PRx. Linear correlations were studied for describing the relationship between PRx variability and the other physiological modalities.</p></div><div><h3>Results</h3><p>The time profile of variability of PRx decreases over the first 12h and was higher for average PRx ∼0. Increased variability of PRx was not linearly linked with average ABP, ICP, or CPP. For coherence between slow waves of ABP and ICP &gt;0.7, the variability in PRx decreased (R = −0.47, p &lt; 0.001).</p></div><div><h3>Discussion and conclusion</h3><p>PRx is a highly variable parameter. PRx short-term dispersion was not related to average ICP, ABP or CPP. The determinants of uncertainty of PRx should be investigated to improve reliability of individualised CA assessment in TBI patients.</p></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 102795"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424000511/pdfft?md5=5f136c6605137604530aac354e2b366c&pid=1-s2.0-S2772529424000511-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sport-related concussion in soccer –a scoping review of available guidelines and a call for action to FIFA & soccer governing bodies","authors":"Andreas K. Demetriades ,&nbsp;Imran Shah ,&nbsp;Niklas Marklund ,&nbsp;Hans Clusmann ,&nbsp;Wilco Peul","doi":"10.1016/j.bas.2024.102763","DOIUrl":"https://doi.org/10.1016/j.bas.2024.102763","url":null,"abstract":"<div><h3>Introduction</h3><p>Sport-related concussions (SRC) have been a concern in all sports, including soccer. The long-term effects of soccer-related head injuries are a public health concern. The Concussion in Sport Group (CISG) released a consensus statement in 2017 and several soccer governing associations have published their own SRC guidelines while referring to it but it is unclear whether this has been universally adopted.</p></div><div><h3>Research question</h3><p>We aimed to investigate whether guidelines published by soccer associations have any discrepancies; and the extent to which they follow the CISG recommendations.</p></div><div><h3>Materials and methods</h3><p>A scoping review of available soccer-specific SRC guidelines was performed via databases PubMed, Google Scholar, and official soccer association websites via web browser Google. The inclusion criteria were soccer-specific SRC guidelines. Comparisons between guidelines were made concerning the following index items: initial (on-site) assessment, removal from play, re-evaluation with neuroimaging, return-to-sport protocol, special populations, and education.</p></div><div><h3>Results</h3><p>Nine soccer associations with available guidelines were included in this review. Guidelines obtained were from official associations in the United Kingdom, United States of America, Canada, Australia, and New Zealand. When compared to each other and the CISG recommendations, discrepancies were found within guidelines regarding the index items. Additionally, major soccer associations in some countries famous for soccer were found to have not published any publicly available guidelines.</p></div><div><h3>Discussion and conclusion</h3><p>SRC guidelines from different soccer associations contain discrepancies which may be detrimental to athletes, both short and long-term. We recommend that all major soccer governing associations publish guidelines that are standardised and accessible to all athletes.</p></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 102763"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424000195/pdfft?md5=7444a396ddee30abda9f8259b2a422b1&pid=1-s2.0-S2772529424000195-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current state of the art of traditional and minimal invasive epilepsy surgery approaches","authors":"Fabian Winter ,&nbsp;Marie T. Krueger ,&nbsp;Daniel Delev ,&nbsp;Tom Theys ,&nbsp;Dirk MP Van Roost ,&nbsp;Kostas Fountas ,&nbsp;Olaf E.M.G. Schijns ,&nbsp;Karl Roessler","doi":"10.1016/j.bas.2024.102755","DOIUrl":"https://doi.org/10.1016/j.bas.2024.102755","url":null,"abstract":"<div><h3>Introduction</h3><p>Open resective surgery remains the main treatment modality for refractory epilepsy, but is often considered a last resort option due to its invasiveness.</p></div><div><h3>Research question</h3><p>This manuscript aims to provide an overview on traditional as well as minimally invasive surgical approaches in modern state of the art epilepsy surgery.</p></div><div><h3>Materials and methods</h3><p>This narrative review addresses both historical and contemporary as well as minimal invasive surgical approaches in epilepsy surgery. Peer-reviewed published articles were retrieved from PubMed and Scopus. Only articles written in English were considered for this work. A range of traditional and minimally invasive surgical approaches in epilepsy surgery were examined, and their respective advantages and disadvantages have been summarized.