Aesthetic surgery journal. Open forum最新文献

{"title":"Enhancing Autologous Fat Graft Retention: The Impact of Inactive Vitamin D3 on Immune Modulation and Extracellular Matrix Remodeling in a Swine Model.","authors":"Rebecca Hohsfield, Amr Elmeanawy, Alexandra M Vagonis, Rachel E Ricketts, Andreea Gavrilescu, Yusuf Surucu, Wayne Vincent Nerone, Jose Antonio Arellano, Hamid Malekzadeh, Fuat Baris Bengur, Yadira Villalvazo, Shengyang Jin, Bahaa Shaaban, Shawn J Loder, Jeff Gusenoff, Lauren E Kokai","doi":"10.1093/asjof/ojag076","DOIUrl":"10.1093/asjof/ojag076","url":null,"abstract":"<p><p>Autologous fat grafting (AFG) is a widely utilized surgical technique, but graft survival rates remain inconsistent and unpredictable. The aim of this study was to evaluate the efficacy of oral vitamin D3 (VD3) on long-term AFG retention in a porcine model and examine its mechanisms. Inguinally harvested adipose tissue from 3 female Yucatán pigs was autologously grafted into 16 dorsal sites (5 cc per graft). Pig 1 received no treatment; Pig 2 received oral VD3 (100 K IU) thrice weekly postoperatively; Pig 3 received oral VD3 (100 K IU) thrice weekly for 2 weeks preoperatively and continuously postoperatively. Pigs were sacrificed at 3 months. Grafts were extracted and evaluated for histological, volumetric, and molecular changes. Hematoxylin and eosin, Sirius red, immunohistochemistry (IHC), and quantitative polymerase chain reaction tests were performed. VD3 improved AFG volume retention at 3 months (<i>P</i> = .01). VD3 enhanced adipocyte viability and vascular migration into the graft core, measured by perilipin⁺ (<i>P</i> = .003) and CD31⁺ (<i>P</i> = .003) IHC, respectively. VD3-treated grafts showed a decrease in pro-inflammatory cytokine tumor necrosis factor-α expression compared with the control (<i>P</i> = .0005) and an increase in pro-regenerative M2 macrophages (<i>P</i> = .002). VD3 increased graft extracellular matrix (ECM) composition (<i>P</i> = .03) and Collagen III (<i>P</i> = .001). No significant differences were observed in fibrosis markers (transforming growth factor beta and Collagen I) or adiposity biomarkers (adipocyte count and adiponectin). In this pilot study, oral VD3 significantly increased fat graft retention, likely through modulation of inflammation, enhanced ECM remodeling, and improved vascular migration into the graft core. These findings support the potential of VD3 to improve AFG outcomes in large animal models. <b>Level of Evidence: 5 (Therapeutic)</b>  For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag076"},"PeriodicalIF":1.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stepwise Evaluation of Nasal Breathing After Functional Rhinofiller: A Prospective Peak Nasal Inspiratory Flow-Based Study.","authors":"Matteo Basso, Emanuela Di Lella, Manuele Casale, Simone Di Giovanni, Giovanni Cristalli, Francesco Marchetti","doi":"10.1093/asjof/ojag168","DOIUrl":"https://doi.org/10.1093/asjof/ojag168","url":null,"abstract":"<p><strong>Background: </strong>Nonsurgical rhinoplasty with hyaluronic acid (HA) fillers is widely used for aesthetic nasal correction; however, its potential impact on nasal respiratory function remains underexplored. Structural alterations of the nasal tip and columella may influence the external nasal valve and nasal airflow dynamics.</p><p><strong>Objectives: </strong>To prospectively evaluate the functional effects of a two-step HA rhinofiller technique on nasal breathing using objective and subjective assessment tools, and to determine the individual contribution of columellar and nasal tip augmentation.</p><p><strong>Methods: </strong>Nine adult female patients with functional nasal breathing impairment related to reduced tip support underwent a standardized two-step rhinofiller procedure. Nine adult female patients seeking nonsurgical rhinofiller treatment for aesthetic nasal concerns, with concomitant varying degrees of subjective nasal obstruction, underwent a standardized two-step rhinofiller procedure. Sequential HA injections were performed at the columella and nasal tip. Objective nasal airflow was measured using peak nasal inspiratory flow (PNIF) at baseline, after the first injection, and after the second injection. Subjective breathing quality was assessed using a visual analog scale (VAS) at baseline, at 10 days, and at 60 days.</p><p><strong>Results: </strong>Mean PNIF increased significantly after columellar injection (+17.7%) and showed a further significant improvement following nasal tip augmentation (+5.4%), resulting in an overall PNIF increase of 24.0% compared with baseline. Subjective VAS scores improved significantly at 10 days and remained significantly higher than baseline at 60 days. No complications were observed.