Annals of blood最新文献_第7页

Immunoserologic and hemotherapy considerations in patients undergoing hematopoietic progenitor cell transplantation 造血祖细胞移植患者的免疫血清学和血液治疗注意事项

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-86

Sajjad Hassan, Chester Andrzejewski Jr

{"title":"Immunoserologic and hemotherapy considerations in patients undergoing hematopoietic progenitor cell transplantation","authors":"Sajjad Hassan, Chester Andrzejewski Jr","doi":"10.21037/aob-21-86","DOIUrl":"https://doi.org/10.21037/aob-21-86","url":null,"abstract":"With increasing evidence of the success of hematopoietic progenitor cell (HPC) transplantation in the cure of many benign and malignant diseases, such interventions have been performed at increasing rates for the past several years. Due to myelosuppression caused by the conditioning and graft-versus-host disease (GVHD) prophylaxis regimens, blood component transfusions are almost inevitably needed. During transplantation, patient's hematopoietic lineages reconstitute to the HPC donor's progenitor cell types. Therefore, specific immunoserologic and hemotherapeutic aspects need to be considered for the selection of blood components during different phases of transplantation for successful outcomes. Those considerations include but are not limited to ABO and human leucocyte antigen (HLA) compatibility of the transfused blood components with either or both the patient and the HPC donor according to the particular phase of transplantation, and the special blood component processing to reduce the risk of transfusion associated graft-versus-host disease (TA-GVHD), cytomegalovirus (CMV) transmission in CMV seronegative patients and immune mediated platelets refractoriness. Complications may still arise, particularly in major, minor, or bidirectional ABO mismatched transplantations and/or due to the HLA mismatch and alloimmunization. Here we discuss the indications, immunoserologic considerations and the special component processing of red blood cells (RBCs), platelets, granulocytes, and plasma transfusions, based upon the current evidence and describe the prevention and management of salient, pertinent complications.Copyright © 2022 The authors.","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48875680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrids and microconversions in RH genes: investigation and implication in transfusion therapy RH基因的杂交和微转化:研究及其在输血治疗中的意义

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-55

Y. Fichou

引用次数: 0

γδ T cells and their roles in immunotherapy: a narrative review γδT细胞及其在免疫治疗中的作用

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-33

Yuyuan Chen, Jiawei Li, Xujia Zeng, Wenhui Yuan, Yan Xu

{"title":"γδ T cells and their roles in immunotherapy: a narrative review","authors":"Yuyuan Chen, Jiawei Li, Xujia Zeng, Wenhui Yuan, Yan Xu","doi":"10.21037/aob-21-33","DOIUrl":"https://doi.org/10.21037/aob-21-33","url":null,"abstract":"Objective: In order to understand the activation mechanism of γδ T cells and their role in tumor immunity and autoimmune diseases. Background: γδ T cells are a conserved population of natural lymphocytes with a variety of structural and functional heterogeneities, accounting for approximately 0.5% to 10% of total peripheral blood lymphocytes in healthy adults. As a “bridge” between innate and acquired immunity, they have an important role in tumor surveillance. Methods: γδ T cells are considered to be effective anti-tumor effector cells, which can kill tumor cells through direct and indirect methods; γδ T cells can secrete a variety of cytokines, such as tumor necrosis factor α (TNF- α ), γ -interferon (IFN- γ ), perforin, etc., thus, they own the ability to kill tumor cells directly, and can also regulate other innate and adaptive immune cells, and then achieve the purpose of indirectly killing tumor cells, thereby establishing anti-tumor immunity. A unique feature of γδ T cells is that they recognize antigens in a non-major histocompatibility complex (MHC)-restricted manner, and they have strong cytotoxicity to a variety of cancer cells, which make them have important clinical application value. Conclusions: In this review, we provide an overview of the activation mechanisms of γδ T cells and their role in tumor immunity and autoimmune diseases. These studies provide insights into γδ T cell function to facilitate more targeted approaches for tumor therapy.","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48808774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface to special series—transfusion therapy: principles and practices 输血疗法:原则与实践

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-2021-05

P. Mintz

引用次数: 0

Cryopreserved platelets: a narrative review of its current role in transfusion therapy 低温保存血小板在输血治疗中的作用综述

