Applications in engineering science最新文献

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Hindered thermal warping triggers tensile cracking in the cores of compressed columns of a fire-loaded tunnel segment structure: Efficiency and accuracy of beam theory prediction, compared to FEM 受阻碍的热翘曲引发火灾荷载隧道管片结构压缩柱芯的拉伸开裂:与有限元法相比,梁理论预测的效率和准确性
Applications in engineering science Pub Date : 2023-06-01 DOI: 10.1016/j.apples.2023.100128
Maximilian Sorgner , Rodrigo Díaz Flores , Hui Wang , Christian Hellmich , Bernhard L.A. Pichler
{"title":"Hindered thermal warping triggers tensile cracking in the cores of compressed columns of a fire-loaded tunnel segment structure: Efficiency and accuracy of beam theory prediction, compared to FEM","authors":"Maximilian Sorgner ,&nbsp;Rodrigo Díaz Flores ,&nbsp;Hui Wang ,&nbsp;Christian Hellmich ,&nbsp;Bernhard L.A. Pichler","doi":"10.1016/j.apples.2023.100128","DOIUrl":"10.1016/j.apples.2023.100128","url":null,"abstract":"<div><p>The nonlinear Finite Element Method (FEM) is the current gold standard for the thermo-mechanical analysis of reinforced concrete structures. As an alternative, this paper is devoted to a model reduction strategy which reduces the CPU time by a factor of 500. This strategy combines Fourier series-based solutions for the thermal conduction problem, and thermo-elastic Timoshenko beam theory. Temperature histories known to be relevant for fire accidents enter series solutions quantifying the conduction of heat into a closed cell frame consisting of slabs, walls, and columns. Corresponding temperature profiles are translated into thermal eigenstrains. The latter are represented as the sum of three portions: (i) their cross-sectional averages (called thermal eigenstretches); (ii) their cross-sectional moments (called thermal eigencurvatures); and (iii) the remaining eigenstrain distributions (called eigenwarping). The latter portion is hindered at the cross-sectional scale, giving rise to non-linearly distributed self-equilibrated thermal stresses. The eigenstretches and eigencurvatures, in turn, are constrained at the scale of the frame structure. Together with external mechanical loads, they enter the exact solutions of thermo-elastic Timoshenko beam theory with equivalent cross-sections accounting for the different material properties of concrete and steel. Axial normal stresses, quantified from beam-theory-related normal forces and bending moments, are superimposed with the hindered-warping-induced stresses. These stresses agree well with corresponding results obtained by the nonlinear FEM. As regards the load carrying behavior of the columns, excessive thermal tensile strains at the periphery of the columns trigger, in the core of the columns, large tensile stresses which even exceed the strength of concrete. Respective cracking events are considered through reduced effective columnar cross-sections. Right after initiation of cracking, around 12<!--> <!-->min after the start of the heating process, the cracks propagate for some 30<!--> <!-->sec quite rapidly, and very much slower thereafter. If the initial cross-sections of the columns are increased, more pronounced hindered thermal warping, together with less quickly evolving compressive forces, results in earlier cracking. Overall, it is concluded that tensile cracking is the key material non-linearity, at least during the first 30<!--> <!-->min of the fire test, with maximum temperatures up to 300<!--> <!-->°C.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"14 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48256854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Adaptive mesh refinement for the phase field method: A FEniCS implementation 相位场法的自适应网格细化:一种FEniCS实现
Applications in engineering science Pub Date : 2023-06-01 DOI: 10.1016/j.apples.2023.100127
F. Freddi, L. Mingazzi
{"title":"Adaptive mesh refinement for the phase field method: A FEniCS implementation","authors":"F. Freddi,&nbsp;L. Mingazzi","doi":"10.1016/j.apples.2023.100127","DOIUrl":"10.1016/j.apples.2023.100127","url":null,"abstract":"<div><p>This paper reports insightful implementation details of the global adaptive refinement procedure for the phase-field method recently published in Freddi and Mingazzi (2022). Phase field approaches reproduce cracks within solids in a smeared manner. The small transition zone between broken and unbroken material, whose width is controlled by an internal scale length parameter, permits to precisely replicate complex sharp crack topologies only if an extremely fine mesh is adopted. Starting from a coarse mesh, the