Annals of nuclear cardiology最新文献

{"title":"JSNC 2024 in Omiya","authors":"Ichiro Matsunari","doi":"10.17996/anc.23-003","DOIUrl":"https://doi.org/10.17996/anc.23-003","url":null,"abstract":"","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Heart Segmentation and Absolute Quantitation of Cardiac &lt;sup&gt;123&lt;/sup&gt;I-metaiodobenzylguanidine Sympathetic Imaging Using SPECT/CT","authors":"Shintaro Saito, Kenichi Nakajima, Takayuki Shibutani, Hiroshi Wakabayashi, Hiroto Yoneyama, Takahiro Konishi, Hiroshi Mori, Aki Takata, Seigo Kinuya","doi":"10.17996/anc.23-00002","DOIUrl":"https://doi.org/10.17996/anc.23-00002","url":null,"abstract":"Background: A three-dimensional (3D) approach to absolute quantitation of 123I-metaiodobenzylguanidine (MIBG) sympathetic nerve imaging using single-photon emission tomography (SPECT) / computed tomography (CT) is not available. Therefore, we calculated absolute cardiac counts and standardized uptake values (SUVs) from images of 72 consecutive patients with cardiac and neurological diseases using 123I-MIBG SPECT/CT and compared them with conventional planar quantitation. We aimed to develop new methods for 3D heart segmentation and the quantitation of these diseases. Methods: We manually segmented early and late SPECT/CT images of the heart in 3D, then calculated mean (SUVmean) and maximum (SUVmax) SUVs. We analyzed correlations between SUVs and planar heart-to-mediastinum ratios (HMRs), and between washout rates (WRs) derived from the SUVs and planar data. We also categorized WRs as normal or abnormal using linear regression lines determined by the relationship between SPECT/CT and planar WRs, and assessed agreement between them. Results: We calculated SUVmean and SUVmax from all early and late 123I-MIBG SPECT/CT images. Planar HMRs correlated with early and late SUVmean (R2=0.59 and 0.73, respectively) and SUVmax (R2=0.46 and 0.60, respectively; both p<0.0001). The SPECT/CT WRs determined based on SUVmean and SUVmax (R2=0.79 and 0.45, p<0.0001) closely correlated with planar WRs. Agreement of high and low WRs between planar WRs and SPECT/CT WRs calculated using SUVmax and SUVmean reached 88.1% and 94.4% respectively. Conclusions: We found that sympathetic nervous activity could be absolutely quantified in 3D from 123I-MIBG SPECT/CT images. Therefore, we propose a new method for quantifying sympathetic innervation on SPECT/CT images.","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135316655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between 18F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification.","authors":"Yuriko Okamura, R. Nakanishi, H. Hashimoto, Kyoko Ota, R. Okubo, T. Yabe, R. Noike, S. Mizumura, K. Kishi, S. Homma, T. Ikeda","doi":"10.21203/rs.3.rs-1202858/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-1202858/v1","url":null,"abstract":"Introduction: Although 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been widely utilized to assess the extent of inflammation, the association between the extent and severity of atherosclerosis and 18F-FDG uptake on PET remains unexamined. The current study aimed to investigate whether aortic calcium (AC) scores were associated with increased aortic uptake of 18F-FDG on PET. Methods: A total of 167 consecutive patients with suspected lung cancer but unproven malignancy who underwent non-contrast-enhanced computed tomography (CT) and 18F-FDG PET/CT were enrolled. The average standardized uptake values in the ascending aorta were used to calculate the target-to-background ratio (Mean TBR). The total (thoracic and abdominal) AC scores were measured on non-contrast-enhanced chest and abdominal CT using the Agatston method, and were categorized into three groups (0, 1-399, and ≥400). The relationship between total AC scores and 18F-FDG uptake in the ascending aorta was assessed using multivariate linear regression analysis. Results: In total, 68.26% were male, and a mean age was 67.10±14.70 years. Mean TBR values