American heart journal plus : cardiology research and practice最新文献

{"title":"Myocardial biomarkers in coronary microvascular dysfunction: Response to ranolazine","authors":"Katherine E. Hampilos ,&nbsp;Anum Asif ,&nbsp;Puja K. Mehta ,&nbsp;Daniel S. Berman ,&nbsp;Galen Cook-Wiens ,&nbsp;Michael D. Nelson ,&nbsp;Carl J. Pepine ,&nbsp;C. Noel Bairey Merz ,&nbsp;Janet Wei","doi":"10.1016/j.ahjo.2025.100513","DOIUrl":"10.1016/j.ahjo.2025.100513","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with coronary microvascular dysfunction (CMD) are at increased risk of developing heart failure with preserved ejection fraction (HFpEF). We hypothesized that higher myocardial biomarkers (ultra-high sensitivity cardiac troponin I [u-hs-TnI]) and ventricular dysfunction (N-terminal pro-BNP [NT-proBNP]) would be related to greater ischemia improvement on the late sodium channel inhibitor ranolazine.</div></div><div><h3>Methods</h3><div>We analyzed CMD participants with baseline myocardial biomarkers randomized to ranolazine or placebo (RWISE trial: <span><span>NCT01342029</span><svg><path></path></svg></span>). Ischemia response was change in global myocardial perfusion reserve index (∆MPRI) or Seattle Angina Questionnaire (∆SAQ).</div></div><div><h3>Results</h3><div>Among 64 randomized participants with u-hs-TnI and 40 with NT-proBNP, higher u-hs-TnI related to improved ∆MPRI (<em>r</em> = 0.26, <em>p</em> = 0.04), but not ∆SAQ (<em>r</em> = 0.03, <em>p</em> = 0.80) on ranolazine. There was no relation with NT-proBNP.</div></div><div><h3>Conclusions</h3><div>These findings suggest that higher u-hs-TnI signals greater ischemia improvement on ranolazine. Further studies evaluating ischemia therapies in CMD are needed to develop potential HFpEF prevention targets.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"52 ","pages":"Article 100513"},"PeriodicalIF":1.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and epidemiological profile of infective endocarditis in Chile - A systematic review of descriptive analysis","authors":"César Del Castillo ,&nbsp;Alicia Tapia ,&nbsp;Arnulfo Begazo ,&nbsp;Miguel Oyonarte","doi":"10.1016/j.ahjo.2025.100511","DOIUrl":"10.1016/j.ahjo.2025.100511","url":null,"abstract":"<div><h3>Background</h3><div>Infective endocarditis (IE) is still a complex disease despite advances in modern medicine, with diverse epidemiology and clinical manifestation, and poor prognosis. Several recommendations have recently been published but it is uncertain if they can be extrapolated to every country.</div></div><div><h3>Objectives</h3><div>To describe our national clinical and epidemiological profile on IE.</div></div><div><h3>Methodology</h3><div>A systematic search through PubMed, Scielo, and abstracts book of Chilean Congress since 2012. Studies assessing adult patients with IE from Chile reporting information related to epidemiology, clinical manifestation, treatment, and complications have also been consulted.</div></div><div><h3>Results</h3><div>Ten registries were included. The mean age was 53.9-year-old, and most cases were male (64 %) with arterial hypertension (42 %). Most cases were from the central and southern zones of Chile. The most frequent clinical symptoms were fever and heart failure, with acute presentation (63.5 %), aortic valve (72.2 %), and native valve involvement (83.7 %). Predominantly, it was medical treatment over surgical treatment (57.7 versus 42.3 %), with main surgical indications due to local cardiac complications (66 %) and heart failure related (65.9 %). Complications included mechanical valve damage in 24.7 %, and embolism in 27.7 %. Staphylococcus sp. (28 %) was the predominant microorganism, particularly <em>Staphylococcus aureus</em>, and negative microbiological studies were seen in 34 %. In-hospital mortality was 24.8 %, whereas global mortality was 33.3 %.</div></div><div><h3>Conclusion</h3><div>This systematic review highlights epidemiological and clinical aspects of IE across Chile, such as acute presentation, predominance of aortic valve involvement, and <em>S. aureus</em> infection. However, there is a lack of prospective registries, therefore reflecting the need to collect richer information.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"52 ","pages":"Article 100511"},"PeriodicalIF":1.