proposed refinement process utilizes an energetic criterion to selectively refine the elements on which cracks may propagate. In fully broken areas, where the phase field is no longer evolving, a specific refinement is adopted to capture the high displacement gradient. The implementation is performed within the open-source finite element software FEniCS (ver. 19.1.0) which provides a framework for automated solutions of partial differential equations. The fundamental aspects of the code are described starting from the functional definition to the various steps of the refinement technique. A representative example is illustrated to supply further information on the code functionality. The code can be downloaded from <span>https://github.com/LorenzoMingazzi/AGu-AGal</span><svg><path></path></svg> and be used to easily apply the proposed refinement strategy to different problems or as a starting point for more sophisticated formulations.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"14 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44011082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Mechanical response of elastic materials with density dependent Young modulus 杨氏模量随密度变化的弹性材料力学响应
Applications in engineering science Pub Date : 2023-06-01 DOI: 10.1016/j.apples.2023.100126
Vít Průša, Ladislav Trnka
{"title":"Mechanical response of elastic materials with density dependent Young modulus","authors":"Vít Průša,&nbsp;Ladislav Trnka","doi":"10.1016/j.apples.2023.100126","DOIUrl":"10.1016/j.apples.2023.100126","url":null,"abstract":"<div><p>The experimental as well as theoretical engineering literature on porous structures such as metal foams, aerogels or bones often relies on the standard linearised elasticity theory, and, simultaneously, it frequently introduces the concept of “density dependent Young modulus”. We interpret the concept of “density dependent Young modulus” literally, that is we consider the linearised elasticity theory with the generalised Young modulus being a function of the current density, and we briefly summarise the existing literature on theoretical justification of such models. Subsequently we numerically study the response of elastic materials with the “density dependent Young modulus” in several complex geometrical settings.</p><p>In particular, we study the extension of a right circular cylinder, the deflection of a thin plate, the bending of a beam, and the compression of a cube subject to a surface load, and we quantify the impact of the density dependent Young modulus on the mechanical response in the given setting. In some geometrical settings the impact is almost nonexisting—the results based on the classical theory with the constant Young modulus are nearly identical to the results obtained for the density dependent Young modulus. However, in some cases such as the deflection of a thin plate, the results obtained with constant/density dependent Young modulus differ considerably despite the fact that in both cases the infinitesimal strain condition is well satisfied.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"14 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42650738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Investigations on design limits and improved material utilization of press-fit connections using elastic-plastic design 使用弹塑性设计研究压配合连接的设计极限和提高材料利用率
Applications in engineering science Pub Date : 2023-03-01 DOI: 10.1016/j.apples.2022.100124
Jan Falter, Hansgeorg Binz , Matthias Kreimeyer
{"title":"Investigations on design limits and improved material utilization of press-fit connections using elastic-plastic design","authors":"Jan Falter,&nbsp;Hansgeorg Binz ,&nbsp;Matthias Kreimeyer","doi":"10.1016/j.apples.2022.100124","DOIUrl":"10.1016/j.apples.2022.100124","url":null,"abstract":"<div><p>Today, there are a number of analytical and numerical calculation methods for the elastic-plastic design of press-fit connections. However, these are largely constrained by their restriction to elastic-ideal-plastic material behavior. In addition, recommendations for limiting the plasticized hub cross section that have been provided to date do not exploit the full potential of the materials, with the result that opportunities for lightweight design and improved transmission capacity have remained unused so far. Yet, no experimental validations exist to this end, which is why the existing design method could not be validated until today. In addition, there is still a lack of research on how to evaluate the potential for increasing the force and torque transmission under consideration