increased progressively with total AC score 0, 1-399, and ≥400 (1.01±0.07, 1.08±0.09, and 1.11±0.11, respectively; p<0.00001). Multivariate linear regression analysis revealed that increased total AC scores of 1-399 (β=0.06, 95% CI: 0.01-0.11, p=0.02) and ≥400 (β=0.11, 95% CI: 0.06-0.16, p<0.001) were significantly associated with higher Mean TBR. Conclusions: The current study demonstrated that total AC scores were associated with Mean TBR. Patients with a greater extent and severity of aortic calcifications may possess increased atherosclerotic inflammatory activity as measured by 18F-FDG PET/CT.","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"38 1","pages":"57-66"},"PeriodicalIF":0.0,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85898575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATTR Amyloidosis Concomitant with Parkinsonism and Cardiac Sympathetic Neuropathy.","authors":"Fumika Haga,&nbsp;Masayoshi Oikawa,&nbsp;Joh Akama,&nbsp;Takatoyo Kiko,&nbsp;Shinya Yamada,&nbsp;Akiomi Yoshihisa,&nbsp;Kazuhiko Nakazato,&nbsp;Yasuchika Takeishi","doi":"10.17996/anc.22-00162","DOIUrl":"https://doi.org/10.17996/anc.22-00162","url":null,"abstract":"W ild-type transthyretin amyloidosis (ATTRwt) is an infiltrative disease in which amyloid fibrils derived from transthyretin are deposited in various tissues without mutations in TTR gene. Symptoms mainly manifest in joints, ligaments, and the heart, leading to carpal tunnel syndrome, spinal canal stenosis, cardiac hypertrophy, arrhythmia, and heart failure (1). 123 I-metaiodobenzylguanidine (MIBG) scintigraphy is widely used to evaluate cardiac sympathetic innervation in patients with chronic heart failure. In addition, it is applied to the differential diagnosis of Parkinson’s disease from other neurodegenerative parkinsonism, characterized by reduced accumulation of 123 I-MIBG in the heart (2). Here we report the case of ATTRwt presenting parkinsonism concomitant with reduced accumulation of 123 I-MIBG scintigraphy in the heart.","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"8 1","pages":"117-119"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749751/pdf/8_117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Validation of Japanese Normal Myocardial Perfusion Imaging Databases Using Semi-conductor Gamma Camera (D-SPECT): Japanese Society of Nuclear Cardiology Working Group Reports.","authors":"Naoya Matsumoto,&nbsp;Shonosuke Sugai,&nbsp;Yasuyuki Suzuki,&nbsp;Nobuo Iguchi,&nbsp;Mamoru Nanasato,&nbsp;Keisuke Kiso,&nbsp;Yasuyo Taniguchi,&nbsp;Tatsuya Yoneyama,&nbsp;Koichi Okuda,&nbsp;Kenichi Nakajima","doi":"10.17996/anc.22-00163","DOIUrl":"https://doi.org/10.17996/anc.22-00163","url":null,"abstract":"<p><p><i>Objective</i>: A working group (WG) of the Japanese Society of Nuclear Cardiology (JSNC) determined Japanese normal databases of myocardial perfusion single-photon emission computed tomography (SPECT) on semi-conductor gamma camera (D-SPECT), and the aim of this study was to validate its clinical utility. <i>Materials and methods</i>: The normal myocardial perfusion SPECT (MPS) databases of Japanese patients in the ²⁰¹Tl stress/redistribution protocol (²⁰¹Tl protocol), ^99mTc stress/rest or rest/stress protocol (^99mTc protocol), and rest ^99mTc/stress ²⁰¹Tl simultaneous acquisition dual-isotope protocol (SDI protocol) were created by JSNC WG. The WG collected clinical cases for the ²⁰¹Tl protocol (male/female [m/f], 8/8), ^99mTc protocol (m/f, 9/7), and SDI protocol (m/f, 10/10) from WG participating hospitals. Four WG members read those clinical cases on a 17-segment and 5-point scale (0-4). Using the most frequent values as the score for each segment, weighted κ values were calculated with the scores obtained from quantitative perfusion software (QPS). <i>Results</i>: Weighted κ values were as follows; ²⁰¹Tl stress/female, 0.77; ²⁰¹Tl rest/female, 0.74; ²⁰¹Tl stress/male, 0.81; ²⁰¹Tl rest/male, 0.68; ^99mTc stress/female, 0.77; ^99mTc rest/female, 0.62; ^99mTc stress/male, 0.77; ^99mTc rest/male, 0.75; SDI stress/female, 0.87; SDI rest/female, 0.82; SDI stress/male, 0.87; SDI rest/male, 0.85. <i>Conclusions</i>: The diagnostic accuracy of Japanese MPS normal databases on D-SPECT were comparable with nuclear cardiology expert reading and further clinical applications are expected.