Atherosclerosis plus最新文献

{"title":"Conditional deletion of Ccl2 in smooth muscle cells does not reduce early atherosclerosis in mice","authors":"Stine Gunnersen ,&nbsp;Jeong Tangkjær Shim ,&nbsp;Fan Liu ,&nbsp;Uwe J.F. Tietge ,&nbsp;Charlotte Brandt Sørensen ,&nbsp;Jacob Fog Bentzon","doi":"10.1016/j.athplu.2023.12.004","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.12.004","url":null,"abstract":"<div><h3>Background and aims</h3><p>C–C motif chemokine ligand 2 (CCL2) is a pro-inflammatory chemokine important for monocyte recruitment to the arterial wall and atherosclerotic plaques. Global knockout of <em>Ccl2</em> reduces plaque formation and macrophage content in mice, but the importance of different plaque cell types in mediating this effect has not been resolved. Smooth muscle cells (SMCs) can adopt a potentially pro-inflammatory function with expression of CCL2. The present study aimed to test the hypothesis that SMC-secreted CCL2 is involved in early atherogenesis in mice.</p></div><div><h3>Methods</h3><p>SMC-restricted Cre recombinase was activated at 6 weeks of age in mice with homozygous floxed or wildtype <em>Ccl2</em> alleles. Separate experiments in mice lacking the Cre recombinase transgene were conducted to control for genetic background effects. Hypercholesterolemia and atherosclerosis were induced by a tail vein injection of recombinant adeno-associated virus (rAAV) encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and a high-fat diet for 12 weeks.</p></div><div><h3>Results</h3><p>Unexpectedly, mice with SMC-specific <em>Ccl2</em> deletion developed higher levels of plasma cholesterol and larger atherosclerotic plaques with more macrophages compared with wild-type littermates. When total cholesterol levels were incorporated into the statistical analysis, none of the effects on plaque development between groups remained significant. Importantly, changes in plasma cholesterol and atherosclerosis remained in mice lacking Cre recombinase indicating that they were not caused by SMC-specific CCL2 deletion but by effects of the floxed allele or passenger genes.</p></div><div><h3>Conclusions</h3><p>SMC-specific deficiency of <em>Ccl2</em> does not significantly affect early plaque development in hypercholesterolemic mice.</p></div>","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"55 ","pages":"Pages 12-20"},"PeriodicalIF":1.6,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000512/pdfft?md5=7d5a4c8de844186df973dac21adc4df3&pid=1-s2.0-S2667089523000512-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma lipids in Pseudoxanthoma Elasticum (PXE) patients: A comparative study with population-based reference values and Non-PXE controls","authors":"Iris M. Harmsen ,&nbsp;Frank L.J. Visseren ,&nbsp;Madeleine Kok ,&nbsp;Pim A. de Jong ,&nbsp;Wilko Spiering","doi":"10.1016/j.athplu.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.12.003","url":null,"abstract":"<div><h3>Background and aims</h3><p>– Pseudoxanthoma elasticum (PXE) is a rare genetic disease caused by pathogenic mutations in the ABCC6 gene, resulting in low values of inorganic pyrophosphate (PPi). While low PPi is thought to contribute to arterial calcification, it remains unclear whether this fully explains premature calcification in PXE. It has been hypothesized that the ABCC6 gene could be related to dyslipidemia, which could contribute to vascular calcification seen in PXE. The aim of this study is to evaluate the relation between PXE and plasma lipid concentrations in a large cohort of PXE patients compared with reference values for the general population and compared with non-PXE controls.</p></div><div><h3>Methods</h3><p>– The plasma concentrations of total cholesterol, HDL-cholesterol, tiglycerides, and LDL-cholesterol of 312 PXE patients were compared to age- and sex-matched modeled data of the general Dutch population. Differences in median lipid levels were compared with Mann-Whitney-U test. Secondly, plasma lipid concentrations of 44 PXE patients were compared to 44 not-genetically related relatives (spouses or friends), with linear models adjusted for age, sex and BMI.</p></div><div><h3>Results</h3><p>– Total cholesterol in PXE patients was 5.6 [IQR 4.6–6.4] mmol/L versus 5.3 [IQR 4.7–6.0] mmol/L (p &lt; 0.01) in the general population; triglycerides were 1.1 [IQR 0.9–1.7] mmol/L versus 1.0 [0.7–1.4] mmol/L (p &lt; 0.01); HDL-c was 1.4 [IQR 1.2–1.7] mmol/L versus 1.5 [IQR 1.2–1.8] mmol/L (p = 0.03) and LDL-c was 3.3 [IQR 2.7–4.1] mmol/L versus 3.2 [IQR 2.7–3.8] mmol/L (p = 0.01). In the patient control analysis with 44 pairs and age, sex and BMI adjusted, comparison with the non-PXE controls only triglycerides were significantly different (mean difference: 0.38 (0.13–0.63)).