Archives of clinical and biomedical research最新文献

{"title":"Assessment of the Countries’ Readiness to Detect and Control Cholera Outbreaks in the WHO African Region","authors":"Vincent Dossou Sodjinou, M. Keita, D. Chamla, J. Kimenyi, F. Braka, A. Talisuna, Harsh Lata, G. Mbayo, Fred Kapaya, Tamayi Mlanda, Nannie Ishata Conteh, Abdou Salam Gueye.","doi":"10.26502/acbr.50170277","DOIUrl":"https://doi.org/10.26502/acbr.50170277","url":null,"abstract":"Introduction: Cholera remains one of the major threats to the global health security the World Health African at least ten affected yearly. Objective: This study assessed the countries’ readiness to prevent, detect, respond and recover from cholera outbreaks. Methods: This descriptive and cross-sectional study targeted 28 countries at risk of cholera. A readiness tool, covering all pillars required by the global health security was developed. Criteria, fit-tested with the regional framework for cholera elimination by 2030, were defined for each pillar. Based on experts’ opinion, each pillar and corresponding criteria were weighted. Data was collected in each country through group discussion of multi-sectoral cholera teams. The data collected were analyzed and visualized through an online Power BI tool. The readiness for each pillar was rated good if the pillar assessment result reached at least 80 % of expected points. The readiness was moderate if ranging between 50 % and 80 %. The readiness was limited if the rating was below 50%. The readiness status of each country was based on the same criteria. Results: The overall countries’ readiness level to detect and respond to cholera was insufficient. Of the 23 responding countries, there was no country with good readiness. Seven countries had moderate readiness while sixteen had limited readiness level. Laboratory was the best performing pillar with good readiness reported in eight countries. Only three countries had good readiness level for surveillance, two countries for infection prevention and control, and one country respectively for coordination and, water sanitation and hygiene. Conclusion: Countries in the WHO African Region were not adequately prepared to prevent or control cholera outbreak. Such readiness assessment provided critical information about areas of improvement across the 11 pillars and should be regularly undertaken to monitor progress in readiness capacity in the Region.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unnatural Nucleotides: Exploring the Information Storage System of DNA","authors":"A. Yadav, Khushi Khera, K. Kaur, Rekha Mehrotra","doi":"10.26502/acbr.50170306","DOIUrl":"https://doi.org/10.26502/acbr.50170306","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Anterior Abdominal Wall Layers Thickness under the influence of Age and Sex, Using Computed Tomography Imaging in Ibn-Sina Hospital, Khartoum, Sudan 2021","authors":"Ayman E Abbas, Mohammad Hatem Alrawi, Esra Ali Mahjoub Saeed","doi":"10.26502/acbr.50170311","DOIUrl":"https://doi.org/10.26502/acbr.50170311","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Value of NT-proBNP and Performance Myocardial Index as an Echocardiographic Predictor of Early Cardiac Involvement in Patients with Carcinoid Syndrome","authors":"I. Nițu, I. Baciu, S. Găloiu, C. Căpăţană, Iulia Florentina Burcea, Daniela Greere, C. Poiană","doi":"10.26502/acbr.50170284","DOIUrl":"https://doi.org/10.26502/acbr.50170284","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kartagener Syndrome Associated with a Family History of Dextrocardia – First Patient to be reported in Romania","authors":"A. Catană, Enikő Kutasi, Florica Ana Chis, Cristian Popiţa, Sanda Mariela Militaru","doi":"10.26502/acbr.50170285","DOIUrl":"https://doi.org/10.26502/acbr.50170285","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVIDSeq as Laboratory Developed Test (LDT) for Diagnosis of SARS-CoV-2 Variants of Concern (VOC).","authors":"Rob E Carpenter,&nbsp;Vaibhav K Tamrakar,&nbsp;Sadia Almas,&nbsp;Emily Brown,&nbsp;Rahul Sharma","doi":"10.26502/acbr.50170309","DOIUrl":"https://doi.org/10.26502/acbr.50170309","url":null,"abstract":"<p><p>Rapid classification and detection of SARS-CoV-2 variants have been critical in comprehending the virus's transmission dynamics. Clinical manifestation of the infection is influenced by comorbidities such as age, immune status, diabetes, and the infecting variant. Thus, clinical management may differ for new variants. For example, some monoclonal antibody treatments are variant-specific. Yet, a U.S. Food and Drug Administration (FDA)-approved test for detecting the SARS-CoV-2 variant is unavailable. A laboratory-developed test (LDT) remains a viable option for reporting the infecting variant for clinical intervention or epidemiological purposes. Accordingly, we have validated the Illumina COVIDSeq assay as an LDT according to the guidelines prescribed by the College of American Pathologists (CAP) and <i>Clinical Laboratory Improvement Amendments</i> (CLIA). The limit of detection (LOD) of this test is Ct<30 (~15 viral copies) and >200X genomic coverage, and the test is 100% specific in the detection of existing variants. The test demonstrated 100% precision in inter-day, intra-day, and intra-laboratory reproducibility studies. It is also 100% accurate, defined by reference strain testing and split sample testing with other CLIA laboratories. Advanta Genetics LDT COVIDSeq has been reviewed by CAP inspectors and is under review by FDA for Emergency Use Authorization.