</p><p><strong>Conclusions: </strong>A targeted two-step functional rhinofiller protocol using HA can significantly improve nasal airflow and patient-perceived breathing quality. Columellar augmentation appears to provide the greatest functional benefit, supporting the concept of rhinofiller as a minimally invasive functional intervention in selected patients.</p><p><strong>Level of evidence 2 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag168"},"PeriodicalIF":1.9,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Glucagon-Like Peptide-1 Receptor Agonist-Induced Nutritional Deficiencies on Skin Health: A Narrative Review With a Proposed Framework for the Aesthetic Practitioner.","authors":"Justin Karlin, Zhaoping Li, Kami Parsa","doi":"10.1093/asjof/ojag169","DOIUrl":"https://doi.org/10.1093/asjof/ojag169","url":null,"abstract":"<p><p>Semaglutide and tirzepatide have reshaped obesity care, and aesthetic practitioners increasingly encounter patients with rapid-weight-loss-associated facial volume loss and skin changes. Nutritional deficiency may be an underrecognized contributor to impaired dermal repair during glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy. The authors reviewed and synthesized evidence across metabolic pharmacology, facial anatomy and aesthetics, dermatologic histology, and clinical nutrition. PubMed, Embase, and the Cochrane Library were searched from January 2019 to March 2026, supplemented by foundational studies in collagen biology and post-weight-loss skin histology. GLP-1RA-mediated caloric restriction can reduce intake of micronutrient cofactors required for collagen biosynthesis and wound repair. Vitamin D deficiency reaches 13.6% at 12 months, and ∼22.4% of patients have at least one documented deficiency within 1 year. Deficiencies in vitamin D, iron, vitamin B12, folate, zinc, copper, and protein may plausibly compound rapid fat-compartment depletion and collagen remodeling. Direct GLP-1RA effects on dermal cells remain preclinical and should be interpreted cautiously. In summary, GLP-1RA-associated facial aging changes are multifactorial. The authors propose a risk-stratified framework for aesthetic practitioners emphasizing dietary optimization, selective supplementation, targeted laboratory assessment in at-risk patients, coordination with prescribing clinicians, and procedural timing when nutritional status is optimized. Prospective studies are needed to determine whether correcting deficiencies improves aesthetic or surgical outcomes. <b>Level of Evidence:</b> 5 (Therapeutic) For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag169"},"PeriodicalIF":1.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facelift Under Local Anesthesia: A Retrospective Single-Center Series of 117 Patients Undergoing Deep Plane, High SMAS, and Coronal Rhytidectomy.","authors":"Mariagiovanna Lombardi, Martina Ponzo, Eric Santamaria, Fibian Chaterinee Luna Aguilar, Francesco D'Andrea, Humberto Gustavo Martìnez, Luis Raùl Cajamarca Bermeo, Jesus Carlos Ceballos Villalva, Nicolàs Ricardo Brito, Pier Paolo Perrella, Ludovica De Gregorio, Daniela Guerrero Salazar, Lida Mendoza Andrade, Enrique Chávez Serna","doi":"10.1093/asjof/ojag166","DOIUrl":"https://doi.org/10.1093/asjof/ojag166","url":null,"abstract":"<p><strong>Background: </strong>Facelift surgery is increasingly performed in an outpatient setting, and local anesthesia with minimal sedation may reduce the anesthesiologic burden while preserving patient cooperation. However, the safety of local-anesthesia pathways for procedures of varying extent, including deep plane rhytidectomy, high SMAS facelift, and coronal rhytidectomy, remains incompletely characterized.</p><p><strong>Objectives: </strong>To evaluate the feasibility and early safety of a standardized local-anesthesia pathway in a single-center retrospective series of primary aesthetic cervicofacial lifting procedures and to contextualize the findings within the existing literature on awake facial rejuvenation.</p><p><strong>Methods: </strong>A retrospective analysis was conducted of consecutive primary aesthetic facelifts performed under local anesthesia between March 6, 2024, and January 14, 2026.</p><p><strong>Results: </strong>Overall, 117 procedures were included: 90 deep plane facelifts, 6 high superficial musculoaponeurotic system (SMAS) facelifts, and 21 coronal rhytidectomies. The cohort included 110 women (94.0%) and 7 men (6.0%), with a mean age of 56.53 ± 7.92 years and a mean BMI of 24.6 ± 3.1 kg/m². Concomitant procedures were performed in 16 patients (13.7%). The mean operative time was 5.0 ± 0.6 hours (range, 3.5-8.0 hours). No case required conversion to general anesthesia or early termination. Six complications were documented (6/117, 5.13%), all occurring in the deep plane subgroup (6/90, 6.7%).