Biomedical research and clinical reviews最新文献

{"title":"The Role of Mutations on Gene NAGA, in Schindler Syndrome","authors":"S. Asadi","doi":"10.31579/2692-9406/029","DOIUrl":"https://doi.org/10.31579/2692-9406/029","url":null,"abstract":"Schindler syndrome is an inherited genetic disorder that mainly causes neurological problems. Schindler's syndrome is caused by a mutation in the NAGA gene, which is located in the long arm of chromosome 22 as 22q13.2.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49586138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Evaluation of Proximate, Vitamin and Amino Acid Profile of Leaf, Stem Bark and Root of Indigofera Tinctoria","authors":"A. J.O","doi":"10.31579/2692-9406/026","DOIUrl":"https://doi.org/10.31579/2692-9406/026","url":null,"abstract":"Medicinal plants contain substances with high therapeutic value because they contain multiple bioactive chemicals. Chemical analysis of Indigofera tinctoria leaves, stem bark and roots was evaluated. The result revealed that proximate composition of Indigofera tinctoria leaves contained 12.49 % moisture content (M.C), 87.51 % dry matter (DM), 30.53 % crude protein (CP), 19.02 % crude fibre (CF), 2.44 % ether extract (EE), 13.86 % ash, 36.59 % carbohydrate (CHO) and 254.1 kcal/100g energy (ME). Indigofera tinctoria stem bark contained M.C (6.40 %), DM (93.60 %), CP (5.11 %), CF (54.49 %), EE (2.00 %), ash (10.42 %), CHO (29.98 %) and ME (156.0 kcal/100g). Indigofera tinctoria roots contained MC, DM, CP, CF, EE, ash, CHO and ME at 10.04 %, 89.60 %, 8.22 %, 40.88 %, 1.21 %, 8.43 %, 42.47 % and 210.0 kcal/100g respectively. Vitamin analysis showed that Indigofera tinctoria leaves, stem bark and roots contained β- carotene (8.45, 2.88 and 5.11 mg/100 g), Vitamin B1 (1.94, 0.33 and 1.00 mg/100 g), Vitamin B2 (0.71, 0.21 and 0.50 mg/100 g), Vitamin B3 (0.66, 0.34 and 0.48 mg/100 g), Vitamin B6 (0.32, 0.21 and 0.30 mg/100 g), Vitamin B7 (0.63, 0.01 and 0.16 mg/100 g), Vitamin B9 (0.26, 0.10 and 0.18 mg/100 g), Vitamin B12 (0.21, 0.03 and 0.10 mg/100 g), Vitamin C (14.0, 3.56 and 9.44 mg/100 g), Vitamin D (0.10, 0.01 and 0.06 mg/100 g) and Vitamin K (0.17, 0.07 and 0.12 mg/100 g). Amino acid analysis revealed the presence of threonine, leucine, lysine, valine, tryptophan, glycine, phenylalanine, histidine, methionine, alanine, serine, proline, aspartate, glutamic acid, tryrosine and cysteine in Indigofera tinctoria leaves, stem bark and roots at (7.65 %, 1.22 % and 3.03 %), (5.76, 1.09 % and 2.46 %), (3.11 %, 1.21% and 2.00 %), (7.21 %, 3.53 % and 4.09 %), (1.45%, 0.03% and 1.00 %), (4.76 %, 0.08 % and 2.33 %), (6.33 %, 2.45 % and 3.49 %), (7.42 %, 2.00 % and 3.00 %), (3.49 %, 0.01 % and 2.00 %), (2.41 %, 0.56 % and 1.20 %), (5.23 %, 1.22 % and 1.76 %), (2.87 %, 0.57 % and 1.00 %), (5.32 %, 2.11 % and 3.56 %), (9.66 %, 4.21 % and 5.11 %), (2.45 %, 0.57 % and 1.67 %) and (1.85 %, 0.81 % and 0.89 %) respectively. It was concluded that Indigofera tinctoria leaves, stem bark and roots are loaded with significant quantity of nutrients, vitamins and amino acid (leaves ˃ roots ˃ stem bark).","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44488388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Cases and Deaths: A Comparison among Bangladesh, India and Pakistan","authors":"B. M. Kibria","doi":"10.31579/2692-9406/043","DOIUrl":"https://doi.org/10.31579/2692-9406/043","url":null,"abstract":"This paper compares the number of infected cases and deaths of an ongoing pandemic of COVID-19 outbreak for Bangladesh, India and Pakistan for the period of March 8, 2020 to September 21, 2020. Comparisons among countries using absolute numbers are not comparable due to different factors, such as population sizes, rates of per 100,000 and also because not all countries are affected equally and at the same time. Following Middelburg and Rosendaal (2020), we graphically compare the number of cases and deaths expressed as a percentage of the cases and deaths on the reference day 25 after the first reported death. To see the impact of reference days, several later reference days are also considered in this study. From these comparisons, clear differences were observed among countries. Among these three countries, it is observed that Bangladesh had the most extreme flattening of the curve, followed by Pakistan and then India. We observed that the epidemic developed in India much more rapidly as compare to Bangladesh and Pakistan.