</p></div><div><h3>Results</h3><p>The following approaches and techniques are discussed: minimally invasive diagnostics in epilepsy surgery, anterior temporal lobectomy, functional temporal lobectomy, selective amygdalohippocampectomy through a transsylvian, transcortical, or subtemporal approach, insulo-opercular corticectomies compared to laser interstitial thermal therapy, radiofrequency thermocoagulation, stereotactic radiosurgery, neuromodulation, high intensity focused ultrasound, and disconnection surgery including callosotomy, hemispherotomy, and subpial transections.</p></div><div><h3>Discussion and conclusion</h3><p>Understanding the benefits and disadvantages of different surgical approaches and strategies in traditional and minimal invasive epilepsy surgery might improve the surgical decision tree, as not all procedures are appropriate for all patients.</p></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 102755"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424000110/pdfft?md5=4cb746ee6b619469417314d687c58162&pid=1-s2.0-S2772529424000110-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140014403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amantadine for functional improvement in patients with traumatic brain injury: A systematic review with meta-analysis and trial sequential analysis","authors":"Hantz Filbert C. Siy,&nbsp;Michael Louis A. Gimenez","doi":"10.1016/j.bas.2024.102773","DOIUrl":"https://doi.org/10.1016/j.bas.2024.102773","url":null,"abstract":"<div><h3>Introduction</h3><p>TBIs contribute in over one-third of injury-related deaths with mortality rates as high as 50% in trauma centers serving the most severe TBI. The effect of TBI on mortality is about 10% across all ages. Amantadine hydrochloride is one of the most commonly prescribed medications for patients undergoing inpatient neurorehabilitation who have disorders of consciousness.⁶ It is a dopamine (DA) receptor agonist and a N-Methyl-D-aspartate (NMDA) receptor antagonist via dopamine release and dopamine reuptake inhibition. The current study will synthesize the current available evidence and show the effect of Amantadine in functional improvement after TBI.</p></div><div><h3>Research question</h3><p>Does Amantadine have an effect on functional improvement of TBI patients?</p></div><div><h3>Material and methods</h3><p>This systematic review included all randomized placebo-controlled trials that compare the use of Amantadine versus placebo for functional improvement of patients after TBI. Outcome measures included DRS, GCS and/or GOS scores.</p></div><div><h3>Results</h3><p>Three studies with a total of 281 patients were included in the quantitative analyses. GRADE assessments show that there was a high certainty of evidence for functional improvement in terms of DRS scores.</p></div><div><h3>Discussion and conclusion</h3><p>Evidence of this review show that the use of Amantadine may have a beneficial effect on functional outcome in moderate to severe traumatic brain injuries among adult patients. Given the still-limited body of knowledge, more relevant studies must be made exploring the impact of Amantadine therapies on promoting functional recovery within the brain injury rehabilitation care continuum, with the goals of achieving larger sample sizes and establishing the early- or later-treatment beneficial effects.</p></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 102773"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424000298/pdfft?md5=90439e715248683847cecce8d54f55ef&pid=1-s2.0-S2772529424000298-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence guidance in skull base surgery: Applications and limitations – A systematic review","authors":"Eric Suero Molina ,&nbsp;Michael Bruneau ,&nbsp;Gilles Reuter ,&nbsp;Mostafa Shahein ,&nbsp;Luigi M. Cavallo ,&nbsp;Roy T. Daniel ,&nbsp;Ekkehard M. Kasper ,&nbsp;Sebastien Froelich ,&nbsp;Emanuel Jouanneau ,&nbsp;Romain Manet ,&nbsp;Mahmoud Messerer ,&nbsp;Diego Mazzatenta ,&nbsp;Torstein R. Meling ,&nbsp;Pierre-Hugues Roche ,&nbsp;Henry WS. Schroeder ,&nbsp;Marcos Tatagiba ,&nbsp;Massimiliano Visocchi ,&nbsp;Daniel M. Prevedello ,&nbsp;Walter Stummer ,&nbsp;Jan F. Cornelius","doi":"10.1016/j.bas.2024.103328","DOIUrl":"10.1016/j.bas.2024.103328","url":null,"abstract":"<div><h3>Introduction</h3><p>Intraoperative fluorescence guidance is a well-established surgical adjunct in high-grade glioma surgery. In contrast, the clinical use of such dyes and technology has been scarcely reported in skull base surgery.