</p><p><strong>Conclusions: </strong>In selected patients, primary facelift surgery under local anesthesia appears feasible across a broad spectrum of cervicofacial lifting techniques when performed within a structured pathway including preoperative screening, standardized infiltration, maintenance of verbal responsiveness, and careful hemodynamic monitoring. Patient selection, procedural predictability, and proactive control of anxiety, pain, blood pressure, and nausea/vomiting are likely more important than any single anesthetic formula.</p><p><strong>Level of evidence 4 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag166"},"PeriodicalIF":1.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Aesthetic Rectus Diastasis Repair: The Minimally Invasive Robotic Endoscopic Lipoabdominoplasty Technique.","authors":"Alexandre Sanfurgo de Carvalho","doi":"10.1093/asjof/ojag164","DOIUrl":"https://doi.org/10.1093/asjof/ojag164","url":null,"abstract":"<p><strong>Background: </strong>Rectus diastasis is a prevalent condition associated with functional impairment and aesthetic deformity. Although minimally invasive techniques have emerged, they remain limited by technical constraints and incomplete integration with body contouring procedures.</p><p><strong>Objectives: </strong>The aim of this study was to report the clinical experience of the authors with the Minimally Invasive Robotic Endoscopic Lipoabdominoplasty (MIRELA) technique for rectus diastasis repair and abdominal contouring.</p><p><strong>Methods: </strong>A retrospective descriptive study was conducted including 55 female patients who underwent MIRELA between 2023 and 2025. After loss to follow-up, 53 patients were included in the final analysis. The procedure combined VASER-assisted liposculpture with robotic-assisted extraperitoneal rectus plication using the da Vinci Xi system. Demographic characteristics, perioperative variables, postoperative complications, reinterventions, and hospital readmissions were evaluated. Continuous variables were reported as mean ± standard deviation, and categorical variables as frequencies and percentages.</p><p><strong>Results: </strong>The mean age was 39.4 ± 5.1 years, and the mean follow-up was 6 months, ranging from 4 to 9 months. Mean BMI was 21.9 ± 3.4 kg/m²; among patients with available BMI category data, 89.8% were classified within the normal weight range. Mean rectus diastasis width was 3.22 ± 0.95 cm, with 66.0% of patients presenting a diastasis ≥3 cm. Concomitant umbilical hernia was present in 75.5% of cases. All procedures were completed under general anesthesia, with a mean operative time of 190.0 ± 6.1 min. No intraoperative or postoperative complications, reinterventions, or hospital readmissions were observed.</p><p><strong>Conclusions: </strong>MIRELA is a feasible and reproducible technique that integrates robotic-assisted precision with minimally invasive aesthetic surgery principles. It represents a promising option for a very selected group of patients with minimal-to-moderate rectus diastasis and no excess skin requiring cutaneous excision. Further studies with longer follow-up are required.</p><p><strong>Level of evidence 4 therapeutic: </strong>For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag164"},"PeriodicalIF":1.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazil HARMONY: Improved Satisfaction With Facial Appearance and Psychosocial and Social Well-Being Following Combined Facial Aesthetic Treatment.","authors":"Ada Trindade de Almeida, Lilia Ramos Dos Santos Guadanhim, Ediléia Bagatin, Vivian Barzi Loureiro, Fabiana Wanick, Bruna Felix Bravo, Raquel de Melo Carvalho, Leticia Oba Galvão, Régia Patriota, Graeme Kerson, Shirley Chung, Camila Cazerta de Paula Eduardo","doi":"10.1093/asjof/ojag159","DOIUrl":"10.1093/asjof/ojag159","url":null,"abstract":"<p><strong>Background: </strong>Multimodal facial aesthetic treatment has potential benefits that extend beyond facial enhancements.</p><p><strong>Objectives: </strong>The aim of this study was to assess satisfaction with improvement in facial appearance and quantify the psychological, social, and emotional impact of comprehensive, multimodal, full-face aesthetic injectable treatment.