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Stigma in Developing Societies","authors":"S. Shafti","doi":"10.31579/2692-9406/042","DOIUrl":"https://doi.org/10.31579/2692-9406/042","url":null,"abstract":"Stigmatizing attitudes toward persons with mental syndromes are prevalent in the general population and even among mental health professionals, a problem that may result easily in public avoidance, constant discrimination, and declined help-seeking behavior. The effect of stigma is twofold: Public stigma is the response that the public has to people with mental disorder. Self-stigma is the bigotry which persons with mental disorder turn against themselves. The WHO has advised that stigma is one of the largest barricades to treatment engagement, even if management is operative, even in low-income nations. While before and according to a series of researches the outcome of severe mental illness is generally better in developing societies than in developed countries, and it has been suggested that stigma is less severe or non-existent in unindustrialized nations, the current studies and observations do not confirm such an optimistic hint and the idea that stigma attached to mental illness is a global phenomenon seems a reasonable inference. In the present article, the issue of stigmatization, deinstitutionalization, national goal setting, and real situation of various modules of psychiatric rehabilitation, in the context of social or public psychiatry, especially in developing countries, is discussed, from a practical point of view.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart cardiac’s sounds signals segmentation by using the discrete wavelet transform (DWT)","authors":"S. Debbal","doi":"10.31579/2692-9406/052","DOIUrl":"https://doi.org/10.31579/2692-9406/052","url":null,"abstract":"The presence of abnormal sounds in one cardiac cycle, provide valuable information on various diseases.Early detection of various diseases is necessary; it is done by a simple technique known as: phonocardiography. The phonocardiography, based on registration of vibrations or oscillations of different frequencies, audible or not, that correspond to normal and abnormal heart sounds. It provides the clinician with a complementary tool to record the heart sounds heard during auscultation. The advancement of intracardiac phonocardiography, combined with signal processing techniques, has strongly renewed researchers’ interest in studying heart sounds and murmurs. This paper presents an algorithm based on the denoising by wavelet transform (DWT) and the Shannon energy of the PCG signal, for the detection of heart sounds (the first and second sounds, S1 and S2) and heart murmurs. This algorithm makes it possible to isolate individual sounds (S1 or S2) and murmurs to give an assessment of their average duration.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-COV-2/COVID19 Induce Kawasaki-Like Disease in Children Experience of Republic of Moldova: A Report of Five Cases","authors":"N. Revenco","doi":"10.31579/2692-9406/055","DOIUrl":"https://doi.org/10.31579/2692-9406/055","url":null,"abstract":"Infection with SARS-CoV-2 virus is a serious challenge for the entire medical and scientific community. Medical institutions are facing record numbers of patients and conflicting claims about SARS-CoV-2 and due to its mutagenic properties, thanks to the D614G protein from Coronavirus (CoV) defining the determines the mutagenicity of SARS - CoV and MERS-CoV [1,2]. With the expansion of the COVID-19 Pandemic, researchers have reported [3] clinical cases of multisystemic inflammatory syndrome in children (MIS-C), similar to Kawasaki disease (KD). Due to the absence of a diagnostic marker for KD, the latter is established according to the criteria of the American Society of Cardiology, in this situation with associated SARS-CoV-2 infection. We deem it appropriate to report five clinical cases of KD that met the criteria for defining an MIS-C case as defined by WHO.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patient-Centric Care Approach to Facilitate the Design of an Artificial Intelligence Application in Geriatric Care Management of Heart Failure Readmissions","authors":"T. Wan","doi":"10.31579/2692-9406/056","DOIUrl":"https://doi.org/10.31579/2692-9406/056","url":null,"abstract":"The examination of human factors’ role in moderating medical interventions and hospitalizations and/or rehospitalization of heart failure (HF) patients. Objectives: The primary purpose of this study is two-fold: 1) to show relevant human factors influencing the rehospitalization of persons with heart failure by developing a systematic algorithm generated from the cited randomized trials; and 2) to examine how the self-care principles, such as choice/efficacy, restfulness, healing environment, activity, trust, interpersonal relationships, outlook, and nutrition, may reduce heart failure readmissions. Methods: The meta-analytic approach generated a theoretically relevant and empirically validated self-care management decision support protocol for HF. Statistical modeling of the effects of eight human factors for the reduction of HF readmissions was presented. Findings: The systematic review and meta-analysis approach documents the results of randomized clinical trials that affect heart failure hospitalization by selected human factors. A patient-centered decision support system was developed to facilitate the self-care management of heart failure. Discussion: Our research generates systematic knowledge about the importance of human-factor principles in the provision of geriatric care for heart failure. Using shared decision-making strategies under the population health management approach could enhance the quality of care and reduce costly readmissions of heart failure, particularly for elderly patients.