of the strain hardening of the material during plastic deformation. The lack of knowledge today prevents a targeted design and thereby the industrial application of this type of connection; the transmission capacity and lightweight design potentials have thus remained unused until now (<span>Kröger and Binz, 2020</span>). This article presents the actual design and joining limits of hubs made of EN AW-5083 (AlMg4,5Mn), which were determined as part of an Industrial Collective Research (IGF) project. This allows the hub materials to be better utilized, which leads to a reduction in mass and/or an increase in the force and torque transmission. In addition, the experimental validation of the numerical investigations helps to establish the design method in industrial practice.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"13 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45413793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Multi-field formulations for solving plane problems involving viscoelastic constitutive relations 求解粘弹性本构关系平面问题的多场公式
Applications in engineering science Pub Date : 2023-03-01 DOI: 10.1016/j.apples.2022.100120
S. Ananthapadmanabhan, U. Saravanan
{"title":"Multi-field formulations for solving plane problems involving viscoelastic constitutive relations","authors":"S. Ananthapadmanabhan,&nbsp;U. Saravanan","doi":"10.1016/j.apples.2022.100120","DOIUrl":"10.1016/j.apples.2022.100120","url":null,"abstract":"<div><p>This article reports a multi-field numerical formulation for solving plane problems involving viscoelastic materials. Stress fields satisfying equilibrium equations are constructed using Airy’s potentials which are expressed as a linear combination of <span><math><msup><mrow><mi>C</mi></mrow><mrow><mn>2</mn></mrow></msup></math></span> basis functions. The strain field is derived from a continuous displacement field obtained from a linear combination of <span><math><msup><mrow><mi>C</mi></mrow><mrow><mn>0</mn></mrow></msup></math></span> basis functions. An appropriate linear combination of these stress and displacement basis functions is determined such that the resulting stress and strain fields satisfy the constitutive relation subjected to the satisfaction of the constraints arising from the boundary conditions. Since a viscoelastic constitutive relation involves stress, strain, and their rates, stress and displacement degrees of freedom or their rates can be considered as optimization variables for minimizing the error in satisfying the constitutive relation. Two Algorithms are proposed based on this choice of optimization variable. Accuracy and efficiency of the proposed algorithms are studied through five different boundary value problems involving four forms of the viscoelastic constitutive relations and for two loading histories. Using the developed rectangular element, viscoelastic beam bending problem is solved for the different constitutive relations studied.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"13 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47830854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mathematical modelling and parameter classification enable understanding of dynamic shape-change issues adversely affecting high energy-density battery metal anodes 数学建模和参数分类能够理解对高能量密度电池金属阳极产生不利影响的动态形状变化问题
Applications in engineering science Pub Date : 2023-03-01 DOI: 10.1016/j.apples.2022.100125
Benedetto Bozzini , Elisa Emanuele , Jacopo Strada , Ivonne Sgura
{"title":"Mathematical modelling and parameter classification enable understanding of dynamic shape-change issues adversely affecting high energy-density battery metal anodes","authors":"Benedetto Bozzini ,&nbsp;Elisa Emanuele ,&nbsp;Jacopo Strada ,&nbsp;Ivonne Sgura","doi":"10.1016/j.apples.2022.100125","DOIUrl":"10.1016/j.apples.2022.100125","url":null,"abstract":"<div><p>Owing to the difficulty of studying materials in real-life battery context, research on metal anodes, suffers from a methodological gap between materials- and device-orientated studies. This gap can be bridged by quantitatively linking the electrical response of the device to the evolution of the material inside the cell. The capability of establishing this link, on the one hand, allows to frame the correct space- and time-scales that are relevant to device research and, on the other hand, helps pinpoint the global observables that can be associated with molecular-level information and imaging. This study contributes to the construction of a conceptual platform, that will enable to rationalize the electrical response of the device on the basis of materials-relevant quantities. To this aim: (i) we have developed a PDE-based mathematical model for the response of a single symmetric cell with metal electrodes; (ii) we have validated it with high-quality data from Zn/Zn symmetric coin-cell cycling in weakly acidic alkaline aqueous electrolyte, containing quaternary ammonium additives, and (iii) we have carried out a parameter-classification task for the experimental data, that notably extended the physico-chemical insight into the mechanism of action of anode-stabilizing additives.