Advanced Biomedical Research最新文献_第6页

Evaluation of the Incidence of the Esophagogastric Pre-Cancerous Mucosal Lesions after Bariatric Surgery. 减肥手术后食管胃癌前粘膜病变发生率的评价。

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_148_22

Behrooz Keleidari, Hamid Melali, Mohsen Mahmoudieh Dehkordi, Masoud Sayadi, Fatemeh Allahbakhshian Farsani, Mohammad Fakhrolmobasheri, Mahmood Mostafavi

{"title":"Evaluation of the Incidence of the Esophagogastric Pre-Cancerous Mucosal Lesions after Bariatric Surgery.","authors":"Behrooz Keleidari, Hamid Melali, Mohsen Mahmoudieh Dehkordi, Masoud Sayadi, Fatemeh Allahbakhshian Farsani, Mohammad Fakhrolmobasheri, Mahmood Mostafavi","doi":"10.4103/abr.abr_148_22","DOIUrl":"https://doi.org/10.4103/abr.abr_148_22","url":null,"abstract":"Background: Bariatric surgery is associated with significant risk reduction for obesity-related and hormone-mediated cancers; however, few studies report gastric or esophageal cancer development after bariatric surgery. This study evaluates the incidence of pre-cancerous mucosal lesions one year after bariatric surgery.Materials and methods: Eligible patients for omega-loop gastric bypass and classic Roux-en-Y gastric bypass (RYGB) underwent upper endoscopy before bariatric surgery and one year after the procedure. Several biopsies were obtained from esophagogastric mucosa, all of which were evaluated by pathologists regarding the development of any pre-cancerous lesion.Results: A total of 108 patients were included in the study. Seventy-one underwent omega bypass and 37 classic RYGB. Follow-up endoscopy indicated no dysplastic changes in esophagogastric mucosa one year after the surgery. The number of patients with gastric intestinal metaplasia was 22 and 25 before and after the surgery, respectively, which was not a statistically significant increase.Conclusion: Bariatric surgeries might not increase the risk of developing pre-cancerous lesions in the esophagogastric mucosa. Further epidemiological studies may help to establish this finding.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"140"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/0f/ABR-12-140.PMC10331545.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9814971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evaluation of HERV-K np9, rec, gag Expression in Isolated Human Peripheral Blood Mononuclear Cell (PBMC) of Gastric and Colon Cancer. HERV-K np9、rec、gag在胃癌和结肠癌人外周血单个核细胞中的表达

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_288_22

Shaian Tavakolian, Majid Iranshahi, Ebrahim Faghihloo

{"title":"The Evaluation of HERV-K np9, rec, gag Expression in Isolated Human Peripheral Blood Mononuclear Cell (PBMC) of Gastric and Colon Cancer.","authors":"Shaian Tavakolian, Majid Iranshahi, Ebrahim Faghihloo","doi":"10.4103/abr.abr_288_22","DOIUrl":"https://doi.org/10.4103/abr.abr_288_22","url":null,"abstract":"Background: In the current age of diagnostic approaches in cancer, countless efforts have been allocated to identify novel and efficient biomarkers to detect cancer in its early stages. We focused on evaluating the correlation between the progression of gastrointestinal cancer, a leading cause of cancer death worldwide, and human endogenous retrovirus (HERV).Materials and methods: In this study, we conducted a study on the peripheral blood mononuclear cells (PBMC) gathered from gastric and colon cancer patients. We focused on HERV-K rec, np9, gag expression analysis by quantitative real-time PCR, after extraction of RNA and synthesizing cDNA.Results: Unlike np9 whose expression increased significantly in the colon and gastric cancers, the mRNA level of the rec gene declined in both cancers. Moreover, our data illustrated that the over-expression of the gag gene was only observed in colon cancerous cells rather than gastric malignancy.Conclusions: Overall, given the correlation between the expression level of HERV-associated genes and gastrointestinal cancer, our study suggests that these genes could be considered beneficial markers for cancer diagnosis. However, researchers should conduct studies in future articles on whether these genes can be employed as biomarkers in gastrointestinal cancer.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"131"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/15/ABR-12-131.PMC10331531.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9814973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Relative Frequency of Epstein-Barr Virus Infection in Patients with Recurrent Breast Cancer Compared with Patients with Nonrecurrent Breast Cancer. 复发性乳腺癌患者与非复发性乳腺癌患者Epstein-Barr病毒感染相对频率的比较

