Biomedical research and clinical reviews最新文献_第8页

Prostasomes (Exosomes) Mediate Functional Abilities to Recipient Cells through Transfer of Proteins and Nucleic Acids: A Comprehensive Model for Exosomal Intercellular Communication 前列腺体(外泌体)通过蛋白质和核酸的转移介导受体细胞的功能能力:外泌体细胞间通讯的综合模型

Biomedical research and clinical reviews Pub Date : 2021-01-01 DOI: 10.31579/2692-9406/061

G. Ronquist

引用次数: 0

In clear water no fish can live. Water purification promote global warming, decline of countries 在清澈的水中没有鱼可以生存。净水促进全球变暖，国家衰落

Biomedical research and clinical reviews Pub Date : 2020-12-24 DOI: 10.31579/2692-9406/004

S. Ozaki

引用次数: 2

Evaluation of the effectiveness of hyaluronic acid for the treatment of seborrheic dermatitis of the face 透明质酸治疗面部脂溢性皮炎的疗效评价

Biomedical research and clinical reviews Pub Date : 2020-12-18 DOI: 10.31579/2692-9406/031

G. Hakobyan, I. Komissarova, Z. Evsyukova, Elena Ribakova, Armen Haruthyunyan

{"title":"Evaluation of the effectiveness of hyaluronic acid for the treatment of seborrheic dermatitis of the face","authors":"G. Hakobyan, I. Komissarova, Z. Evsyukova, Elena Ribakova, Armen Haruthyunyan","doi":"10.31579/2692-9406/031","DOIUrl":"https://doi.org/10.31579/2692-9406/031","url":null,"abstract":"Objectives: The aim of the study was to assess the efficacy of 5% hyaluronic acid crem for the treatment of seborrheic dermatitis of the face. Materials and methods: A total of 49 patients (28 men and 21 women, age from 31 to 64 years) with seborrheic dermatitis of the face were selected for the study. A single-site, prospective observational study of 5% hyaluronic acid cream for the treatment of facial seborrheic dermatitis was conducted from 2016 to 2020. All patients underwent a thorough clinical examination according to the generally accepted scheme. Treatment planning includes a thorough history and physical examination, preoperative laboratory examination. At each visit, degrees of scale, erythema, and pruritus were evaluated. To assess the effectiveness of patients were given a questionnaire to fill out the questions. The questionnaire evaluated the 5% hyaluronic acid crem effectiveness of the treatment. Outcome was the evolution of the Investigator Global Assessment (IGA) scale, assessing erythema, scale / scaling, seborrhea and pruritus, all measured on a five-point scale, from 0: no signs / symptoms to 4: very severe sign / symptom. Subjects were assessed at baseline after 4 and 8 weeks. Results: Baseline IGA scores (mean ± SD) were 9 ± 3 (range: 5-13). The use of the EDS significantly reduced the IGA score by 67% at 4 week and by 83% at 8 week. The condition improved from baseline in 92.3% of subjects. Conclusion: 5% hyaluronic acid crem has been effective in reducing erythema, scales, seborrhea, and itching. No local side effects were reported.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43588998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Full-thickness skin grafts (FTSG) with a new technique 一种新技术的全层皮肤移植

Biomedical research and clinical reviews Pub Date : 2020-12-18 DOI: 10.31579/2692-9406/030

R. Staubach, Glosse H, F. S., A. Tripp, U. Mehlig

{"title":"Full-thickness skin grafts (FTSG) with a new technique","authors":"R. Staubach, Glosse H, F. S., A. Tripp, U. Mehlig","doi":"10.31579/2692-9406/030","DOIUrl":"https://doi.org/10.31579/2692-9406/030","url":null,"abstract":"Introduction: Full-thickness skin grafts (FTSG) have long been an indispensable and frequently practiced standard procedure in plastic surgery. The defatting and thinning of the grafts with scissors or scalpel to a thickness of 0,8 – 1,2 mm is very time-consuming even for experienced surgeons in the case of large transplants. Devices for full-thickness skin graft defatting are not available on the market. For this reason, we developed a relatively simple device that enables complete and safe degreasing and thinning of the graft in the shortest possible time. Materials and Methods: The machine has a dimension of 38cm width, 24cm length, 23cm height. The cutting thickness can be set to 0.6mm, 0.8mm, and 1.0mm. The central part is a crimper run manually with a crank to guide the specimen through a cutting blade. The machine is made of stainless steel, can be completely disassembled, and is easy to sterilize. Results: With this device small and very large skin grafts up to 15 cm in width can get completely defatted within a few seconds. Discussion: The time for defatting is reduced by many times. Precious operating time is spared. It can be assumed that the healing of the graft is improved due to a more complete defatting, a much shorter manipulating time of the skin and a more even cut surface compared to the manual procedure. The risk of defects in the graft and of injury of the surgeon is minimized compared to manual preparation.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41960887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprint-The Effect of Bone Marrow Derived Mesenchymal Stem Cells on the Survival of Random Skin Flap on Sterptozotocin-Induced Diabetic Rats 骨髓间充质干细胞对糖尿病大鼠随机皮瓣成活的影响

