Annals of blood最新文献_第10页

A narrative review of PD-1 and autoimmune diseases PD-1与自身免疫性疾病综述

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/AOB-20-86

Yanan Deng, Feng Huang, Jie Wang

引用次数: 1

Patient blood management—it is about transfusing blood appropriately 患者血液管理——这是关于适当输血

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-70

R. Gammon, Emily Coberly, R. Dubey, Aikaj Jindal, Shaughn Nalezinski, Jessica Varisco

引用次数: 6

A narrative review on progress and development of anti-CD36 antibody detection 综述了抗cd36抗体检测的研究进展

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-48

Xiuzhang Xu, S. Santoso

引用次数: 0

Transfusion therapy in sickle cell disease 镰状细胞病的输血治疗

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-67

Y. Tanhehco, P. Shi, J. Schwartz

引用次数: 1

Molecular genetics of the Rh blood group system: alleles and antibodies—a narrative review Rh血型系统的分子遗传学：等位基因和抗体——叙述性综述

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-20-84

A. Floch

{"title":"Molecular genetics of the Rh blood group system: alleles and antibodies—a narrative review","authors":"A. Floch","doi":"10.21037/aob-20-84","DOIUrl":"https://doi.org/10.21037/aob-20-84","url":null,"abstract":"Objective: This work proposes a review of the antibodies which have been associated with variant RHD and RHCE alleles, except null alleles. Background: The data on this topic is dispersed in the literature. Methods: A review of the articles referenced in PubMed and of abstract books from major conferences was performed. Most antibodies have been published in full-length articles, and several more have been reported in conference abstracts. The anti-D antibodies reported in carriers of D variants and the antibodies to CE antigens reported in carriers of CE variants were listed, including antibodies to low prevalence antigens. The RHCE alleles for which the RH10 (V) and RH20 (VS) phenotypes have been reported were also collected. The reports of antibody formation were compared to the prevalence evaluated by the Erythrogene database in the 1000 Genomes dataset. Conclusions: It is noted in this review that studies reporting anti-D or antibodies to CE antigens associated with Rh variants only rarely include detailed serological descriptions of the findings. This review lists several alleles which are not exceptional, and for which no carrier has been reported to form the antibody to the expressed antigen(s) (e.g., no allo-anti-D has been reported so far in carriers of RHD *01EL.01 , c.1227A). Considering the antibody reports in carriers or absence thereof and the prevalence for each RH allele, it may become possible to propose case-by-case recommendations for more RH alleles in the near future. 20 (RH49)","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49529742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Blood banking in solid organ transplantation 实体器官移植中的血库

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-72

G. Ramsey

{"title":"Blood banking in solid organ transplantation","authors":"G. Ramsey","doi":"10.21037/aob-21-72","DOIUrl":"https://doi.org/10.21037/aob-21-72","url":null,"abstract":"Over 150,000 organ transplants are performed annually worldwide, and transfusion medicine support is crucial for each patient. Liver transplants have posed the greatest challenge for transfusion support, including 4-9% rates of preoperative red blood cell (RBC) alloimmunization, and higher-end blood use is associated with adverse outcomes. However, with effective patient blood management, means/medians of 4-9 allogeneic RBC units per case and 75th percentiles of 7-12 units or lower are reported. Heart or lung transplant RBC transfusions averaged around 3 units, but COVID-19 lung transplants needed a median 8 units (75th percentile 15) due to dense adhesions. Passenger lymphocyte syndrome due to donor anti-A/B induce hemolysis after 6% of ABO-unmatched kidneys, 19% of livers and 29% of intestinal transplants. ABO-incompatible transplants are achieved by desensitization, A subgroup organs, or tolerance in infants. However, interlaboratory reproducibility of anti-A/B titers in these patients remains problematic. ABH structures are predominantly type 2 in RBCs and hearts, type 4 in kidneys and secretor-dependent type 1 in liver bile ducts and arteries. These anatomic differences suggest that anti-A/B assessments and therapeutic adsorptions might be improved by using organ-tailored ABH glycans. Therapeutic plasma exchange (TPE) and extracorporeal photopheresis (ECP) are widely employed for antibody removal and rejection treatment. As organ transplantation expands globally, transfusion medicine will continue to be integral to patient care. © 2022 AME Publishing Company. All Rights Reserved.","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41970550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bacterial culture of platelets with the large volume delayed sampling approach: a narrative review 血小板细菌培养与大容量延迟采样方法:叙述性回顾