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tako-Tsubo syndrome. Approach to the subject and Report of 2 cases","authors":"C. Pazos","doi":"10.31579/2692-9406/074","DOIUrl":"https://doi.org/10.31579/2692-9406/074","url":null,"abstract":"Takotsubo syndrome, or stress cardiomyopathy, is a relatively rare transient and reversible cardiomyopathy, although its diagnosis has increased in recent years, it presents as an acute coronary syndrome (ACS) or acute heart failure, its incidence is unknown exactly in Latin America and in Cuba. We present 2 cases seen in our hospital, both 63 and 55-year-old women with typical precordial pressure pain, the first triggering psychological stress and the second physical, with electrocardiographic changes consistent with anterior infarction and cardiogenic shock, which were found in the coronary angiographic study observed normal coronary arteries and ventriculography determined apical ballooning of the left ventricle characteristic of the syndrome, with subsequent recovery and favorable clinical evolution at 6 months.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70019178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid Therapy (FT) Complications: Volumetric Overload (VO) in the patho-Aetiology of VO Shocks (VOS) and the Acute Respiratory Distress Syndrome (ARDS)","authors":"A. Ghanem","doi":"10.31579/2692-9406/037","DOIUrl":"https://doi.org/10.31579/2692-9406/037","url":null,"abstract":"Fluid therapy (FT) was introduced during WW2. Ever since its complications have been frequently reported but notably some serious complications have been overlooked. The role of volumetric overload (VO) in inducing VU shocks (VOS) and causing the acute respiratory distress syndrome (ARDS) has remained overlooked, unrecognized, and underestimated till recently. The role of FT complications in inducing VOS and causing ARDS is hard to detect because VOS is a shock that complicates another existing shock seamlessly and un-noticed. The author attributes this to the faulty rules on FT dictated by the wrong Starling’s law that causes many errors and misconceptions of FT which mislead physicians into giving too much fluid during shock resuscitation. The research findings on the wrong Starling’s law and how it has been corrected based on the hydrodynamic of the porous orifice (G) tube and the newly recognized VOS and the new patho-aetiology and therapy of ARDS are summarized here. Other authors in support of this contention are quoted. The errors on current FT and its corrections are given. Finally, a new prospective cohort study on FT and ARDS is recommended and a call for new guidelines on FT is urgently needed.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma towards Patients with Chronic Obstructive Pulmonary Disease: To Help or To Judge?","authors":"I. Khan","doi":"10.31579/2692-9406/063","DOIUrl":"https://doi.org/10.31579/2692-9406/063","url":null,"abstract":"Chronic Obstructive Pulmonary Disease (COPD), the third leading cause of mortality worldwide, is a highly incapacitating irrevocable health problem, with pulmonary and extra-pulmonary manifestations. According to Suzanne Hurd and Claude Lenfant, it is “the only chronic disease for which the finger of blame can be pointed to a single risk factor – tobacco smoking”. However, only 15-20% of smokers are afflicted. Whereas smoking is far from being the only cause, substantial proportion of COPD cases cannot be explained by smoking alone. The visibility of distressing and frightening physical manifestations of symptoms leads to serious ‘‘observable’’ consequences, such as disability or lack of control, public use of oxygen and rescue inhalers. As a result “they are disqualified from full social acceptance”. However, the stigma is not the only factor responsible for the miseries of those with COPD. In fact, there are many misconceptions in this scenario which have been discussed. The need of a huge awareness campaign for the public to improve their understanding of lung diseases (notably COPD) has been highlighted. The patient, healthcare professionals and the health services should be prepared to play their new role in the management of a chronic disease like COPD “requiring “ongoing management over a period of years or decades”. The importance of a self-management strategy has been emphasised.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70019128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}