Patients at Risk of Pulmonary Fibrosis Post Covid-19: Pulmonary Sequelae and Humoral Response

M. Hernández Porto, T. Delgado, A. Aguirre-Jaime, M. J. Ramos, S. Campos, O. Acosta, Ana Belén Llanos, M. Lecuona
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Abstract

Background: The COVID-19 pandemic is one of the major public health problems. The aim of this study is to characterize patients hospitalized for COVID-19 pneumonia at risk of pulmonary fibrosis and to know the amount of protective antibodies and their permanence in these patients. Methods: Follow-up study of the humoral response in hospitalized patients at risk of pulmonary fibrosis post-COVID-19 who were followed up for one year after hospital discharge. Results: The study included 72 patients, 52 of whom had pre-existing chronic comorbidities. COVID-19 clinical severity was rated in 6% as mild, 58% as moderate and 36% as severe. After one year follow-up, forty percent had pulmonary sequelae, the most frequent being mild pulmonary fibrosis. All patients presented RBD IgG, 88% IgA after 8-9 months. The amount of RBD IgG was similar at 4-5 and 8-9 months post-COVID-19. There was no difference in RBD IgG level according to COVID-19 severity ( P = .441, P = .594). Conclusions: The amount of RBD IgG is maintained throughout the convalescent phase and could protect against new reinfections in patients at risk of pulmonary fibrosis Post Covid-19. However, it does not seem to predict the development or not of pulmonary fibrosis.
Covid-19后肺纤维化风险患者:肺后遗症和体液反应
背景:新冠肺炎大流行是重大公共卫生问题之一。本研究的目的是表征COVID-19肺炎住院患者的肺纤维化风险,并了解这些患者的保护性抗体的数量及其持久性。方法:对新冠肺炎合并肺纤维化危险住院患者出院后随访1年的体液反应进行随访研究。结果:该研究包括72例患者,其中52例已有慢性合并症。新冠肺炎的临床严重程度有6%被评为轻度,58%被评为中度,36%被评为重度。经过一年的随访,40%的人有肺部后遗症,最常见的是轻微的肺纤维化。8-9个月后,所有患者均出现RBD IgG, IgA占88%。感染后4 ~ 5个月和8 ~ 9个月RBD IgG含量相似。不同严重程度RBD IgG水平差异无统计学意义(P = .441, P = .594)。结论:RBD IgG在整个恢复期均可维持,可预防新发再感染。然而,它似乎不能预测肺纤维化的发展与否。
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