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"13 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44051856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in endovascular aortic repair 血管内主动脉修复的研究进展
Applications in engineering science Pub Date : 2022-12-01 DOI: 10.1016/j.apples.2022.100116
Timothy D. Chilton , Matthew R. Smeds , Kristofer M. Charlton-Ouw
{"title":"Advances in endovascular aortic repair","authors":"Timothy D. Chilton ,&nbsp;Matthew R. Smeds ,&nbsp;Kristofer M. Charlton-Ouw","doi":"10.1016/j.apples.2022.100116","DOIUrl":"10.1016/j.apples.2022.100116","url":null,"abstract":"<div><p>The treatment of degenerative aortic disease has largely shifted to endovascular repair due to lower short-term morbidity and mortality with similar costs and operative times when compared to the traditional open approach. Ongoing endograft development in combination with improved endovascular techniques have allowed vascular surgeons to extend endovascular treatment offerings to previously hostile and unfavorable patient anatomy. Modern endografts are now placed using smaller delivery systems designed to better accommodate a diverse patient population. New endograft designs allow for improved, patient-specific surgical plan. In patients where endovascular repair is desired but commercially available grafts are not available, endograft modification and adjunctive stenting remains an alternative.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"12 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666496822000322/pdfft?md5=943bd535b20174b8908324cbd01077ee&pid=1-s2.0-S2666496822000322-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46281051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
In Silico Modelling of Aortic Strain and Strain Rate in Aortic Coarctation Treated with Stent Angioplasty with Comparison to Clinical Cohorts 支架成形术治疗主动脉缩窄的主动脉应变和应变率的计算机模拟与临床队列的比较
Applications in engineering science Pub Date : 2022-12-01 DOI: 10.1016/j.apples.2022.100123
Nicholas Gaddum , Des Dillon-Murphy , Richard Arm , Isma Rafiq , Radomir Chabiniok , Gareth Morgan , Tobias Schaeffter , Tarique Hussain
{"title":"In Silico Modelling of Aortic Strain and Strain Rate in Aortic Coarctation Treated with Stent Angioplasty with Comparison to Clinical Cohorts","authors":"Nicholas Gaddum ,&nbsp;Des Dillon-Murphy ,&nbsp;Richard Arm ,&nbsp;Isma Rafiq ,&nbsp;Radomir Chabiniok ,&nbsp;Gareth Morgan ,&nbsp;Tobias Schaeffter ,&nbsp;Tarique Hussain","doi":"10.1016/j.apples.2022.100123","DOIUrl":"10.1016/j.apples.2022.100123","url":null,"abstract":"<div><h3>Objective</h3><p>Treatment of aortic coarctation has seen a shift from traditional surgical repair to the use of aortic stents. The aim of this study was to assess the impact upon hemodynamics and arterial strain when aortic coarctation is treated with a stent using an experimental coarctation model, and to confirm any findings in a clinical cohort using MRI.</p></div><div><h3>Methods</h3><p>An experimental patient model included a silicone arterial tree, and ventricular stroke profile was derived from patient MRI data. Pressure, flow and aortic strain was measured before and after stent placement in the model. A clinical study comprised of strain measurements using MRI in two patient cohorts; those treated with a stent, and those treated with surgical repair.</p></div><div><h3>Results</h3><p>Before stent placement, peak strain decreased as the pulse propagated away from the aortic valve. After stent placement however, peak strain was amplified as it approached the stent, despite peak systolic pressure having dropped by 20 mmHg. Introduction of the stent caused an almost three fold increase in aortic strain rate to 150%.<em>s</em> <sup>−</sup> <sup>1</sup>. Echoing these results the stented patient group's strain increased from 28% +/- 14% in the ascending aorta to 43% +/- 24% (<em>p</em> &lt; 0.05) pre-coarctation. This was not seen in those with surgical repair of coarctation, (ascending aorta 40% +/- 22% compared to the pre-coarctation aorta strain 38% +/- 20%, <em>p</em> = 0.81).</p></div><div><h3>Conclusions</h3><p>Despite a reduced systolic pressure gradient through a stented coarctation, dramatic increases in strain and strain rate could attribute subsequent pathologies in the aorta proximally.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"12 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666496822000395/pdfft?md5=cfbe97d81d936ce1c2aa668d725e764d&pid=1-s2.0-S2666496822000395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47084589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dimensional reduction of a poromechanical cardiac model for myocardial perfusion studies 用于心肌灌注研究的孔隙力学心脏模型的降维
