Archives of clinical and biomedical research最新文献_第2页

Detection of Her 2/Neu Equivocal Immunochemistry by Fish in Breast Carcinoma – A Study from Single Tertiary Care Hospital Fish检测Her 2/ new模棱两可免疫化学在乳腺癌中的作用——来自单一三级医院的研究

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.26502/acbr.50170367

Naiding Momota, Choudhury Biswadeep, Duttagupta Sumita, Deuri Biman, Dasgupta Nivedita, Deb Saurav, Sharma Jyotika

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Methotrexate Induced Neurotoxicity in Osteosarcoma: Case Report and Narrative Review of the Literature Published On: 甲氨蝶呤诱导骨肉瘤神经毒性:病例报告及文献综述

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.26502/acbr.50170359

Irene Tsappa, Pampina Pilavaki, E. Fotiou, Anastasia Costanntinidou

{"title":"Methotrexate Induced Neurotoxicity in Osteosarcoma: Case Report and Narrative Review of the Literature Published On:","authors":"Irene Tsappa, Pampina Pilavaki, E. Fotiou, Anastasia Costanntinidou","doi":"10.26502/acbr.50170359","DOIUrl":"https://doi.org/10.26502/acbr.50170359","url":null,"abstract":", lymphomas, and acute lymphoblastic leukaemia [1,4]. Patients under this treatment may experience a variety of side effects. Oral mucositis, gastrointestinal toxicity, nephrotoxicity, and myelosuppression are the commonest ones [5,6]. Only up to 11% of patients may develop a form of neurotoxicity [1]. MTX induced Abstract Methotrexate (MTX) is a cytotoxic antimetabolite, which interferes with folic acid metabolism. The term high dose Methotrexate (HDMTX) refers to doses over 500 mg /m2 which are currently used to treat not only hematological malignancies but also solid neoplasms. Patients receiving intravenous (IV) HDMTX as part of their regime often experience a variety of side effects such as oral and gastrointestinal mucositis, nephrotoxicity and bone marrow suppression. Approximately 11% of these patients develop neurological symptoms and signs suggestive of MTX induced neurotoxicity, a condition, which is further, classified as acute, subacute and chronic depending on the time of onset. In this report we present a 22-year-old female with a high grade chondroblastic osteosarcoma of the pelvis who developed an isolated central facial nerve palsy acutely after the administration of IV HDMTX. Furthermore, we conducted a narrative review using Pubmed and included all patients with osteosarcoma who developed a transient or a permanent neurologic deficit during their treatment with IV HDMTX. Most patients presented with symptoms involving higher cognitive function, seizures and stroke like symptoms. To our knowledge this is the first case with isolated central facial nerve palsy acutely after the administration of IV HDMTX.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of terminal cleaning using ATP methodology: comparison of bleach and quaternary ammonium compound plus biguanide 用ATP方法评价终端清洗:漂白剂和季铵化合物加双胍的比较

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.22491/2357-9730.129414

Paola Cristini Gama Silva, Caroline Deutschendorf, Thiago Costa Lisboa, Cristofer Farias da Silva

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Relação entre a infecção por Helicobacter pylori e doenças metabólicas: uma revisão integrativa 幽门螺杆菌感染与代谢疾病的关系:一项综合综述

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.22491/2357-9730.125129

Felipe Augusto de Sousa Moraes, Gabriel Ribeiro Maximo, Giovana Alice Sampaio Soares, Mônica Santiago Barbosa

{"title":"Relação entre a infecção por Helicobacter pylori e doenças metabólicas: uma revisão integrativa","authors":"Felipe Augusto de Sousa Moraes, Gabriel Ribeiro Maximo, Giovana Alice Sampaio Soares, Mônica Santiago Barbosa","doi":"10.22491/2357-9730.125129","DOIUrl":"https://doi.org/10.22491/2357-9730.125129","url":null,"abstract":"Helicobacter pylori é uma bactéria Gram-negativa que acomete cerca de 50% da população mundial. A infecção causada por H. pyloriestá associada com algumas enfermidades gástricas. Entretanto, estudos mais recentes têm demonstrado a etiologia do microrganismo em doenças extra gástricas, como doenças metabólicas. O trabalho teve como objetivo realizar uma pesquisa na literatura de artigos que avaliaram a associação da infecção por H. pyloricom doenças metabólicas, com foco em diabetes. Foram utilizadas as seguintes bases de dados, PubMed, Medline, LILACS e SciELO. Termos combinados juntamente com o operador booleano “AND” em português e em inglês foram empregados. O resultado do levantamento bibliográfico totalizou 31 artigos. A infecção por H. pyloripossivelmente está relacionada com a síndrome metabólica. A relação pode ser decorrente da inflamação crônica, redução dos movimentos gastrointestinais, falta de secreção de ácido gástrico e interferência na produção ou secreção de alguns hormônios. Apesar dos estudos demonstrarem que entre os indivíduos infectados por H.pyloria prevalência da síndrome metabólica é maior e que a erradicação do microrganismo favorece a melhora dos índices glicêmicos, mais pesquisas são requeridas. A compreensão da etiologia da infecção porH. pyloriem doenças metabólicas, pode auxiliar em políticas públicas de erradicação da bactéria.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aorto-enteric fistula: a case report 主动脉-肠瘘1例