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/AOB-21-4

G. Delage

{"title":"Bacterial culture of platelets with the large volume delayed sampling approach: a narrative review","authors":"G. Delage","doi":"10.21037/AOB-21-4","DOIUrl":"https://doi.org/10.21037/AOB-21-4","url":null,"abstract":"Bacterial contamination of platelets leading to post-transfusion sepsis (PTS) represents a significant risk to patients, even in the era of bacterial culture using a sample obtained 24 hours postcollection and inoculated into a single blood culture bottle. Various approaches are available for mitigation of this risk, one of which is large volume delayed sampling (LVDS) culture. LVDS aims to increase detection of contaminated platelets compared to 24-hour, single aerobic bottle culture by increasing the sample volume in order to inoculate two or more blood culture bottles, and increasing the delay before sampling, thus allowing additional time for bacteria present in a contaminated platelet product to multiply before sampling. Three establishments have implemented LVDS as their strategy for enhancing safety of platelets. Their collective experience points to a reduction in the residual risk of PTS following transfusion of contaminated platelets when compared to historical data. LVDS as a strategy to enhance platelet safety has the advantage of simplicity when compared to various two-step approaches that involve an early culture followed by either re-culture or rapid testing. With a seven-day shelf-life, LVDS leads to decreased platelet outdates when compared to 24-hour single bottle culture with a five-day shelf-life, and an increased age of platelets at","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43285086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Correlation analyses between age and indices in routine blood laboratory tests suggest potential aging biomarkers 年龄与常规血液实验室检测指标之间的相关性分析提示潜在的衰老生物标志物

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-20-79

Menghan Sun, Xinpeng He, Lipeng Mao, Tengyu Ma, Jieping Deng, L. Gao, Pengcheng Wang, Guobing Chen

{"title":"Correlation analyses between age and indices in routine blood laboratory tests suggest potential aging biomarkers","authors":"Menghan Sun, Xinpeng He, Lipeng Mao, Tengyu Ma, Jieping Deng, L. Gao, Pengcheng Wang, Guobing Chen","doi":"10.21037/aob-20-79","DOIUrl":"https://doi.org/10.21037/aob-20-79","url":null,"abstract":"Background: Aging, especially its related immune senescence, is an important risk factor for many diseases, including neurodegenerative diseases, cardiovascular diseases and tumors. One major hurdle to study aging is the lack of a comprehensive set of biomarkers to evaluate and predict the progress of aging. The biomarkers for immune senescence are crucial for effective vaccination and optimal immunotherapy. Methods: In this study, to identify potential biomarkers linked to aging from routine blood laboratory tests, we analyzed the correlations between aging and indices in peripheral blood cell population, cytokines, Complete Blood Count and Blood Chemistry panel. Furthermore, we analyzed the differences of immune cells and inflammatory cytokines among different age groups. In addition, differential gene expression was evaluated by using whole transcriptome data of 258 samples, which was subsequently used for pathway analysis. Results: Our results showed significant correlations between some of the indices with aging, and some were also associated with genders and ethnics. Transitional B Cells were negatively correlated with aging, and several cytokines, including CCL22, CXCL9, IL21, IL23A and IL31, were related to aging as well. In addition, we found several genes associated with aging, including SERPINA1 , ORM2 , MS4A1 , ETS1 , CD27 and IL7R . Conclusions: Our study demonstrated that changes of a couple of indices from routine blood laboratory tests and gene expression had correlation to aging, and these could potentially be used as biomarkers of aging.","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48020651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular genetics and genomics of the ABO blood group system ABO血型系统的分子遗传学和基因组学

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/AOB-20-71

F. Yamamoto

{"title":"Molecular genetics and genomics of the ABO blood group system","authors":"F. Yamamoto","doi":"10.21037/AOB-20-71","DOIUrl":"https://doi.org/10.21037/AOB-20-71","url":null,"abstract":"The A and B oligosaccharide antigens of the ABO blood group system are produced from the common precursor, H substance, by enzymatic reactions catalyzed by A and B glycosyltransferases (AT and BT) encoded by functional A and B alleles at the ABO genetic locus, respectively. In 1990, my research team cloned human A, B, and O allelic cDNAs. We then demonstrated this central dogma of ABO and opened a new era of molecular genetics. We identified four amino acid substitutions between AT and BT and inactivating mutations in the O alleles, clarifying the allelic basis of ABO. We became the first to achieve successful ABO genotyping, discriminating between AA and AO genotypes and between BB and BO, which was impossible using immunohematological/serological methods. We also identified mutations in several subgroup alleles and also in the cis-AB and B(A) alleles that specify the expression of the A and B antigens by single alleles. Later, other scientists interested in the ABO system characterized many additional ABO alleles. However, the situation has changed drastically in the last decade, due to rapid advances in next-generation sequencing (NGS) technology, which has allowed the sequencing of several thousand genes and even the entire genome in individual experiments. Genome sequencing has revealed not only the exome but also transcription/translation regulatory elements. RNA sequencing determines which genes and spliced transcripts are expressed. Because more than 500,000 human genomes have been sequenced and deposited in sequence databases, bioinformaticians can retrieve and analyze this data without generating it. Now, in this era of genomics, we can harness the vast sequence information to unravel the molecular mechanisms responsible for important biological phenomena associated with the ABO polymorphism. Two examples are presented in this review: the delineation of the ABO gene evolution in a variety of species and the association of single nucleotide variant (SNV) sites in the ABO gene with diseases and biological parameters through genome-wide association studies (GWAS).Copyright © Annals of Blood. All rights reserved.","PeriodicalId":72211,"journal":{"name":"Annals of blood","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48238695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A narrative review on platelet rich plasma: hope or hype? 关于富含血小板血浆的叙述性综述：希望还是炒作？

Annals of blood Pub Date : 2021-01-01 DOI: 10.21037/aob-21-57

Reena Yaman, T. Kinard

引用次数: 4