Annals of nuclear cardiology最新文献

{"title":"Cardiac Amyloidosis, Should We See It from the Side or the Front?","authors":"Takashi Kudo","doi":"10.17996/anc.24-00004","DOIUrl":"10.17996/anc.24-00004","url":null,"abstract":"","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carnitine Administration and ¹²³I-BMIPP Washout Rate in Hemodialysis Patients with Triglyceride Deposit Cardiomyovasculopathy.","authors":"Ken-Ichi Hirano, Keita Kodama, Hideyuki Miyauchi, Yasuyuki Nagasawa, Yusuke Nakano, Masaki Matsunaga, Tetsuya Amano, Kenichi Nakajima","doi":"10.17996/anc.23-00014","DOIUrl":"10.17996/anc.23-00014","url":null,"abstract":"<p><p>Triglyceride deposit cardiomyovasculopathy (TGCV) is an emerging rare heart disease with high mortality, characterized by defective intracellular lipolysis of triglycerides (TG). We developed diagnostic criteria for TGCV, in which low washout rate of BMIPP (BMIPP-WR) is a key factor. The working group of the Japan Society of Nuclear Cardiology recently published practice recommendations for measuring BMIPP-WR. We reported that hemodialysis (HD) patients with TGCV exhibited a markedly higher cardiovascular risk than those without TGCV. Secondary carnitine deficiency is common in patients undergoing HD, as carnitine is removed from the circulation. However, clinical evidence linking carnitine levels to BMIPP-WR is limited. Here we report the effect of L-carnitine administration on the BMIPP-WR in 9 chronic HD patients with TGCV in a retrospective cohort. The mean age at TGCV diagnosis was 59 years. Following standard doses of oral L-carnitine administration, plasma free carnitine levels significantly increased. However, BMIPP-WR was not changed. In normal condition, most BMIPP taken up were esterified/incorporated into TG pool, hydrolyzed by intracellular lipases, and then transported by carnitine shuttle to mitochondria. In TGCV, intracellular TG lipolysis is defective. During the intracellular metabolism of BMIPP, carnitine shuttling occurs downstream of TG lipolysis. Therefore, even when carnitine levels were increased, BMIPP-WR did not change in patients with TGCV who underwent chronic HD. A phase IIb/III clinical trial for TGCV, is underway (jRCT2051210177). Increased awareness of the disease concept of TGCV, along with its diagnostic principles and procedures using BMIPP scintigraphy, is warranted.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Implications of the Washout Phenomenon in Technetium-99m (^99mTc-) Labeled Compounds for Myocardial Perfusion Imaging.","authors":"Yasuyo Taniguchi","doi":"10.17996/anc.24-00010","DOIUrl":"10.17996/anc.24-00010","url":null,"abstract":"<p><p>The technetium (Tc) labeled myocardial perfusion compounds are tracers that have been taken up into myocytes and retained in mitochondria several times, thus reflecting the activity of myocytes at the time of injection. However, under certain conditions, \"reversed redistribution\" is known to occur. This review summarized the unique properties of imaging with the Tc myocardial perfusion tracers.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Generation SPECT Cameras Based on Cadmium-Zinc Telluriide Technology.","authors":"Ichiro Matsunari","doi":"10.17996/anc.24-00011","DOIUrl":"10.17996/anc.24-00011","url":null,"abstract":"<p><p>Despite recent developments in positron emission tomography technology, cardiac single photon emission computed tomography (SPECT) imaging continues to be the main stream of nuclear cardiology because of its high accessibility and wider clinical use. For SPECT imaging, cadmium-zinc telluride (CZT) based detectors have advantages over conventional Anger type detectors with more flexible camera design thanks to the small sized CZT detectors and high contrast imaging because of its high energy resolution. Approximately 15 years ago, CZT-based cardiac SPECT cameras became commercially available, resulting in great success in clinical practice. However, this was just the beginning of the CZT era. To date, CZT-based general purpose whole-body camera and 3 dimensional full-ring SPECT systems have been developed and become commercially available with promising initial results. Although there still are areas to be addressed before wider clinical use, the CZT-based technology may provide significant progresses in nuclear cardiology as new generation SPECT systems. Finally, newer materials for the semiconductor detectors are under investigation or development, suggesting that there will be more developments in cardiac SPECT technology.