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Preparation, thermal and mechanical properties of zinc Sulphide/Polypropylene composites
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-06 DOI: 10.1016/j.apt.2025.104807
Jiahui Yu , Zhiling Xu , Zhiqi Liu , Na Li , Yue Zhao , Huiming Di , Yuting Zhao , Zhiqiu Yang , Yongcang Ying
{"title":"Preparation, thermal and mechanical properties of zinc Sulphide/Polypropylene composites","authors":"Jiahui Yu ,&nbsp;Zhiling Xu ,&nbsp;Zhiqi Liu ,&nbsp;Na Li ,&nbsp;Yue Zhao ,&nbsp;Huiming Di ,&nbsp;Yuting Zhao ,&nbsp;Zhiqiu Yang ,&nbsp;Yongcang Ying","doi":"10.1016/j.apt.2025.104807","DOIUrl":"10.1016/j.apt.2025.104807","url":null,"abstract":"<div><div>Zinc sulfide pigments are the most important inorganic white, apart from titanium dioxide and zinc oxide pigments. Here, we proposed the combined method of hydrothermal synthesis, calcination and sand milling to prepare zinc sulphide nanoparticles (ZnS NPs). ZnS NPs were mainly prepared by the precipitation reaction between zinc salt solution and sodium sulfide solution, followed by calcination under nitrogen condition, and concluded with grounding by sand mill. The particle size, crystal structure, and whiteness of ZnS NPs were analyzed by various characterization tools. Importantly, the crystal structures of ZnS NPs were transformed from sphalerite to wurtzite during the calcination process, without any change after sand grinding. ZnS/Polypropylene (ZnS/PP) composites were prepared by melt blending method, and then hot pressing into sheets. ZnS/PP composites exhibited better thermal stability than neat polypropylene from the thermogravimetric and limiting oxygen index analysis. ZnS/PP composites also improved the tensile strength and elongation at break of PP. Moreover, the morphology of the tensile fracture surface of ZnS/PP composites showed the uniform distribution of ZnS NPs within PP matrix and the ductile fracture mode. We anticipate that this work may shed light on fabricating efficient ZnS NPs and thermal stable ZnS-polymer composites.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104807"},"PeriodicalIF":4.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143200922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of electrostatic interaction between particle and substrate on the colloidal layer structure prepared by convective self-assembly
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-06 DOI: 10.1016/j.apt.2025.104811
Akane Oka , Tetsuya Yamamoto , Hidetaka Kawakita , Keisuke Ohto , Shintaro Morisada
{"title":"Effect of electrostatic interaction between particle and substrate on the colloidal layer structure prepared by convective self-assembly","authors":"Akane Oka ,&nbsp;Tetsuya Yamamoto ,&nbsp;Hidetaka Kawakita ,&nbsp;Keisuke Ohto ,&nbsp;Shintaro Morisada","doi":"10.1016/j.apt.2025.104811","DOIUrl":"10.1016/j.apt.2025.104811","url":null,"abstract":"<div><div>By soap-free emulsion polymerization using an anionic or a cationic initiator, the poly(methyl methacrylate) (PMMA) particles of a sub-micron size with negative or positive charge were prepared and then employed for the colloidal layer fabrication through the convective self-assembly (CSA) using a glass substrate to investigate the effect of the electrostatic interactions between the particle and the substrate on the resulting layer structures. In the case of the negatively charged PMMA particle, the electrostatic repulsions between the particle and the substrate as well as between the particles led to the formation of the ordered close-packed colloidal layers. When the CSA with the positively charged PMMA particles were carried out at low particle volume fraction, the colloidal layers with disordered structure were formed due to the electrostatic attraction between the particle and the substrate. With an increase in the particle volume fraction, the surface structure of the colloidal layers of the positively charged PMMA particles changed from disordered to ordered while the internal structure remained disordered. This is probably because the electrostatic repulsion that the undeposited particles receive from the particles already deposited on the substrate becomes dominant over the electrostatic attraction from the substrate.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104811"},"PeriodicalIF":4.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143200921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On DEM simulation of loose packing behaviour of fine and cohesive particles
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-05 DOI: 10.1016/j.apt.2025.104809
Kimiaki Washino , Ei L. Chan , Dorian Faroux , Takuya Tsuji , Tatsuya Takahashi , Shuji Sasabe
