Archives of clinical and biomedical research最新文献_第9页

Survival Patterns of COVID-19 Pneumonia Patients with False-Negative PCR Results Transferred to the Intensive Care Unit from the Emergency Department PCR结果为假阴性的COVID-19肺炎患者从急诊科转入重症监护病房的生存模式

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170258

Meltem Songur Kodik, Esin Ozturk, Y. Altuncı, E. Ozçete, S. Yalçınlı, M. Ersel, Deniz Akyol, S. Bayraktaroğlu, O. Goksel, Ahmet Enes Celik

引用次数: 0

The Effects of Glucagon-Like Peptide-1 Receptor Agonists of Liraglutide on Bone Turnover Makers Among Type 2 Diabetes Mellitus Patients: A Meta-Analysis of Randomized Controlled Trials 利拉鲁肽胰高血糖素样肽-1受体激动剂对2型糖尿病患者骨转化生成因子的影响:一项随机对照试验的荟萃分析

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170231

Jing Kang, Sha Lei, Jinlan Guan

{"title":"The Effects of Glucagon-Like Peptide-1 Receptor Agonists of Liraglutide on Bone Turnover Makers Among Type 2 Diabetes Mellitus Patients: A Meta-Analysis of Randomized Controlled Trials","authors":"Jing Kang, Sha Lei, Jinlan Guan","doi":"10.26502/acbr.50170231","DOIUrl":"https://doi.org/10.26502/acbr.50170231","url":null,"abstract":"Objective: Liraglutide are associated with a decreased risk of fracture among Type 2 Diabetes Mellitus Patients (T2DM) but the mechanism is unclear, the effect of liraglutide on Bone Mineral Density (BMD) and Bone Turnover Markers (BTMs) were taken into consideration. Method: We searched for randomized controlled trials of liraglutide in PubMed, Embase, the Cochrane Library, Web of Science, CNKI and VIP database up to October 2021. Heterogeneity among studies was examined by Cochrane Q test. Results: 7 pieces of eligible literature involving 478 patients were divided into the liraglutide treatment group (n = 241) and control group (n = 237) in this meta-analysis. Based on fixed effect model, liraglutide had no beneficial Arch Clin Biomed Res 2022; 6 (1): 134-144 DOI: 10.26502/acbr.50170231 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 135 effect on BMD (MD: 0.00; 95% CI: (-0.01, 0.02); p=0.69, I2=0%), but there were significant increase effects of liraglutide on bone gla protein (BGP, MD: 0.63; 95% CI: (0.23, 1.03); p=0.002, I2=36%), Bone specific alkaline phosphatase (BAP, MD: 0.85; 95% CI: (0.30, 1.40); p=0.002, I2=23%) and PINP (MD: 6.90; 95%CI: (5.71, 8.09); p =0.002) compared to conventional treatment. Moreover, liraglutide decrease serum β cross-linked C-telopeptide of type I collagen (β-CTX, MD: 0.03; 95%CI: (0.01, 0.05); p = 0.0005, I2 =0%). Conclusions: This meta-analysis demonstrated that liraglutide significantly increae OC, BAP, PINP and reduce βCTX content compared to conventional treatment in T2DM patients, but the difference was no beneficial effect on BMD. This finding may provide additional evidence for the use of liraglutide to improve skeletal health in T2DM patients.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ptsd, Depersonalization and Psychosomatic Symptoms in Health Care Workers During the Covid-19 Outbreak Covid-19疫情期间医护人员的创伤后应激障碍、人格解体和心身症状

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170254

K. Kontoangelos, G. Poulakou, M. Economou, K. Leontis, P. Fragkou, I. Baraboutis, V. Rapti, E. Tsagalou, Konstantinos Koufatzidis, S. Sympardi, K. Argyraki, P. Panagopoulos, G. Latsios, Christos Papageorgiou, Sofia Tsiori, S. Tsiodras, M. Dimopoulos, K. Syrigos, C. Papageorgiou

