Andes pediatrica : revista Chilena de pediatria最新文献_第5页

[Severe atopic dermatitis in childhood in the era of personalized medicine]. [个性化医疗时代的儿童严重特应性皮炎]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.5049

Rosario Agüero Ureta, Edinson López Bravo, Maria Trinidad Hasbún Zegpi

{"title":"[Severe atopic dermatitis in childhood in the era of personalized medicine].","authors":"Rosario Agüero Ureta, Edinson López Bravo, Maria Trinidad Hasbún Zegpi","doi":"10.32641/andespediatr.v95i3.5049","DOIUrl":"10.32641/andespediatr.v95i3.5049","url":null,"abstract":"Atopic dermatitis (AD) is a chronic, non-infectious inflammatory dermatosis, with increasing prevalence in recent decades. Due to its chronic and recurrent nature, it diminishes the quality of life of patients and their families. In recent years, advances in the understanding of AD's pathophysiology have driven the development of targeted therapies such as monoclonal antibodies (mAbs) and Janus kinase inhibitors (JAKis) which modulate the immune system through specific signaling pathways, providing effective alternatives to traditional systemic immunosuppressive agents. Four targeted therapies have been approved in the USA for the treatment of severe/refractory cases: dupilumab, tralokinumab, abrocitinib, and upadacitinib. This manuscript aims to present an update on the pathophysiology of AD, describe the new treatments available, and provide an analysis of the initial results of the use of these treatments in the pediatric population. We concluded that the high cost of these treatments often limits their prescription to situations where cases of atopic dermatitis are resistant to other conventional therapeutic options or when the disease reaches a severe degree. This underscores the importance of careful and accurate decision-making in the medical management of AD to ensure the efficient use of these therapeutic resources.","PeriodicalId":72196,"journal":{"name":"Andes pediatrica : revista Chilena de pediatria","volume":"95 3","pages":"236-243"},"PeriodicalIF":0.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Solitary splenic neoplasm as an unusual presentation in an adolescent with sporadic Burkitt lymphoma]. [患有散发性伯基特淋巴瘤的青少年中出现异常表现的孤立性脾肿瘤]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 Epub Date: 2024-04-14 DOI: 10.32641/andespediatr.v95i3.4824

Carlos Julian Diaz-Torres, Ricardo Abanto Hinostroza

{"title":"[Solitary splenic neoplasm as an unusual presentation in an adolescent with sporadic Burkitt lymphoma].","authors":"Carlos Julian Diaz-Torres, Ricardo Abanto Hinostroza","doi":"10.32641/andespediatr.v95i3.4824","DOIUrl":"10.32641/andespediatr.v95i3.4824","url":null,"abstract":"Burkitt lymphoma is a non-Hodgkin B-cell lymphoma with a high prevalence in the pediatric population. Abdominal manifestations are well known in sporadic Burkitt lymphoma and vary from nonspecific symptoms to intestinal obstruction due to intussusception; however, mass-like splenic involvement has been scarcely described.Objective: To present a case of a patient with a splenic mass whose histopathological analysis revealed Burkitt lymphoma.Clinical case: A 13-year-old female patient presented with abdominal pain, progressive weight loss, and fever. Imaging studies showed a splenic mass, intestinal thickening, and ileal intussusception. Histopathological analysis of spleen biopsy revealed Burkitt lymphoma. After the first cycle of chemotherapy (BFM95-NHL protocol), abdominal symptoms resolved; no other signs suggestive of intussusception were observed, as well as a significant reduction of the splenic mass was observed.Conclusions: Burkitt lymphoma in pediatric patients can present as a well-defined splenic tumor, causing no splenomegaly. In addition, its management does not require surgery since it can be resolved with chemotherapy.","PeriodicalId":72196,"journal":{"name":"Andes pediatrica : revista Chilena de pediatria","volume":"95 3","pages":"297-302"},"PeriodicalIF":0.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Congenital Central Hypoventilation Syndrome: neonatal diagnosis and management]. [先天性中枢通气不足综合征：新生儿诊断与管理]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.5044