{"title":"On DEM simulation of loose packing behaviour of fine and cohesive particles","authors":"Kimiaki Washino ,&nbsp;Ei L. Chan ,&nbsp;Dorian Faroux ,&nbsp;Takuya Tsuji ,&nbsp;Tatsuya Takahashi ,&nbsp;Shuji Sasabe","doi":"10.1016/j.apt.2025.104809","DOIUrl":"10.1016/j.apt.2025.104809","url":null,"abstract":"<div><div>While Discrete Element Method (DEM) is widely used to simulate fine and cohesive granular materials, accurately capturing real-life packing behaviour requires further investigation on the (i) types of attraction forces and (ii) cluster formation during free fall. In the present study, simulations of various scenarios have been performed to investigate the impacts of particle insertion methods on the resultant packing fraction. The results suggest that the introduction of initial vertical velocity fluctuations during stream insertion can lead to consistent formation of clusters of free falling particles, which is a key factor for achieving loose packing of cohesive particles. We then tested and compared two commonly used attraction force models: the JKR surface adhesion force and non-bonded van der Waals force models. It is revealed that the packing fractions and coordination numbers of the final beds are comparable across different attraction force models as long as the following two conditions are met at the same time: (i) the surface energy density is adjusted (by approximately 2.6 times) to match the total potential energy between a pair of particles and (ii) the initial vertical velocity fluctuations are assigned to form particle clusters during free fall.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104809"},"PeriodicalIF":4.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143200920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing nanoparticles: The role of process parameters in thermal plasma synthesis
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-05 DOI: 10.1016/j.apt.2025.104793
Kwangjae Park , Yusuke Hirayama , Masaya Shigeta
{"title":"Designing nanoparticles: The role of process parameters in thermal plasma synthesis","authors":"Kwangjae Park ,&nbsp;Yusuke Hirayama ,&nbsp;Masaya Shigeta","doi":"10.1016/j.apt.2025.104793","DOIUrl":"10.1016/j.apt.2025.104793","url":null,"abstract":"<div><div>This study comprehensively investigated the effects of feed and cooling rates on the formation and particle diameter of Fe nanopowders synthesized using the thermal plasma process. The particle diameters of the Fe nanopowders were analyzed by microscopic observations, X-ray diffraction, and small-angle X-ray scattering measurements. The experimental results indicated that the mean particle diameter decreased as the feed rate decreased, and quenching was applied. Numerical simulations were employed to examine the effects of the feed and cooling rates on the nanoparticle diameter and to visualize the particle growth mechanism. According to the results of the numerical study, the feed and cooling rates were identified as critical experimental parameters that significantly affect the homogeneous nucleation, total concentration of vapor atoms, and frequency of heterogeneous condensation on nuclei, ultimately determining the final diameter of the nanoparticles. This study bridges experimental and numerical analyses, clarifies particle growth mechanisms, and demonstrates the feasibility of designing nanoparticles with sizes ranging from a few to hundreds of nanometers that can be utilized in a multitude of applications using thermal plasma processes.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104793"},"PeriodicalIF":4.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triboelectric charging model for particles with rough surfaces
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-04 DOI: 10.1016/j.apt.2025.104787
Simon Jantač , Jarmila Pelcová , Jana Sklenářová , Marek Drápela , Holger Grosshans , Juraj Kosek
{"title":"Triboelectric charging model for particles with rough surfaces","authors":"Simon Jantač ,&nbsp;Jarmila Pelcová ,&nbsp;Jana Sklenářová ,&nbsp;Marek Drápela ,&nbsp;Holger Grosshans ,&nbsp;Juraj Kosek","doi":"10.1016/j.apt.2025.104787","DOIUrl":"10.1016/j.apt.2025.104787","url":null,"abstract":"<div><div>The triboelectric charging of particles depends on the contact area of the particle and the contacting surface. Even though the surface topology determines the real contact area, particle charging models do not account for surface roughness. In this paper, we combine contact mechanics and triboelectrification models to predict the charging of rough particles. First, a laser confocal microscope was used to measure the statistical descriptors of polyethylene (PE) particles surface topology. Then, we described particle surfaces by distributing spheroidal asperities on the smooth particle core until the surface roughness reached the measured value. The Hertz contact mechanics model was used to predict the deformation of the asperity-covered particle and the resulting real contact area in dependence on impact velocity. Finally, we introduced the real contact area into the condenser model for triboelectric particle charging. The accuracy of the new model predictions was demonstrated by comparing it to a more complex surface reconstructions that account for the fractal surface topology. Furthermore, the model’s predicted particle saturation charges agree well with our shaker experiments and with experimental data in the literature on the charging of plane surfaces. The developed triboelectric charging model for particles with rough surfaces is simple and requires only standard descriptors of the surface topology; thus, it suits large-scale simulations of electrifying powder flows.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104787"},"PeriodicalIF":4.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DEM study for investigating the mixing effect of two differently sized grinding media in an agitated media mill
