BME frontiers最新文献_第6页

Impact of Poly(Ester Amide) Structure on Properties and Drug Delivery for Prostate Cancer Therapy. 聚（酯酰胺）结构对前列腺癌症治疗的性质和药物递送的影响。

IF 5

BME frontiers Pub Date : 2023-08-10 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0025

Junfu Zhang, Liying Wang, Mengting Ding, Xinru You, Jun Wu, Jun Pang

{"title":"Impact of Poly(Ester Amide) Structure on Properties and Drug Delivery for Prostate Cancer Therapy.","authors":"Junfu Zhang, Liying Wang, Mengting Ding, Xinru You, Jun Wu, Jun Pang","doi":"10.34133/bmef.0025","DOIUrl":"10.34133/bmef.0025","url":null,"abstract":"Objective: We aim to develop a polymer library consisting of phenylalanine-based poly(ester amide)s (Phe-PEAs) for cancer therapy and investigate the structure-property relationship of these polymers to understand their impact on the drug delivery efficiency of corresponding nanoparticles (NPs). Impact Statement: Our study provides insights into the structure-property relationship of polymers in NP-based drug delivery applications and offers a potential polymer library and NP platform for enhancing cancer therapy. Introduction: Polymer NP-based drug delivery systems have demonstrated substantial potential in cancer therapy by improving drug efficacy and minimizing systemic toxicity. However, successful design and optimization of these systems require a comprehensive understanding of the relationship between polymer structure and physicochemical properties, which directly influence the drug delivery efficiency of the corresponding NPs. Methods: A series of Phe-PEAs with tunable structures was synthesized by varying the length of the methylene group in the diol part of the polymers. Subsequently, Phe-PEAs were formulated into NPs for doxorubicin (DOX) delivery in prostate cancer therapy. Results: Small adjustments in polymer structure induced the changes in the hydrophobicity and thermal properties of the PEAs, consequently NP size, drug loading capacity, cellular uptake efficacy, and cytotoxicity. Additionally, DOX-loaded Phe-PEA NPs demonstrated enhanced tumor suppression and reduced side effects in prostate tumor-bearing mice. Conclusion: Phe-PEAs, with their finely tunable structures, show great promise as effective and customizable nanocarriers for cancer therapy.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":"4 ","pages":"0025"},"PeriodicalIF":5.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encapsulation of Ru(II) Polypyridine Complexes for Tumor-Targeted Anticancer Therapy. Ru（II）多吡啶配合物的包封用于肿瘤靶向抗癌治疗。

BME frontiers Pub Date : 2023-08-01 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0024

Johannes Karges

引用次数: 1

Antibacterial Chemodynamic Therapy: Materials and Strategies. 抗菌化学动力学治疗：材料与策略。

BME frontiers Pub Date : 2023-07-17 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0021

Chenyang Jia, Fu-Gen Wu

{"title":"Antibacterial Chemodynamic Therapy: Materials and Strategies.","authors":"Chenyang Jia, Fu-Gen Wu","doi":"10.34133/bmef.0021","DOIUrl":"https://doi.org/10.34133/bmef.0021","url":null,"abstract":"The wide and frequent use of antibiotics in the treatment of bacterial infection can cause the occurrence of multidrug-resistant bacteria, which becomes a serious health threat. Therefore, it is necessary to develop antibiotic-independent treatment modalities. Chemodynamic therapy (CDT) is defined as the approach employing Fenton and/or Fenton-like reactions for generating hydroxyl radical (•OH) that can kill target cells. Recently, CDT has been successfully employed for antibacterial applications. Apart from the common Fe-mediated CDT strategy, antibacterial CDT strategies mediated by other metal elements such as copper, manganese, cobalt, molybdenum, platinum, tungsten, nickel, silver, ruthenium, and zinc have also been proposed. Furthermore, different types of materials like nanomaterials and hydrogels can be adopted for constructing CDT-involved antibacterial platforms. Besides, CDT can introduce some toxic metal elements and then achieve synergistic antibacterial effects together with reactive oxygen species. Finally, CDT can be combined with other therapies such as starvation therapy, phototherapy, and sonodynamic therapy for achieving improved antibacterial performance. This review first summarizes the advancements in antibacterial CDT and then discusses the present limitations and future research directions in this field, hoping to promote the development of more effective materials and strategies for achieving potentiated CDT.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":"4 ","pages":"0021"},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Porosity on Piezoelectric Characteristics of Polyvinylidene Fluoride Films for Biomedical Applications. 孔隙率对医用聚偏氟乙烯薄膜压电特性的影响。