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"8 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749750/pdf/8_36.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between ¹⁸F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification.","authors":"Yuriko Okamura,&nbsp;Rine Nakanishi,&nbsp;Hidenobu Hashimoto,&nbsp;Sunao Mizumura,&nbsp;Sakae Homma,&nbsp;Takanori Ikeda","doi":"10.17996/anc.22-00160","DOIUrl":"https://doi.org/10.17996/anc.22-00160","url":null,"abstract":"<p><p><i>Introduction</i>: Although ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been widely utilized to assess the extent of inflammation, the association between the extent and severity of atherosclerosis and ¹⁸F-FDG uptake on PET remains unexamined. The current study aimed to investigate whether aortic calcium (AC) scores were associated with increased aortic uptake of ¹⁸F-FDG on PET. <i>Methods</i>: A total of 167 consecutive patients with suspected lung cancer but unproven malignancy who underwent non-contrast-enhanced computed tomography (CT) and ¹⁸F-FDG PET/CT were enrolled. The average standardized uptake values in the ascending aorta were used to calculate the target-to-background ratio (Mean TBR). The total (thoracic and abdominal) AC scores were measured on non-contrast-enhanced chest and abdominal CT using the Agatston method, and were categorized into three groups (0, 1-399, and ≥400). The relationship between total AC scores and ¹⁸F-FDG uptake in the ascending aorta was assessed using multivariate linear regression analysis. <i>Results</i>: In total, 68.26% were male, and a mean age was 67.10±14.70 years. Mean TBR values increased progressively with total AC score 0, 1-399, and ≥400 (1.01±0.07, 1.08±0.09, and 1.11±0.11, respectively; p<0.00001). Multivariate linear regression analysis revealed that increased total AC scores of 1-399 (<i>β</i>=0.06, 95% CI: 0.01-0.11, p=0.02) and ≥400 (<i>β</i>=0.11, 95% CI: 0.06-0.16, p<0.001) were significantly associated with higher Mean TBR. <i>Conclusions</i>: The current study demonstrated that total AC scores were associated with Mean TBR. Patients with a greater extent and severity of aortic calcifications may possess increased atherosclerotic inflammatory activity as measured by ¹⁸F-FDG PET/CT.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"8 1","pages":"57-66"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749753/pdf/8_57.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10406392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Resting Myocardial Blood Flow Using Rubidum⁸² Positron Emission Tomography in Regions with MRI-Confirmed Myocardial Scar.","authors":"Merrill Stewart,&nbsp;Sangeeta Shah,&nbsp;Richard Milani,&nbsp;Daniel Morin,&nbsp;Robert Bober","doi":"10.17996/anc.21-00137","DOIUrl":"https://doi.org/10.17996/anc.21-00137","url":null,"abstract":"<p><p><i>Background</i>: Resting myocardial blood flow (rMBF) within regions of myocardial scar as measured by positron emission tomography (PET) has not yet been assessed with the radiotracer Rubidium⁸² (Rb⁸²) or correlated with scar thickness. Cardiac magnetic resonance imaging (cMRI) offers high spatial resolution and identifies myocardial scar with late gadolinium enhancement (LGE). Using Rb⁸² PET, we sought to characterize rMBF in regions of myocardial scar of varying thicknesses determined by cMRI. <i>Methods/Results</i>: Patients with a history of myocardial infarction, a resting Rb⁸² PET study and a cMRI were identified. On cMRI, regions of infarction, defined as >50% LGE with akinesis, were sub-categorized as 50-75% LGE or >75% LGE, corresponding with increasing transmural scar thickness. PET zones of infarct based on size and %LGE by cMRI were quantified for mean and minimum rMBF. Mean rMBF (cc/min/g) in infarct zones with >75% LGE was 0.32±0.07 with a minimum rMBF of 0.19±0.03. In infarct zones with 50-75% LGE, rMBF was 0.45±0.14 (50-75% vs. >75%, p=0.002). <i>Conclusions</i>: We identified rMBF within cMRI confirmed regions of myocardial scar of varying thicknesses. rMBF has an inverse relationship with the extent of LGE on cMRI, with the most severe regions (>75% LGE) having mean and minimal rMBF (cc/min/g) of 0.32±0.07 and 0.19±0.03, respectively.