Monserrat Valdés Carrillo, Marcela Diaz Caamaño, Francisco Prado Atlagic, Antonio Huerta Armijo, Mirna García Mora, Alejandra Hernandez Gómez, Romina D Alessandri Demelchiore

{"title":"[Congenital Central Hypoventilation Syndrome: neonatal diagnosis and management].","authors":"Monserrat Valdés Carrillo, Marcela Diaz Caamaño, Francisco Prado Atlagic, Antonio Huerta Armijo, Mirna García Mora, Alejandra Hernandez Gómez, Romina D Alessandri Demelchiore","doi":"10.32641/andespediatr.v95i3.5044","DOIUrl":"10.32641/andespediatr.v95i3.5044","url":null,"abstract":"Congenital Central Hypoventilation Syndrome (CCHS) is a rare genetic condition affecting the autonomic nervous system and respiratory center due to mutations in the PHOX2B gene, and it is associated with alveolar hypoventilation during sleep and sudden death. It requires early invasive mechanical ventilation (IMV).Objective: To report a neonatal case successfully treated with non-invasive ventilatory support (NVS), avoiding tracheostomy.Clinical case: Full-term newborn, whose mother uses nocturnal NVS due to CCHS. During the transition period, she presented desaturations associated with hypercapnia and respiratory acidosis, without pulmonary involvement. She developed severe hypoventilation during sleep, with no respiratory effort, peripheral oxygen saturation (SpO2) < 80%, plus respiratory acidosis. While awake, she had good respiratory effort and normal SpO2 without assistance. Noninvasive continuous positive airway pressure and oxygen therapy worsened her condition while sleeping. Complete NVS with nasal interface and bi-level airway positive pressure, inspiratory/expiratory pressure 14-16/4 cm H2O, normalized SpO2 during sleep, and arterial blood gases while awake. Sequencing of the PHOX2B gene confirmed the presence of a heterozygous pathogenic variant with the 20/26 genotype. At 2 months of age, she was discharged maintaining NVS with nasal interface and 0 PEEP, achieving adequate neurodevelopment.Conclusion: We highlight the importance of genetic diagnosis of CCHS in neonates with clinical presentation of early alveolar hypoventilation, especially if there is a family history. We are not aware of other reports of neonatal onset in which NVS prevents IMV, in this potentially lethal pathology.","PeriodicalId":72196,"journal":{"name":"Andes pediatrica : revista Chilena de pediatria","volume":"95 3","pages":"303-308"},"PeriodicalIF":0.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Dr. Eloísa Díaz Insunza (1866-1950) and the comprehensive health of Chilean schoolchildren]. [Eloísa Díaz Insunza 博士（1866-1950 年）与智利学童的全面健康】。］

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.5207

Alejandro Donoso Fuentes

引用次数: 0

[Response to the letter to editor entitled: Prevalence of asthma and associated risk factors in schoolchildren from an area of indigenous peoples]. [对题为 "原住民地区学龄儿童哮喘发病率及相关风险因素 "的致编辑信的回复]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.5202

Myriam Betancourt Astete, Juan Andrés Navarro R

引用次数: 0

[Strategie of the "acute respiratory disease room" in two tertiary referral clinics: a retrospective multicenter cohort study]. [两家三级转诊诊所的 "急性呼吸道疾病室 "战略：一项回顾性多中心队列研究]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.4942

Janneth Milena Avendafto-Vanegas, Alix Viviana García Arias, Henry Mauricio Parada Gereda, Maria Andrea Jaramillo Portella, Ricardo Alfonso Merchán Chaverra, Jorge Medina Parra

