Archives in biomedical engineering & biotechnology最新文献

Filtered Back-Projection Reconstruction with Non-Uniformly Under-Sampled Projections. 非均匀欠采样投影的滤波反投影重建。

Archives in biomedical engineering & biotechnology Pub Date : 2022-01-01

Gengsheng L Zeng, Megan Zeng

引用次数: 0

Human-Designed Filters May Outperform Machine-Learned Filters. 人类设计的过滤器可能比机器学习的过滤器更好。

Archives in biomedical engineering & biotechnology Pub Date : 2022-01-01

Gengsheng L Zeng

引用次数: 0

Spatio-Temporal Analysis of the Shroud of Turin 都灵裹尸布的时空分析

Archives in biomedical engineering & biotechnology Pub Date : 2021-07-30 DOI: 10.33552/abeb.2021.05.000620

P. Dassonville

引用次数: 0

Evaluation of the Effectiveness of Polyphenols from Grape and Apple Combined with Saffron on Erectile Function: An Observational Study 葡萄、苹果多酚与藏红花对勃起功能的影响:一项观察性研究

Archives in biomedical engineering & biotechnology Pub Date : 2021-07-28 DOI: 10.33552/abeb.2021.05.000619

F. Herpin

引用次数: 0

Human Natural Regulatory T Cells Recognize Peptides of the Heavy Constant Region of IgG with High Sequence Homology with Peptides Derived from Pathogens 人类自然调节性T细胞识别IgG重恒定区的肽，其序列与来自病原体的肽具有高同源性

Archives in biomedical engineering & biotechnology Pub Date : 2021-07-22 DOI: 10.33552/abeb.2021.05.000618

A. Franco

{"title":"Human Natural Regulatory T Cells Recognize Peptides of the Heavy Constant Region of IgG with High Sequence Homology with Peptides Derived from Pathogens","authors":"A. Franco","doi":"10.33552/abeb.2021.05.000618","DOIUrl":"https://doi.org/10.33552/abeb.2021.05.000618","url":null,"abstract":"Human natural regulatory T cells (nTreg) that control the differentiation of pro-inflammatory T cells recognize the heavy constant region of immunoglobulins G (Fc). We defined 16 peptides, 15 amino acids long, out of the whole Fc sequence immunogenic in healthy donors and patients with Rheumatoid Arthritis, a systemic autoimmune disease. In Immunology it is still debated how the thymic selection of T cells that recognize “self” peptides occurs as these T cells could be potentially harmful. However, nTreg recognize “self” and are very important in controlling the immune homeostasis. Here we show by screening the Immune epitope Data Base (IEDB) that the immunodominant Fc peptides that stimulate nTreg have a very high sequence homology with “non-self” peptides derived from a variety of pathogens. These results suggest that T cells with T cell receptors that recognize “self” peptides could be rescued from the negative selection in the thymus by engaging antigenic peptides with high sequence homology and or that pathogens may inhibit the immune regulation by jeopardizing nTreg expansion by T cell receptor antagonism.","PeriodicalId":72276,"journal":{"name":"Archives in biomedical engineering & biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44870095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmapheresis Affects Оphthalmological Parameters and Oxidative Stress in Patients with Multiple Sclerosis and Neuromyelitis Optica 血浆置换对多发性硬化和视神经脊髓炎患者Оphthalmological参数和氧化应激的影响

Archives in biomedical engineering & biotechnology Pub Date : 2021-07-06 DOI: 10.33552/abeb.2021.05.000617

A. Momchilova

引用次数: 0

Handgrip Endurance in Healthy Elderly People 健康老年人的握力耐力

Archives in biomedical engineering & biotechnology Pub Date : 2021-06-04 DOI: 10.33552/abeb.2021.05.000615

Soshi Miyahara

{"title":"Handgrip Endurance in Healthy Elderly People","authors":"Soshi Miyahara","doi":"10.33552/abeb.2021.05.000615","DOIUrl":"https://doi.org/10.33552/abeb.2021.05.000615","url":null,"abstract":"In general, there are many items for measuring physical function. Among them, handgrip strength is easy to use because it can be easily measured in a short time (3 to 5 seconds). There are few reports that evaluate handgrip endurance, we reported it. The subjects were 16 people (78.2±3.7 years old) living in Hiroshima City. Using a grip strength meter T.K.K.5401 (Takei Kiki Co., Ltd.), the maximum force in the dominant handgrip strength was measured while holding for 20 seconds, and the average value per second was calculated from the obtained results. As a comparison group, 11 students (21.5±0.5 years old, hereafter: young group) enrolled also performed similar measurements. Result: The maximum grip strength was significantly lower in the elderly group than in the young group. The change in grip strength for 20 seconds in each group was significantly lower than the maximum value in the young group after 16 seconds had passed since the start of the grip exercise. On the other hand, in the elderly group, no decrease in grip strength was observed within 20 seconds after the start of the grip exercise (interaction effect p<0.01). Comparing the transition of the elapsed time from the maximum value, the young group showed a significant decrease after 12 seconds from the start, but the elderly group did not show a significant decrease. Conclusion: The elderly group did not show a significant decrease in handgrip endurance for 20 seconds. When momentary exertion of power is required in daily life, if the purpose cannot be achieved, other means and ingenuity are required to achieve the purpose. In the future, I would like to find out the relevance and risk with evaluation other items, whether it will be one index in physical fitness tests.","PeriodicalId":72276,"journal":{"name":"Archives in biomedical engineering & biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45855718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Infrared Spectrum for the New Nanomolecules ASi, CSi, TSi and Gsi 新型纳米分子ASi、CSi、TSi和Gsi的红外光谱研究