</p><p><strong>Methods: </strong>In this prospective, open-label, multisite study, participants (<i>n</i> = 64) sequentially received a combination of a hybrid injectable containing hyaluronic acid (HA) plus calcium hydroxyapatite, HA injectables, and onabotulinumtoxinA over 5 months. The primary efficacy endpoint was change in FACE-Q Satisfaction with Facial Appearance Overall scale score. Secondary endpoints included the following assessments: FACE-Q Aging Appraisal, Psychological Function, Social Function, and Satisfaction with Skin; Global Aesthetic Improvement Scale (GAIS); Periorbital Aesthetic Appearance Questionnaire (PAAQ); and participant self-perception of facial age. Outcomes were measured as change in score from baseline to final visit.</p><p><strong>Results: </strong>Participants demonstrated significant improvement on the FACE-Q Satisfaction with Facial Appearance Overall scale (mean score increase = 46.6; <i>P</i> < .0001). In secondary efficacy analyses, significant improvement was observed on FACE-Q Psychological Function, Social Function, Aging Appraisal, and Satisfaction with Skin scales (<i>P</i> < .0001) and PAAQ (<i>P</i> < .0001). All investigators and participants noted improvement in facial appearance on the GAIS. A majority (85.5%) of participants reported improvement in age-related facial appearance. Most participants documented mild or moderate injection-site reactions (ISRs), and mean ISR durations ranged from 1.0 to 14.5 days.</p><p><strong>Conclusions: </strong>The Brazil HARMONY study provides further support that a combination of HA injectables, biostimulators, and neuromodulators leads to significant improvements in participant satisfaction and psychological and social well-being on validated patient-reported outcome scales.</p><p><strong>Level of evidence 4 therapeutic: </strong></p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag159"},"PeriodicalIF":1.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13603039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Tariq to \"Association Between Proton Pump Inhibitor Use and Short-term Postoperative Complications Following Abdominoplasty: A Multi-Institutional Cohort Study\" by Wolf et al.","authors":"Muhammad Ifrahim Tariq","doi":"10.1093/asjof/ojag170","DOIUrl":"https://doi.org/10.1093/asjof/ojag170","url":null,"abstract":"","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag170"},"PeriodicalIF":1.9,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Salvage Protocol for the Treatment of Severe Postrhinoplasty Nasal Vestibular Stenosis: A Case Report.","authors":"Than Trong Huy Hoang, Quoc Khanh Pham Trinh, Nguyen Hoang Nhan, Lam Hoang Phuong, Bui Cao Vinh, Duong Cong Dien","doi":"10.1093/asjof/ojag158","DOIUrl":"10.1093/asjof/ojag158","url":null,"abstract":"<p><p>Severe nasal vestibular stenosis is an increasingly recognized iatrogenic complication of cosmetic rhinoplasty. Multiply-revised cases are particularly difficult to manage because previous procedures may compromise the vestibular microcirculation, whereas prolonged stenting alone risks ischemic restenosis. We describe an individualized, staged multimodal salvage approach and illustrate it in a single patient. Stage 1 reopened the obstructed vestibule with scar excision, a local skin flap, and a custom stent, followed by ∼3 months of cold atmospheric plasma (CAP) and monthly intralesional platelet-rich plasma (PRP) intended to condition the scar bed and improve tissue pliability. Stage 2 provided definitive aesthetic reconstruction tailored to the anatomical defects, supported by a 12-month adjunctive regimen of tapered nasal stenting, peri-incisional PRP, a CAP cycle alternating antimicrobial and wound-healing modes, and intralesional triamcinolone acetonide at escalating concentrations (5-40 mg/mL). The patient was a 27-year-old woman with bilateral vestibular stenosis and complete left nostril obstruction after 15 previous nasal procedures. After Stage 1, bilateral airflow was clinically improved and the vestibular tissue was softer and better perfused on examination at 3 months. Stage 2 employed a philtral advancement flap, costal and auricular cartilage grafts, and a buccal mucosal graft. At more than 3 years, nasal airflow and aesthetic contour remained stable on clinical assessment, with no recurrence of stenosis and no further stenting. This single case suggests that a staged surgical strategy combined with a structured biologic and stenting regimen may be a useful salvage option; further cases and objective functional assessment are required to confirm its value. <b>Level of Evidence</b>: 4 (Therapeutic).</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag158"},"PeriodicalIF":1.