{"title":"[Strategie of the \"acute respiratory disease room\" in two tertiary referral clinics: a retrospective multicenter cohort study].","authors":"Janneth Milena Avendafto-Vanegas, Alix Viviana García Arias, Henry Mauricio Parada Gereda, Maria Andrea Jaramillo Portella, Ricardo Alfonso Merchán Chaverra, Jorge Medina Parra","doi":"10.32641/andespediatr.v95i3.4942","DOIUrl":"10.32641/andespediatr.v95i3.4942","url":null,"abstract":"Respiratory diseases are one of the main causes of morbidity and mortality in children under 5 years of age. The acute respiratory disease (ERA in Spanish) room strategy implemented in Colombia is an important tool to reduce hospitalization and mortality rates in this population.Objective: To describe the health outcomes of the implementation of the ERA room strategy in two health institutions in Bogota.Patients and method: Multicenter descriptive study including 1785 patients admitted to the ERA rooms of two institutions in Bogota, between December 2019 and 2022. Data on sex, age, admission diagnosis, length of stay in ERA room, education provided, and post discharge follow-up were collected. The main outcomes were evaluated through hospitalization requirement, ICU requirement, and post discharge improvement.Results: 1785 patients were included during the study period. 57% were male; median age was 26.6 months (IQR: 11.8 to 40.6); length of stay in ERA room was 2.62 hours (IQR: 1.73 to 4.88); 91.65% of family members and/or caregivers received educational measures.Conclusions: This study describes the results of the implementation of the ERA room strategy; the low proportion of patients requiring hospitalization is evident. Additionally, the education provided to parents and caregivers on home management is relevant, as well as the post discharge follow-up of this cohort of patients with acute respiratory disease.","PeriodicalId":72196,"journal":{"name":"Andes pediatrica : revista Chilena de pediatria","volume":"95 3","pages":"279-286"},"PeriodicalIF":0.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Isometric muscle torque in Chilean children and adolescents evaluated by manual maintenance dynamometry: a reliability study]. [智利儿童和青少年的等长肌肉扭矩：可靠性研究]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.4956

Ivonne Jorquera-Cáceres, Danayra Vega-Arriagada, Dannae Núñez-González, Eduardo Guzmán-Muñoz, Marcelo Castillo-Retamal, Tuillang Yuing-Farias, Francisco José Berral de la Rosa, Guillermo Mendez-Rebolledo

{"title":"[Isometric muscle torque in Chilean children and adolescents evaluated by manual maintenance dynamometry: a reliability study].","authors":"Ivonne Jorquera-Cáceres, Danayra Vega-Arriagada, Dannae Núñez-González, Eduardo Guzmán-Muñoz, Marcelo Castillo-Retamal, Tuillang Yuing-Farias, Francisco José Berral de la Rosa, Guillermo Mendez-Rebolledo","doi":"10.32641/andespediatr.v95i3.4956","DOIUrl":"https://doi.org/10.32641/andespediatr.v95i3.4956","url":null,"abstract":"The measurement of isometric muscle torque with hand-held dynamometry is a technique little studied in the pediatric setting for the evaluation of maximal isometric muscle strength.Objective: to determine the reliability of hand-held dynamometry to obtain the maximal isometric torque of upper and lower limb muscle groups in Chilean children and adolescents.Patients and methods: Crosssectional study. Seventy-two participants aged between 7 and 15 years were selected from a school in Talca. Maximal isometric torque was recorded in 15 muscle groups of upper and lower limbs through hand-held dynamometry. Intra- and inter-rater evaluation was used, applying the intraclass correlation coefficient (ICC) to determine the reliability of the tests and Bland-Altman plots to evaluate concordance.Results: The results demonstrated good to excellent inter-rater reliability (ICC = 0.850.98) and intra-rater reliability (ICC = 0.87-0.98). Only two groups, hip extensors and abductors, showed good inter-rater reliability (ICC = 0.85 and ICC = 0.88, respectively); and one group, the ankle dorsiflexors, showed good intra-rater reliability (ICC = 0.87). 100% of the tests presented at least 95.8% inter- and intra-rater agreement on the Bland-Altman plots.Conclusion: The evaluation of isometric muscle torque using hand-held dynamometry is a reliable procedure for use in different growth periods.","PeriodicalId":72196,"journal":{"name":"Andes pediatrica : revista Chilena de pediatria","volume":"95 3","pages":"252-262"},"PeriodicalIF":0.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Narrative medicine in pediatric: teaching and practice]. [儿科叙事医学：教学与实践]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.5083

Pamela Jofré, Rodrigo Vergara

引用次数: 0

[Virtual reality in the outpatient: reducing anxiety and fear in venous puncture]. [门诊中的虚拟现实：减少静脉穿刺中的焦虑和恐惧]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.5114