BME frontiers Pub Date : 2023-07-07 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0009

Jack T Kloster, Matthew J Danley, Victor K Lai, Ping Zhao

{"title":"Effects of Porosity on Piezoelectric Characteristics of Polyvinylidene Fluoride Films for Biomedical Applications.","authors":"Jack T Kloster, Matthew J Danley, Victor K Lai, Ping Zhao","doi":"10.34133/bmef.0009","DOIUrl":"https://doi.org/10.34133/bmef.0009","url":null,"abstract":"Objective: The objective of this work is to study the effects of porosity on mechanical and piezoelectric properties of polyvinylidene fluoride (PVDF) films for biomedical applications. Impact Statement: By investigating the piezoelectric properties of PVDF and the porosity effect on its electromechanical performance, there is potential for further development of PVDF as a hemodynamic sensor that can lead to further technological advancements in the biomedical field, benefiting patients and physicians alike. Introduction: PVDF thin films have shown potential in the application of hemodynamic flow sensing and monitoring the effects on blood flow caused by prosthetic valve implantation via the transcatheter aortic valve replacement operation. The piezoelectric performance of PVDF films can be influenced by the porosity of the material. Methods: In this study, strain tracking was performed on thin film PVDF specimens with various levels of porosity and pore sizes to determine the mechanical properties of the specimens. The mechanical properties were used to model the PVDF material in COMSOL multiphysics software, in which compression test simulations were performed to determine the piezoelectric coefficient d33 of the PVDF. Results: A decline in the elastic modulus was found to be highly inversely correlated with porosity of the specimens and the simulation results show that elastic modulus had a much greater effect on the piezoelectric properties than Poisson's ratio. Conclusion: A combination of experimental and computational techniques was able to characterize and correlate the mechanical properties of PVDF films of varying porosities to their piezoelectric properties.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":"4 ","pages":"0009"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BME2.1: The Need for a Systems Approach to Addressing Race-Based Disparities in Health and Health Care. BME2.1：需要一种系统方法来解决卫生和医疗保健中基于种族的差异。

IF 5

BME frontiers Pub Date : 2023-06-21 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0023

Naomi C Chesler, Gilda A Barabino

引用次数: 0

Organotypic Models for Functional Drug Testing of Human Cancers. 人类癌症功能性药物测试的器官型模型。

BME frontiers Pub Date : 2023-06-16 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0022

Yu Ling Huang, Lindsay K Dickerson, Heidi Kenerson, Xiuyun Jiang, Venu Pillarisetty, Qiang Tian, Leroy Hood, Taranjit S Gujral, Raymond S Yeung

引用次数: 0

Nanoantidotes: A Detoxification System More Applicable to Clinical Practice. 纳米解毒剂：一种更适用于临床实践的解毒系统。

BME frontiers Pub Date : 2023-05-18 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0020

Jiazhen Yang, Jianxun Ding

引用次数: 0

Clinical Peptidomics: Advances in Instrumentation, Analyses, and Applications. 临床肽组学：仪器、分析和应用进展。

IF 5

BME frontiers Pub Date : 2023-05-15 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0019