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update of ¹⁸F-flurpiridaz.","authors":"Naoya Matsumoto","doi":"10.17996/anc.24-00008","DOIUrl":"10.17996/anc.24-00008","url":null,"abstract":"<p><p>The novel positron emission tomography (PET) myocardial perfusion imaging tracer, ¹⁸F-flurpiridaz (flurpiridaz), was discussed in 2023 at the Annals of Nuclear Cardiology. In a Phase III trial in 2020 by Maddahi et al., flurpiridaz demonstrated higher sensitivity (71.9%) than ^99mTc-labeled single photon emission computed tomography (SPECT) (53.7%) for detecting ≥50% coronary artery stenosis but did not meet the non-inferiority criterion in specificity. This led to a second Phase III trial, the AURORA trial, which showed flurpiridaz PET to be more sensitive (80.3%) and not inferior (63.8%) in specificity compared to SPECT. The trial highlighted flurpiridaz's superior diagnostic accuracy, especially in women and obese patients. The tracer's ability to measure coronary blood flowreserve suggests its potential future use in clinical practice, possibly offering more accurate functional ischemia diagnostics and predicting cardiac events. The findings indicate that ¹⁸F-flurpiridaz could be a significant advancement in coronary artery disease diagnosis.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"49-50"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Sympathetic Nerve Function in Patients with Severe Aortic Stenosis Prior and After Transcatheter Aortic Valve Implantation: Evaluation by 5-Year Risk Model.","authors":"Ryuta Egi, Kenji Fukushima, Yohji Matsusaka, Tomohiko Yamane, Akira Seto, Ichiro Matsunari, Yoshie Nakajima, Shintaro Nakano, Ichiei Kuji","doi":"10.17996/anc.23-00008","DOIUrl":"10.17996/anc.23-00008","url":null,"abstract":"<p><p><i>Background</i>: While the non-invasive assessment of cardiac sympathetic nerve dysfunction is readily accessible, its applicability in invasive intervention for structural heart disease has received limited investigation. Our study aimed to clarify the cardiac sympathetic nerve function in patients with severe Aortic stenosis (AS) and its postoperative changes after transcatheter aortic valve implantation (TAVI) using ¹²³I-metaiodobenzylguanidine scintigraphy (MIBG) in combination with 5-year mortality prediction model. <i>Methods</i>: Consecutive 26 patients (83±5ys, male 4) with severe AS who underwent MIBG prior TAVI procedures were retrospectively enrolled. Of those, 15 patients underwent postoperative-follow up MIBG. The early and delayed heart-to-mediastinum ratio (e- and d-H/M), and washout rate (WR) were obtained from MIBG planner imaging. The MIBG 5-year mortality prediction model was employed to compare pre and after TAVI. Cardiac function and wall thickness were evaluated with transthoracic echocardiography. <i>Results</i>: Preoperative e-H/M, d-H/M, and WR were 2.4±0.5, 2.3±0.4, and 29±14% respectively, and WR showed significant correlation to left ventricular ejection fraction (LVEF) and brain natriuretic peptide (BNP) (r=-0.4 and 0.6; p=0.03, and 0.001 for LVEF and BNP, respectively). 