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13604826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Assessment of Systematic Reviews on Gluteal Augmentation Using a Measurement Tool to Assess Systematic Reviews (AMSTAR-2).","authors":"Elisa Bertulla, Edoardo Raposio","doi":"10.1093/asjof/ojag162","DOIUrl":"https://doi.org/10.1093/asjof/ojag162","url":null,"abstract":"<p><p>Gluteal augmentation has become increasingly popular in aesthetic surgery, with fat grafting, implants, and fillers as the main techniques. This study aims to assess the methodological rigor of available reviews using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR-2) and to explore associations with publication characteristics, including citations, journal impact factor, year of publication, and PRISMA adherence. A systematic literature search of PubMed, Scopus, and the Cochrane Library was performed. Two authors independently screened studies and extracted data. Methodological quality was assessed with AMSTAR-2. Correlations between AMSTAR scores and publication features were evaluated using Spearman's rank correlation, and differences by PRISMA adherence were tested with the Mann-Whitney <i>U</i> test. Interrater reliability was assessed with Cohen's kappa. Thirteen systematic reviews were included. Most focused on safety and complication rates of fat grafting vs implants. According to AMSTAR-2, 11 reviews were rated \"critically low\" and 2 \"low.\" Spearman correlations indicated a moderate positive association between AMSTAR score and year of publication (<i>r</i> = 0.46) and a weak-to-moderate association with the number of included studies (<i>r</i> = 0.39). No significant associations were observed with journal impact factor or citation count. PRISMA adherence was reported in 69% of reviews but did not significantly affect AMSTAR scores (<i>P</i> = .536). Although systematic reviews on gluteal augmentation are increasing, their methodological quality remains largely low. Future reviews should implement prospectively registered protocols, comprehensive search strategies, and rigorous risk-of-bias assessment to provide reliable guidance for clinical practice. <b>Level of Evidence:</b> 3 (Therapeutic) For image description, please refer to the figure legend and surrounding text.</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag162"},"PeriodicalIF":1.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Histological Tissue Responses Following Fractional Nonablative 1470 nm Laser Exposure: A Pilot In Vivo Human Study.","authors":"Paweł Kubik, Wojciech Gruszczyński, Aleksandra Pawłowska, Maciej Malinowski, Maria-Luiza Piesiaków, Brygida Baran, Agnieszka Pawłowska-Kubik, Łukasz Kodłubański, Dariusz Grzanka, Paulina Antosik, Bartłomiej Łukasik","doi":"10.1093/asjof/ojag161","DOIUrl":"https://doi.org/10.1093/asjof/ojag161","url":null,"abstract":"<p><p>Fractional nonablative lasers enable controlled dermal heating while preserving epidermal integrity. The 1470 nm wavelength shows strong water absorption and moderate penetration, but in vivo human histological data on early tissue responses remain limited. The aim of this report was to characterize early, time-dependent histological responses and assess short-term histologic tolerability of a fractional 1470 nm laser (LaserMe). Eighteen healthy adults were enrolled and allocated to 6 treatment groups according to energy setting and spot spacing. For the present analysis, only samples treated at 28 and 50 mJ/point were included, because the 5 mJ/point setting produced no measurable histological response. Clinical assessment and full-thickness skin biopsies were performed at baseline, immediately after treatment, and on Days 3 and 10. Histology was evaluated using hematoxylin-eosin and Masson's trichrome staining. Treatment produced spatially confined micro-injury zones with the preservation of surrounding tissue. Immediately posttreatment, localized changes were observed at the dermal-epidermal junction with minimal epidermal involvement. By Day 3, re-epithelialization and basement membrane restoration were evident. By Day 10, epidermal continuity was fully restored, with reduced dermal thermal alteration and mild inflammatory infiltrates consistent with reparative processes. Higher energy increased dermal penetration without extending superficial epidermal damage. Fractional 1470 nm laser exposure induces a predictable, localized histological response consistent with possible early tissue remodeling and suggests favorable short-term histologic tolerability in healthy adult skin. This exploratory preliminary report provides mechanistic insight into nonablative laser-tissue interactions and was not designed to assess clinical efficacy or long-term safety. <b>Level of Evidence:</b> 4 (Therapeutic).</p>","PeriodicalId":72118,"journal":{"name":"Aesthetic surgery journal. Open forum","volume":"8 ","pages":"ojag161"},"PeriodicalIF":1.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}