Applications in engineering science Pub Date : 2022-12-01 DOI: 10.1016/j.apples.2022.100121
Radomír Chabiniok , Bruno Burtschell , Dominique Chapelle , Philippe Moireau
{"title":"Dimensional reduction of a poromechanical cardiac model for myocardial perfusion studies","authors":"Radomír Chabiniok ,&nbsp;Bruno Burtschell ,&nbsp;Dominique Chapelle ,&nbsp;Philippe Moireau","doi":"10.1016/j.apples.2022.100121","DOIUrl":"10.1016/j.apples.2022.100121","url":null,"abstract":"<div><p>In this paper, we adapt a previously developed poromechanical formulation to model the perfusion of myocardium during a cardiac cycle. First, a complete model is derived in 3D. Then, we perform a dimensional reduction under the assumption of spherical symmetry and propose a numerical algorithm that enables us to perform simulations of the myocardial perfusion throughout the cardiac cycle. These simulations illustrate the use of the proposed model to represent various physiological and pathological scenarios, specifically the vasodilation in the coronary network (to reproduce the standard clinical assessment of myocardial perfusion and perfusion reserve), the stenosis of a large coronary artery, an increased vascular resistance in the microcirculation (microvascular disease) and the consequences of inotropic activation (increased myocardial contractility) particularly at the level of the systolic flow impediment. Our results show that the model gives promising qualitative reproductions of complex physiological phenomena. This paves the way for future quantitative studies using clinical or experimental data.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"12 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666496822000371/pdfft?md5=5aeb03fa0103bdbc774288bd7014dac0&pid=1-s2.0-S2666496822000371-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46579971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Review of devices and clinical need for non-blood contacting mechanical circulatory support 非血液接触式机械循环支持设备及临床需求综述
Applications in engineering science Pub Date : 2022-12-01 DOI: 10.1016/j.apples.2022.100122
Shannon N. Ingram , Melanie P. Hager , Michael R. Moreno , John C. Criscione
{"title":"Review of devices and clinical need for non-blood contacting mechanical circulatory support","authors":"Shannon N. Ingram ,&nbsp;Melanie P. Hager ,&nbsp;Michael R. Moreno ,&nbsp;John C. Criscione","doi":"10.1016/j.apples.2022.100122","DOIUrl":"10.1016/j.apples.2022.100122","url":null,"abstract":"<div><p>LVADs have been in clinical use for a half-century and have advanced through at least 3 generations resulting in compact, durable, and powerful pumps that can deliver blood flow that exceeds the needs of the body at rest. In so doing, these devices have become the best alternative to transplant for patients with end-stage heart failure. That said, the blood contacting interface of these pumps is likely the cause of complications and contraindications that persist with successive generations. Patients with elevated risk for side effects or patients with biventricular failure and other conditions represent the 25% of patients that are not candidates for LVAD therapy. Such patients represent the clinical need for non-blood contacting mechanical circulatory support. The clinical use of direct cardiac compression devices is limited, and there are no devices available for human use. Technological challenges remain, yet these devices continue to be developed and tested in animal models of heart failure.</p></div>","PeriodicalId":72251,"journal":{"name":"Applications in engineering science","volume":"12 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666496822000383/pdfft?md5=c1e3155cc2330b935b9fcb96b6d4907f&pid=1-s2.0-S2666496822000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43137977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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