Archives in biomedical engineering & biotechnology Pub Date : 2021-05-21 DOI: 10.33552/abeb.2021.05.000614

R. Gobato

{"title":"Infrared Spectrum for the New Nanomolecules ASi, CSi, TSi and Gsi","authors":"R. Gobato","doi":"10.33552/abeb.2021.05.000614","DOIUrl":"https://doi.org/10.33552/abeb.2021.05.000614","url":null,"abstract":"biolog-Abstract The core of the work is based on the replacement of carbon atoms by silicon atoms, on the basis of four standard bases of DNA: A, C, G and T (adenine, cytosine, guanine, thymine). Determining with minimum computational methods via ab initio Hartree-Fock methods, infrared spectrum and their peak absorbance frequencies. The option for simple replacement of carbon by silicon is due to the peculiar characteristics between both. Atomic interactions under non-carbon conditions were studied, with only the Hydrogen, Silicon, Nitrogen and Oxygen atoms, in CNTP, for the four standard bases of DNA, A, C, G and T, thus obtaining by quantum chemistry four new compounds, named here as: ASi, CSi, GSi and TSi. Computational calculations admit the possibility of the formation of such molecules, their existence being possible via quantum chemistry. Calculations obtained in the ab initio Unrestricted and Restrict Hartree-Fock method, (UHF and RHF) in the set of bases used Effective core potential (ECP) minimal basis, UHF CEP-31G (ECP split valance) and UHF CEP-121G (ECP triple-split basis), CC-pVTZ (Correlation-consistent valence-only basis sets triple-zeta) and 6-311G**(3df, 3pd) (Gaussian functions quadruple-zeta basis sets).","PeriodicalId":72276,"journal":{"name":"Archives in biomedical engineering & biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44327837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Role of CRISPR-Cas/9 in Hematological Disorders: A Review CRISPR-Cas/9在血液疾病中的作用综述

Archives in biomedical engineering & biotechnology Pub Date : 2021-05-20 DOI: 10.33552/abeb.2021.05.000613

Sameer Sharma

{"title":"Role of CRISPR-Cas/9 in Hematological Disorders: A Review","authors":"Sameer Sharma","doi":"10.33552/abeb.2021.05.000613","DOIUrl":"https://doi.org/10.33552/abeb.2021.05.000613","url":null,"abstract":"Over the past two decades, advances in molecular biology and genetics have greatly extended our knowledge of hematological diseases. Every year hematological disease are affecting million people from malignancies to acquired coaglupathiesis. However, the characterization of genes of interest remains a great challenge. The optimal way to unravel the roles of particular genes is to manipulate their functions via gene deletion, insertion or modification. Genome engineering is defined as the deliberate modification of an organism’s genetic material. From the 1980s several studies unravel the genetic mutation and their effect on human disease to determine the malignancies and advance diagnosis, prevention and diagnosis. Earlier gene editing technology were homologous recombination which was less efficient, time consuming & laborintensive process. Later in subsequent years, Zinc finger nucleases [ZFNs] & transcription activator-like effector nucleases [TALENs], was introduced to stimulate cellular DNA repair pathways. But there are so many limitations, so to overcome those limitation CRIPR associated CAS9 protein has introduce to start a new era of genome editing. From past few years CRISPR have change the path of genome editing be developing plant and animal models and the alleviation of human disease like hematological disorders. According to research crRNA sequence have significance role in targeting DNA [1,2]. To established CRISPR/Cas9 Jinek et al, 2012 introduce crRNA and tracrRNA into a single 100 nucleotide and a guider RNA which helps in the breaking of double stranded DNA and thus successfully genome editing done in human and mouse cells [3]. In the hematopoietic setting, CRISPR/Cas9 gene editing has been applied both in research and in clinical translation studies. CRISPER/Cas9 can be used to treat the clonal hematopoiesis by recapitulate the genetic mutation in patient. The main goal is to restore the immune system by the next generation genomics studies coupled with CRISPR/Cas9. Several companies develops their Abstract","PeriodicalId":72276,"journal":{"name":"Archives in biomedical engineering & biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44251114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ACTG Based on Silicon Getting News Structures Asi, Csi, Tsi And Gsi 基于硅获取信息结构Asi、Csi、Tsi和Gsi的ACTG

Archives in biomedical engineering & biotechnology Pub Date : 2021-05-04 DOI: 10.33552/ABEB.2021.05.000612

R. Gobato

引用次数: 10