102±28 days after TAVI, either H/M or WR did not show significant improvement among enrolled patients (2.5±0.3, 2.3±0.4, and 30±11% for e-, d-H/M, and WR for after TAVI), while the BNP level was significantly reduced (128±691 and 94±194 pg/dl, for pre vs. after, p=0.008). Five patients showed a significant recovery in WR (37.0±13.8 and 28.8±8.5% for pre and post, p=0.04), and left ventricular wall thickness was significantly thinner compared to those who did not recover (15.2±3.2 vs 11.2±2.4, p=0.02; 14.2±2.9 vs 10.8±1.8, p=0.02 for intraventricular septum and posterior wall, respectively). In 5-year prediction risk model, 7 patients showed a significant reduction in mortality risk, and the patients who did not show risk reduction had significantly reduced renal function (eGFR 57.5±18.8 vs. 38.2±11.3 ml/min/1.73m², p=0.03 for recovered vs. not recovered). <i>Conclusion</i>: After a 3-month follow-up after TAVI, diverse response in cardiac MIBG parameters were observed among patients with severe AS, despite successful valve replacement. Cardiac MIBG serves as a non-invasive tool that can comprehensively evaluate and surrogate the severity of heart failure resulting from a multi-factorial condition.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"6-15"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral Planar Imaging of ^99mTc-pyrophosphate Scintigraphy in Patients with Suspected Transthyretin Cardiac Amyloidosis.","authors":"Toshinori Saitou, Tadao Aikawa, Osamu Manabe, Shinichiro Fujimoto, Yuya Matsue, Atsushi Nagase, Hiroaki Toyama, Tamaki Kudo, Noriko Oyama-Manabe, Tohru Minamino","doi":"10.17996/anc.24-00002","DOIUrl":"10.17996/anc.24-00002","url":null,"abstract":"<p><p><i>Background</i>: Lateral planar ^99mTc-pyrophosphate (PYP) imaging is recommended as a standardized acquisition method because it helps separate extracardiac uptake from the myocardium. We evaluated its discriminatory performance in detecting myocardial PYP uptake, using single-photon emission computed tomography (SPECT) as a reference standard. <i>Methods</i>: We retrospectively evaluated 170 patients who underwent PYP imaging for suspected transthyretin cardiac amyloidosis. Anterior and lateral planar imaging and SPECT were performed 3 h after PYP administration. The myocardial PYP uptake on planar and SPECT images was visually assessed and quantified using the heart-to-contralateral lung uptake (H/CL) ratio. The heart-to-mediastinum uptake (H/M) ratio was calculated as the mean count of the region of interest in the heart divided by that in the superior mediastinum on lateral planar images. <i>Results</i>: Patients with PYP SPECT-positive results had significantly higher H/M ratios at 3 h than those with PYP SPECT-negative results (1.23 [interquartile range: IQR, 1.15-1.43] vs. 1.08 [IQR, 1.02-1.16]; <i>P</i><0.001). A reclassification analysis that added the H/M ratio to visual scores for detecting positive PYP SPECT yielded a significant improvement with a net reclassification improvement (NRI) of 0.56 (95%CI, 0.25-0.87; <i>P</i><0.001) and integrated discrimination improvement (IDI) of 0.038 (95%CI, 0.005-0.072; <i>P</i>=0.026). The H/M ratio significantly improved the predictive ability of SPECT findings based on the visual scores and H/CL ratio with an NRI of 0.49 (95%CI, 0.18-0.81; <i>P</i>=0.003) and IDI of 0.036 (95%CI, 0.004-0.069; <i>P</i>=0.029). <i>Conclusions</i>: Adding the H/M ratio derived from lateral planar PYP imaging to visual scores or the H/CL ratio on anterior planar images improved the accuracy of detecting significant myocardial uptake on SPECT.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Quantitative Diagnostic Method Using ^99mTc-pyrophosphate Lateral Planar Images to Distinguish Between Transthyretin Amyloid Cardiomyopathy and False-Positive Images Due to Blood Pools.","authors":"Junko Hara, Shiro Ishii, Honami Kobiyama, Kenji Fukushima, Natsumi Kawamoto, Ryo Yamakuni, Hiroki Suenaga, Yuuki Muto, Shigeyasu Sugawara, Akihiko Sato, Masayoshi Oikawa, Yasuchika Takeishi, Hiroshi Ito","doi":"10.17996/anc.24-00001","DOIUrl":"10.17996/anc.24-00001","url":null,"abstract":"<p><p><i>Background</i>: This study investigated the feasibility of using a quantitative diagnostic method based on ^99mTc-pyrophosphate