Lin Li, Jing Wu, Christopher J Lyon, Li Jiang, Tony Y Hu

{"title":"Clinical Peptidomics: Advances in Instrumentation, Analyses, and Applications.","authors":"Lin Li, Jing Wu, Christopher J Lyon, Li Jiang, Tony Y Hu","doi":"10.34133/bmef.0019","DOIUrl":"10.34133/bmef.0019","url":null,"abstract":"Extensive effort has been devoted to the discovery, development, and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions. Genomic and transcriptomic profiling are well-established means to identify disease-associated biomarkers. However, analysis of disease-associated peptidomes can also identify novel peptide biomarkers or signatures that provide sensitive and specific diagnostic and prognostic information for specific malignant, chronic, and infectious diseases. Growing evidence also suggests that peptidomic changes in liquid biopsies may more effectively detect changes in disease pathophysiology than other molecular methods. Knowledge gained from peptide-based diagnostic, therapeutic, and imaging approaches has led to promising new theranostic applications that can increase their bioavailability in target tissues at reduced doses to decrease side effects and improve treatment responses. However, despite major advances, multiple factors can still affect the utility of peptidomic data. This review summarizes several remaining challenges that affect peptide biomarker discovery and their use as diagnostics, with a focus on technological advances that can improve the detection, identification, and monitoring of peptide biomarkers for personalized medicine.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":"4 ","pages":"0019"},"PeriodicalIF":5.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials for Fighting Multidrug-Resistant Biofilm Infections. 抗多药生物膜感染的纳米材料。

BME frontiers Pub Date : 2023-04-24 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0017

Vincent M Rotello

{"title":"Nanomaterials for Fighting Multidrug-Resistant Biofilm Infections.","authors":"Vincent M Rotello","doi":"10.34133/bmef.0017","DOIUrl":"10.34133/bmef.0017","url":null,"abstract":"Multidrug-resistant bacterial infections represent a dire threat to global health. The development of antibiotic resistance in bacteria coupled with the lack of development of new antibiotics is creating infections requiring antibiotics of last resort, and even some infections for which we have no available treatment. Biofilm-based infections present some of the most challenging targets for treatment. The biofilm matrix provides a physical barrier that can impede access of antibiotics and antimicrobials to resident bacteria. The phenotypic diversity found in biofilms further exacerbates the difficulty of eliminating infections, with quiescent \"persister\" cells evading therapeutics and re-initiating infections after treatment. Nanomaterials provide a tool for combatting these refractory biofilm infections. The distinctive size regime and physical properties of nanomaterials provide them with the capability to penetrate and disrupt biofilms. Nanomaterials can also access antimicrobial pathways inaccessible to conventional antimicrobials, providing a synergistic strategy for treating biofilm infections. This review will summarize key challenges presented by antibiotic resistance and biofilms when treating infection and provide selected examples of how nanomaterials are being used to address these challenges.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":"4 ","pages":"0017"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design Strategies for Cellular Nanosponges as Medical Countermeasures. 作为医疗对策的细胞纳米海绵的设计策略。

BME frontiers Pub Date : 2023-04-20 eCollection Date: 2023-01-01 DOI: 10.34133/bmef.0018

Shuyan Wang, Dan Wang, Mingxuan Kai, Wei-Ting Shen, Lei Sun, Weiwei Gao, Liangfang Zhang

{"title":"Design Strategies for Cellular Nanosponges as Medical Countermeasures.","authors":"Shuyan Wang, Dan Wang, Mingxuan Kai, Wei-Ting Shen, Lei Sun, Weiwei Gao, Liangfang Zhang","doi":"10.34133/bmef.0018","DOIUrl":"https://doi.org/10.34133/bmef.0018","url":null,"abstract":"The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously. Among various nanomedicine platforms, cell membrane-coated nanoparticles, namely, \"cellular nanosponges,\" stand out for their broad-spectrum neutralization capability challenging to achieve in traditional countermeasure technologies. Such ability is attributable to their cellular function-based rather than target structure-based working principle. Integrating cellular nanosponges with various synthetic substrates further makes their applications exceptionally versatile and adaptive. This review discusses the latest cellular nanosponge technology focusing on how the structure-function relationship in different designs has led to versatile and potent medical countermeasures. Four design strategies are discussed, including harnessing native cell membrane functions for biological neutralization, functionalizing cell membrane coatings to enhance neutralization capabilities, combining cell membranes and functional cores for multimodal neutralization, and integrating cellular nanosponges with hydrogels for localized applications. Examples in each design strategy are selected, and the discussion is to highlight their structure-function relationships in complex disease settings. The review may inspire additional design strategies for cellular nanosponges and fulfill even broader medical applications.","PeriodicalId":72430,"journal":{"name":"BME frontiers","volume":"4 ","pages":"0018"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1