Biomedical research and clinical reviews Pub Date : 2020-11-09 DOI: 10.31579/2692-9406/007

F. Chehelcheraghi, Khadijah Rezazadeh, K. Anbari

{"title":"Reprint-The Effect of Bone Marrow Derived Mesenchymal Stem Cells on the Survival of Random Skin Flap on Sterptozotocin-Induced Diabetic Rats","authors":"F. Chehelcheraghi, Khadijah Rezazadeh, K. Anbari","doi":"10.31579/2692-9406/007","DOIUrl":"https://doi.org/10.31579/2692-9406/007","url":null,"abstract":"Background and Objective: Wound dressing and healing in diabetic patients is encountered with many problems. This study aimed to investigate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the survival of random skin flap (RSF) on Streptozotocin-induced diabetic rats (STZ) using an optical microscope. Materials & Methods: In this study, 60 male Albino Wistar rats were used (average weight 250-300 gr). The rats were divided into six groups: 1) Health-Non (HN), 2) Health-Cells (HC), 3) Health-Sham (HS), 4) Diabetic-Non (DN) that were became diabetic by injecting STZ 70 mg/kg intraperitoneally), 5) Diabetic-Sham (DS), and 6) Diabetic-Cell (DC). In all groups, the day of surgery was considered as the zero day, on the back area of animal, the flap was created with a size of 8 × 3 cm and the BM-MSCs were performed. The sampling was performed on day 7 after surgery from the region where Transitional Zone (TZ) necrosis was initiated. Results: BM-MSCs increased the number of blood vessels (P=0.009) and the histology parameters (wound demarcation P=0.0001, granulation tissue P=0.0001) significantly compared to the control group. But this increase was not significant in the area of the survival region. Conclusion: It was concluded that after treatment with BM-MSCs, the wound healing process in both non-diabetic and diabetic groups was increased in accordance with histological characteristics.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42991888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth Performance, Caeca Microbial Population and Immune Response of Starter Broiler Chicks Fed Aqueous Extract of Balanites Aegyptiaca and Alchornea Cordifolia Stem Bark Mixture 埃及巴兰与堇青花茎皮混合水提物对肉仔鸡生长性能、盲肠微生物种群及免疫应答的影响

Biomedical research and clinical reviews Pub Date : 2020-10-27 DOI: 10.31579/2692-9406/022

M. Bashir

{"title":"Growth Performance, Caeca Microbial Population and Immune Response of Starter Broiler Chicks Fed Aqueous Extract of Balanites Aegyptiaca and Alchornea Cordifolia Stem Bark Mixture","authors":"M. Bashir","doi":"10.31579/2692-9406/022","DOIUrl":"https://doi.org/10.31579/2692-9406/022","url":null,"abstract":"A total of Two hundred and fifty (250), 1-day old (Cobb) broiler chicks with mixed sex were used to evaluate the the growth performance, caeca microbial population and immune response of starter broiler chicks fed aqueous extract of Balanites aegyptiaca and Alchornea cordifolia stem bark mixture (BACM). Birds were reared on a deep litter system and randomly divided into five treatment with five replicates consisting of 10 birds each in a completely randomized design. Treatment 1 (T1) were given basal diet + 0 % BACM, T2, T3, T4 and T5 were fed 20, 40, 60 and 80 ml/liter BACM respectively. The experiment lasted for 28 during which clean feed and water were offered ad libitum. The results obtained revealed that the average weight gain (AWG), feed conversion ratio (FCR) and mortality were influenced by the dietary treatments (P<0.05). Birds in T5 had the highest AWG and FCR (1159.3 g, 1.57) followed by T4 (1070.2 g, 1.70), T3 (1047.4 g, 1.74), T2 (981.1 g, 1.86) and T1 (850.7 g, 2.14) respectively. Activities of superoxide dismutase (SDA), glutathione peroxidase (GPx), catalase (CAT) ,malonyldialdehyde (MLA) and antibody titres against Newcastle and gumboro disease were significantly affected by BACM (P<0.05). Caeca microbial population of Escherichia coli and Lactobacilli were significantly different among the treatments (P<0.05). E. coli count in T1 were higher compared to other treatments (P<0.05), Lactobacilli population increased in T2, T3, T4 and T5 compared to T1. It was concluded that BACM can be fed to broiler chicks at 80 ml/litre without any negetive effect on the performance and immune response of birds.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43454194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Tripartite Mechanism of Neural Memory: Proof-of-Concept with Neuromimetic Impedence Electrodes 神经记忆的三方机制：模拟神经阻抗电极的概念证明