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-31

M. Lozano, J. Cid

{"title":"Cryopreserved platelets: a narrative review of its current role in transfusion therapy","authors":"M. Lozano, J. Cid","doi":"10.21037/aob-21-31","DOIUrl":"https://doi.org/10.21037/aob-21-31","url":null,"abstract":"To review the current role of cryopreserved platelets (CPP) in transfusion medicine. Background: The short shelf life of platelet concentrates (PCs) provokes logistic problems in providing timely PC transfusions during long holiday periods when long or major transportation barriers exists (severe weather, military operations…) or for patients highly alloimmunized by HLA/HPA antibodies. In the European Union the only approved strategy authorized to circumvent the limited storage time of PCs is the cryopreservation using 6% dimethyl sulfoxide (DMSO), at temperature of –80 ℃ or below. Methods: A review of articles referenced in PubMed published in English before 2020 studying the effect of cryopreservation on platelets in vivo and in vitro was performed. Conclusions: Using in vitro techniques available to characterize platelets, significant changes in the structure and function of CPP after thawing are detected. The changes detected suggest that cryopreservation provokes an increase in the procoagulant activity of platelets. However, in vivo studies in healthy volunteers and in patients, have shown the efficacy and safety of the transfusion of CPP in different clinical scenarios. Nevertheless, its current use is limited to situations where liquid stored platelets is not available mainly in military operations, for patients with complex HLA/HPA alloimmunization or for patients with massive bleeding.","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45498284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Considerations on terminology and database organization for blood group genotyping data 血型基因分型数据的术语和数据库组织的思考

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-42

F. Wagner

引用次数: 0

Impact of RHCE variability and complexity in transfusion medicine: a narrative review 输血医学中RHCE变异性和复杂性的影响:一篇叙述性综述

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-76

Emilia Sippert, C. Arnoni, M. Rios

引用次数: 1

Transfusion-transmitted infections Transfusion-transmitted感染

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-60

E. Bloch

{"title":"Transfusion-transmitted infections","authors":"E. Bloch","doi":"10.21037/aob-21-60","DOIUrl":"https://doi.org/10.21037/aob-21-60","url":null,"abstract":"Blood transfusion is remarkably safe in high-income countries (HICs), where safeguards have long protected the blood supply against the major transfusion transmissible infections (TTIs). Globally, surprisingly few pathogens have been implicated in transfusion transmitted infection and most pathogens do not merit specific intervention. Nonetheless, pathogens are emerging much more frequently than is often appreciated, thus necessitating constant vigilance and individual assessment of transfusion-associated risk. Factors that inform the need for intervention include the ramifications (i.e., severity) of infection with a given pathogen, the likelihood of detection in the absence of a defined intervention, tolerance of standard processing and storage conditions (e.g., refrigeration), transfusion transmissibility and clinical penetrance (i.e., development of symptoms following transfusion transmission). Different approaches that have been used to protect the blood supply include donor selection and risk-based deferral, laboratory screening (i.e., using highly sensitive and specific serological and/or molecular assays), bacterial culture (platelets) and pathogen reduction (PR). Each approach has both strengths as well as limitations, whereby strategies are devised to meet national or regional risk, while balancing available resources. TTIs, as a direct reflection of blood transfusion safety, highlight a World divided. In HICs, hypervigilance is increasingly disproportionate to risk; this has contributed to policies and interventions that have been wasteful, incurring enormous cost at marginal—if any—clinical gain. By contrast, many of the routine measures regarded as effective in HICs are conspicuously deficient or even absent in lowand middle-income countries (LMICs) where blood transfusion thus remains a major mode of disease transmission.","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45668289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Liver failure resolved via corticosteroids plus plasma exchange in a patient with hepatocellular carcinoma receiving nivolumab immunotherapy: case report 一例接受nivolumab免疫治疗的肝细胞癌患者通过皮质类固醇联合血浆置换治疗肝功能衰竭：病例报告

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-65

Yurong Gu, Yufeng Zhang, Yuehua Huang, Yanhua Bi, Zhengran Li, Jia-Qi Zhu

引用次数: 1

Passive transfusion of anti-D: a case report to enhance awareness of donor screening and clinical significance 被动输血抗- d 1例:提高供体筛选意识及临床意义

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-68

Devin R. Allison, Daniel R. Walker, Emily Coberly, Detlef G. Ritter

引用次数: 0