</p></div><div><h3>Research question</h3><p>We aimed to systematically review the clinical applications of different fluorophores in both open and endonasal skull base surgery.</p></div><div><h3>Material and methods</h3><p>We performed a systematic review and discussed the current literature on fluorescence guidance in skull base surgery.</p></div><div><h3>Results</h3><p>After a comprehensive literature search, 77 articles on skull base fluorescence guidance were evaluated. A qualitative analysis of the articles is presented, discussing clinical indications and current controversies. The use of intrathecal fluorescein was the most frequently reported in the literature. Beyond that, 5-ALA and ICG were two other fluorescent dyes most extensively discussed, with some experimental fluorophore applications in skull base surgery.</p></div><div><h3>Discussion and conclusion</h3><p>Intraoperative fluorescence imaging can serve as an adjunct technology in skull base surgery. The scope of initial indications of these fluorophores has expanded beyond malignant glioma resection alone. We discuss current use and controversies and present an extensive overview of additional indications for fluorescence imaging in skull base pathologies. Further quantitative studies will be needed in the future, focusing on tissue selectivity and time-dependency of the different fluorophores currently commercially available, as well as the development of new compounds to expand applications and facilitate skull base surgeries.</p></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 103328"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424005848/pdfft?md5=878ac3f48636f4c32493baaab46ca828&pid=1-s2.0-S2772529424005848-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142171574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of current treatment modalities and clinical outcome of giant saccular aneurysms of the basilar apex","authors":"Andreas Theofanopoulos ,&nbsp;Lucas Troude ,&nbsp;Milad Neyazi ,&nbsp;Sajjad Muhammad","doi":"10.1016/j.bas.2024.103333","DOIUrl":"10.1016/j.bas.2024.103333","url":null,"abstract":"<div><h3>Introduction</h3><p>Giant aneurysms of the basilar apex represent formidable challenges as the high rupture rate of untreated lesions must be balanced against the technical complexity and potential morbidity of intervention.</p></div><div><h3>Research question</h3><p>Review of treatment modalities and outcomes of patients harboring giant (&gt;2.5 cm) basilar apex saccular aneurysms, in an effort to refine treatment decision-making.</p></div><div><h3>Material and methods</h3><p>A systematic literature review through the PubMed and Scopus databases was performed according to the PRISMA guidelines to identify cases of giant basilar apex saccular aneurysms treated either microsurgically or endovascularly. Patients’ demographics, aneurysm size, preoperative and postoperative neurologic status, angiographic and clinical outcomes as well as follow-up information were obtained.</p></div><div><h3>Results</h3><p>Data from 32 studies fulfilling the inclusion criteria, including 49 patients (32 treated surgically and 17 endovascularly) was obtained. Mean patient age at presentation was 51.69 years, with a male-to-female ratio of 1:2. Mean maximum aneurysm diameter was 30.57 mm. A favorable outcome (mRS 0–2) was reported on 70.6% of endovascular and 56.3% of open surgical cases. Complete aneurysm occlusion was achieved in 55.6% of the open and 23.5% of the endovascular cases. Death rate was 33% for endovascular and 15.6% for open cases; the higher mortality of endovascular treatment is mainly attributed to the mass effect from continued brainstem compression after treatment.</p></div><div><h3>Discussion and conclusion</h3><p>Higher rates of complete occlusion but higher morbidity are associated with microsurgery compared to endovascular modalities. Severe, clinically apparent brainstem mass effect may require decompression associated with microsurgery, when technically feasible.</p></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 103333"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772529424005897/pdfft?md5=5286dc0c5fc03873ed67f4f7068070a7&pid=1-s2.0-S2772529424005897-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral decubitus anterior exposure of the L4-5 disc maintains safety compared with supine positioning","authors":"A. Buckland ,&nbsp;N.V. Huynh ,&nbsp;A.K. Calek ,&nbsp;J.A. Thomas ,&nbsp;D. Robinson ,&nbsp;M. Medley ,&nbsp;L. Eisen","doi":"10.1016/j.bas.2024.103024","DOIUrl":"10.1016/j.bas.2024.103024","url":null,"abstract":"","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"4 ","pages":"Article 103024"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142359448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}