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_381_21

Reza Eshraghi Samani, Masoumeh Safaee, Pardis Nematollahi, Babak Amraei

{"title":"Evaluation of the Relative Frequency of Epstein-Barr Virus Infection in Patients with Recurrent Breast Cancer Compared with Patients with Nonrecurrent Breast Cancer.","authors":"Reza Eshraghi Samani, Masoumeh Safaee, Pardis Nematollahi, Babak Amraei","doi":"10.4103/abr.abr_381_21","DOIUrl":"https://doi.org/10.4103/abr.abr_381_21","url":null,"abstract":"Background: The roles of Epstein-Barr virus (EBV) in breast cancer and breast lymphoma by transfecting EBV DNA have been indicated in different studies, but few investigations have been conducted on its roles in recurrence of breast cancer. Here, we aimed to evaluate the roles of EBV in recurrent breast cancer tissue.Materials and methods: This is a cross-sectional retrospective study that was performed in 2020-2021 in Isfahan on patients with breast cancer. The study population consisted of 30 tissue samples from recurrent breast cancer and 30 samples from nonrecurrent breast cancer. We collected demographic data of patients including age using a checklist. Other collected data were type of cancer, stages of cancer, tumor size in greatest dimension, lymph node involvements, and presence of metastasis. Furthermore, we evaluated all of the pathology samples from both groups for the presence of DNA of EBV and compared the data of both groups.Results: The DNA of EBV was positive in 8 patients of the relapsed group (26.6%) and 7 patients in the nonrelapsed patients (23.3%). There was no significant difference between two groups regarding positive DNA of EBV (P = 0.39). There were no significant differences between two groups of positive DNA of EBV with and without recurrent breast cancer regarding type of cancer (P = 0.63), stage of cancer (P = 0.19), tumor size in greatest dimension (P = 0.31), mean lymph node involvement (P = 0.27), number of lymph node involvement (P = 0.43), and metastasis (P = 0.69).Conclusion: EBV might have no significant role in recurrence of breast cancer.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/56/ABR-12-34.PMC10086641.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9305341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Music During General Anesthesia on Anesthetic Consumption During Vitrectomy Surgery. 玻璃体切割手术中全身麻醉时音乐对麻醉消耗的影响。

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_444_22

Ardeshir Tajbakhsh, Sohrab Salimi, Narsis Daftarian, Dariush Abtahi

{"title":"Effect of Music During General Anesthesia on Anesthetic Consumption During Vitrectomy Surgery.","authors":"Ardeshir Tajbakhsh, Sohrab Salimi, Narsis Daftarian, Dariush Abtahi","doi":"10.4103/abr.abr_444_22","DOIUrl":"https://doi.org/10.4103/abr.abr_444_22","url":null,"abstract":"Background: Controversy remains about the positive role of music during general anesthesia and postoperative recovery. We, therefore, tested the hypothesis that intraoperative exposure to classical music reduces the propofol necessary to maintain the bispectral index (BIS) close to 50 during vitrectomy surgery.Materials and methods: This double-blind clinical study is evaluating 50 patients undergoing vitrectomy surgery under general anesthesia. Patients were randomly assigned to music and white noise groups, and relevant sounds were played to patients after induction of anesthesia. The two groups were compared for the use of propofol as an anesthetic to maintain a BIS near 50 and for postoperative pain, anxiety, nausea, and vomiting.Results: Propofol consumption to maintain the set BIS score was much lower in the music group than in the white noise group (78.72 ± 25.76 microgram/kg/min and 117.91 ± 36.78 microgram/kg/min, respectively, P-value = 0.000). Postoperative pain scores were also much lower in the music group than in the white noise group (P-value = 0.000) and anxiety levels between these two groups did not differ (P-value = 0.870). No patient in the music group had complaints of postoperative nausea and vomiting (PONV) compared to six patients in the white noise group (P-value = 0.011).Conclusions: Listening to music during general anesthesia for vitrectomy surgery can reduce the use of anesthetics, postoperative pain, and PONV. Further, controlled studies are necessary to confirm our results.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/eb/ABR-12-59.PMC10186032.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9483849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Lymphovascular Space Invasion (LVSI) with Histological Tumor Grade and Myometrial Invasion in Endometrial Carcinoma: A Review Study. 子宫内膜癌淋巴血管间隙浸润(LVSI)与组织学肿瘤分级和子宫肌层浸润的关系综述