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a first of a kind robotic radiation protection technology to reduce scatter exposure during diagnostic procedures and percutaneous coronary interventions","authors":"Wojciech E. Krzyzanowski,&nbsp;Pawel Radecki,&nbsp;Marta K. Szczerbińska,&nbsp;Kamil Dawidczyk,&nbsp;Mikołaj Kosek,&nbsp;Krzysztof Romanik,&nbsp;Wojciech Suchcicki,&nbsp;Dariusz Karwowski,&nbsp;Paweł R. Natkowski","doi":"10.1016/j.ahjo.2025.100512","DOIUrl":"10.1016/j.ahjo.2025.100512","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the effectiveness of the Radiaction system in providing comprehensive protection to medical personnel during fluoroscopy-guided procedures in an Interventional Cardiology (IC) laboratory. The system confines the imaging beam and blocks scatter radiation at its source, enhancing safety for the Cath lab staff.</div></div><div><h3>Methods</h3><div>A prospective, non-randomized, controlled study compared real-time procedures with and without Radiaction. Sensors were placed around the room and on the main physician to measure radiation exposure during 82 diagnostic and 24 interventional cases without the Radiaction system and 65 diagnostic and 39 interventional cases with Radiaction.</div></div><div><h3>Results</h3><div>Results demonstrated a significant reduction in radiation exposure with the Radiaction system. Across all cases, the overall reduction in radiation was 74.7 % for all sensor locations and 82.9 % for the main physician. Diagnostic procedures exhibited a reduction of 73 % with the Radiaction system and Interventional procedures demonstrated a 79 % reduction across all sensors with the Radiaction system. Calculations were conducted to estimate the reduction during the time that the system was deployed, revealing an 85.7 % reduction across all sensors and 95.1 % for the main physician, reflecting the full potential of the system when used during 100 % of the X-ray time. Users expressed high satisfaction with the system, citing its user-friendly nature, and seamless integration into clinical workflow.</div></div><div><h3>Conclusions</h3><div>The Radiaction system significantly reduced radiation exposure in all cases compared to cases conducted without Radiaction. These findings support the potential of the Radiaction system to offer full-body protection from scattered radiation to all medical personnel in the IC suite, emphasizing its value in enhancing occupational safety in medical environments.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"52 ","pages":"Article 100512"},"PeriodicalIF":1.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of climate change and the environment on cardiovascular health and role of healthcare","authors":"Anastasia S. Mihailidou ,&nbsp;Martha Gulati","doi":"10.1016/j.ahjo.2025.100510","DOIUrl":"10.1016/j.ahjo.2025.100510","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"52 ","pages":"Article 100510"},"PeriodicalIF":1.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The formation of cholesterol crystals and embolization during myocardial infarction","authors":"Jamal Mughal ,&nbsp;Venkat R. Katkoori ,&nbsp;Stefan Mark Nidorf ,&nbsp;Megan Manu ,&nbsp;George S. Abela","doi":"10.1016/j.ahjo.2025.100509","DOIUrl":"10.1016/j.ahjo.2025.100509","url":null,"abstract":"<div><div>Cholesterol crystals (CCs) released into the coronary circulation during plaque rupture have multiple adverse impacts on both the arterial conduit as well as the myocardium. CCs form within the atheromatous plaque by the saturation of free cholesterol deposition via facilitated LDL-c entry because of a dysfunctional endothelium. Once formed, CCs are viewed as a foreign body and activate inflammation via the innate immune system. Eventually, an inflamed atheromatous plaque ruptures by virtue of the growth and expansion of CCs that begin to occupy a greater volume than the liquid phase cholesterol. In some instances, the sharp edges of CCs can puncture and tear the plaque's fibrous cap causing rupture leading to thrombosis and myocardial infarction. In these circumstances, CCs are released from the ruptured plaque and travel down the coronary artery where they can scrape the endothelial lining which enhances vasospastic activity, further worsening ischemia. Moreover, when CCs lodge in the distal arteriolar and capillary beds, they not only obstruct blood flow to further aggravate ischemia but also activate an inflammatory response in the myocardium that leads to further tissue injury. Treatment of CCs has thus far been limited but studies using statins, aspirin and colchicine have demonstrated them to be effective in dissolving CCs that may provide additional benefits for both prevention and potentially for acute cardiovascular events.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"51 ","pages":"Article 100509"},"PeriodicalIF":1.