scintigraphy (PYP) lateral planar images to differentiate between PYP-positive (myocardial uptake) and false-positive (blood pool uptake) scans. <i>Methods</i>: The study included 93 consecutive patients with suspected transthyretin amyloid cardiomyopathy (ATTR-CM) who underwent PYP between April 2022 and December 2023. Patients were categorized using planar anterior PYP images according to the Perugini visual grading system; patients with grades ≥ 2 were analyzed. Whether the uptake of the ventricle was in the blood pool or the myocardium was confirmed by transaxial single-photon emission tomography (SPECT). The heart-to-mediastinum ratios (H/M ratio) of the left lateral planar images at 1- and 3-h were calculated by placing a circular region of interest in the heart and cephalodorsal side of the heart to determine optimal cut-off values. <i>Results</i>: Among the PYP images, the study analyzed 15 positives diagnosed as ATTR-CM and 10 false positives. Significant differences were observed in the H/M ratio at 1- and 3-h (both <i>p</i><0.01), with 100% sensitivity and specificity using cut-off values of 1.22 and 1.21 at 1- and 3-h, respectively. The interclass correlation coefficients (2, 1) between the two readers were 0.919 and 0.958 for the 1- and 3-h H/M ratios, respectively. <i>Conclusions</i>: Lateral planar PYP imaging can exclude PYP false-positive cases caused by blood pools in a simple and quantitative manner using only a 1-h planar image, possibly obviating the need for SPECT imaging.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"True Opinions of Nuclear Cardiology Practitioners on Semiconductor SPECT Systems: A Multi-Center Survey-Based Review.","authors":"Emi Tateishi","doi":"10.17996/anc.24-00009","DOIUrl":"10.17996/anc.24-00009","url":null,"abstract":"<p><p>Nuclear cardiac imaging has advanced significantly with the development of semiconductor single photon emission computed tomography (SPECT) systems using cadmium zinc telluride detectors. These systems provide superior sensitivity and resolution compared to conventional anger-type SPECT systems, improving image quality and diagnostic accuracy. This study, conducted through a multi-center survey among nuclear cardiology practitioners, assessed changes in clinical practice following the implementation of semiconductor SPECT. Results showed shorter scan times, increased examination throughput, and reduced artifacts. However, challenges associated with semiconductor SPECT systems were also identified, including system-specific artifacts and cases that are difficult to image using these systems. These findings highlighted both the advantages and limitations of semiconductor SPECT in real-world clinical practice.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"10 1","pages":"51-54"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice Recommendation for Measuring Washout Rates in &lt;sup&gt;123&lt;/sup&gt;I-BMIPP Fatty Acid Images","authors":"Kenichi Nakajima, Hideyuki Miyauchi, Ken-ichi Hirano, Shinichiro Fujimoto, Michitomo Kawahito, Takashi Iimori, Takashi Kudo","doi":"10.17996/anc.23-00005","DOIUrl":"https://doi.org/10.17996/anc.23-00005","url":null,"abstract":"The purpose of this practice recommendation is to specifically identify the critical steps involved in performing and interpreting 123I-β-methyl-iodophenyl-pentadecanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and measurement of washout rate (WR) from the heart. This document will cover backgrounds, patient preparation, testing procedure, visual image interpretation, quantitation methods using planar and SPECT studies, and reporting of WR. The pitfall and some tips for the calculation of 123I-BMIPP WR are also included. The targets of global and regional WR calculation include ischemic heart disease, cardiomyopathy, heart failure, and triglyceride deposit cardiomyovasculopathy, an emerging rare heart disease.","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}