</p></div><div><h3>Conclusion</h3><p>–The lipid profiles of PXE patients are marginally different from the general population or compared to a matched control group, but the differences are unlikely to be clinically relevant<strong>.</strong> It is therefore unlikely that plasma lipids contribute to the premature vascular calcifications in PXE patients.</p></div>","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"55 ","pages":"Pages 5-11"},"PeriodicalIF":1.6,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000500/pdfft?md5=f246b1ef66cc5f76a4507f16cab4fd8a&pid=1-s2.0-S2667089523000500-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138839661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction preferentially alters low-abundant, long-chain unsaturated phospholipid and sphingolipid species in plasma high-density lipoprotein subpopulations","authors":"Maharajah Ponnaiah ,&nbsp;Emile Zakiev ,&nbsp;Marie Lhomme ,&nbsp;Fabiana Rached ,&nbsp;Laurent Camont ,&nbsp;Carlos V. Serrano Jr. ,&nbsp;Raul D. Santos ,&nbsp;M. John Chapman ,&nbsp;Alexander Orekhov ,&nbsp;Anatol Kontush","doi":"10.1016/j.athplu.2023.12.001","DOIUrl":"10.1016/j.athplu.2023.12.001","url":null,"abstract":"<div><h3>Aim</h3><p>High-density lipoprotein (HDL) particles in ST-segment elevation myocardial infarction (STEMI) are deficient in their anti-atherogenic function. Molecular determinants of such deficiency remain obscure.</p></div><div><h3>Methods</h3><p>Five major HDL subpopulations were isolated using density-gradient ultracentrifugation from STEMI patients (n = 12) and healthy age- and sex-matched controls (n = 12), and 160 species of phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylglycerol, phosphatidylserine, phosphatidic acid, sphingomyelin and ceramide were quantified by LC-MS/MS.</p></div><div><h3>Results</h3><p>Multiple minor species of proinflammatory phosphatidic acid and lysophosphatidylcholine were enriched by 1.7–27.2-fold throughout the majority of HDL subpopulations in STEMI. In contrast, minor phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, sphingomyelin and ceramide species were typically depleted up to 3-fold in STEMI vs. control HDLs, while abundances of their major species did not differ between the groups. Intermediate-to-long-chain phosphatidylcholine, phosphatidylinositol and phosphatidylglycerol species were more affected by STEMI than their short-chain counterparts, resulting in positive correlations between their fold decrease and the carbon chain length. Additionally, fold decreases in the abundances of multiple lipid species were positively correlated with the double bond number in their carbon chains. Finally, abundances of several phospholipid and ceramide species were positively correlated with cholesterol efflux capacity and antioxidative activity of HDL subpopulations, both reduced in STEMI vs controls. KEGG pathway analysis tied these species to altered glycerophospholipid and linoleic acid metabolism.</p></div><div><h3>Conclusions</h3><p>Minor unsaturated intermediate-to-long-chain phospholipid and sphingolipid species in HDL subpopulations are most affected by STEMI, reflecting alterations in glycerophospholipid and linoleic acid metabolism with the accumulation of proinflammatory lysolipids and maintenance of homeostasis of major phospholipid species.</p></div>","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"55 ","pages":"Pages 21-30"},"PeriodicalIF":1.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000482/pdfft?md5=d1c9c5b6eb0e82b02af9dfadd2e5c21a&pid=1-s2.0-S2667089523000482-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139023406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTCA in children with severe heterozygous familial hypercholesterolaemia: Screening for subclinical atherosclerosis","authors":"M. Doortje Reijman ,&nbsp;Sibbeliene E. van den Bosch ,&nbsp;D. Meeike Kusters ,&nbsp;Willemijn E. Corpeleijn ,&nbsp;Barbara A. Hutten ,&nbsp;Irene M. Kuipers ,&nbsp;R. Nils Planken ,&nbsp;Albert Wiegman","doi":"10.1016/j.athplu.2023.12.002","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.12.002","url":null,"abstract":"<div><p>Familial hypercholesterolemia (FH) is one of the most common genetically inherited disorders in the world. Children with severe heterozygous FH (HeFH), i.e. untreated low-density lipoprotein cholesterol (LDL-C) levels above the 90th percentile for age and sex among FH mutation carriers, can have LDL-C levels that overlap levels of children with homozygous FH (HoFH), but treatment regimen and cardiovascular follow-up to prevent cardiovascular disease are less intensive in children with severe HeFH. In children with HoFH, subclinical atherosclerosis can already be present using computed tomography coronary angiography (CTCA). The question remains whether this is also the case in children with severe HeFH who have a high exposure to elevated LDL-C levels from birth onwards as well. We calculated the cumulative LDL-C exposure (CE_total [mmol]) in four children with severe HeFH and performed computed tomography coronary angiography (CTCA). These children, aged 13, 14, 15 and 18 years, had CE_total of 71.3, 97.8, 103.6 and 136.1 mmol, respectively. None of them showed abnormalities on cardiovascular imaging, despite high LDL-C exposure. The results of this study, do not give us an indication to recommend performing CTCA routinely in children with severe HeFH.