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the quality of care for heart failure hospitalizations in inflammatory arthritis – A population-based cohort study","authors":"Bindee Kuriya ,&nbsp;Lihi Eder ,&nbsp;Sahil Koppikar ,&nbsp;Jessica Widdifield ,&nbsp;Anna Chu ,&nbsp;Jiming Fang ,&nbsp;Irene Jeong ,&nbsp;Douglas Lee ,&nbsp;Jacob Udell","doi":"10.1016/j.ahjo.2025.100503","DOIUrl":"10.1016/j.ahjo.2025.100503","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with inflammatory arthritis (IA) face an elevated risk of heart failure (HF). However, whether the quality of HF care in IA patients differs from other high-risk groups, such as those with diabetes mellitus (DM), remains unclear.</div></div><div><h3>Methods</h3><div>This population-based cohort study in Ontario, Canada, included patients who experienced their first HF hospitalization and survived to discharge. Patients were categorized into four groups: IA alone, DM alone, IA + DM, and a general population comparator. We assessed quality care measures within 30 days of hospitalization (echocardiogram, electrocardiogram, chest x-ray) and physician follow-up within 7 days. Guideline-directed medical therapy (GDMT) adherence was evaluated within 90 days and classified as perfect, moderate, or poor. Logistic regression was used to determine whether IA was independently associated with lower HF care quality.</div></div><div><h3>Results</h3><div>Among 101,645 eligible hospitalizations, 1987 had IA + DM, 3849 had IA alone, 33,553 had DM alone, and 62,256 were general comparators. While all groups showed high adherence to testing, IA patients (with or without DM) had significantly lower GDMT use compared to DM patients (<em>p</em> &lt; 0.001). IA was independently linked to lower odds of moderate or perfect GDMT adherence.</div></div><div><h3>Conclusion</h3><div>Although adherence to HF testing quality measures was high, IA patients were less likely to receive GDMT than those with DM. Further research is needed to understand the reasons for lower GDMT use in IA and its impact on HF outcomes such as re-hospitalization and mortality.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"51 ","pages":"Article 100503"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock: A systematic review and meta-analysis","authors":"Tanawat Attachaipanich ,&nbsp;Suthinee Attachaipanich ,&nbsp;Kotchakorn Kaewboot","doi":"10.1016/j.ahjo.2025.100506","DOIUrl":"10.1016/j.ahjo.2025.100506","url":null,"abstract":"<div><h3>Background</h3><div>Acute myocardial infarction (AMI) complicated by cardiogenic shock has a high mortality rate. Mechanical circulatory support (MCS) has been increasingly used; however, the optimal timing for MCS insertion remains uncertain. This study aimed to evaluate outcomes of pre-percutaneous coronary intervention (PCI) vs post-PCI MCS insertion in AMI patients with cardiogenic shock.</div></div><div><h3>Methods</h3><div>A systematic search using 4 databases, including PubMed, Embase, Web of Science, and Cochrane CENTRAL, was conducted from inception to October 25, 2024. Studies comparing outcomes of MCS insertion pre-PCI vs post-PCI in this setting were included.</div></div><div><h3>Results</h3><div>There were 36 studies with a total of 6218 participants were included in this meta-analysis, using a random-effects model. Most of the included studies were non-randomized and retrospective. Early MCS insertion (prior to PCI) was associated with a lower risk of in-hospital mortality compared to late insertion (post-PCI), with an odds ratio (OR) of 0.46 (95%CI 0.36 to 0.57), <em>p</em> &lt; 0.01. Subgroup analysis by MCS type (IABP, Impella, and ECMO) demonstrated that early insertion prior to PCI significantly reduced in-hospital mortality, regardless of the MCS type. Early MCS insertion prior to PCI was also associated with lower 30-day mortality (OR 0.62, (95%CI 0.43 to 0.89), <em>p</em> = 0.01) and 6-month mortality (OR 0.53, (95%CI 0.34 to 0.83), p = 0.01) compared to late insertion. There was no difference in 1-year mortality or in MCS-related complications.</div></div><div><h3>Conclusions</h3><div>Early MCS insertion prior to PCI is potentially associated with reduced in-hospital, 30-day, and 6-month mortality compared to post-PCI insertion in AMI patients with cardiogenic shock.