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-04 DOI: 10.1016/j.apt.2025.104810
ORyo Miyazawa , Ryuto Kamo , Yutaro Takaya , Susumu Gunji , Kenichi Momota , Satoshi Shiina , Kyoko Okuyama , Hidehiro Kamiya , Chiharu Tokoro
{"title":"DEM study for investigating the mixing effect of two differently sized grinding media in an agitated media mill","authors":"ORyo Miyazawa ,&nbsp;Ryuto Kamo ,&nbsp;Yutaro Takaya ,&nbsp;Susumu Gunji ,&nbsp;Kenichi Momota ,&nbsp;Satoshi Shiina ,&nbsp;Kyoko Okuyama ,&nbsp;Hidehiro Kamiya ,&nbsp;Chiharu Tokoro","doi":"10.1016/j.apt.2025.104810","DOIUrl":"10.1016/j.apt.2025.104810","url":null,"abstract":"<div><div>The effects of using large and small media in an agitated media mill were investigated by performing experiments and discrete element method (DEM) simulations to improve grinding efficiency and reduce operating time. Four conditions were examined: only large or small media, the same number of large and small media, and an excess of small media. Experimental results showed that the addition of small media resulted in a sharper particle size distribution and a smaller grinding limit compared with only large or small media condition. Furthermore, since the temperature rise of the cooling water under the large-media-only condition was higher than small and large media mixing condition, it suggested that more energy was lost during the grinding process. In the DEM simulations, In the case of only small media use, the collision energy was not enough to grind material. Using the same number of large and small media, the collision energy was not significantly different from that of the large-media-only condition and the number of collision points could be increased without decreasing the collision energy by improving the collision of the large media to small media and the agitator shaft. Based on the above mechanism, the improve of grinding efficiency and the reduction of grinding limit were explained by DEM.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104810"},"PeriodicalIF":4.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of the axial solid holdup profile by locating the splash zone in the riser
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-03 DOI: 10.1016/j.apt.2025.104791
Na Yeon Kim , Dong Hun Lee , Hyungwon Jang , Jeong-Hoo Choi , Ji Bong Joo , Daewook Kim , Yooseob Won , Ho-Jung Ryu
{"title":"Determination of the axial solid holdup profile by locating the splash zone in the riser","authors":"Na Yeon Kim ,&nbsp;Dong Hun Lee ,&nbsp;Hyungwon Jang ,&nbsp;Jeong-Hoo Choi ,&nbsp;Ji Bong Joo ,&nbsp;Daewook Kim ,&nbsp;Yooseob Won ,&nbsp;Ho-Jung Ryu","doi":"10.1016/j.apt.2025.104791","DOIUrl":"10.1016/j.apt.2025.104791","url":null,"abstract":"<div><div>The axial solid holdup profile in the riser was investigated to provide an upgraded entrainment model in a more prescriptive manner. The height and solid holdup of the dense zone, and the decay factor had to be determined reflecting the effect of the riser pressure drop. The dense-zone height (<span><math><mrow><msub><mi>z</mi><mi>d</mi></msub></mrow></math></span>) and the level of the top of the splash zone (<span><math><mrow><msub><mi>z</mi><mrow><mi>spl</mi></mrow></msub></mrow></math></span>) were examined in fast fluidized beds. Correlations for <span><math><mrow><msub><mi>z</mi><mi>d</mi></msub></mrow></math></span> and <span><math><mrow><msub><mi>z</mi><mrow><mi>spl</mi></mrow></msub></mrow></math></span> were proposed based on the mechanism responsible for effects of the riser pressure drop, the gas velocity in the riser, and the particle size and density. The correlations were appropriate to provide the decay factor and the solid holdup of the dense zone. Overcoming the limits of existing models, the model proposed by this study was significant with highly improved accuracy. Wall effects on <span><math><mrow><msub><mi>z</mi><mi>d</mi></msub></mrow></math></span> and <span><math><mrow><msub><mi>z</mi><mrow><mi>spl</mi></mrow></msub></mrow></math></span> were remarkable.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104791"},"PeriodicalIF":4.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic study on the properties of self-assembled gels for mining based on the valence modulation of inorganic salt cations
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-03 DOI: 10.1016/j.apt.2025.104803
Haiming Yu , Han Qi , Yao Xie , Wang Li , Xin Qiao