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_52_23

Azita Rafiee, Fereshteh Mohammadizadeh

引用次数: 0

Impact of using standard and high-resolution exposure modalities of cone-beam computed tomography (CBCT) system for dental implants dimension measurements 使用锥形束计算机断层扫描(CBCT)系统的标准和高分辨率暴露模式对种植体尺寸测量的影响

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_386_21

Hossein Taheri, Mojdeh Mehdizadeh, Parvaneh Rostamzadeh

{"title":"Impact of using standard and high-resolution exposure modalities of cone-beam computed tomography (CBCT) system for dental implants dimension measurements","authors":"Hossein Taheri, Mojdeh Mehdizadeh, Parvaneh Rostamzadeh","doi":"10.4103/abr.abr_386_21","DOIUrl":"https://doi.org/10.4103/abr.abr_386_21","url":null,"abstract":"Background: This study aimed to analyze the effects of standard and high-resolution exposures on the diagnostic accuracy of CBCT in the evaluation of dental implant dimensions.Materials and Methods: A descriptive–analytical study was carried out on 40 dry human mandibles with appropriate ridge quality based on panoramic radiography. CBCT (Soredex, Cranex 3D, Finland) with a large field of view (FOV) and CMOS flat panel detector were used. CBCT with standard and a high resolution was performed in each mandible. Axial images, reconstructed by OnDemand 3D software, were processed to prepare cross-sectional images from the areas marked by gutta-percha, and then measured by a ruler with an accuracy of 0.01 millimeter in the computer. Measurements were recorded by two observers and the obtained data were compared with the real ones.Results: The results showed suitable repeatability in radiologic measurements (r = 0.971), which is indicative of the high reliability of intraobserver measurement. The measurement of width with high-resolution exposure indicated a significant difference with the real condition (P < 0.001); however, this difference was not significant in the case of standard resolution (P > 0.05). Measurement of height with high resolution showed a significant difference with the real condition in the right mandible (P = 0.04) and left mandible (P = 0.05); however, this difference was not significant in standard resolution (P > 0.05).Conclusion: Based on our findings, the standard CBCT resolution modality is suggested for dental implant images due to its higher accuracy than high-resolution methods for diagnosing the implant dimensions.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"282 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135799617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Magnetic Resonance Imaging (MRI) Findings following posterior Sagital Ano-Recto Plasty (PSARP) in Severe Incontinent Children with High Imperforate Anus (IA) 后矢状肛门-直肠成形术(PSARP)治疗严重尿失禁伴肛门高度闭锁(IA)患儿的磁共振成像(MRI)评价

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_207_22

Mehrdad Hosseinpour, Bijan Ziyaee, Masoud Nazem, Maryam Riahinezhad

{"title":"Evaluation of Magnetic Resonance Imaging (MRI) Findings following posterior Sagital Ano-Recto Plasty (PSARP) in Severe Incontinent Children with High Imperforate Anus (IA)","authors":"Mehrdad Hosseinpour, Bijan Ziyaee, Masoud Nazem, Maryam Riahinezhad","doi":"10.4103/abr.abr_207_22","DOIUrl":"https://doi.org/10.4103/abr.abr_207_22","url":null,"abstract":"Background: The aim of this study was to evaluate pelvic MRI accuracy for measurement of anatomical land marks in severe fecal incontinent (FI) children with high imperforate anus (IA).Materials and Methods: A total of 80 children (40 cases and 40 controls) aged more than 4 years with severe FI were assessed. Magnetic resonance imaging was performed by a radiologist with the same device. For pelvic anatomical land marks measurement, we measured the ano-rectal angel and hiatal/pc ratio.Results: The mean of ano-rectal angel was 118.67 ± 25.2 mm in cases and 132.07 ± 13.8 mm in control group (P = .004). H/PCR was 0.63 ± 0.05 in cases and 0.62 ± 0.45 in controls (P = NS). There was no significant correlation between [INSIDE:1] (r = 0.25, P = 0.36) or ano-rectal angle measurement (r = 0.16, P = 0.05) and FI score in patients with severe FI.Conclusions: Pelvic magnetic resonance imaging could be accurately used is measuring the ano-rectal angle is high IA children with severe FI which leads to selected patients who may have benefits of reoperation.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135102668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of spinocerebellar ataxia autosomal recessive 21 presented with liver disease 一个罕见的脊髓小脑性共济失调常染色体隐性遗传21表现为肝脏疾病