{"title":"Ptsd, Depersonalization and Psychosomatic Symptoms in Health Care Workers During the Covid-19 Outbreak","authors":"K. Kontoangelos, G. Poulakou, M. Economou, K. Leontis, P. Fragkou, I. Baraboutis, V. Rapti, E. Tsagalou, Konstantinos Koufatzidis, S. Sympardi, K. Argyraki, P. Panagopoulos, G. Latsios, Christos Papageorgiou, Sofia Tsiori, S. Tsiodras, M. Dimopoulos, K. Syrigos, C. Papageorgiou","doi":"10.26502/acbr.50170254","DOIUrl":"https://doi.org/10.26502/acbr.50170254","url":null,"abstract":"Objective: Coronavirus disease (COVID-19) was first reported in Wuhan, China, in December 2019. Since then, it has been rapidly spreading throughout the world. Healthcare workers serve at the forefront of infectious diseases to provide care to patients. A lack of therapeutic agents and vaccines for COVID-19 has exacerbated the fear and burden experienced by hospital workers. Methods: The sample consisted of 204 health workers (internists, cardiologists, pneumonologists, oncologists, nurses) 117 male and 87 female: During the initial evaluation, all the participants were assessed with the following psychometric questionnaires: A. The SCL -90 scale B. The Greek version of the Cambridge Depersonalization Scale and C. the Greek version of the Davidson Trauma Scale (DTS). Results: The scales of CDS (r = 0.509, r=0.456, p<0.001) and DTS (r = 0.482, r=0.408, p<0.001) are highly correlated with the scale of somatization. The SCL-90 scale of obsessive-compulsive is highly correlated with both scales of DTS (r = 0.273, p<0.001 and r=0.184, p<0.001). Depression is highly correlated with both scales of CDS (r = 0.315, r=0.276, p<0.001) and DTS (r = 0.452, r=0.352, p<0.001). Discussion: Health professionals must deal with possible psychological, work-related consequences during the COVID-19 crisis, such as posttraumatic stress, anxiety, depression or depersonalization. Preventive measures to reduce the psychological effect of pandemia should be implemented for these health workers.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational and Clinical Significance of DAMPs, PAMPs, and PRRs in Trauma-induced Inflammation. DAMPs, PAMPs和PRRs在创伤性炎症中的转化和临床意义。

Archives of clinical and biomedical research Pub Date : 2022-01-01 Epub Date: 2022-08-26 DOI: 10.26502/acbr.50170279

Vikrant Rai, Gillian Mathews, Devendra K Agrawal

{"title":"Translational and Clinical Significance of DAMPs, PAMPs, and PRRs in Trauma-induced Inflammation.","authors":"Vikrant Rai, Gillian Mathews, Devendra K Agrawal","doi":"10.26502/acbr.50170279","DOIUrl":"https://doi.org/10.26502/acbr.50170279","url":null,"abstract":"<p><p>Increased morbidity and mortality after polytrauma due to multiple organ failure (MOF) is a major concern for clinicians. Systemic inflammatory response syndrome (SIRS) and sepsis are the major underlying causes. Damage-associated molecular proteins (DAMPs) released after polytrauma induce an inflammatory immune response to repair the tissue, however, persistent inflammation finally results in immunosuppression and MOF. During immunosuppression, additional exposure of the traumatized tissue to pattern-associated molecular patterns (PAMPs) further adds to the continuum of inflammatory cascade causing sepsis. These two hits worsen the condition of the patient and increase morbidity and mortality. Thus, it is critical to stratify the patient based on trauma severity and inflammatory biomarkers levels and design treatment accordingly for a better clinical outcome. Although some of the molecular mechanisms involved in SIRS and MOF after polytrauma have been reported, there is limited information on the critical factors related to the study of DAMPs and PAMPs, including the timing of sampling (time elapsed after trauma), source of sampling (blood, urine, saliva), proteomics and metabolomics, multiplex plasma assay, comparative interpretation of the results from various sources and diagnostic value, and interpretation on the translational and clinical significance. Additionally, there is limited literature on DAMPs like heat shock proteins, mitochondrial DNA, neutrophil extracellular traps, and their role in SIRS and MOF. Further, it is also important to distinguish between the biomarkers of SIRS and sepsis in a time-bound window to have a better clinical outcome. This critical review focuses on these aspects to provide comprehensive information and thought-provoking discussion to design future investigation and clinical trials.</p>","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":" ","pages":"673-685"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33477121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Effectivity Analysis of COVID-19 Vaccines Against Emerging Variants of SARS-CoV-2 COVID-19疫苗对新出现的SARS-CoV-2变体的有效性分析

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170236

U. Saeed, Zahra Zahid Piracha, Hafsa Ashraf, Saba Tasneem, Sara Rizwan Uppal, Tabinda Islam, Maheen Fatima, A. Abid, Rehan Uppal, R. Uppal