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.22491/2357-9730.125213

Ricardo Henrique Bilycz Corrêa, Mateus Torres Avelar de Lima, Eduardo Neumann Tavares, Franco Andreas Scola, Mariana Mendes Knabben

引用次数: 0

Covid-19: Como informações baseadas em evidências auxiliaram um hospital terciário durante o primeiro ano pandêmico Covid-19:基于证据的信息如何在大流行的第一年帮助一家三级医院

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.22491/2357-9730.125970

Tázia Lopes de Castro, Andrea Cássia Pereira Sforsin, Vanusa Barbosa Pinto, Tiago Arantes, Maria Alice Pimentel Falcão

引用次数: 0

Novel Ultrasound Liver Attenuation Imaging for Detection of Liver Steatosis: Comparison with MRI Based Imaging Methods with Liver Biopsy as A Reference Standard 新型超声肝衰减成像检测肝脂肪变性:与以肝活检为参考标准的MRI成像方法的比较

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.26502/acbr.50170368

Chileka Chiyanika, Kin Hung Liu, Vincent Wai-Sun Wong, Winnie Chiu Wing Chu

引用次数: 0

Rapid Real-time Squiggle Classification for Read until using RawMap. 使用RawMap之前读取的快速实时波形分类。

Archives of clinical and biomedical research Pub Date : 2023-01-01 Epub Date: 2023-01-28 DOI: 10.26502/acbr.50170318

Harisankar Sadasivan, Jack Wadden, Kush Goliya, Piyush Ranjan, Robert P Dickson, David Blaauw, Reetuparna Das, Satish Narayanasamy

{"title":"Rapid Real-time Squiggle Classification for Read until using RawMap.","authors":"Harisankar Sadasivan, Jack Wadden, Kush Goliya, Piyush Ranjan, Robert P Dickson, David Blaauw, Reetuparna Das, Satish Narayanasamy","doi":"10.26502/acbr.50170318","DOIUrl":"10.26502/acbr.50170318","url":null,"abstract":"<p><p>ReadUntil enables Oxford Nanopore Technology's (ONT) sequencers to selectively sequence reads of target species in real-time. This enables efficient microbial enrichment for applications such as microbial abundance estimation and is particularly beneficial for metagenomic samples with a very high fraction of non-target reads (> 99% can be human reads). However, read-until requires a fast and accurate software filter that analyzes a short prefix of a read and determines if it belongs to a microbe of interest (target) or not. The baseline Read Until pipeline uses a deep neural network-based basecaller called Guppy and is slow and inaccurate for this task (~60% of bases sequenced are unclassified). We present RawMap, an efficient CPU-only microbial species-agnostic Read Until classifier for filtering non-target human reads in the squiggle space. RawMap uses a Support Vector Machine (SVM), which is trained to distinguish human from microbe using non-linear and non-stationary characteristics of ONT's squiggle output (continuous electrical signals). Compared to the baseline Read Until pipeline, RawMap is a 1327X faster classifier and significantly improves the sequencing time and cost, and compute time savings. We show that RawMap augmented pipelines reduce sequencing time and cost by ~24% and computing cost by 22%. Additionally, since RawMap is agnostic to microbial species, it can also classify microbial species it is not trained on. We also discuss how RawMap may be used as an alternative to the RT-PCR test for viral load quantification of SARS-CoV-2.</p>","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"7 1","pages":"45-57"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022530/pdf/nihms-1875752.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9705992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Inflammatory Markers in Diabetics versus Non- Diabetics with Covid-19 and their Impact on Morbidity and Mortality Outcomes 糖尿病与非糖尿病合并Covid-19患者炎症标志物的比较研究及其对发病率和死亡率结果的影响

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.26502/acbr.50170364

Vathul B Subramanian, B. H, P. Kulkarni

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Hard to Swallow: Remembering to Check for Impacted Dentures in Elderly Patients Presenting with Swallowing Difficulty 吞咽困难:在出现吞咽困难的老年患者中记得检查假牙

Archives of clinical and biomedical research Pub Date : 2023-01-01 DOI: 10.26502/acbr.50170328

Priyavarshini Ramesh, Cerys Morgan, M. Fertleman, Louis John Koizia

引用次数: 0