</p></div>","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"55 ","pages":"Pages 1-4"},"PeriodicalIF":1.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000494/pdfft?md5=9f0a311f58a088f3bd203e52bb9938bc&pid=1-s2.0-S2667089523000494-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of lipid clinic referral and attendance in a multi-ethnic adult population in South London","authors":"Aya Ayoub ,&nbsp;Ralph K. Akyea ,&nbsp;Veline L’Esperance ,&nbsp;Salma Ayis ,&nbsp;Divya Parmar ,&nbsp;Stevo Durbaba ,&nbsp;Mark Fisher ,&nbsp;Riyaz Patel ,&nbsp;Seeromanie Harding ,&nbsp;Anthony S. Wierzbicki ,&nbsp;Nadeem Qureshi ,&nbsp;Mariam Molokhia","doi":"10.1016/j.athplu.2023.07.003","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.07.003","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"54 ","pages":"Page S7"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000160/pdfft?md5=ef92cab5230075321108f7d4e645efdd&pid=1-s2.0-S2667089523000160-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should the Sampson LDL cholesterol equation replace the Friedewald equation in routine clinical practice? A comparison of three equations against a beta quantification method","authors":"M. Abbas,&nbsp;C. Boot,&nbsp;A. Luvai","doi":"10.1016/j.athplu.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.07.002","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"54 ","pages":"Page S7"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000159/pdfft?md5=509c38a65b9e7ce68d47fbb99968d28f&pid=1-s2.0-S2667089523000159-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient demographics and clinical characteristics among patients with a premature myocardial infarction and lipoprotein(a) measurement: a retrospective analysis of the South Tyneside and Sunderland NHS Foundation Trust in the UK","authors":"E. Connell ,&nbsp;H. Traynor ,&nbsp;G. Martin ,&nbsp;L. Martin ,&nbsp;S. Junejo ,&nbsp;P.E. Carey","doi":"10.1016/j.athplu.2023.07.013","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.07.013","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"54 ","pages":"Page S2"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000263/pdfft?md5=5b043f3bfd59a9a9b649c085fda9b38b&pid=1-s2.0-S2667089523000263-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolocumab & Inclisiran dual therapy for further LDL lowering in a very high cardiovascular risk Familial Hypercholesterolaemia patient with heterozygous gain of function PCSK9 mutation","authors":"R. Gingell ,&nbsp;P. Das ,&nbsp;Y.P. Teoh","doi":"10.1016/j.athplu.2023.07.020","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.07.020","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"54 ","pages":"Pages S4-S5"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000330/pdfft?md5=4e4e785e597fcb3bf3758ef3634cd22e&pid=1-s2.0-S2667089523000330-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of familial hypercholesterolaemia (FH)-causing variants and impact on LDL-C concentration in European, South Asian, and African ancestry groups of the UK Biobank","authors":"J. Gratton ,&nbsp;S.E. Humphries ,&nbsp;M. Futema","doi":"10.1016/j.athplu.2023.07.015","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.07.015","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"54 ","pages":"Page S3"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000287/pdfft?md5=2cb1d039bc74ad88d9851e02fe032ce5&pid=1-s2.0-S2667089523000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a pharmacist-led clinic in optimising lipid therapy for secondary prevention in vascular and diabetic foot patients","authors":"M. Hart ,&nbsp;J. Rees ,&nbsp;J.L. Newton ,&nbsp;G. Stansby ,&nbsp;K. Munac ,&nbsp;A. Luvai","doi":"10.1016/j.athplu.2023.07.021","DOIUrl":"https://doi.org/10.1016/j.athplu.2023.07.021","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"54 ","pages":"Page S5"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089523000342/pdfft?md5=9d7469d1473334db37041e956b40a983&pid=1-s2.0-S2667089523000342-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}