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_139_22

Hosein Saneian, Narges Zare, Majid Khademian

引用次数: 0

Comparison of the Effectiveness of Two Types of Commercial Endotracheal Tube Holders, with the Conventional Method in a Manikin Model. 两种商用气管插管支架与传统方法在人体模型上的有效性比较。

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_192_21

Mehdi Nasr Isfahani, Alireza Abootalebi, Khatere Ghaznavi, Leila Kamali Dolatabadi

{"title":"Comparison of the Effectiveness of Two Types of Commercial Endotracheal Tube Holders, with the Conventional Method in a Manikin Model.","authors":"Mehdi Nasr Isfahani, Alireza Abootalebi, Khatere Ghaznavi, Leila Kamali Dolatabadi","doi":"10.4103/abr.abr_192_21","DOIUrl":"https://doi.org/10.4103/abr.abr_192_21","url":null,"abstract":"Background: Endotracheal intubation is employed to create a safe airway in patients requiring mechanical ventilation. The relatively high prevalence rate of unplanned displacement of the endotracheal tube (ETT) can be associated with serious complications. This study was conducted to evaluate the effectiveness of a newly designed tube holder in Iran (Irafit), the Thomas ETT holder and the traditional method using adhesive tape.Materials and methods: The present manikin-based study was performed on the human mannequin. For this purpose, the mannequin was first subjected to oral intubation by a skilled emergency medicine specialist. Then, three methods of adhesive tape, Irafit-ETT holder, and Thomas-ETT holder were used. The mean of displacement in width of the mouth, length of the ETT, and depth as well as ETT removal was recorded.Results: The results of the present study revealed that the displacement in depth was significantly less in the Irafit-ETT holder as compared with the other two groups following the application of a tug (P < 0.001). The displacement in the length of the ETT with and without the application of a tug was significantly less in the Irafit-ETT holder and Thomas-ETT holder groups as compared with the adhesive tape group (P < 0.001).Conclusion: According to the results of the present study, it can be stated that both ETT holder devices (Thomas vs. Irafit) were not distinct in terms of displacements in length and width; however, the Iranian model was more successful in minimizing the displacement in depth.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/6d/ABR-12-30.PMC10086637.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9298835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Success Rate and Safety of Nasotracheal Intubation by Conventional and Finger-Guided Method in Patients Undergoing Maxillofacial Surgery. 颌面外科常规与指路鼻气管插管成功率及安全性比较。

Advanced Biomedical Research Pub Date : 2023-01-01 DOI: 10.4103/abr.abr_255_21

Seyed Jalal Hashemi, Hamidreza Shetabi, Reihanak Talakoub, Avishan Aminizad

{"title":"Comparison of Success Rate and Safety of Nasotracheal Intubation by Conventional and Finger-Guided Method in Patients Undergoing Maxillofacial Surgery.","authors":"Seyed Jalal Hashemi, Hamidreza Shetabi, Reihanak Talakoub, Avishan Aminizad","doi":"10.4103/abr.abr_255_21","DOIUrl":"https://doi.org/10.4103/abr.abr_255_21","url":null,"abstract":"Background: Different techniques have been introduced to reduce the complications of nasotracheal intubation. The aim of this study was to compare the incidence of nasotracheal intubation complications in finger-guided and conventional methods.Materials and methods: In this double-blind randomized trial study, 70 patients who were candidates for oral and maxillofacial surgery who required nasal intubation were included in the study finally of which 33 patients with conventional method and 35 patients with finger-guided tubes in the nasopharynx were analyzed at the end of the study. Variables such as success rate, hemodynamic response, and complications of intubation were compared between the two groups.Results: There was no significant difference between the two groups in terms of hemodynamic response to intubation (P > 0.05). There was a significant difference between the two groups in terms of success in tracheal intubation (P < 0.05). There was a significant difference between the two groups in terms of epistaxis immediately after intubation (P < 0.05). There was no significant difference between the two groups in terms of nasal turbine fractures (P > 0.05). However, the frequency of submucosal intubation in the conventional method was significantly higher than the other group (P = 0.02).Conclusion: Nasotracheal intubation using the finger guiding technique in the nasopharynx is associated with a higher success rate and less complications after intubation such as epistaxis and submucosal intubation compared to the conventional method.","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/dd/ABR-12-35.PMC10086639.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9305338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0