{"title":"Effectivity Analysis of COVID-19 Vaccines Against Emerging Variants of SARS-CoV-2","authors":"U. Saeed, Zahra Zahid Piracha, Hafsa Ashraf, Saba Tasneem, Sara Rizwan Uppal, Tabinda Islam, Maheen Fatima, A. Abid, Rehan Uppal, R. Uppal","doi":"10.26502/acbr.50170236","DOIUrl":"https://doi.org/10.26502/acbr.50170236","url":null,"abstract":"SARS-CoV-2 is an mRNA virus that has plunged the whole world into serious trouble for the last two years. Due to continuous transmission, the virus mutates rapidly and new strains emerged which made vaccines less effective. The study aims to describe the impact of major vaccines on different variants of COVID-19. The successful launch of the COVID-19 vaccine raised hope for the extinction of pandemics and return to pre-quarantine life around the globe. Clinical trials revealed all major vaccines provide a short-term satisfactory level of protection against the disease but none of the vaccines is ensuring 100% safety against all variants. Efficacy drop of several vaccines has also been observed against the B.1.1.7, B.1.617, B.1.351 P.1 variants of concern. Phase 3 and phase 4 clinical trials need to be conducted on major vaccines. Chinese vaccines are expected to be most effective against the delta strain yet having no satisfactory results against SOIY.V2, B.1.1.7, and P.1 Arch Clin Biomed Res 2022; 6 (1): 209-216 DOI: 10.26502/acbr.50170236 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 210 strains. While the western world has a hawk-eye on mRNA vaccines (BNT162b2 and mRNA-1273) having the highest efficacy rate (around 90-95%). Sputnik V vaccine is recently approved for use in more than 66 countries but its effectiveness against all variants of concern (VOC) is not guaranteed. The analysis revealed that overall vaccination is capable to provide 72% efficacy in terms of protection against deaths. None of the vaccines proved to be 100 % effective against all strains of COVID-19 but developed antibodies to fight better and increased chances of survival.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Adolfsson-Björnsson Activity Scale (ABAS) Improves Description of Patient Characteristics Adolfsson-Björnsson活动量表(ABAS)改善了患者特征的描述

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170256

L. Adolfsson, Per Lundin, Hanna C. Björnsson Hallgren

{"title":"The Adolfsson-Björnsson Activity Scale (ABAS) Improves Description of Patient Characteristics","authors":"L. Adolfsson, Per Lundin, Hanna C. Björnsson Hallgren","doi":"10.26502/acbr.50170256","DOIUrl":"https://doi.org/10.26502/acbr.50170256","url":null,"abstract":"(ABAS) Abstract Background and purpose: Age and gender have been regarded important for surgical decision making and used as inclusion criteria for clinical trials. Individual demands and level of activity have been less considered. A self-administered scale, defining subjectively assessed level of activity involving the upper extremities was therefore developed. The primary purpose of this study was to present the scale. Secondarily to investigate its reliability and correlation with age and gender. Patients and Methods: A scale with 8 categories ranging from extremely demanding to non-demanding activities, separated according to hand dominance, was constructed. Reliability testing was performed on 103 healthy individuals of both genders with a wide age range (20-86). 241 patients, median age 58 years (range 18-97), with different upper extremity injuries completed the scale. Participants were instructed to mark activities representative for their normal activity level. Correlation with age and gender was then investigated using Spearman Correlation Coefficient (SCC). Results: The level of activity ranged from 1, corresponding to minimal use of the arm, to 8 defined as elite sports. For test-retest Intraclass Correlation Coefficient (ICC) was 0.89 for the dominant and 0.90 for the non-dominant arm. Correlations between gender, age and level of activity were weak. Interpretation: The scale was found reliable and feasible to use. Age and gender were weakly correlated with level of activity and patients with low and high activities found in all ages and both genders. The activity scale allows improved description of patients included in clinical trials and can aid in treatment decision making but is primarily not intended for measurement of treatment outcome.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients at Risk of Pulmonary Fibrosis Post Covid-19: Pulmonary Sequelae and Humoral Response Covid-19后肺纤维化风险患者:肺后遗症和体液反应