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"8 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754780/pdf/8_7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Method to Suppress the Effect of Subdiaphragmatic Activity in ^99mTc Myocardial Perfusion SPECT and Evaluation of Its Usefulness Using a Myocardial Phantom.","authors":"Atsushi Komuro,&nbsp;Satomi Teraoka,&nbsp;Yasushi Ishikawa,&nbsp;Masanori Tsuboko,&nbsp;Mika Tanno,&nbsp;Kouichi Ishimori,&nbsp;Kazuo Funaki,&nbsp;Jiro Izumida,&nbsp;Tomiyoshi Saito","doi":"10.17996/anc.22-00154","DOIUrl":"https://doi.org/10.17996/anc.22-00154","url":null,"abstract":"<p><p><i>Background</i>: Smoothing in ^99mTc myocardial perfusion single-photon emission computed tomography (SPECT) often increases myocardial artifacts due to subdiaphragmatic activity near the heart. To reduce these artifacts, we developed a new process flow, masking on unsmoothed images (MUS), that includes the extraction of the myocardium by masking before smoothing. <i>Methods</i>: This study evaluated the relationships between matrix sizes and distances to the subdiaphragmatic activity using the MUS method compared to conventional methods using a combination of image reconstruction methods (filtered back-projection [FBP] and ordered subset expectation maximization [OSEM]) with or without corrections (attenuation [AC], scatter [SC], and resolution recovery [RR]) using a myocardial phantom. The results were compared for two matrix sizes (pixel sizes) (128×128 [3.3 mm] and 64×64 [6.6 mm]); four subdiaphragmatic activity distances (5, 10, 15, and 20 mm); and three reconstruction methods (FBP without correction; OSEM with RR; and OSEM with AC, SC, and RR). <i>Results</i>: In the conventional method, increasing distance resulted in interference with myocardial perfusion SPECT evaluation however, the artifacts were less apparent when the MUS method was applied. The images converted to 64×64 did not show the same effect as the 128×128 images, even when RR was used. The MUS method was useful for acquisition at 128×128, along with the use of RR in the reconstruction process. <i>Conclusion</i>: MUS mitigated the effects of subdiaphragmatic activity on myocardial perfusion SPECT, particularly combined with 128×128 acquisitions and iterative reconstruction with RR.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"8 1","pages":"30-35"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749759/pdf/8_30.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gateway to a Bright Future","authors":"N. Iguchi","doi":"10.17996/anc.22-002","DOIUrl":"https://doi.org/10.17996/anc.22-002","url":null,"abstract":"","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77227464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for Standardization of Myocardial Perfusion SPECT Imaging 1.0.","authors":"Taku Aoki,&nbsp;Kotatsu Tsuboi,&nbsp;Kazutaka Miki,&nbsp;Kenichi Takenaka,&nbsp;Hiroyuki Tsushima,&nbsp;Akio Nagaki,&nbsp;Keiichi Matsumoto,&nbsp;Kenta Miwa,&nbsp;Kazuaki Mori,&nbsp;Takashi Yamanaga,&nbsp;Masahisa Onoguchi","doi":"10.17996/anc.22-004","DOIUrl":"https://doi.org/10.17996/anc.22-004","url":null,"abstract":"","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"8 1","pages":"91-102"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749746/pdf/8_91.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10419008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}