Biomedical research and clinical reviews Pub Date : 2020-10-14 DOI: 10.31579/2692-9406/021

Gerard Marx, C. Gilon

{"title":"Tripartite Mechanism of Neural Memory: Proof-of-Concept with Neuromimetic Impedence Electrodes","authors":"Gerard Marx, C. Gilon","doi":"10.31579/2692-9406/021","DOIUrl":"https://doi.org/10.31579/2692-9406/021","url":null,"abstract":"The idea that neural signaling is the basis of mental processes has a long history. We graphically summarize salient developments in the neurobiology of signaling, as a Timeline. In particular, we review the “tripartite mechanism” of neural memory, which centers on the interactions between a neuron with its surrounding extracellular matrix (nECM) doped with metals and neurotransmitters (NTs). Essentially, the neuron employs the nECM as its “memory material”, wherein it uses dopants to encode cognitive units of information (termed “cuinfo”). The NTs, which elicit bodily reactions (feelings), also encode past feelings as emotions, which “color” mental states in real-time and in memory. In the interest of developing experimental tests of the tripartite mechanism, impedance glass electrodes were covalently coated with an exemplar NT (oxytocin) or a sulfated tetra-saccharide analog of the nECM, were constructed and tested. The two types of coated, neuro-mimetic electrodes, termed “neulectrodes”, were capable of detecting metals, such as Hg+2, Pb+2, Cd+2, Cu+2, and Zn+2 with very high selectivity and sensitivity. The “neulectrodes” demonstrated that the chemodynamic interactions of metal cations with NTs or nECM-saccharide analogues can translate into electrodynamic signals. They experimentally validate the concept of the tripartite mechanism that underlies the chemo-electric encoding of neural memory.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44404298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effect of aluminum oxide powder reinforcement on degree of conversion, monomer release and flexural strength of heat-cured acrylic resin 氧化铝粉增强剂对热固化丙烯酸树脂转化率、单体释放度及抗弯强度的影响

Biomedical research and clinical reviews Pub Date : 2020-10-14 DOI: 10.31579/2692-9406/020

Ibrahim M. Hamouda, Alaa Makke

{"title":"Effect of aluminum oxide powder reinforcement on degree of conversion, monomer release and flexural strength of heat-cured acrylic resin","authors":"Ibrahim M. Hamouda, Alaa Makke","doi":"10.31579/2692-9406/020","DOIUrl":"https://doi.org/10.31579/2692-9406/020","url":null,"abstract":"Objectives: Effect and correlation of aluminum oxide powder on degree of conversion, residual monomer and flexural properties of heat-cured acrylic resin specimens were studied. Materials and methods: Heat-cured acrylic resin and aluminum oxide powders were used. Specimens of specific dimensions from unreinforced and reinforced acrylic resins using stainless steel plates were prepared. Degree of conversion was determined using FTIR Spectrometer. Released monomer was measured using isocratic high-performance liquid chromatography. Flexural strength was tested using three point-bending test. Results: Aluminum oxide reinforcement showed increased degree of conversion than that of the unreinforced specimens. Released monomer from reinforced specimens was lower than that of unreinforced specimens. Deflection at fracture of reinforced specimens was lower than that of unreinforced specimens. Flexural strength was increased by addition of 2.5 % and 5% aluminum oxide. There was a positive correlation between degree of conversion and flexural strength. There was a negative correlation between degree of conversion and monomer release. Conclusions: Aluminum oxide powder increased degree of conversion and flexural strength but reduced monomer release and deflection at fracture. There was a positive correlation between degree of conversion and flexural strength. There was a negative correlation between degree of conversion and monomer release. Clinical relevance: Aluminum oxide powder could reinforce the week acrylic resin denture base materials. Degree of monomer conversion during processing of acrylic resin denture base materials is very critical in determination of monomer release and mechanical properties of acrylic resin in service.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45960535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Etiology and Clinical Features of Acute Flaccid Paralysis among Children in Gadarif, Sudan 苏丹加达里夫儿童急性弛缓性麻痹的病因学和临床特征