</p>","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"6 6","pages":"954-970"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802674/pdf/nihms-1854775.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10475770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge Distillation for COVID-19 Therapeutics","authors":"Shiyao Zhai, Yuhan Gao, Kailai Peng, Qun Chen, Qian He, Li Fang, Linling Li, Bowen Zhong, Yu-Ying Dong, Chenggang Yan, Peiwu Qin, D. Y","doi":"10.26502/acbr.50170233","DOIUrl":"https://doi.org/10.26502/acbr.50170233","url":null,"abstract":"The novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 is threatening the world's economy and healthcare with urgent therapeutic demand. Clinical and scientific studies have made promising progress in ameliorating and treating COVID-19. The unprecedented effort has brought several vaccines approved for emergency use, and prevalent vaccination is advocated globally. However, methods that can effectively clear the virus and terminate transmission are not available. The variants and uncontrolled circulations bring persistent challenges Arch Clin Biomed Res 2022; 6 (1): 153-183 DOI: 10.26502/acbr.50170233 Archives of Clinical and Biomedical Research Vol. 6 No.1 – February 2022. [ISSN 2572-9292]. 154 for therapeutics and vaccines. In this review, we discuss the ongoing treatments, the mechanism, and potential optimization of various therapeutics. We review the viral pathogenesis and epidemiology and provide insights for prospective therapeutics and vaccine evolution, which will help clinical doctors and researchers in this pandemic.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Earliness of Detection and Notification of Major Infectious Threats to Global Health Security in Benin","authors":"Vincent Dossou Sodjinou, Paul Ahoumènou AYELO, L. Salami, A. Kpozèhouen, Dona Marius-Edgard Ouendo","doi":"10.26502/acbr.50170235","DOIUrl":"https://doi.org/10.26502/acbr.50170235","url":null,"abstract":"Introduction Early detection and notification can reduce morbidity and mortality from an event.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and diabetes are the strongest predictors of post-acute COVID-19 in Coptic clergy and monks","authors":"Michael Y. Henein, R. Shenouda, Magdi Z. Matter, I. Bytyçi","doi":"10.26502/acbr.50170252","DOIUrl":"https://doi.org/10.26502/acbr.50170252","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Short Term High Dose Oral Vitamin D Therapy on the Inflammatory Markers in Patients with COVID 19 Disease","authors":"Maheshwar Lakkireddy, Srikanth Goud Gadiga, R. Malathi, Madhu Latha Karra, Issv Prasad Murthy Raju, Ragini, Sangeetha Chinapaka, Sai Baba KSS, Manohar Kandakatla","doi":"10.26502/acbr.50170273","DOIUrl":"https://doi.org/10.26502/acbr.50170273","url":null,"abstract":"Introduction: COVID 19 is known to cause immune dysregulation and vitamin D is a known immunomodulator. This study aims to objectively investigate the effect of short term high dose vitamin D therapy in reducing the inflammatory markers of COVID-19. Materials and Methods: Consented COVID-19 patients with hypovitaminosis D were evaluated for inflammatory markers (N/L ratio, CRP, LDH, IL6, Ferritin) along with vitamin D on 0 th day and 9 th / 11 th day as per their respective BMI category. Subjects were allotted to VD and NVD groups. VD group received Pulse D therapy (a short term high dose supplementation of 60,000 IUs of vitamin D for 8 or 10 days depending upon their BMI) in addition to the standard treatment. NVD group received standard treatment alone. Differences in the variables between the two groups were analysed for statistical significance. Results: Eighty seven out of one hundred and thirty subjects have completed the study (VD:44, NVD:43). Vitamin D level has increased from 15 ng/ml to 81 ng/ml in VD group and highly significant (p<0.01) reduction of all the measured inflammatory markers was noted. Reduction of markers in NVD group was insignificant (p>0.05). The difference in the reduction of markers between the groups (NVD vs VD) was highly significant (p<0.01). Conclusions: Therapeutic improvement in vitamin D to 80-100 ng/ml has significantly reduced the inflammatory markers associated with COVID-19 without any side effects. Hence, adjunctive short term high dose vitamin D therapy can be added safely to the existing treatment protocols of COVID-19 for improved outcomes.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}