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"50 ","pages":"Article 100506"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein C deficiency with recurrent systemic thrombosis associated with compound heterozygous PROC missense variants","authors":"Mikio Shiba ,&nbsp;Shuichiro Higo ,&nbsp;Yu Morishita ,&nbsp;Yasuhiro Ichibori ,&nbsp;Yoshihiro Kin ,&nbsp;Yasushi Sakata ,&nbsp;Yoshiharu Higuchi","doi":"10.1016/j.ahjo.2024.100496","DOIUrl":"10.1016/j.ahjo.2024.100496","url":null,"abstract":"<div><div>Herein, we identified compound heterozygous <em>PROC</em> missense variants in a protein C deficient patient with recurrent thrombotic events, including intestinal necrosis, extrahepatic portal vein obstruction, and lower limb venous thrombosis. The patient's protein C activity and antigen levels were extremely low (&lt;10 % and 5 %, respectively). Exome sequencing analysis revealed two rare missense variants (c.76G&gt;A:p.Val26Met in exon 3 and c.1000G&gt;A:p.Gly334Ser in exon 9), both confirmed to be associated with protein C deficiency and one synonymous variant (c.423G&gt;T:p.Ser141Ser in exon 6) in <em>PROC</em>. PCR amplification of genomic DNA spanning these exons followed by Sanger sequencing analysis revealed that the c.76G&gt;A and the synonymous c.423G&gt;T variants were in the same allele, whereas the c.1000G&gt;A variant was on the opposite allele, indicating compound heterozygosity. Western blot analysis of Huh-7 and HEK293T cells transfected with expression vectors encoding <em>PROC</em> with or without these variants demonstrated that Gly334Ser-PROC expression levels were significantly decreased in culture media collected from HEK293T cells, while the expression levels of protein C with these variants were not significantly altered in cell lysates. This suggests that these variants may affect both protein activity and the secretory process of protein C.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"50 ","pages":"Article 100496"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study","authors":"Matthew Cheung ,&nbsp;Nathaniel Moulson ,&nbsp;Jinelle C. Gelinas ,&nbsp;Ali Daraei ,&nbsp;Sarah M. Bradwell ,&nbsp;Carolyn Taylor ,&nbsp;Neil D. Eves ,&nbsp;Graeme J. Koelwyn ,&nbsp;Thomas M. Roston","doi":"10.1016/j.ahjo.2025.100501","DOIUrl":"10.1016/j.ahjo.2025.100501","url":null,"abstract":"<div><h3>Study objective</h3><div>Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disorder increasingly characterized by concomitant metabolic syndrome. Cardiac rehabilitation (CR) has been shown to improve metabolic parameters in populations with heart failure and myocardial infarction. However, there is a paucity of data on the impact of CR in the HCM population with metabolic syndrome. We designed the REHAB-HCM study to explore the feasibility, safety, and efficacy of CR in HCM patients with metabolic syndrome.</div></div><div><h3>Design</h3><div>Prospective observation cohort study.</div></div><div><h3>Setting</h3><div>A multi-disciplinary HCM clinic and Multidisciplinary Exercise-based Cardiac Rehabilitation program.</div></div><div><h3>Participants</h3><div>Patients aged 18–80 years old diagnosed with HCM and metabolic syndrome, defined by the American Heart Association and American College of Cardiology guidelines, and the National Cholesterol Education Adult Treatment Panel III (NCEP-ATP III) criteria.</div></div><div><h3>Intervention</h3><div>A structured 3-month CR program with 6 months extended follow-up of physical activity levels.</div></div><div><h3>Main outcome measures</h3><div>Feasibility (e.g., attendance), safety (e.g., major adverse events and exercise-related harms), and efficacy pertaining to long term improvements in physical activity levels, metabolic health, cardiorespiratory fitness, quality of life, and systemic and cellular markers of inflammation.</div></div><div><h3>Conclusion</h3><div>This prospective cohort study will address an important knowledge gap by evaluating the effect of an organized CR program in HCM patients and metabolic syndrome. It is anticipated that exercise and CR will be feasible and beneficial for this complex patient population without significant exercise-related harms.</div></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"50 ","pages":"Article 100501"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultivating a thriving environment for women in cardiology through leadership and inclusion","authors":"Renée P. Bullock-Palmer ,&nbsp;Martha Gulati ,&nbsp;Gina Lundberg ,&nbsp;Monika Sanghavi ,&nbsp;Odayme Quesada ,&nbsp;Nosheen Reza ,&nbsp;Julia Grapsa ,&nbsp;Jessica Lee ,&nbsp;Annabelle Santos Volgman ,&nbsp;Laxmi Mehta ,&nbsp;Sandra J. Lewis ,&nbsp;Kamala P. Tamirisa","doi":"10.1016/j.ahjo.2025.100500","DOIUrl":"10.1016/j.ahjo.2025.100500","url":null,"abstract":"","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"50 ","pages":"Article 100500"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143223676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}