Biomedical research and clinical reviews Pub Date : 2020-09-26 DOI: 10.33702/CNCNR.2020.2.1.1

M. Ahmed, K. Abdalla, Samia O. Masaad, Y. Abubakar, Amar Mohammed Mahjoub

{"title":"Etiology and Clinical Features of Acute Flaccid Paralysis among Children in Gadarif, Sudan","authors":"M. Ahmed, K. Abdalla, Samia O. Masaad, Y. Abubakar, Amar Mohammed Mahjoub","doi":"10.33702/CNCNR.2020.2.1.1","DOIUrl":"https://doi.org/10.33702/CNCNR.2020.2.1.1","url":null,"abstract":"Acute Flaccid Paralysis (AFP) is a rare but a serious neurological condition characterized by sudden weakness or paralysis of one or more extremities, the respiratory or bulbar muscles and reduced muscle tone without other obvious cause. Death occurs in about 7.5% of AFP affected patients worldwide. AFP is the most common sign of acute polio. Therefore, AFP studies are important for surveillance during polio outbreaks to differentiate polio cases from AFP cases. There is a lack of information about the clinical features & causative factors of AFP among children in Gadarif, Sudan. The identification of AFP cases and its causative factors are important in the management & prevention of the disease. This study assessed the etiology and the clinical features of AFP among children in Gadarif, Sudan aiming at effective management & prevention of the disease. It was a prospective cross sectional study conducted at Gadarif Pediatrics Teaching Hospital during the period of January 2017-December 2019. It comprised 73 children with confirmed AFP, ages 6 months to < 15 years old. Our study revealed that Poliomyelitis was not the cause of AFP. AFP was significantly affected children with youngest ages 0-5 years old and from the rural areas. Guillain-Barré syndrome (GBS) was the leading cause of AFP followed by meningitis, traumatic neuritis and hypokalemia and we believed that infections were the main triggers of GBS. Gender did not affect the prevalence of the AFP. Fever and paraplegia were the most prevalent clinical signs at onset of the weakness. Over 50% of the AFP victims showed symmetric paralysis. It is obviously that AFP-based awareness, provision of high-quality health services and fighting of illiteracy and poverty in the rural areas of Sudan are urgently needed for effective management of AFP.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43726957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Albizia lebbeck Stem Bark Aqueous Extract as Alternative to Antibiotic Feed Additives in Broiler Chicks Diets: Haematology, Serum Indices and Oxidative Status 合欢茎皮水提物在肉仔鸡饲粮中替代抗生素饲料添加剂:血液学、血清指标和氧化状态

Biomedical research and clinical reviews Pub Date : 2020-09-11 DOI: 10.31579/2692-9406/018

A. J.O

{"title":"Albizia lebbeck Stem Bark Aqueous Extract as Alternative to Antibiotic Feed Additives in Broiler Chicks Diets: Haematology, Serum Indices and Oxidative Status","authors":"A. J.O","doi":"10.31579/2692-9406/018","DOIUrl":"https://doi.org/10.31579/2692-9406/018","url":null,"abstract":"A total of Three hundred and seventy five (375) one day old (Ross 308) broiler chicks with mixed sex were used to examine the effects of Albizia lebbeck stem bark (ATSM) aqueous extract as alternative to antibiotic feed additives in broiler chicks diets: haematology, serum biochemical indices and oxidative status. Birds were divided to five treatments with five replicates of fifteen (15) birds in a completely randomized design. Treatment 1 (basal diet + 0 % ATSM), treatment 2 (basal diet +1.2 grams Oxytetracycline per litre of water), treatment 3 (basal diet + 10 ml ATSM per liter of water), treatment 4 (basal diet + 20 ml ATSM per litre of water) and treatment 5 (basal diet + 30 ml ATSM per liter of water) and the trial lasted for 56 days. Results on some haematological parameters revealed that red blood cell (RBC), pack cell volume (PCV), haemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), white blood cell (WBC) and its differentials were significantly ((P<0.05) different among the treatments. Total protein, glucose, urea, cholesterol, creatinine, aspartate aminotransaminase (AST) and alanine aminotransferase (ALT) were significantly ((P<0.05) affected by ATSM. Activities of superoxide dismutase (SDA), glutathione peroxidase (GPx), catalase (CAT) and malonyldialdehyde (MLA) were significantly influenced by ATSM (P<0.05). It was concluded that ATSM could be administered to broiler chicks at 30 ml/litre without any negative effect on the general performance of birds.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42991928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2