Begoña Pérez-Moneo, Marta Gayo Bellido, Estefanía Barral Mena, Ma Ángeles Pérez-Moneo Agapito, Laura Correyero García, Raquel Baños Fuerte

{"title":"[Virtual reality in the outpatient: reducing anxiety and fear in venous puncture].","authors":"Begoña Pérez-Moneo, Marta Gayo Bellido, Estefanía Barral Mena, Ma Ángeles Pérez-Moneo Agapito, Laura Correyero García, Raquel Baños Fuerte","doi":"10.32641/andespediatr.v95i3.5114","DOIUrl":"10.32641/andespediatr.v95i3.5114","url":null,"abstract":"Up to 80% of children admitted to a hospital experience pain, mainly associated with venipuncture.Objective: To analyze whether the use of virtual reality (VR) headsets during venipuncture can modify the perception of pain, anxiety, and fear in pediatrics.Patients and method: Open label, randomized clinical trial. The presence of intellectual, visual, or hearing impairment were considered exclusion criteria. Two anxiety and fear scales were administered before and after the procedure, and the Wong-Baker face pain scale at the end. The following were recorded: number of venipuncture attempts, duration of the procedure, and side effects.Results: 78 patients were included, 38 males and a mean age of 9.63 years. In the intervention group, the mean pain value was 2.87, with a mean difference (MD) of -0.85 compared with the control one (95% confidence interval (CI) -2.02 to 0.33). There was a significant reduction in the level of anxiety and fear, with MDs of -2.59 (95%CI: -3.92 to -1.26) and -0.85 points (95%CI: -1.45 to -0.24), respectively.Conclusions: the use of VR headsets in venipuncture in hospital daytime care decreases the level of anxiety and fear in children and seems to reduce pain, without adverse effects. The venipuncture procedure has the same success rate and does not increase its duration.","PeriodicalId":72196,"journal":{"name":"Andes pediatrica : revista Chilena de pediatria","volume":"95 3","pages":"272-278"},"PeriodicalIF":0.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Impact of buried versus exposed flexible intramedullary nails osteosynthesis on pediatric forearm fractures]. [埋入式与外露式柔性髓内钉接骨术对小儿前臂骨折的影响]。

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Andes pediatrica : revista Chilena de pediatria Pub Date : 2024-06-01 DOI: 10.32641/andespediatr.v95i3.4926

Abdulrahim Dündar, Sehmuz Kaya

{"title":"[Impact of buried versus exposed flexible intramedullary nails osteosynthesis on pediatric forearm fractures].","authors":"Abdulrahim Dündar, Sehmuz Kaya","doi":"10.32641/andespediatr.v95i3.4926","DOIUrl":"https://doi.org/10.32641/andespediatr.v95i3.4926","url":null,"abstract":"In elastic stable intramedullary nailing (ESIN), there are different opinions among surgeons on whether to leave the nail buried in the same arm or to leave it exposed.Objective: To determine the risk of re-fracture in patients with a nail buried directly into the amr or left exposed as a treatment for forearm fractures, and to investigate postoperative complications.Patients and method: The study included 113 pediatric patients with a forearm fracture of both diaphyses. Two groups were formed according to whether the nail was buried (Group B, n: 53) in the same arm or left exposed (Group E, n: 60). Data on the number of open reductions, the time to nail removal, the anesthesia type used for its removal, the number of re-fractures, skin infection, and nail entry site irritation were analyzed.Results: The mean union times between the groups were not significantly different (P = 0.371). The mean time of nail removal in group B (16.02 ± 1.29 weeks) was significantly longer than that of group E (6.65 ± 0.95 weeks) (P < 0.001). Open reduction rates were similar between groups (P = 0.401). The general anesthesia rate for nail removal in group B (77.4%) was significantly higher than group E (11.7%) (P < 0.001). The re-fracture rate was higher in patients who underwent open reduction in both groups (P < 0.001).Conclusion: The results of this study demonstrated that, despite the increased infection rate, leaving the nail exposed did not increase the re-fracture rate, which was associated with open reduction.","PeriodicalId":72196,"journal":{"name":"Andes pediatrica : revista Chilena de pediatria","volume":"95 3","pages":"263-271"},"PeriodicalIF":0.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0