{"title":"Mechanistic study on the properties of self-assembled gels for mining based on the valence modulation of inorganic salt cations","authors":"Haiming Yu ,&nbsp;Han Qi ,&nbsp;Yao Xie ,&nbsp;Wang Li ,&nbsp;Xin Qiao","doi":"10.1016/j.apt.2025.104803","DOIUrl":"10.1016/j.apt.2025.104803","url":null,"abstract":"<div><div>This research aims to enhance the efficacy of dust reduction through water injection techniques on dust sources in coal mine environments. Focusing on a uniform acid distribution water injection method, we investigated the influence of inorganic salt cations on self-assembled gels, analyzing factors such as viscosity, rheological properties, wormlike micelle length, and hydrogen bond formation. The study reveals the internal mechanisms by which inorganic salt cations affect wormlike micelle behavior within self-assembled gels. Results suggest that increasing cationic valence correlates with enhanced viscosity of the self-assembled gel (SSA). Notably, the self-assembled gel containing Al<sup>3+</sup> (SSA/Al<sup>3+</sup>) exhibited the highest viscosity, reaching 0.48 Pa.s. Both wormlike micelle length and solution potential showed an upward trend, with micelle length in SSA/Al<sup>3+</sup> solution reaching 154 nm. The SSA/Al<sup>3+</sup> system formed tenfold more hydrogen bonds than the self-assembled gel without ion addition (SSA/None), indicating enhanced intermolecular forces and promoted cluster aggregation. Micelle radius expanded from 26.21 Å to 53.83 Å. In conclusion, this study analyzes the mechanism by which different cations influence the tackifying effect of self-assembled gels, in order to provide a theoretical basis for the application of self-assembled gels in coal mining operations.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 3","pages":"Article 104803"},"PeriodicalIF":4.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of heat treatment on structural and magnetic features of nanostructured Ni-Co-Mn-Al Heusler alloy obtained by planetary ball mills
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-01 DOI: 10.1016/j.apt.2025.104783
M. Triki, M. Azzaz
{"title":"Effect of heat treatment on structural and magnetic features of nanostructured Ni-Co-Mn-Al Heusler alloy obtained by planetary ball mills","authors":"M. Triki,&nbsp;M. Azzaz","doi":"10.1016/j.apt.2025.104783","DOIUrl":"10.1016/j.apt.2025.104783","url":null,"abstract":"<div><div>This paper investigates the structural, microstructural and magnetic properties observed at room temperature and after high-temperature heat treatment of Ni-Co-Mn-Al Heusler alloy, produced by high-energy ball milling. A number of characterization techniques were employed to study morphology, structural composition, thermal transitions, phase changes and magnetic shifts, including: room and high temperature XRD analysis, SEM-EDXS, DSC, TEM and VSM. The obtained alloy is a homogeneous mixture of agglomerated rounded grains with an average size of around 60 µm, composed mainly of a metastable martensitic phase (<em>L</em>1<sub>0</sub>) and a minority austenitic phase (B2). High-temperature XRD characterization confirms the complete formation of the ordered B2 Heusler phase from 573 K. Crystallite size increases with temperature, but microdeformations drop significantly due to relaxation of residual stresses. Magnetic measurements show that magnetization saturation, and coercivity values increase after each high-temperature heat treatment, making the alloy’s magnetic behavior softer. The increase in saturation magnetization values indicates that a greater number of magnetic domains are aligned in the same direction within the material, enabling it to be more magnetized. This improvement in magnetic performance makes the material more suitable for various applications such as transformers, electric motors or magnetic sensors.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 2","pages":"Article 104783"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jet-milling co-grounds of APIs with polysorbate 80, lecithin and sucrose esters: Particle characteristics and impacts on agglomeration and dissolution efficiency
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-02-01 DOI: 10.1016/j.apt.2024.104764
Wanlop Weecharangsan , Robert J. Lee
{"title":"Jet-milling co-grounds of APIs with polysorbate 80, lecithin and sucrose esters: Particle characteristics and impacts on agglomeration and dissolution efficiency","authors":"Wanlop Weecharangsan ,&nbsp;Robert J. Lee","doi":"10.1016/j.apt.2024.104764","DOIUrl":"10.1016/j.apt.2024.104764","url":null,"abstract":"<div><div>The jet-milling co-grounds of active pharmaceutical ingredients (APIs) with excipients, including polysorbate 80 (PS), lecithin (LT) and sucrose esters (SEs), were characterized for particle size, specific surface area, scanning electron microscopy (SEM), and dissolution testing. Particle size analysis indicated that increasing proportion of PS or LT in the co-grounds either increased or maintained particle size, while the SEs-API co-grounds exhibited a reduction or no change in size. Specific surface area increased with higher proportions of SEs in the co-grounds but decreased for PS-API and LT-API co-grounds. SEM analysis showed that PS and LT promoted agglomeration in the co-grounds, while SEs reduced agglomeration. Dissolution profiles fluctuated depending on the extent of agglomeration. In conclusion, co-grinding with PS, LT and SEs can enhance the dissolution efficiencies of APIs. SEs, in particularly, demonstrated the ability to reduce agglomeration and improve the dissolution efficiency, suggesting that SEs may aid in simplifying the manufacturing process of poorly water-soluble drugs and enhanced their dissolution performance.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 2","pages":"Article 104764"},"PeriodicalIF":4.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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