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170299

M. Hernández Porto, T. Delgado, A. Aguirre-Jaime, M. J. Ramos, S. Campos, O. Acosta, Ana Belén Llanos, M. Lecuona

{"title":"Patients at Risk of Pulmonary Fibrosis Post Covid-19: Pulmonary Sequelae and Humoral Response","authors":"M. Hernández Porto, T. Delgado, A. Aguirre-Jaime, M. J. Ramos, S. Campos, O. Acosta, Ana Belén Llanos, M. Lecuona","doi":"10.26502/acbr.50170299","DOIUrl":"https://doi.org/10.26502/acbr.50170299","url":null,"abstract":"Background: The COVID-19 pandemic is one of the major public health problems. The aim of this study is to characterize patients hospitalized for COVID-19 pneumonia at risk of pulmonary fibrosis and to know the amount of protective antibodies and their permanence in these patients. Methods: Follow-up study of the humoral response in hospitalized patients at risk of pulmonary fibrosis post-COVID-19 who were followed up for one year after hospital discharge. Results: The study included 72 patients, 52 of whom had pre-existing chronic comorbidities. COVID-19 clinical severity was rated in 6% as mild, 58% as moderate and 36% as severe. After one year follow-up, forty percent had pulmonary sequelae, the most frequent being mild pulmonary fibrosis. All patients presented RBD IgG, 88% IgA after 8-9 months. The amount of RBD IgG was similar at 4-5 and 8-9 months post-COVID-19. There was no difference in RBD IgG level according to COVID-19 severity ( P = .441, P = .594). Conclusions: The amount of RBD IgG is maintained throughout the convalescent phase and could protect against new reinfections in patients at risk of pulmonary fibrosis Post Covid-19. However, it does not seem to predict the development or not of pulmonary fibrosis.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Biofilm Formation and Virulence Genes Expression and Antibiotic Resistance Pattern in Proteus mirabilis, Isolated from Patients of Dhaka Medical College Hospital 达卡医学院医院奇异变形杆菌生物膜形成与毒力基因表达及耐药模式的关系

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170257

Nafisa Jabin Mishu, Shamsuzzaman Sm, Khaleduzzaman Hm, Modina Ansary Nabonee, Nigha zannat dola, A. Haque

引用次数: 4

Chest CT Severity Score in COVID-19 at the Time of Admission and Relationship with Outcome and Duration of Admission-an Early Promising Prognostic Indicator 入院时COVID-19胸部CT严重程度评分及其与预后和住院时间的关系——一个早期有希望的预后指标

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170243

Jitendra Parmar, Drashti Patel, Tapan Patel, Sandip Shah, Manoj K. Singh, Shanti Bhushan Prasad

{"title":"Chest CT Severity Score in COVID-19 at the Time of Admission and Relationship with Outcome and Duration of Admission-an Early Promising Prognostic Indicator","authors":"Jitendra Parmar, Drashti Patel, Tapan Patel, Sandip Shah, Manoj K. Singh, Shanti Bhushan Prasad","doi":"10.26502/acbr.50170243","DOIUrl":"https://doi.org/10.26502/acbr.50170243","url":null,"abstract":"Purpose: The CT Severity Score has great significance in assessing the extent of pneumonia involvement with differentiation of mild, critical and severe types and helps clinicians achieve early diagnosis and accurate treatment. Material and methods: 100 COVID-19 positive patients were analyzed for CT-SS and its correlation with clinical severity, laboratory markers and duration of hospital stay. The ROC curve was analyzed to obtain the optimum CT-SS threshold to discriminate patients in the common group from the patients of severe & critical groups and discriminate patients in the critical group from the patients of severe & common groups. Results: The study comprised 57 common category, 23 severe category and 20 critical category patients. The mean chest CT-SS score was highest in critical patients (35.95), higher in severe patients (25.52) than common patients (12.18) with mean duration of admission was 13.35, 12 and 7.65 days respectively (p-value of 0.000). The optimum CT-SS threshold for discriminating patients in the common group from the patients of severe & critical groups was 21.5 with sensitivity of 93%, specificity of 86%. The optimum Arch Clin Biomed Res 2022;6 (2): 277-289 DOI: 10.26502/acbr.50170243 Archives of Clinical and Biomedical Research Vol. 6 No. 2 – April 2022. [ISSN 2572-9292]. 278 CT-SS threshold for discriminating patients in the critical group from the patients of severe & common groups was 28.5 with a sensitivity & specificity of 90%. Conclusion: Initial Chest CT-SS showed significant association with duration of hospital stay and shortterm prognosis of patients. Chest CT Severity Score can be used to evaluate the clinical severity of the patients on initial scans, to differentiate common, severe and critical patients and decide their management.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Estimating the Prevalence of Fungal Nail Infections and Potential Concerns for Central Disease Surveillance Hub in Pakistan 估计巴基斯坦指甲真菌感染的流行程度和中央疾病监测中心的潜在问题

Archives of clinical and biomedical research Pub Date : 2022-01-01 DOI: 10.26502/acbr.50170260

Sara Rizwan Uppal, R. Uppal, Aftab Ahmad Khan, U. Saeed, Zahra Zahid Piracha, Zuhaib Ali

引用次数: 0